Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
Researchers at Johns Hopkins School of Medicine have discovered that the AMPA receptor protein moves to its destination with the help of the 4.1N protein, forming long-term memories. The study found that 4.1N is required to maintain strong connections between neurons, making memories stick.
Researchers at Johns Hopkins have discovered a tiny protein called Rhes responsible for brain cell damage in Huntington's disease. The findings explain the unique pattern of brain damage and offer a strategy for new therapy.
Scientists discover that restoring leptin sensitivity to a specific area of POMC neurons in the brain's hypothalamus can cure severe diabetes and increase activity levels in mice. The findings suggest a new therapeutic pathway for treating insulin-resistant diabetes, potentially stimulating exercise willpower.
A study conducted by Michigan Medicine scientists found that a deficiency in the p53 gene in the brain leads to glioblastoma, a type of adult brain cancer. The researchers discovered that neural stem cells in the subventricular zone may be the origin of this aggressive cancer, suggesting a new target for treatment and early screening.
Researchers found that a deficiency in tumor suppressor gene p53 leads to glioblastoma, a highly aggressive type of brain cancer. The study suggests that targeting the subventricular zone, where neural stem cells reside, may improve treatment outcomes and enable early detection.
Researchers at MIT found that neurons in the prefrontal cortex fire in unison and send signals to the visual cortex to generate high-frequency waves associated with attention, learning, and consciousness. This neural synchrony enables communication between distant brain regions.
Researchers used fMRI to study participants engaging in a complex risky choice task, revealing different brain regions predicting specific choices and individual strategic biases. The findings indicate that the neural mechanisms of choice reflect more than competition between decision variables.
Researchers at the University of Oregon have developed a new method to isolate RNA from specific cells using a chemically modified gene from Toxoplasma gondii. This approach allows for precise study of gene expression and cellular differences, opening up new avenues for research in development, neurobiology, and disease studies.
Researchers at Duke University Medical Center studied monkeys playing a game similar to
The University of Granada has developed an artificial simulator of the nervous system to analyze functions and test new medicines. The EDLUT simulator allows researchers to study new diseases and improve robots inspired by human bodies.
Researchers found that brain cells in the lateral intraparietal cortex predict direction choice and uncertainty, revealing a link between decision making and certainty. The study suggests a simple mechanism underlying both, bringing certainty under the same rubric as choice and reaction time.
Researchers have identified a protein responsible for regulating branched-chain amino acid catabolism, which may be linked to Maple Syrup Urine Disease. Additionally, immune cells called V-alpha-24-invariant NKT cells can indirectly affect neuroblastoma growth by killing tumor-associated cells that promote its growth.
A new study found that neurons in the visual word form area of the left visual cortex prefer individual real words over pronounceable nonsense words. This discovery supports experience-driven tuning of neurons to real words and provides evidence for neural plasticity beyond lower-level representations.
Researchers found that each whole word is processed by its own set of neurons in the brain's left visual cortex. This discovery may provide insights into reading disorders and inform the development of new treatments.
Researchers Francois Abboud and Ann M. Schreihofer have unraveled how the brain regulates blood pressure and flow through communication with blood vessels. Their work has led to clinical advances, including a pacemaker-like device to lower blood pressure in hypertensive individuals.
Researchers have identified a group of cells as direct targets of deep brain stimulation (DBS) using optogenetics, which reduces disease symptoms by preferentially activating neurons linked to the subthalamic nucleus region. The technique allows precise stimulation and measurement of treatment effects simultaneously in animals with Par...
Researchers at Heidelberg University Hospital have shown that certain immune cells in the blood inhibit inflammation after a stroke. Regulatory T lymphocytes (Treg) play a key role in this protection and may offer a new approach to stroke therapy.
Scientists have identified the two neural centers responsible for regulating sleep patterns, revealing that disruptions to these centers can cause jet lag. The study found that deep sleep is more closely tied to light-dark cycles, while REM sleep follows a separate internal clock, leading to a delay in adaptation to new schedules.
Researchers found that thermosensory neurons in C. elegans help regulate response to increasing heat by changing steroid signaling pathways, which affect longevity. This system allows worms to reduce the effect of warm temperature on aging processes, similar to how warm-blooded animals control their body temperature.
Scientists successfully observed extensive nerve cell death in zebrafish with a severe form of Alzheimer's disease, enabling targeted search for drugs to stop dementia. This breakthrough allows for the testing of drugs on living organisms.
