Articles tagged with Neurons
Scientists have discovered that a specific region of the brain, known as the ventrolateral preoptic nucleus (VLPO), plays a crucial role in regulating sleep and body temperature. Activating these cells causes a profound drive to sleep, while excessive stimulation can lead to prolonged sleep and a drop in body temperature.
Research reveals that a single dose of cocaine can irreversibly alter brain circuits surrounding neurons associated with addiction. This discovery may lead to the development of medications targeting the extracellular matrix to reverse addiction.
Researchers found that viruses like West Nile and Zika can kill neurons in the gut, disrupting bowel movement and causing intestinal blockages. The study provides clues to sudden onset of digestive woes and potentially points to a new strategy for preventing such conditions.
Researchers discovered that brain-enriched miRNA (miR-124) plays a crucial role in neuronal survival, contrary to previous assumptions. The study identified 98 miR-124 targeted genes that have direct physiological functions, protecting neurons from death.
Researchers used a novel method to analyze individual brain cells in mice, revealing specific genes that may play roles in traumatic brain injury. Treatments targeting these genes, such as thyroid hormone therapy, showed promise in improving learning and memory tasks.
Binghamton University researchers developed 'neuristor' circuits that mimic biological neurons, enabling complex computations using minimal power. The team created niobium dioxide devices without electroforming, making them more efficient and scalable.
Scientists have found spiking neurons in the tiny roundworm C. elegans, which could help understand fundamental principles of brain computation. The discovery overturns decades of dogma and reveals a unique coding mechanism that allows the worm's olfactory neurons to encode information in two ways.
A new study demonstrates how visual cortex neurons learn to recognize familiar faces regardless of their location. Participants who reported stronger familiarity with peers more consistently recognized the other individual in different parts of their visual field.
Researchers at Case Western Reserve University developed a new method to generate brain stem cells, paving the way for greater understanding of myelin disease. The findings also provide new insights and therapeutic strategies for Pelizaeus-Merzbacher disease, a rare genetic disorder affecting male children.
Researchers found that DEET interferes with Caenorhabditis elegans' neural circuitry, jumbling their response to certain odors. This knowledge could help develop more effective DEET alternatives.
A mathematic model developed by researchers at the University of Basel's Biozentrum demonstrates how different variants of genes enable random diversity in neurons. This diversity is achieved by combining isoforms in a way that results in precise and exclusive neuron function.
Researchers used machine learning to detect small DNA changes in single brain cells, revealing thousands of previously unknown variations. The study found that these changes peaked during a key stage of brain development, implying a regulated process.
ASTN2 helps move proteins away from the membrane, supporting neuronal connections; defects lead to neurodevelopmental disorders like autism and intellectual disabilities. The cerebellum's complex roles in cognition and language may be linked to ASTN2 dysfunction.
A new study explores why people keep eating despite feeling full, showing that two tiny clusters of cells battle for control and the opioid system gets involved. Researchers found that stimulating POMC neurons decreases appetite, while AgRP neurons drive eating when both are activated.
Researchers have made the first direct observations of water in lipid bilayers used to model cell membrane fusion. The study provides new insights into diseases associated with disrupted cell fusion and could lead to treatments for degenerative diseases.
Scientists report that senescent cells accumulate in certain brain cells prior to cognitive loss, but eliminating them diminishes tau protein aggregation and memory loss. The study identifies two brain cell types, microglia and astrocytes, as prone to senescence.
Researchers at Scripps Research are advancing compounds that protect neurons in diseases caused by toxic protein accumulation. In an animal model of ALS, the compounds improved strength and movement. The goal is to optimize these compounds into effective treatments for neurodegenerative diseases.
Researchers used a larval zebrafish model to explore neural mechanisms of general anesthesia. The study revealed that the locus coeruleus (LC) plays a modulatory role in both the induction of and emergence from intravenous general anesthesia via a cooperative mechanism with norepinephrine (NE).
Scientists developed a machine learning technique to predict human cell organization using only black and white images generated by brightfield microscopy. This allows for the exploration of cellular structures in ways that were previously impossible, particularly in live cells.
Researchers at St. Jude Children's Research Hospital created a massive database of gene activity in individual cells during embryonic development and after birth, enabling scientists to trace specific developmental trajectories in the cerebellum. The analysis will aid understanding of brain development and provide a foundation for unde...
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a previously unknown astrocyte subpopulation that plays a key role in driving brain inflammation. The newly discovered 'ieAstrocytes' are activated early in neuroinflammatory diseases, such as multiple sclerosis and Alzheimer's disease.
