Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
A team of researchers from Baylor College of Medicine has found a key component in the formation of long-term memory in fruit flies. The study showed that increased calcium influx into mushroom body neurons parallels the creation of new synapses associated with long-term memory, and can be blocked by specific laboratory techniques.
A team of researchers at UCSD School of Medicine has identified a genetic regulatory pathway that controls the choice between proliferation and differentiation in neural cells. Defects in this pathway result in brain malformations, such as Dandy-Walker malformation, which affects motor development and causes progressive skull enlargement.
A team of researchers at Johns Hopkins Medicine has discovered a natural toxin, PAR-polymer, responsible for most tissue and organ damage after a period of blood oxygen loss followed by restored blood flow. The toxin triggers cell death through a process called parthanatos, which can be prevented with potential new treatments.
A study published in the Journal of Biology found that chemotherapy drugs can cause long-term damage to brain cells, killing neural stem cells and oligodendrocytes, and impairing neural stem cell division. This may explain the adverse neurological side effects observed in some cancer patients treated with chemotherapy.
A study published in the Proceedings of the National Academy of Sciences reveals that VIP synchronizes biological clocks, clarifying its role alongside GABA. Without VIP, cells lose synchrony, indicating its coordinator function.
A study reveals human-specific sequence changes in DNA sequences regulating nerve cell adhesion molecules, leading to the uniquely human features of brain development and function. The researchers identified accelerated evolution of conserved noncoding sequences near genes involved in neuronal cell adhesion.
Researchers tracked brain activity in rats while they tasted water, salt water, and sugar water, finding that a formerly disliked taste became pleasurable when the rats were deprived of salt. This study provides new insights into how the brain processes pleasure and has implications for understanding eating disorders and addiction.
Researchers identified 'sociality' neurons in bird brains, which promote positive affiliation and are more active in gregarious species. The study's findings have implications for understanding social behavior in animals, including humans.
A study published in BMC Biology found that G-CSF protein reduces the size of the affected brain area by a third when injected four hours after a stroke, and restores motor functions in rats. Regular delayed injections of G-CSF starting up to three days after experimental stroke are also effective.
Researchers at Boston Children's Hospital have identified a novel pathway that influences the timing of nerve-cell production, favoring neuron over astrocyte formation. This discovery may provide insights into diseases such as Alzheimer's disease, schizophrenia, and autism.
Researchers at Johns Hopkins Medicine have identified a critical protein player in cell communication, which controls calcium flow into cells. This finding sheds new light on the rare cognitive disorder Williams-Beuren syndrome, associated with overly social behavior and spatial learning defects.
A study finds that the mutant huntingtin protein disrupts energy metabolism, leading to neurodegeneration in Huntington's disease. Researchers discovered that PGC-1a levels are lower in affected cells, suggesting a protective role for the protein.
A study published in NeuroImage found structural abnormalities in the planum temporale of individuals with Williams syndrome, which may explain their enhanced auditory skills. Despite smaller brain volumes, the temporal lobe was found to be of normal volume, suggesting that other factors contribute to their unique abilities.
Researchers discovered that food anticipation activates key hunger centers in the brain, while satiety circuits respond to the first bites of food. The study sheds light on the intricate processes governing appetite regulation and suggests a potential link between hormones like leptin and brain activity.
Researchers at the University of Texas Medical Branch at Galveston discovered that curcumin blocks the activity of gastrointestinal hormone neurotensin, implicated in colorectal cancer development. Curcumin reduces IL-8 production, accelerating tumor growth and metastasis.
A specific taste receptor, Gr66a, has been identified as responsible for the detection of caffeine's bitter taste in fruit flies. The receptor plays a crucial role in mediating caffeine's perception and is also involved in the processing of other methylxanthines.
Researchers found that slow theta oscillations tune into high-gamma waves, allowing areas of the brain to coordinate activity and transmit information. This coupling enables top-down executive processes like attention and memory to be connected to low-level perceptions and actions.
Researchers at Carnegie Mellon University are studying the mechanisms that underlie neuronal synchronization, which is thought to be involved in perception and consciousness. The study aims to understand how normal gamma oscillations are generated and how alterations in this synchrony contribute to schizophrenia.
Researchers at Harvard University have identified two compounds, LTB4 and LXA4, that stimulate stem cell growth in the brain. These findings may lead to new therapeutic approaches for neurological disorders such as Parkinson's disease.
