Articles tagged with Neurons
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Texas Medical Branch have found that shutting down gastrin-releasing peptide receptors can dramatically suppress neuroblastoma tumor formation and slow its spread. This breakthrough could lead to the development of new therapies for this devastating disease.
Dr. Edwin Monuki will study choroid plexus epithelial cells, which produce cerebrospinal fluid to promote normal nervous system health and function. Success in generating these cells could lead to clinical therapies and screens for new drugs for neurological disorders.
A study published in Nature Neuroscience identifies GABA as a key player in regulating energy balance, leading to leaner mice with increased energy expenditure and resistance to diet-induced obesity. The discovery suggests that targeting GABA release may be an effective strategy for tackling obesity and metabolic disease.
Scientists at Boston Children's Hospital have identified the Otx2 protein as a key factor in triggering brain plasticity, allowing the brain to rewire and adapt. This discovery has implications for understanding developmental disorders like autism and potential treatments for improving learning and cognitive function.
A new study from Indiana University and the University of Montreal provides a model for understanding random synchronization in brain neurons. The findings suggest that spontaneous neural activity can help the brain remain flexible and responsive to external events, potentially leading to better treatments for conditions like epilepsy.
Researchers at the University of California-Irvine have discovered that adult stem cells in the mammalian brain originate from ependymal cells lining the ventricles. These cells can be coaxed into dividing, providing a promising approach to treating neurological disorders and injuries such as Parkinson's disease and stroke.
Researchers created a laboratory model to study Alzheimer's disease mechanisms at the molecular level. The model found that amyloid beta peptides cause a 'leaky' membrane, disrupting normal impulse transmission and leading to cell toxicity.
Researchers at Imperial College London have discovered the key nerve connections that enable flies to maintain a steady gaze while flying and responding to obstacles. This finding could lead to improvements in technical control systems for autonomous air vehicles.
Mutations in PS1 and PS2 proteins disrupt calcium ion flow, leading to increased amyloid beta production. The study identifies the inositol trisphosphate receptor as a potential target for new therapeutic options.
Briscoe's work revealed a novel mechanism that allows cells to integrate time of exposure and concentration of Shh to mount a graded response, leading to a paradigm shift in understanding cell identity specification. His research has far-reaching implications for the control of cell identity in various contexts.
Scientists have discovered that inhibiting an enzyme involved in programmed cell death can protect brain regions from neurodegeneration in living birds. The research has the potential to help develop clinical strategies for treating strokes and human age-related diseases such as Alzheimer's, Parkinson's, and dementia.
A recent study published in Neuron reveals that the brain's decision-making region encodes information associated with the magnitude and delay of rewards. This finding sheds light on why humans and animals prefer immediate over delayed rewards, known as temporal discounting.
Researchers from Harvard Medical School and Brandeis University used a full-genome RNAi screen to identify genes essential for brain development in neurons. The study revealed unexpected roles for genes involved in signaling, protein trafficking, and cytoskeletal proteins.
Researchers discovered that statins increase the development of oligodendrocytes from glial progenitor cells, a crucial reservoir for brain cell customization. The findings suggest potential benefits and risks associated with statin use in brain health and dementia prevention.
Researchers found that humans prefer novel stimuli over familiar ones and associate novelty with activation of the ventral striatum, a region linked to reward anticipation. This suggests humans use novelty as a substitute for true choice uncertainty.
Researchers at Rutgers University discovered a protein that suppresses cell division in brain cells, effectively 'putting the brakes' on Alzheimer's disease. The study suggests that when this brake fails, dementia results.
Researchers have genetically programmed embryonic stem cells to become nerve cells when transplanted into the brain, resulting in tangible therapeutic improvement in mice with stroke. The new nerve cells integrate into the existing network and provide cognitive benefits.
Researchers discovered that BK channels become abnormally active after a seizure, leading to neuronal overexcitability, which may be associated with epilepsy development. A BK channel antagonist reversed abnormal excitability, offering new hope for individuals suffering from epilepsy.
Researchers identified two peptides, NORQ and Hcrt, as crucial regulators of stress-induced analgesia in mice. The peptides interact with each other to modulate pain perception, suggesting a potential link to medical conditions caused by excessive stress.
Scientists are using a powerful supercomputer to create a model of normal human language that can read, comprehend, and repeat basic words. The 'Chatter Box' project aims to understand how the brain supports language function and how it breaks down after brain damage.
