Neuroplasticity
Articles tagged with Neuroplasticity
Genomic Press launches Brain Health, a new peer-reviewed journal of lifelong brain resilience, with inaugural interview featuring Luísa Pinto on glial plasticity
Genomic Press launches Brain Health, a new peer-reviewed journal dedicated to the science of lifelong brain resilience, featuring research on glial plasticity and recovery from depression. The inaugural issue explores the intersection of fields including cognitive reserve, sleep, aging biology, nutritional psychiatry, and social sciences.
Can a deaf person's brain turn silence into vision?
Researchers found that a deaf person's brain can reorganize sensory systems through selective deactivation, not just increased activation. The auditory cortex in deaf individuals responds to visual stimuli with organized deactivations, representing visual spatial features.
USC study identifies brain rewiring mechanism that may aid stroke recovery
Researchers discovered that stroke survivors with severe motor impairment show signs of brain 'youthfulness' in undamaged regions, suggesting the brain's ability to adapt and compensate. This finding provides new insights into neuroplasticity and may guide personalized rehabilitation strategies.
Caffeine helps restore memory function after sleep loss, NUS Medicine study shows
A NUS Medicine study reveals that caffeine can restore social memory impaired by sleep deprivation. Caffeine targets a specific brain pathway to reverse disruptions in neural communication and plasticity. The study provides insights into the effects of caffeine on cognitive function and memory.
Novel study shows physical activity reshapes neural connectivity and makes the brain more resilient after childhood trauma
Research in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging reveals that lifetime physical activity can reshape neural connectivity, strengthening the brain's internal communication and optimizing its response to stress. The study challenges traditional deficit-focused views of adversity, offering a more dynamic and hope...
Treatment with psychedelics may provide a missing link towards long-term PTSD recovery
Treatment with psychedelics triggers large-scale reconfiguration of brain network dynamics driven by myelin remodeling, which might augment or sustain therapeutic effects. The study suggests that enhancing myelination could be a viable strategy to promote longer-term neural health and recovery from PTSD.
Dopamine selects, astrocytes refine: a new mechanism for motor-learning circuit rewiring
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Computer exercises improve the brain’s pathways after traumatic brain injury
Researchers found that computerized cognitive games improved neuroplasticity in adults with chronic traumatic brain injuries, leading to better cognitive performance. The study revealed changes in white matter associated with improved processing speed, attention, and working memory.
Brain research: “Pulse generators” grow and shrink as memories are formed
Scientists have observed changes in brain cells' signal transmission during learning processes, shedding light on the brain's adaptability. The study found that axon initial segments, responsible for generating electrical signals, can lengthen or shorten in response to experiences, influencing neuronal activity.
How do brains stay stable, and when might a dose of flexibility be helpful?
Scientists at Salk Institute find protein CCN1, secreted by astrocytes, maintains stable neural circuits in adult brains. The discovery could lead to new therapeutics for brain injury and stroke.
UT San Antonio physicists' groundbreaking discoveries open new paths to combating diseases
Researchers at UT San Antonio have discovered the molecular mechanisms generating electrical oscillations in microtubules, a frequency similar to that observed during brain activity. This discovery could lead to therapies preventing or reversing memory loss and improving neuroplasticity.
Scientists identify five ages of the human brain over a lifetime
Researchers identified five phases of brain structure, each supported by four turning points between birth and death, revealing key developments in cognitive performance, neural efficiency, and regional compartmentalization. The study provides context for understanding why brains develop differently at various stages of life.
New findings in split-brain science: Even minimal fiber connections can unify consciousness
Researchers found that a small section of intact corpus callosum is enough to sustain full integration of the two brain halves, contrary to previous assumptions. The discovery has implications for epilepsy surgery and brain injury recovery.
Infants born with hearing loss show disruptions in brain design, underscoring the urgency of intervention
Research finds infants with sensorineural hearing loss lack normal left-hemisphere language specialization. Early auditory stimulation and language exposure can help preserve brain development.
The flexible brain: How circuit excitability and plasticity shift across the day
Neural signals respond differently depending on time of day, with reduced activity at sunrise and enhanced at sunset. Blocking adenosine reveals a key regulator of cortical excitability across the day.
Drinking for two? Prenatal alcohol exposure rewires the brain and fuels compulsive behavior, new study finds
A new study reveals how prenatal alcohol exposure impairs key brain cells and circuits, leading to cognitive inflexibility and increased risk of compulsive alcohol use. Researchers identified a specific brain cell affected by early alcohol exposure, providing a clear target for developing more effective treatments of FASD.
Cellular railroad switches: how brain cells route supplies to build memories
Researchers found that Rab4 boosts neural connection strengthening while Rab10 decreases it, directing supplies to the surface of growing connections. This discovery may lead to new strategies for protecting memory in neurodegenerative conditions like Alzheimer's disease.
Vision therapy reverses concussion-related double and blurred vision, NJIT-led study finds
A recent study published in the British Journal of Sports Medicine found that vision therapy can effectively treat concussion-related eye coordination disorders, including convergence insufficiency and accommodation insufficiency. Nearly 90% of patients in the treatment group were able to see normally after 12 weeks of therapy.
Antidepressant fluoxetine found to promote brain plasticity in key cells, reshaping their energy systems
A new study reveals that fluoxetine alters how brain cells manage their energy and rebuild connections, potentially helping the brain adapt during depression treatment. This changes may create a window of plasticity or flexibility in the brain.
Tiny worms reveal big secrets about memory
Researchers have found that tiny worms can help understand how memories fade, with dopamine playing a major role. Without dopamine, the worms held onto memories longer than usual, revealing that forgetting is a finely tuned process essential for staying focused and flexible.
