Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
A study from Columbia University Medical Center found that an excess of one type of serotonin receptor in the brain's center may cause antidepressants to fail for half of patients. Researchers created a mouse model with high and low receptor levels, showing that reducing receptors can transform non-responders into responders.
Researchers at MIT have found that cells with higher activity levels are more likely to survive and integrate into the adult brain. This discovery is significant for cell replacement therapies used to treat neurological diseases like Parkinson's and Alzheimer's.
The discovery of Sox2, a protein that regulates stem cell formation, is crucial for spiral ganglion neuron development. The study's findings may lead to the regeneration of these nerve cells, potentially revolutionizing cochlear implant technology and biological treatments for hearing loss.
Researchers used a special peptide to modify laboratory mice's immune systems, reducing characteristic features of Alzheimer's disease. Anti-inflammatory cells were recruited, dampening the local inflammatory response and boosting plaque-degrading enzyme action.
Neuroscientists at MIT have developed a powerful new class of tools that can reversibly shut down brain activity using different colors of light. These 'super silencers' exert exquisite control over the timing of shutdown, allowing researchers to study neural circuits and potentially treat disorders such as chronic pain, epilepsy, and ...
Researchers discovered four small molecules capable of protecting cells from alpha-synuclein toxicity, a hallmark of Parkinson's disease. The compounds improved protein trafficking and decreased mitochondrial damage in multiple models, suggesting potential therapeutic avenues for the disease.
Researchers identified a key molecular switch that drives the onset of Huntington's disease, an incurable neurodegenerative disorder. A subtle change in two amino acids reduced the pathogenic potential of the mutant protein, potentially leading to new treatment strategies.
Researchers found that a synergistic interaction between ?-syn and LRRK2 exacerbates neurodegeneration in Parkinson's disease by disrupting intracellular transport mechanisms. Inhibition of LRRK2 expression may provide a therapeutic strategy to prevent PD-associated neuropathology.
Researchers suggest progesterone as a viable treatment option for traumatic brain injuries due to its ability to protect damaged cells and reduce swelling. The hormone has been shown to improve behavioral outcomes and protect neurons after injury.
Researchers at Tufts University discovered that maternal behavior can stimulate new neuron creation in the brains of adult female rats who have never given birth. The study found increased numbers of new neurons in the subventricular region of the brain in these rats, which exhibited maternal behavior when exposed to foster pups.
Researchers used biosensors to study how anti-psychotic drugs, such as atypical neuroleptics, affect the brain. The study found that these drugs block a particular type of receptor, overriding the increase in acetylcholine they stimulate.
Researchers have found that specific waves in EEG signals can reliably predict neural activity in the brain. By combining EEG and direct neuron recordings, scientists identified a link between 'frequency band coupling' and cell firing rates.
Scientists at Max Planck Institute for Biological Cybernetics develop new method to interpret EEG signals, providing insights into neural activity. By combining EEG and neuron recordings, researchers can accurately predict brain cell activity, shedding light on abnormal EEG waveforms in neurological disorders.
A recent study by Johns Hopkins scientists suggests that repeated ecstasy use significantly raises the risk of developing sleep apnea in otherwise healthy young adults. The researchers found that the more participants had used MDMA in the past, the more severe their apnea was likely to be.
Research by Professor Yasuhiko Minokoshi and Dr. Tetsuya Shiuchi found that meals with sweet taste stimulation activate 'orexin' neurons, reducing blood glucose levels in mice. Pleasant eating habits may prevent hyperglycemia by activating orexin neurons.
Researchers found that naked mole rat brain tissue can survive for over half an hour without oxygen, which could lead to new treatment options for brain injuries caused by heart attacks, strokes, and accidents. This adaptation may also provide insights into how to prevent permanent human brain damage after temporary loss of oxygen.
A new study reveals how our brains fill in gaps to create continuous sound by suppressing slow brain waves during interruptions. This mechanism enhances our understanding of human hearing and may inspire future devices for people with hearing deficits.
Scientists have discovered a direct link between insulin and core body temperature, finding that insulin injection in specific brain areas increases metabolism, brown adipose tissue activity, and core temperature. The study suggests a potential therapeutic area for future drug design and new insights into obesity and diabetes.
Researchers discovered that Srebp2 regulates cholesterol biosynthesis in prion-infected neuronal cells, leading to increased cholesterol levels and potential disease promotion. This finding may lead to new therapy approaches for prion-dependent diseases.
Researchers from NC State University have identified a gene called FoxJ1 that tells embryonic stem cells in the brain when to stop producing nerve cells. This discovery advances understanding of the nervous system and its development, with potential applications for conditions like Parkinson's disease and Alzheimer's.