A new study reveals that ownership increases value by enhancing the salience of possible loss, explaining the aversion to parting with possessions. The endowment effect is linked to increased activation in brain regions associated with predicted gain and loss.
Researchers at Rutgers University found that beta-endorphin peptide-producing neurons in the brain regulate stress response and immune function, controlling tumor growth. The study shows promise for therapeutic treatments to bolster the immune system.
Research reveals new neurons produced in cerebellum of young and adult rabbits, expanding understanding of mammalian neurogenesis. This breakthrough opens new avenues for brain repair and regeneration research in humans.
Researchers found that MeCP2 is a key regulator of genes in the hypothalamus, turning them on and off. Altering MeCP2 levels can cause Rett syndrome or other neurological disorders, highlighting the need for tailored treatments.
Seven pioneering scientists recognized for transforming human knowledge in nanoscience, neuroscience and astrophysics. The Kavli prizes have been awarded to seven scientists who have advanced our understanding of ultra-small matter properties, brain circuitry and quasars.
Researchers identified regulatory sequences that act like zip codes, determining where odour receptors are expressed in olfactory neurons. These elements positively and negatively regulate receptor expression, suggesting a broader role in nervous system development.
Astrocytes have been found to produce a protective protein called metallothionein (MT), which is secreted to surrounding nerves and helps prevent damage from free radicals and metal ions. The level of MT uptake by nearby nerves correlates with the extent of nerve repair.
A new study suggests that embryonic cells giving rise to connective and skeletal tissues of the skull and facial structures do not originate from the neural crest as previously believed. Instead, they come from a distinct thin layer of epidermal epithelial cells next to the neural crest.
A clinical trial found gene therapy to be safe and effective at slowing disease progression in Batten disease, a rare genetic disorder. Neurological function was assessed using a rating scale throughout an 18-month follow-up period.
A Northwestern University study has discovered that multicellular organisms respond to stress in an integrated manner, with two specialized neurons controlling the response of individual cells. This finding challenges the long-held assumption that cells within a multicellular organism respond individually to stress conditions.
Normally functioning prions prevent neurons from self-destruction by inducing overactive brain cells that respond longer and more vigorously to stimulation. This hyperactivity eventually leads to neuron death, potentially explaining why misfolded prions cause dementia.
Yale scientists found that both male and female flies have similar brains and that specific signals can trigger 'male' behavior in females. The study suggests a largely unisex brain, with subtle anatomical differences making the difference between male and female behavior.
Dr. Milan Fiala has received the 2008 Alzheimer Award for his work on phagocytosis of amyloid-beta and inflammation in Alzheimer's disease. His research suggests that the immune system's failure to clear waste products from the brain is a key contributor to the disease.
A new study reveals that yeast mitochondria play a crucial role in regulating cell division, with implications for treating human diseases. The research found that mitochondria can act as the 'command center' directing cell division, and that understanding this process could lead to therapeutic breakthroughs.
Researchers found that perceiving a good reputation activates the brain's reward system in a similar manner to monetary rewards. The study used fMRI experiments on 19 people and found robust activation of reward-related brain areas, particularly the striatum.
A study in flies found that despite sex-based behaviors, their brains have a largely unisex structure, suggesting key switches control the difference between male and female behavior. Researchers discovered that artificial activation of male-specific singing neurons triggered female flies to exhibit male-like behavior.
Researchers found that rats use exploratory sniffing to discriminate odors quickly, with neural responses confirming minimal processing takes place in the olfactory bulb. The study suggests odorant identity may be encoded by sequence of responses rather than peak activation.
A new Alzheimer's vaccine shows promise in clearing beta-amyloid plaques from the brain, but lacks impact on learning and memory impairments. Researchers suggest that a combination of therapies targeting plaque growth and neuron damage may provide better treatment opportunities.
Researchers discovered that astrocytes play a crucial role in cannabinoid signaling, interacting with neurons through endocannabinoid-glutamate signaling. This finding may lead to the development of new treatments for cannabinoid-related drug abuse.
Scientists identified Lis1 gene as essential for neuroepithelial stem cell division in mice, providing insight into brain development and potential link to lissencephaly. The study suggests neural migration defects may be caused by defects in other processes like proliferation and division.
Researchers at Harvard Medical School have identified proteins that promote tumor growth in certain types of cancer, including breast and ovarian cancer. Targeting these proteins with small molecules may lead to new therapeutic options for patients.