Researchers at Johns Hopkins University found that brain cells in a specific region store visual information for up to two seconds, enabling the creation of a stable visual world despite rapid changes. This discovery may have practical implications for understanding and treating disorders such as attention deficit disorder and dyslexia.
Researchers developed a computer program that replicates complex seashell patterns using simple principles from brain function. The 'neural net' model shows how mollusks sense and build their shells based on previous layers, much like the human brain projects memories.
Astrocytes, supportive brain cells, produce inflammatory mediators in response to viral infection. The study provides new insights into the complex mechanisms of inflammation and has significant implications for diagnosis and treatment of brain infections.
Researchers have identified a viral protein, VP16, as the molecular key that prompts herpes simplex virus to exit latency and cause recurrent disease. The study provides a molecular target for designing improved HSV vaccines and treatments, which could also be used in cancer therapy.
Researchers at Salk Institute uncover how the brain uses attention to bring salient details into focus and filter out background clutter. By exploiting the center-surround organization of receptive fields, the brain separates task-relevant information from irrelevant clutter.
A study by MIT researchers found that inhibiting a key brain enzyme in mice reversed schizophrenia-like symptoms, offering potential new drug treatments. The discovery provides insight into the DISC1 gene's role in regulating GSK3B activity and its impact on neural stem cells.
Researchers at Baylor College of Medicine have made a significant discovery in the fight against type 1 diabetes, using adult stem cells to induce liver cells to produce insulin. The study found that a specific gene called neurogenin3 is critical for this process.
A team of researchers has discovered that the enzyme AMP-activated protein kinase (AMPK) is crucial for the survival of neural stem cells that produce new brain cells. This finding opens up new avenues for improving brain function and health by modifying AMPK activity.
A new study reveals that reward-induced stimulus pairing can elicit visual learning in adults without conscious awareness of the stimulus presentation or reward contingencies. This suggests that automatic reinforcement mechanisms rather than directed attention drive improvements in sensory skills.
Researchers at the University of Michigan have developed a nanotech coating that can help brain implants operate longer and improve treatment for various diseases. The coating, made of three components, enables electrodes to interface more smoothly with the brain, reducing tissue damage and improving signal transmission.
A new MIT study sheds light on the underlying neural mechanism of macular degeneration, revealing that deprived neurons respond equally to stimuli at both preferred and non-preferred locations. The findings suggest a relatively passive response to visual deprivation.
Researchers at the University of Calgary have identified a new stress response mechanism in the brain, where stress triggers a protein that removes the ability to slow down the stress response. This finding may lead to a better understanding of the changes in sensitivity to stress resulting from chronic exposure.
Researchers discovered that the locust brain encodes turbulent plumes of odor molecules using surprisingly little neural machinery. The findings suggest a new theory on how animals smell, proposing that individual neurons preserve almost full information about precise temporal dynamics of odors.
Researchers discovered that capsaicin, found in chili peppers, triggers a desensitization process in pain receptors, allowing them to adapt to painful stimuli. This adaptive response enables the receptor to continuously respond to varying stimuli, leading to a shift in responsiveness threshold.
Researchers at Northwestern University identified a key molecular relationship between SIRT1 and heat shock factor 1 that helps protect cells from damage. By activating this pathway, it may be possible to manipulate lifespan and treat age-related diseases such as Alzheimer's and Parkinson's.
Scientists have successfully derived brain stem cells from human embryonic stem cells, providing a continual in vitro supply of diverse types of neural cells. These cells can serve as an inexhaustible source for studying neurodegenerative diseases and possible active agents directly in human neural cells.
A new study reveals that molecular motors in cells operate in a highly coordinated manner to move internal cargo and transport organelles. The findings provide insight into the mechanisms that instruct motor movement, potentially leading to therapies for neurodegenerative disorders such as ALS and Usher syndrome.
Scientists have long debated the function of microsaccades, but researchers at the Salk Institute found they are actively controlled by the superior colliculus. The study reveals that individual neurons in this area are highly specific about which microsaccade directions and amplitudes they command.
A recent Penn study showed that sleep strengthens neural connections in the brain, leading to improved memory formation. The research discovered that a key molecule called NMDAR plays a crucial role in this process, allowing calcium ions to flow into cells and trigger enzymes that strengthen connections during sleep.
Researchers found that extra copies of the LIS1 gene can cause problems, including smaller brains and developmental abnormalities. Studies in mice and human patients revealed a link between the duplicated gene and brain diseases such as schizophrenia and autism.
