Articles tagged with Basal Ganglia Disease
Research links oral bacteria to Parkinson's disease via the gut-brain axis, finding Streptococcus mutans produces metabolite imidazole propionate that contributes to disease progression. Targeting the oral-gut microbiome may offer a new therapeutic approach for Parkinson's treatment.
Researchers used machine learning to detect subtle behavioral changes in mouse models of Parkinson's disease, revealing that high-speed movements are the first affected behaviors. Levodopa treatment improves movement speed but not other attributes of these movements.
Researchers discovered that as birds age, their song gene networks change dramatically, with hub genes driving activity of other genes. This finding could lead to earlier diagnoses and better treatments for Parkinson's disease and Alzheimer's disease.
A global study analyzed brain images of over 2,500 people with Parkinson's disease to identify patterns of neurodegeneration and create metrics for each clinical stage. The research could lead to better diagnostic tools and enable new treatments to be tested and monitored.
A new study reveals that patients with Parkinson's disease who exhibit rest tremor have more dopamine preserved in the caudate nucleus, a part of the brain important for movement planning and cognition. This challenges traditional understanding of how dopamine loss relates to PD symptoms.
In Parkinson's disease, the cerebral cortex compensates for lost dopamine cells by taking over tasks, which determines symptom severity. Exercise can stimulate this compensation and slow down disease progression.
Regular aerobic exercise has been shown to strengthen brain networks between spared regions, improve grey-matter volume, and enhance movement control in individuals with Parkinson's disease. The study published in Annals of Neurology suggests that exercise can stimulate compensatory capacity in the brain, leading to reduced symptoms.
Impaired information flow through the basal ganglia is responsible for Parkinson's disease symptoms. The 'direct pathway' plays a crucial role in initiating voluntary movements, and its disturbance leads to motor symptoms like trembling hands and muscle stiffness.
Researchers found that the direct and indirect pathways in the basal ganglia play a crucial role in controlling actions, with the direct pathway sustaining action and the indirect pathway allowing switching between actions. This new model could have therapeutic implications for treating diseases like OCD and ADHD.
Researchers used non-invasive brain-imaging tool to detect pathways connecting basal ganglia regions, improving understanding of circuitry. The breakthrough could lead to technologies to track disease progression for Parkinson's and other neurological disorders.
Researchers engineered mice lacking a gene involved in iron metabolism and found progressive brain deterioration similar to Parkinson's Disease and Multiple System Atrophy. Iron deposits in key areas of the brain suggest a causative role for iron in these disorders.
Researchers found that low-level manganese exposure accelerates Parkinson's symptoms in rats with pre-Parkinsonism, highlighting the need for further studies on toxic substance effects. Manganese toxicity targets different brain regions, exacerbating neurodegenerative diseases like Parkinson's.
Hopkins researchers identified a dysfunction in HD that affects brain movement correction, leading to jerky movements. The study suggests that subtle jerkiness may appear before clinical symptoms, potentially providing an early diagnostic tool.
Researchers found that pallidotomy surgery for Parkinson's disease improves brain activity in areas responsible for controlling movement and decreases abnormal activation in cerebral areas. The study provides new insight into the brain mechanisms responsible for symptomatic improvement following surgery.