Researchers at Karolinska Institutet identified four types of neurons in the peripheral auditory system, three of which are new to science. The study shows that these neurons play a crucial role in decoding sonic intensity and may lead to new therapies for hearing disorders.
The Center for Sub-Cellular Genomics will develop new technologies to measure genomics elements at the scale of sub-cellular structures in single cells. This may enable new insights into neurogenerative and neuropsychiatric conditions, such as autism and Alzheimer's disease.
A protein called Staufen1 accumulates in cells of patients with degenerative ataxia or amyotrophic lateral sclerosis (ALS), suggesting a potential therapeutic target. Depleting Staufen1 from affected mice improved symptoms, revealing a novel avenue for treating neurodegenerative diseases.
A new AI-powered tool, HEAL, analyzes genome sequences and electronic health records to predict individual risk for developing abdominal aortic aneurysm. The tool may one day help diagnose, treat, and prevent diseases such as AAA, neurological disorders, and cardiovascular conditions.
Researchers from UCI have identified patterns of sugars on the surface of neural stem cells that determine their fate, affecting brain cell formation. This discovery may improve the use of stem cells in transplantation therapies to treat injury and disease.
Researchers from the German Primate Center found that visual attention desynchronizes nerve cell activity, enabling more complex information processing. This insight may provide evidence for mechanisms underlying ADHD and autism, and sheds light on how the brain processes stimuli.
UC San Diego researchers develop rapid and cost-effective method to create human cortical organoids directly from primary cells. The new protocol enables large-scale production of brain organoids, which can be used to better understand human brain function and develop treatments for neurological disorders.
A new 'see-through' EEG device, developed by Boston Children's Hospital researchers, measures individual neurons with fine-grained precision. The transparent microelectrode array enables simultaneous neuroimaging and optogenetics experiments.
Researchers at Kanazawa University discovered a biochemical signaling pathway that cancels out biological noise in the differentiation process of neural stem cells. The JAK/STAT pathway reduces stochastic neuroblast differentiation, contributing to correct organismal development.
Researchers found that fruit flies use a small, bright spot (the simulated sun) as a landmark to fly straight with respect to its position. The study also shows that these flies have compass neurons in their brains associated with this navigational behavior.
Researchers from Far Eastern Federal University have discovered a new group of Kunitz-type peptides in Heteractis magnifica sea anemones, which exhibit neuroprotective properties. The peptides inhibit the development of inflammations and reduce levels of active oxygen forms that cause cell damage.
A team of researchers has identified a neural clock in the brain that organizes the flow of our experiences into an orderly sequence of events. This discovery sheds light on how our brains measure subjective time, which is distinct from external timekeeping mechanisms like clocks and circadian rhythms.
Researchers discovered that cytomegalovirus uses protein IE1 to replicate after PP71 proteins decay, offering potential therapeutic avenues for treatment
Researchers have discovered a key role for O-GlcNAc modifications in enhancing neuronal regeneration after injury. Altering sugar levels on proteins can alter metabolism, leading to improved regeneration outcomes.
A new intelligent machine, Image-Activated Cell Sorting (IACS), sorts cells based on their spatial and morphological properties using an image-driven approach. The platform has been optimized for analyzing individual cells and holds promise for making machine-based discoveries in biological sciences.
A team from NCBS has identified a set of three proteins - PI4KIIIα, Efr3, and TTC7 - crucial for maintaining PIP2 levels on the surface membranes of cells. This helps maintain the signaling system going by rapidly resynthesizing essential molecules.
Researchers discovered that gene regulation is largely digital and stochastic, with genes being on or off for a fraction of time. This finding adds complexity to human diseases, such as neuropsychiatric disorders, and may help better understand dosage-sensitive genes contributing to these conditions.
Researchers at University of Georgia have successfully reproduced the effects of traumatic brain injury and stimulated recovery in neuron cells grown in a petri dish. The procedure has significant implications for studying and treating such injuries.
A recent study published in Nature Communications found that variability in neural responses is not just random noise, but rather due to fluctuations in internally generated signals like attention. This discovery has significant implications for understanding how our brains work and focus, potentially leading to diagnostic tools for ne...
Researchers discovered that endothelial cells instruct neurons on their correct positioning in the cerebral cortex through laminin secretion. This finding highlights the importance of neurovascular communication in brain development and may hold key to treating dementia and mental illness.