Researchers found a dual-brake mechanism controlling chloride transport, which calms hyperactive fetal neurons after birth. This process may benefit people with epilepsy and neuropathic pain by re-establishing natural inhibition.
Scientists at Max Planck Institute for Biological Cybernetics create tiny laser-scanning microscope images brain cells in awake and moving animals, eliminating the need for electrodes. This breakthrough allows researchers to study how the brain generates an internal representation of the outside world.
A new study found that preventative brain radiation therapy for lung cancer patients reduces the risk of developing brain metastases by 10%, but negatively affects short-term and long-term memory. Despite this, the treatment has no significant impact on survival or quality of life.
A randomized study found that preventative brain radiation for nonsmall cell lung cancer patients decreased the risk of brain metastases by over 50%, but increased short and long-term memory loss. The study also showed no significant difference in overall survival between treated and untreated patients.
A recent study found that statins can have profoundly different effects on brain cells, including benefits in reducing cholesterol transporter expression but potential risks in increasing Alzheimer's disease-related proteins. The findings highlight the importance of personalized treatment approaches for individuals taking statin therapy.
Researchers identified populations of neurons coding time with extreme precision in the primate brain's prefrontal cortex and striatum. This fine-scale coverage enables precise timing of actions, such as speaking or driving a car.
A study published in the Journal of Cell Biology reveals that PIKfyve, a lipid kinase, protects neurons from calcium overload by degrading voltage-gated calcium channels. This mechanism may provide new insights into neurodegenerative disorders such as stroke, Parkinson's disease, and Alzheimer's disease.
The company has developed a 2-week method for generating human induced-pluripotent stem cells with a 200-fold increase in yield. This breakthrough has broad implications for pharmaceutical-grade iPSCs production without genetic modification at commercial scale.
Researchers used optogenetics to stimulate 12 cells in fly brains, creating false memories of an unpleasant event. This discovery provides new insights into how simple organisms can form complex cognitive associations.
Researchers at the University of Manchester discovered two types of brain cells with distinct electrical properties that differ significantly between day and night. One type contains a key gene and can survive high levels of excitability, while the other cannot, contradicting accepted theory on how the daily clock works.
A Purdue University researcher has discovered that increasing protein phosphatase 5 (PP5) in neurons reduces reactive oxygen species-induced cell death, a mechanism linked to Alzheimer's disease. PP5 overexpression also prevents amyloid beta-mediated stress pathways.
A UNC study found that the GSK-3 gene plays a crucial role in regulating the balance between neural stem cell proliferation and differentiation. Deleting this gene led to an overabundance of proliferating stem cells, resulting in fewer mature neurons. This discovery has implications for treating neuropsychiatric disorders.
Researchers at Case Western Reserve University found that Merkel cells, responsible for touch perception, originate from the skin, contradicting previous speculation. The study's results provide significant insights into the development and function of Merkel cells, which may hold implications for understanding Merkel cell carcinoma.
Researchers at the University of Michigan have developed brain implants coated with conducting polymer nanotubes, which can record neural signals better than conventional metal electrodes. The new implants may eventually lead to more effective treatment of neurological disorders like Parkinson's disease and paralysis.
Researchers found that the number of cracks in the membrane determines how many proteins are bound, contradicting earlier ideas about affinity. This knowledge could lead to a better understanding of cellular processes and diseases such as depression and Alzheimer's.
Researchers used light-activated proteins to pinpoint the neural cell responsible for a specific behavior in zebrafish, a breakthrough that could lead to new insights into biological systems and synthetic biology applications. This technique may also aid in optimizing biofuels and disease-fighting therapies.
Researchers at Weizmann Institute discovered a new protein partnership between TrkA and CCM2 that leads to pediatric tumor regression. This finding may lead to the development of drugs that induce tumor regression. The study found that TrkA and CCM2 are always expressed together in tumors with high regression rates.
Scientists have developed nanoparticles that can target and destroy glioblastoma multiforme (GBM) brain cancer cells using light-sensitive titanium dioxide material. The 'nanobio hybrids' killed up to 80% of brain cancer cells after exposure to focused white light, making them a promising part of brain cancer therapy.
Researchers at Duke University Medical Center have made a breakthrough in understanding how monkeys weigh costs and benefits when deciding whether to explore new options or stick with what they know. By analyzing neural signals in the posterior cingulate cortex, the team was able to predict which strategy the monkey would employ.