A study funded by NIH found that astrocytes, not neurons, contribute to the urge to sleep when wakefulness is prolonged. The release of adenosine from these support cells causes sleep-inducing effects that can be inhibited by caffeine.
A new study from McGill University finds that MCH neurons are activated during sleep and could be important in regulating the sleep state. The study provides deeper understanding of the sleep-wake cycle and vital insight into the basis of sleep disorders such as narcolepsy.
A recent study published in Nature Medicine reveals that Treg cells limit brain damage after a stroke by blocking neurotoxin production and modulating lymphocyte and microglia action. This discovery offers potential treatments for preserving crucial functions and treating other types of brain damage.
Researchers at UT Southwestern Medical Center identified a compound that liberates cholesterol trapped in cells, shedding light on its transport and suggesting a possible therapeutic target for NP-C disease. The findings show improved liver function and decreased neurodegeneration in mice treated with the compound.
Researchers at the Salk Institute found that stable proteins within the nucleus's control structures can become damaged with age, leading to impaired function and contributing to cellular aging. This discovery provides new insights into the aging process and may lead to novel approaches for treating neurodegenerative diseases.
Scientists are using slices of living human brain tissue to identify new stroke therapies by blocking anoxic depolarization, a wave of death that engulfs and engorges brain cells. The study aims to find treatments that can delay or prevent the destructive electrical activity, potentially improving treatment options for strokes.
Researchers successfully used an engineered herpes virus to block tumor formation in mice by targeting and killing apparent cancer stem cells. The study suggests that early-stage cancer precursor cells with stem-cell-like properties may explain how some cancers form and are treatment resistant.
Researchers discovered that long stretches of DNA containing many genes are silenced in cells as they mature, rather than individual genes. This epigenetic modification, called LOCKS, plays a crucial role in cell differentiation and development.
Researchers have identified a crucial biochemical step involved in nerve cells' response to DNA damage. Cdk5 activation is necessary before ATM can function in neurons, suggesting it as a potential drug target for neurodegenerative diseases. This discovery sheds light on the underlying mechanisms of ataxia telangiectasia and other neur...
Research reveals that a competition between the two sides of the brain causes it to become asymmetrical. A protein known as Fgf8 acts as a magnet to attract nerve cells to one side, while another protein Nodal teams up with it to trigger asymmetric development.
A study published in Neuron found that conflict with the majority opinion triggers a neural response in the brain's error-monitoring system, leading to long-term conforming adjustments. This mechanism is based on reinforcement learning and reinforces social conformity by signaling the most fundamental social mistake.
Researchers at Children's National Medical Center have identified a specific group of precursor cells that develop into the amygdala, a critical brain region for emotional processing. The discovery sheds light on how the amygdala forms during development and could help understand autism and other neurodevelopmental disorders.
Researchers at Hebrew University have made significant breakthroughs in reversing brain birth defects in animal models by using stem cells to replace defective brain cells. In their study, Prof. Joseph Yanai and his team demonstrated that stem cells can induce the host brain to produce large numbers of stem cells, repairing damage and ...
Dr. Joshua Maurer's research aims to unravel the tricks of neuronal wiring using zebrafish. He seeks to replicate brain-like interactions on a glass surface, allowing real-time observation of neuron growth and guidance. This knowledge could lead to better nerve repair strategies in humans.
Researchers identified impaired energy metabolism as a key factor in the initiation of amyloid beta plaques in Alzheimer's disease. This discovery provides new insights into the pathogenesis of AD and highlights the potential for developing new preventative and therapeutic approaches.
Researchers at the University of Rochester found that humans make optimal decisions when their unconscious brain processes information. A test revealed that people's brains subconsciously gather data and reach a confidence threshold before reporting a decision to the conscious mind.
Carbon nanotubes form extremely tight contacts with neuronal cell membranes, creating shortcuts between neurons for enhanced excitability. This breakthrough has the potential to treat traumatic brain injuries, Parkinson's disease, and severe depression by bypassing faulty brain wiring.
Researchers found that when we see an object, multiple motor programs are involuntarily activated, competing for control. The brain uses a common mechanism to filter out irrelevant information, allowing us to execute precise movements.
Five Brown University faculty, including neuroscientist David Berson and brain scientist John Donoghue, have been elected as fellows of the American Association for the Advancement of Science. They were recognized for their contributions to various fields, including visual neuroscience, marine ecology, and cell biology.
Cancer cells and nerve cells share a common way to survive by inhibiting apoptosis through glucose metabolism. This pathway allows both cells to evade death and proliferate uncontrollably in cancer cells but is essential for nerve cell survival.