Researchers found that increasing brain levels of the enzyme ubiquitin C-terminal hydrolase L1 (Uch-L1) can reverse lapses of memory in Alzheimer's mice. This suggests that Uch-L1 may play an important role in the pathogenesis of Alzheimer's disease and could be a new target for therapy.
A new study suggests that constant lighting in NICUs can disrupt the development of premature babies' biological clocks. Researchers found that newborn mice exposed to constant light were unable to maintain coherent rhythms and had difficulty establishing a regular activity cycle.
A novel proteomics study has shown that proteins regulating brain-cell activity behave like volume controls, allowing for incremental levels of activity. This 'homeostatic plasticity' enables neurons to adapt to changing environments.
Researchers discovered that brain neurons combine economic value and spatial information to control decision-making behaviors, contradicting the previous pure economic view. This study has implications for understanding human disorders such as addiction, depression, and obsessive-compulsive disorder.
Scientists from the University of Florida have found that ordinary human brain cells can generate new brain tissue in mice and produce large amounts of new brain cells in culture. This discovery could potentially be used to fight Parkinson's disease, Alzheimer's disease, stroke, and other brain disorders.
Scientists studying the brains of flies, moths, and cuttlefish have made discoveries about the mechanics of how the brain regulates behavior. Researchers have identified specific brain chemicals and regions that allow for rapid color changes in cuttlefish, similar to the human motor cortex.
A team of researchers at the California Institute of Technology has identified a specific region in the brain responsible for processing risk and reward, known as the 'gambling circuitry'. This discovery could help understand abnormal risk-taking behavior in disorders such as addiction and bipolar disorder.
A research team from Massachusetts General Hospital has discovered a potential drug target for Huntington's disease by identifying a novel inhibitor of Poly(ADP-ribose) polymerase (PARP1). PARP1 inhibitors can protect HD-affected cells from damage and energy depletion in laboratory assays.
Researchers identified a new disorder called enteric anendocrinosis caused by a mutation in the Neurogenin-3 gene. Patients with this condition develop type I diabetes and have abnormally low endocrine cells in their intestine, leading to severe malnutrition and growth failure.
Researchers have identified key components in the molecular mechanism of serotonin's action on appetite regulation. Serotonin and drugs that affect its action act on neurons to reduce AgRP release and increase αMSH levels, disrupting function of melanocortin receptors.
Researchers from the UC Davis M.I.N.D. Institute have found significantly fewer neurons in the amygdala of males with autism, a key brain region responsible for emotional responses and social learning. The study provides new insights into the neuroanatomical basis of autism, which may help advance research into this lifelong neurodevel...
A Rice University study has identified the complexin protein as a brake that shortens response time for signal transmission in nerve cells, enabling nearly instantaneous passing of information. This breakthrough sheds light on the mechanisms behind rapid neural signaling.
The brain's craving for a fix motivates humans to absorb knowledge at an optimal rate, driven by the release of natural opiates. This theory, proposed by USC Professor Irving Biederman, suggests that knowledge addiction has strong evolutionary value due to its correlation with perceived intelligence.
Researchers found that women's brains responded with stronger electrical activity when viewing erotic images than non-erotic content, regardless of its pleasantness or disturbance level. The study suggests that the brain processes erotic material differently, potentially due to evolutionary factors.
A study found that urocortin I impairs glucose-sensing neurons, leading to prolonged hypoglycemic responses. The regulation of the counterregulatory response is largely determined by CRFR2-mediated suppression and CRFR1-mediated activation in the hypothalamus.
Scientists at the University of Manchester have identified a previously unknown mechanism by which glucose blocks brain cells responsible for regulating wakefulness. This finding has implications for understanding and treating disorders such as narcolepsy, obesity, and addiction.
Researchers at Harvard Medical School have defined a molecular signaling pathway linking oxidative stress to cell death in brain neurons. The discovery of the MST-FOXO biochemical switch mechanism may provide potential new targets for the diagnosis and treatment of age-related diseases such as Alzheimer's.
A new mechanism explains how glucose inhibits neurons that regulate wakefulness, revealing a role for previously unknown potassium ion channels. Glucose levels affect the firing rate of these neurons, shedding light on cellular pathways regulating vigilance states and energy balance.
The Salk Institute research found that humans have neurons selective for gender based on motion cues, which adjust their selectivity on the fly. This mechanism allows humans to adapt quickly to local gait patterns, reflecting inherent differences in shape and movement.
Researchers have discovered that astrocytes become activated when their whiskers are stimulated, sending signals to the brain. This finding challenges the long-held assumption that astrocytes don't communicate much and suggests they may be part of everyday brain function.