Alcohol consumption during pregnancy can lead to a range of adverse outcomes, including learning disabilities and increased susceptibility to diseases. The destruction of beta-endorphin neurons in the hypothalamus region can result in permanent impairment of stress and immune system functions throughout life.
Researchers at UC Riverside have identified a novel class of compounds that could pave the way for developing inexpensive and safe mosquito repellents. These odorants, including hexanol and 2,3-butanedione, prevent CO2-sensitive neurons in mosquitoes from functioning.
Researchers at Whitehead Institute have shown that a single gene mutation can cause a transmissible neurodegenerative disease in mice, similar to human fatal familial insomnia. The study demonstrates that mutations associated with prion diseases are sufficient to cause the disease and the spontaneous generation of transmissible prions.
Researchers at Tel Aviv University have successfully tracked bone marrow stem cells as they repair damaged brain tissue in a live animal model of Huntington's disease. The innovative use of MRI tracking enables the monitoring of cell viability and migration towards diseased areas, paving the way for potential therapy.
Researchers at Caltech have pinpointed two groups of neurons in fruit fly brains that regulate fat stores, mirroring mammalian brain function. Silencing these neurons led to obese flies, while overactivating them produced lean ones, offering a promising model for studying human obesity and developing new treatments.
Scientists discovered that endocannabinoids in the human body can disable brakes on pain signals, leading to prolonged chronic pain. In contrast, THC from cannabis may worsen toothaches, but could alleviate neuropathic pain.
Researchers found category-specific brain activation in both sighted and blind humans, suggesting innate structure of the human brain. The ventral stream's medial-to-lateral organization reflects preferences for nonliving-to-living stimuli, indicating evolutionary history constraints.
Scientists have demonstrated a direct link between the death of old neurons and their replacement by newly born ones in a living vertebrate. The study found that introducing a chemical inhibitor to slow apoptosis resulted in fewer new neurons being formed, providing insights into age-related diseases.
Scientists have recorded live vesicle fusion on the nano-scale using Fluorescence Resonance Energy Transfer (FRET). This breakthrough allows for real-time measurement of vesicle shape and properties, opening up new avenues for understanding neurological and infectious diseases.
Researchers at the Salk Institute found that human brain cells harbor astonishing genomic variability due to mobile DNA elements. This phenomenon may drive evolution and create neural diversity, making each person unique.
Researchers have isolated a unique protein that affects both gene expression and protein transport, which may lead to new medicine treatments. The findings could provide insights into various biological processes, including cell movement and neural networking.
Researchers at Cedars-Sinai Medical Center have isolated stem-like cells from benign pituitary tumors and shown they can generate new tumors in laboratory mice. The study supports the cancer stem cell hypothesis, suggesting similar mechanisms may be involved in malignant and benign tumor formation.
Researchers discovered a drug that blocks transforming growth factor-beta (TGF-beta) receptors can prevent brain changes associated with epilepsy in rats. This treatment halts hyper-excitability and prevents gene expression changes, offering hope for preventing epilepsy in humans after severe brain injury.
A CU-Boulder study found that chemicals released by the brain's immune system can cause chronic seizures in people who have suffered a traumatic head injury. The research suggests that temporarily shutting down the immune response could prevent the development of acquired epilepsy.
A team of researchers at the Salk Institute has discovered a specific site within an ion channel protein where alcohols directly interact, altering brain cell communication. This finding could lead to novel treatments for alcoholism, drug addiction, and epilepsy.
Researchers found a direct link between smoking and brain damage due to NNK, a tobacco compound that provokes white blood cells to attack healthy brain cells. This can lead to neuroinflammation, conditions like Multiple Sclerosis. NNK is present in all forms of tobacco, also affecting second-hand smokers.
A new study has identified a key protein receptor responsible for tumor cells invading the brain and spinal cord in childhood leukemia. The finding may lead to new drugs that block this receptor and reduce the risk of relapse in some leukemia patients.
A new study found that people with stroke impairments experience delays in gripping and releasing objects, but using an arm support device can improve release speed. Active muscle-stretching exercises also showed promise, helping with grip initiation but delaying release.
Researchers found that microglial cell degeneration contributes to loss of neurons and dementia, contradicting the popular neuro-inflammation theory. The study suggests that anti-inflammatory drugs may not be effective in fighting dementia.
Researchers uncover neural mechanism supporting adaptability and decision-making under uncertainty, with the frontal lobe playing a critical role in tracking evidence and switching behavior.
Research by Emory University scientists identifies a mechanism in mother mice's brains that focuses their awareness on the calls of baby mice. The high-frequency sounds of pups inhibit neurons more attuned to lower frequency sounds, enhancing contrast and making them stand out.