Researchers developed an advanced organoid model for human spinal cord injury and tested a promising regenerative therapy. The treatment triggered neurite growth and reduced scarring in injured organoids, offering validation for its potential to work in humans.
A study published in Stroke identified two proteins, R-spondin 3 (RSPO3) and LGR4, that trigger a signaling pathway to reduce inflammation and promote neurite outgrowth in the ischemic brain. This discovery provides new hope for patients with ischemic stroke by targeting RSPO3/LGR4 signaling.
Research found ginsenoside Rb1 enhances PI3K/Akt and MAPK signaling pathways, promoting neuronal survival and neurite growth in the hippocampus. The study suggests potential anti-dementia effects of ginsenoside Rb1 in Alzheimer's disease.
A study published in Neural Regeneration Research found that hydrolyzed collagen is suitable for nerve cell culture due to its ability to facilitate cell survival and neurite outgrowth. Non-hydrolyzed collagen matrices had no obvious effects on these processes, making hydrolyzed collagen a promising tool for neural tissue engineering.