Articles tagged with Deep Brain Stimulation
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
Researchers found that patients with Parkinson's disease showing little to no Lewy bodies despite long-standing, clinically advanced disease. The study provides new insight into the relationship between clinical symptoms and neuropathological progression.
Researchers created a personalized adaptive DBS system that detects neural signals associated with each step and adjusts stimulation in real time, improving gait symmetry and reducing falls. The study demonstrates the potential for brain stimulation to adapt to behavior itself, opening doors to future therapies.
Deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks. The therapy helps patients recover from severe depression by increasing fractional anisotropy and myelination within specific pathways, suggesting a previously unrecognized mechanism.
A team of international researchers will investigate the underlying biology of psychiatric and cognitive symptoms in Parkinson's disease, with a focus on depression, anxiety, and other non-motor symptoms. The study aims to improve diagnosis and treatment of these symptoms, which are common but poorly understood in the disease.
A new medical technology development initiative, DBS Lead Lock, aims to refine deep brain stimulation lead fixation for improved precision and efficiency. The project, in collaboration with the Marshall Advanced Manufacturing Center, is currently in prototype development.
Researchers have identified a specific brain network that is mainly active in the fast beta frequency range and modulates motor symptoms of Parkinson's disease through deep brain stimulation. Stimulating this network, which communicates at 20-35 Hz, can improve motor symptoms in patients with Parkinson's disease.
A study highlights how social media is transforming neurosurgical education, collaboration, and case consultations globally. Platforms like Neurosurgery Cocktail have democratized neurosurgical knowledge, supporting high-level discourse among experts.
Researchers at Mayo Clinic have developed a new approach to treating drug-resistant epilepsy by mapping each patient's unique brain wave patterns. This method enables physicians to target the precise area in the brain where stimulation is most effective, moving beyond traditional one-size-fits-all treatment.
Researchers identified a potential biomarker that could inform personalized treatment with deep brain stimulation. Half of the participants showed significant improvements, including nine achieving remission, with brain activity at specific frequency ranges predicting response to treatment.
The Mount Sinai team will investigate neural mechanisms underlying bipolar disorder and pioneer novel neuromodulation-based treatment strategies.
Researchers at the University of Pittsburgh and UPMC developed a new treatment for patients with drug-resistant epilepsy. The approach uses deep brain stimulation (DBS) targeted to each patient's unique brain wiring, resulting in a significant reduction in seizures, with some patients becoming seizure-free for months.
Researchers developed new methods to accurately target the centromedian nucleus for deep brain stimulation in patients with drug-resistant epilepsy. Advanced imaging techniques, such as high-resolution MRI and DTI tractography, improve targeting accuracy by identifying specific brain pathways and neural firing patterns.
Researchers developed a safe method to obtain prefrontal cortex biopsies during deep brain stimulation (DBS) surgery in living patients, demonstrating no increased risk of adverse events or cognitive decline. The study's findings establish the safety of this approach and open up new avenues for neuroscience research.
A new study explores catheter-based polarization-sensitive optical coherence tomography (PS-OCT) as a tool for improving the precision of electrode placement in deep brain stimulation. PS-OCT provides high-resolution intraoperative visualization of deep brain structures, distinguishing between white and gray matter more clearly than MRI.
Researchers have identified two brain waves, alpha and delta waves, as key markers for obsessive-compulsive disorder (OCD). These findings could lead to more targeted deep brain stimulation treatments, improving outcomes for patients. The discovery provides a significant breakthrough in understanding OCD and its neural mechanisms.
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
Researchers at Mayo Clinic developed a personalized deep brain stimulation platform to treat drug-resistant epilepsy. The study found that this approach reduced seizures while also improving memory and sleep in patients with temporal lobe epilepsy.
Researchers at UT Health San Antonio are among the first to use adaptive deep brain stimulation technology that adjusts treatment based on a patient's symptoms. This innovative approach offers improved therapy and symptom optimization for patients with Parkinson's disease, dystonia, epilepsy, and essential tremor conditions.
A team of researchers has identified a common brain network that generalized seizures hijack, which is located in the region where deep brain stimulation (DBS) electrodes are placed. This finding could help explain why DBS is effective in alleviating generalized seizures and potentially improve treatment outcomes.
Researchers are testing a brain pacemaker to treat severe alcohol and opioid addiction, aiming to develop effective treatments and understand the brain mechanisms driving addiction disorders. The trial, known as Brain-PACER, uses deep brain stimulation to modulate brain activity and cravings.