A University of Adelaide-led team suggests a potential link between iron handling and rare gene mutations causing Alzheimer's disease. The theory proposes that abnormalities in how neurons handle iron could result in the devastating early onset form of the disease.
Scientists at Michigan State University have discovered a navigational gene in glass catfish that responds to magnetic waves, which may one day be used to treat Parkinson's and epilepsy. The gene, called the electromagnetic-perceptive gene, can be activated using magnets and has shown promise in controlling movement in mice.
Researchers at the University of Minnesota have developed a groundbreaking 3D-printed device that uses regenerative cells to connect living nerve cells above and below spinal cord injury sites. The device has shown promise in improving bladder control, stopping uncontrollable movements, and alleviating pain.
Researchers develop a method to continuously record cells' development using genetic barcodes, allowing them to trace the full developmental lineage of every mature cell. This breakthrough resolves longstanding questions about brain patterning and promises to exponentially increase understanding of cellular growth and disease emergence.
A Stanford study discovered that apoptosis, a well-known form of cell death, spreads through perpetuating waves triggered by positive feedback loops and thresholds. This phenomenon, known as trigger waves, governs the progression of cell death in intact cells, as observed in Xenopus frog eggs.
Researchers at UCLA have demonstrated a promising approach to treating chronic pain by using biomechanical forces to control cell proteins. The study shows that magnetically induced mechanical forces can reduce pain signals in neurons by increasing calcium ions and adapting the cells' response over time.
Researchers at the University of Basel have identified a factor that could support the early detection of neurodegenerative diseases such as Alzheimer's or Parkinson's. FGF21 is induced by cellular stress reactions after disturbances in mitochondria and can be detected prior to neuronal cell death.
Neurons in brain's master clock exhibit regular activity cycle that is disrupted under constant light conditions. Blocking these neurons reduces the severity of shifts in daily rhythms, suggesting a potential mechanism for modern sleep disorders.
Worms use two neural cells to perform critical calculations for finding food, employing a 'Hot or Cold' computation and constant follow-up checks. This system teaches us the importance of having a backup solution to ensure we're moving in the right direction.
Researchers at RIKEN Center for Brain Science discovered that male fruit flies deposit droppings as pheromone-laced landmarks to signal their presence, attracting females and increasing mating chances. This finding highlights the importance of fecal deposits in social communication among flies.
Aryn Gittis' research establishes new therapeutic targets for Parkinson's therapies, using optogenetics to identify a subset of neurons in the globus pallidus that play a critical role in restoring movement. Her findings suggest targeting these cells could repair neural circuit dysfunction in diseases like Parkinson's.
Scientists have developed a new drug discovery system that can specifically target phosphatase enzymes, which were previously considered undruggable. The system identified a molecule that successfully targeted a phosphatase to reduce accumulation of disease-associated proteins in mouse brains.
Engineers at Rice University have developed methods to study the neural patterns driving muscle movements in freshwater hydrae, a species that appears ageless and can regenerate its body parts. By analyzing neural activity and muscle responses, the team hopes to uncover similarities with other animals and gain insights into their nervo...
Researchers at NIST have developed a silicon chip that uses light instead of electricity to precisely distribute optical signals across a miniature brain-like grid. The chip enables complex routing schemes necessary to mimic neural systems and has demonstrated uniform output with low error rates.
A new system has been identified that could reduce neurodegeneration in Huntington's disease by blocking the accumulation of toxic protein aggregates. The system involves a protein called UBR5, which promotes the degradation of mutant huntingtin, leading to a decrease in neurotoxic effects.
A Rutgers-led team of scientists has identified two molecules that protect nerve cells after traumatic brain injury and could lead to new treatments. The study found that speeding the breakdown of guanine protects neurons from injury and retains brain functioning.
Research from Rockefeller University reveals that giant neurons in the brainstem, called nucleus gigantocellularis, express genes linked to nitric oxide production and blood vessel relaxation. This discovery supports their role in initiating behavior and potentially understanding psychiatric disorders like bipolar disorder and ADHD.
Researchers discovered that brain microglia clearance activity in different regions goes hand in hand with natural neuronal degeneration. Microglia can mistakenly attack healthy neurons if their 'eating' behavior is turned on inappropriately, leading to cellular changes associated with neurodegenerative diseases.
Researchers have developed turmeric-based eye drops that can reduce retinal cell loss in rats with glaucoma. The treatment shows promise for diagnosing Alzheimer's disease and has been found to be well-tolerated.