Researchers have identified the specific step in the neurogenesis pathway that Prozac (fluoxetine) stimulates, increasing the number of neurons in the brain. The study's findings lay the foundation for future cell replacement therapies for neurodegenerative diseases.
Researchers have discovered a new compound that specifically targets FKBP38 receptor, reducing programmed cell death in neuronal cells. The compound protects neurons and promotes neural stem cell proliferation, offering potential therapeutic application for stroke and other neurodegenerative diseases.
Researchers have discovered that neurons can produce a key protein linked to Alzheimer's disease under certain conditions. The study uses a unique mouse model to show that apoE production is regulated by the brain's response to injury, shedding light on the mechanisms underlying this complex disorder.
Dr. McCluskey receives the Ajinomoto Award for Young Investigators in Gustation for her work on taste bud regeneration and its relation to the immune system. She aims to understand how macrophages, a type of immune cell, affect neural function in injured nerves.
A study by Harvard Medical School researchers identifies specific neurons in the orbitofrontal cortex that assign values to different goods. This discovery sheds light on choice deficit disorders such as eating disorders and compulsive gambling.
Researchers at Princeton University discovered that retinal ganglion cells organize their actions based on pair interactions rather than group discussions. This finding could shed light on how brain cells work together to make decisions.
Researchers confirm ventral word-form area's causal role in recognizing words by studying a patient whose surgery disrupted the region. The patient showed impaired reading skills but retained object recognition and naming abilities.
Researchers discovered a new mechanism in nerve cells that enables them to filter and transfer signals rapidly, contrary to the traditional Hodgkin-Huxley model. This allows for high precision in transmitting fast-changing signals while ignoring slowly varying stimuli.
Researchers find that growth factor SCF promotes tumor angiogenesis by interacting with normal neurons, leading to worsened prognosis in patients. Decreased SCF expression improves survival in mouse glioma models, highlighting the importance of considering normal cells in cancer treatment.
In a study on Huntington disease, researchers found that cystamine increased brain levels of protective protein HSJ1b and BDNF, suggesting a promising candidate for treatment. The study also revealed that cystamine raises BDNF in an HSJ1b-dependent manner.
A new study published in Neuron suggests that facial recognition relies on a similar neural mechanism as other object recognition, rather than specialized processing. The researchers used computational modeling and fMRI to find that a small group of neurons in the fusiform face area is highly selective for different faces.
Researchers propose a theory that the fusiform face area (FFA) recognizes faces based on selective processing of shapes of facial features. Their computational model and experimental studies support this idea, suggesting that face recognition can be achieved by hierarchical shape detectors.
Researchers at Washington University in St. Louis used a network of interconnected pendulums to demonstrate that introducing disorder can lead to order and synchronization in chaotic systems. The findings have potential applications in understanding neuronal activity and may help explain previously unexplained observations.
Research findings clarify microglia's induction and blockage of oligodendrogenesis in MS, shedding light on disease mechanisms. The study highlights the complex interplay between microglial activation and oligodendrogenesis in MS.
Researchers found that serotonin levels in pacemaker cells are crucial for gasping and auto-resuscitation in babies. Disturbed serotonin levels can lead to a decrease in gasping, making it difficult for the baby to wake up and initiate movement.
A mutation in the EAAT2 gene, which regulates glutamate levels in the brain, is associated with elevated plasma glutamate and increased risk of post-stroke neurological problems. Stroke patients with the mutated allele had higher plasma glutamate levels and more severe neurological outcomes than those with the normal allele.
Scientists at Johns Hopkins Medicine have created a detailed map of the lateral wall of the subventricle zone, suggesting the potential existence of human brain stem cells. The discovery also reveals displaced ependymal cells that may be related to cancer or neurodegenerative diseases.
Researchers found that adding neurotrophins to human embryonic stem cells increases cell survival by 36-fold. This discovery could enable mass production of stem cells for disease treatment and prevent tumor formation.
A subset of brain cells with pacemaking abilities has been identified as essential for gasping in infants, resolving a 15-year-old controversy. The discovery highlights the importance of autoresuscitation and gasping in maintaining oxygen supplies and heart rate during critical low-oxygen conditions.
Researchers at UF identified neural crest cells as the source of sharks' electrical ESP, a previously unknown function. This discovery fortifies the idea that early ancestors may have had the ability to detect electric fields.
Dr. Liu has discovered a mechanism underlying immune system modulation of Multiple Sclerosis (MS) and will optimize therapy using NKT cells. The Muscular Dystrophy Association fellowship award supports her three-year research project.