The Mount Sinai Hospital has become the first in the US to perform a deep brain stimulation (DBS) implantation procedure as part of a clinical trial investigating its effectiveness for treatment-resistant depression. The study aims to gather evidence on the impact of DBS systems developed by healthcare company Abbott.
Researchers at Carnegie Mellon University have developed a new, minimally invasive method called DeepFocus for treating depression and other neural conditions using transnasal electrical stimulation. This technique offers more accurate and efficient targeting of deep brain structures with lower risk.
The FDA has approved a new treatment for Parkinson's disease that can adjust to the individual's brain activity, providing precise stimulation. This technology, known as adaptive deep brain stimulation (aDBS), detects patterns of brain activity and delivers tailored electric pulses to reduce symptoms.
A new study published in the New England Journal of Medicine found that blocking the artery supplying the brain covering reduced re-operations for chronic subdural hematomas by threefold. The EMBOLISE trial followed 400 participants and showed a significant reduction in recurrence rates with a simple, minimally invasive procedure.
Researchers from Charité have shown that deep brain stimulation using electrical impulses can accelerate movement and shorten delays in Parkinson's patients. By decoding the intent preceding voluntary movement seconds before action, they discovered that dopamine significantly speeds up this process.
Researchers at University of Pittsburgh discover that deep brain stimulation instantly improves arm and hand strength and function weakened by traumatic brain injury or stroke. The therapy stimulates the motor thalamus, a key relay hub of movement control, and significantly improves activation of muscles and grip force.
A new study by researchers at MIT and MGH found that even low stimulation currents could sometimes still cause electrographic seizures in awake mice, with a rate of 2.2 percent of tests experiencing seizures. The study cautions against the use of brain stimulation-based therapies without proper monitoring.
A small NIH-funded trial found an implanted device regulated by brain activity can provide continual and improved treatment for Parkinson’s disease symptoms. The study showed adaptive deep brain stimulation (aDBS) was markedly more effective at controlling PD symptoms compared to conventional DBS treatments.
A recent study identified a novel biomarker to predict clinical status in individuals with treatment-resistant OCD undergoing deep brain stimulation therapy. The biomarker targets pathological avoidance behaviors and has shown promising results in improving symptom management.
The Digitally programmable Over-brain Therapeutic (DOT) device, the size of a pea, activates the motor cortex, allowing patients to move their hands. The technology offers greater patient autonomy and accessibility than current neurostimulation-based therapies.
Scientists have identified two thalamic nuclei and the subthalamic nucleus as encoding vital physiological signals from the heart and lungs. This discovery sheds light on how the body and brain communicate, influencing cognitive processes such as emotional regulation and decision-making.
Researchers have identified a network of neurons controlling right-left movements in the brain, which may help treat Parkinson's disease. The discovery provides insight into how essential movements are produced by the brain.
Researchers discuss recent advances in brain mapping, emphasizing the need to establish precise neuromodulation paradigms based on individual characteristics. Individualized brain mapping methods have evolved from manual labeling to staining techniques across multiple subjects.
Researchers developed a wireless method to effectively reduce motor dysfunction in people with Parkinson's disease using magnetogenetics. The treatment showed improved motor function and no significant damage in and around the brain, suggesting it could be a safer alternative to traditional implanted DBS systems.
Researchers at Duke University developed an adaptive deep brain stimulation therapy for Parkinson's disease, targeting two key brain structures and using a novel self-adjusting device. The study found that this approach improved motor symptoms and reduced medication doses in six patients.
A nonrandomized controlled trial found that deep brain stimulation in advanced Parkinson disease improved mobility and maintained quality of life at 5-year follow-up. In contrast, standard-of-care medication worsened quality of life mainly due to its unfavorable effect on mobility.
Researchers discovered that cerebellar nuclei make a surprising contribution to associative learning by strengthening connections with mossy fibers. Optogenetic experiments also showed that the nuclei can support well-timed learning. The study's findings have implications for understanding cerebellum function and potential treatments f...
Researchers found that changing treatment can lead to significant improvement in mobility and quality of life for patients with advanced Parkinson's disease. A nationwide registry is planned to develop scientifically sound guidelines for combination therapies.
A study by researchers at the University of California - Riverside found that certain aspects of video game play can stimulate dopamine release and potentially aid in treating Parkinson's disease symptoms. The research suggests a promising new approach for managing the condition.