A study by Michigan Medicine researchers found that pain levels in patients with fibromyalgia decreased when glutamate levels went down. This suggests that glutamate may play a role in the disease and could be used as a biomarker of disease severity, leading to potential new treatments.
A new study from Northwestern University's Feinberg School of Medicine explores the neural mechanisms behind hunger and food cravings. The research found that when subjects were fasting, their brains responded strongly to visual cues of donuts, highlighting the brain's ability to prioritize needs in a complex environment.
Researchers uncover the specific receptor subtypes affected by chronic nicotine exposure, revealing new insights into its addictive properties. A two-protein complex also protects nerve cells by promoting growth and survival, showing promise as a therapeutic agent.
Neurons can modulate nerve impulses by releasing two neurotransmitters that target the same receptor, accelerating inhibition and enhancing temporal resolution of inhibition. This finding may represent a new way the brain precisely controls nerve impulses in its circuitry.
Researchers suggest that minocycline can limit Japanese Encephalitis (JE) death by reducing neuronal death, microgliosis, and viral titre. The study found that treatment with minocycline provides complete protection against experimental JE, improving behavioral outcome as well.
Researchers at Stanford University School of Medicine used human embryonic stem cells to generate neural cells that helped repair damage in the brains of rats and improved their physical abilities. The study showed promising results, with the transplanted cells forming only three families of neural cells and not forming tumors.
New research reveals VEGF-B's protective effects on nerve cells without inducing angiogenesis, providing new hope for treating neurodegenerative diseases. VEGF-B treatment has shown to inhibit brain cell death in mouse models of stroke and ocular neurodegenerative disorders.
A study by Northwestern University's Feinberg School of Medicine found that chronic pain disrupts the equilibrium of the brain's regions, leading to permanent damage. This constant firing of neurons can alter connections and even cause death.
A study found that eating apples, bananas, and oranges can protect against neurodegenerative diseases like Alzheimer's. The fruits' phenolic phytochemicals prevented neurotoxicity in neuron cells.
A recent study by Weill Cornell Medical College reveals that the brain contains its own store of tissue plasminogen activator (tPA), a powerful enzyme that boosts blood flow to brain cells via nitric oxide synthase. This finding has significant implications for understanding stroke and Alzheimer's disease, and may lead to new treatments.
Scientists at Cold Spring Harbor Laboratory identify a new neural stem cell type, the rosette neuron stem cell (R-NSC), capable of differentiating into region-specific neuronal cell types. The R-NSC has expanded differentiation potential compared to previously identified neural stem cells.
Researchers discover that individual brains are adapted to their unique auditory environment and can learn to localize sounds. The study may lead to more sophisticated hearing aids and speech recognition systems.
UCI researchers have found a novel method to sort stem cells based on their electric charges, which could expedite therapies for conditions like Alzheimer's and Parkinson's diseases. The technique uses electrodes on a tiny glass slide and has the potential to be more cost-effective and quicker than current methods.
A Northwestern University study found that overexcited neurons can cause protein damage in muscle cells due to neurotransmitter imbalance. This imbalance can lead to various diseases, including neurodegenerative disorders and cancer.
Researchers found that boosting autophagy in fruit flies prevented the age-dependent accumulation of cellular damage in neurons and promoted longevity. Boosting autophagy facilitated the removal of damaged molecules that accumulate during cellular aging, which is critical for neurons to stay healthy and functioning.
Researchers at Stanford University School of Medicine have discovered that the immune system plays a role in sculpting away unwanted synapses in the developing brain. The finding could lead to new treatments for neurodegenerative diseases such as glaucoma, Alzheimer's disease, and multiple sclerosis.
Research suggests that neurons in the frontal lobe encode economic value in a 'menu invariant' way, enabling transitive preferences. This finding provides a key insight into the neural circuits underlying decision-making and may shed light on choice deficits associated with frontal lobe damage.
Researchers have discovered a novel method to produce dopamine cells for Parkinson's disease treatment by cultivating ventral midbrain neural stem cells with Wnt5a. This approach yielded substantial recovery in mice with PD-like disease, without tumor development.
Two transporters, SMCT1 and SMCT2, can circumvent the blood-retinal barrier to deliver lactate and ketone bodies to a healthy eye, potentially preventing neuronal cell damage. Understanding these transporters' activity may enable early diagnosis of diabetic retinopathy and natural delivery mechanisms for drugs.