A team of researchers has identified a unique pattern in brain activity that reflects the recovery process in patients with treatment-resistant depression. After six months of deep-brain stimulation therapy, 90% of patients exhibited significant improvement in their symptoms and 70% no longer met the criteria for depression.
A first-in-human trial of deep brain stimulation (DBS) for post-stroke rehabilitation patients has shown that DBS to target the dentate nucleus improves motor impairment and function, with gains nearly tripling initial scores. The study also found significant improvements in quality of life.
Researchers from Tel Aviv University and UCLA developed a method to improve memory consolidation by inducing deep-brain stimulation during sleep. The study found that precise timing of electrical stimulation enhances synchronization between the hippocampus and frontal cortex, leading to improved accuracy in recalling memories.
Researchers found that targeted deep-brain stimulation during a critical sleep cycle improved memory consolidation in patients with epilepsy. The study provided physiological evidence from inside the human brain supporting the main theory for how memory is consolidated during sleep.
Researchers have pinpointed a new neurological target, the mesencephalic locomotor region, to improve walking recovery in people with spinal cord injuries. Electrical stimulation of this area has shown promise in animal models, and a clinical trial is underway.
Research using mice models of Alzheimer's disease found that deep brain stimulation activated only a small population of new neurons, restoring cognitive and non-cognitive functions. The study also identified protein pathways involved in improved memory performance and plaque clearance.
A study published in Frontiers in Surgery finds that patients with schizophrenia and schizoaffective disorder have lower postsurgical mortality than those with Parkinson's disease, suggesting DBS as an ethical option for treatment-refractory cases. Comprehensive consideration of factors is done on a case-by-case basis for successful DBS.
Researchers collected electrophysiological recordings from prefrontal cortical regions in three human subjects with severe treatment-resistant depression. They found lower depression severity correlated with decreased low-frequency neural activity and increased high-frequency activity.
Taiyun Chi develops a neural interface with neural recording channel counts over 10 times higher than current technology and creates a noninvasive deep-brain-stimulation system based on temporally interfering electromagnetic waves.
A new algorithm developed by researchers at Charité improves motor symptoms comparable to standard of care treatment, increasing efficiency in deep brain stimulation for Parkinson's disease. The study suggests a promising result for imaging-based algorithms to simplify clinical practice and improve therapeutic outcomes.
Researchers discovered a brain network that reduces Alzheimer's symptoms when stimulated, paving the way for further studies. A small group of participants benefited from deep brain stimulation, with the optimal stimulation site located at the intersection of two fiber bundles connecting regions deep in the brain.
A recent study suggests that stimulating the intersection of two particular brain networks correlated with better patient outcomes than stimulating nearby sites for patients with Alzheimer's disease. Cognitive improvement was associated with DBS to the direct interface between the fornix and bed nucleus of the stria terminalis.
A new geometrical-shaped magnet structure enables deep brain stimulation to reach 11 centimeters below the scalp, 1.67 times deeper than conventional methods. This improved design offers more focused stimulation and increased treatment potential for psychiatric diseases like major depression.
Researchers from Xi'an Jiaotong-Liverpool University found that brain stimulation combined with a nose spray containing nanoparticles can improve recovery after ischemic stroke. The treatment increased cognitive and motor functions, and weighed more quickly than those treated with TMS alone.
A pooled data analysis found that deep brain stimulation reduced OCD symptoms by 47% and improved substantial outcomes in two-thirds of participants. This treatment approach showed promising results in addressing severe OCD with substantial improvement in approximately half of the patients.
A study published in Molecular Psychiatry reveals that deep brain stimulation (DBS) to the superolateral branch of the medial forebrain bundle can alter metabolic brain changes over 12 months, making it a strong potential therapy for treatment-resistant depression. The results showed that 8 out of 10 patients experienced significant sy...
A multidisciplinary team at UVA Health will use deep brain stimulation to treat refractory neuropathic pain, aiming to modulate pain signals from the insula. The study may shed light on the fundamental nature of pain and identify biological indicators for effective treatment.
Researchers used microcircuit models of basal ganglia and thalamus areas to create multiscale models of Parkinson's patient and healthy control brain. They found that in-silico deep brain stimulation could normalize decreased firing rates in subcortical regions, but also caused differential activity in the motor cortex.
A new circuit model provides an explanation for how deep brain stimulation (DBS) relieves Parkinson's disease motor symptoms by interrupting a vicious cycle between the subthalamic nucleus and the striatum. The model suggests that DBS restores a balance with other rhythm frequencies, enabling better movement control.