Healthy habits can make your brain age more slowly, study finds
A new study found that healthy habits such as optimism, good sleep, and social support are strongly linked to healthier brains. Study participants who reported the most protective factors had brains eight years younger than their chronological age, and their brains aged more slowly over time.
A coordinated dance between two proteins is essential for stronger brain connections
Researchers discovered a precise coordination between two proteins, BDNF and MMP-9, to strengthen specific brain connections. This mechanism is essential for learning, memory, and overall brain health.
Psychedelics offer healing for concussion, traumatic brain injuries
A new review from the University of Victoria suggests that psilocybin and 5-MeO-DMT may help treat concussions and traumatic brain injuries by increasing neuroplasticity and reducing inflammation. The compounds have shown promise in treating depression, anxiety, and other conditions in clinical research.
Gone but not forgotten: the brain’s map of the body remains unchanged after amputation
Despite long-held assumptions, a new study reveals that the brain's somatosensory cortex holds a stable 'body map' even after limb loss. The findings have significant implications for treating phantom limb pain and restoring sensation in prosthetic limbs via brain-computer interfaces.
New research further investigates safety of general anesthesia in infants
A new study published in PNAS found that prolonged and repeated exposure to GABA anesthetic agents in infants under two months leads to accelerated visual cortical development. This may suggest the use of non-GABA-active anesthetics for newborns, as a large multicenter clinical trial is currently underway.
Gilles Martin identifies neurons associated with the suppression of binge drinking
Researchers have identified a specific group of neurons in the brain responsible for suppressing binge drinking behavior. The discovery may lead to new therapeutic targets for treating alcohol dependency and related health challenges.
Pitt study has upended decades-old assumptions about brain plasticity
Researchers have discovered that the brain uses separate synaptic transmission sites to regulate spontaneous and evoked activity, a process essential for learning, memory, and mental health. This dual system enables the brain to maintain stability while adapting and learning.
How molecules can ‘remember’ and contribute to memory and learning
Ion channels can 'remember' previous signals, leading to changes in the receiving neuron that last for hours or days. This collective memory can accumulate over time, reducing communication between neurons and contributing to lifelong learning.
How the brain allows us to infer emotions
Researchers have identified the medial prefrontal cortex (mPFC) as the basis of emotional inference in animals and humans. In a study published in Nature, Xiaowei Gu and Joshua Johansen found that rats can learn inferred emotions by associating a neutral stimulus with an unpleasant experience.
Addressing youth mental health crisis: YMCA Dallas and health experts introduce vital new program
The YMCA of Metropolitan Dallas has developed a new pilot program called 'YES YOU CAN!' focusing on brain plasticity and comprehensive support for children, teens, parents, and counselors. The initiative aims to promote well-being and provide access to expert care through virtual and in-person methods.
Single-dose psychedelic boosts brain flexibility for weeks, peer-reviewed study finds
A single dose of a psychedelic compound can enhance cognitive flexibility for weeks after administration, according to a groundbreaking study. Mice treated with the compound showed improved performance in reversal learning tasks compared to control groups when tested weeks later.
Micronanoplastics found in artery-clogging plaque in the neck
A recent study found that people with plaque in their neck arteries have higher amounts of tiny plastic particles compared to those with healthy arteries. The concentration of these plastics was significantly higher in individuals who had experienced a stroke, mini-stroke, or temporary vision loss due to clogged blood vessels.
Researchers develop an LSD analogue with potential for treating schizophrenia
University of California researchers developed a new drug, JRT, with reduced hallucinogenic potential compared to LSD. The compound has shown promise in treating the negative and cognitive symptoms of schizophrenia, including anhedonia and cognitive function.
Improving rehabilitation after spinal cord injury using a small compound oral drug
Researchers discover edonerpic maleate enhances neural plasticity, supporting cortical reorganization and improving motor control in non-human primates with SCI. The compound promotes AMPA receptor movement to areas responsible for motor control, strengthening existing neural connections.
Don't let this stress you out
Researchers at Kyoto University investigated the effects of two-hit stress on mouse behavior, revealing significant changes in the cerebellum. The study found increased microglia turnover, neuronal loss, and decreased brain connectivity, correlating with anxiety-like behaviors and mental disorders.
Don't let this stress you out
Researchers at Kyoto University investigated the effects of two-hit stress on mice, finding that it leads to increased microglia activity, neuronal loss, and decreased brain connectivity. Microglia replacement therapy showed promise in rescuing affected mice, with female mice exhibiting higher stress resilience.
$4.9 million grant enables test of psychedelic MDMA as enhancement for PTSD therapy
A new clinical trial will use MDMA in combination with Prolonged Exposure therapy to enhance treatment outcomes for individuals with PTSD. Researchers believe MDMA shows potential in improving PTSD symptoms by increasing neuroplasticity and processing traumatic memories.
Pusan National University develops one-step 3d microelectrode technology for neural interfaces
The new μETF method simplifies fabrication of flexible 3D microelectrode arrays for neural applications. It reduces stimulation thresholds by 1.7 times and improves spatial resolution compared to traditional flat electrodes. The technology has potential in brain-computer interfaces, wearable electronics, and lab-on-a-chip systems.
Can lab-grown neurons exhibit plasticity?
Researchers at Tohoku University developed lab-grown neurons that form complex networks resembling animal nervous systems. These networks exhibit diverse neuronal ensembles and can be reconfigured through repetitive stimulation, mimicking neural plasticity.
Desert ants use the polarity of the geomagnetic field for navigation
Researchers found that desert ants rely on the polarity of the geomagnetic field to navigate during learning walks, contradicting previous findings in other insects. The team manipulated magnetic fields and observed the ants' behavior, concluding that a compass-like navigation system is useful for short-distance navigation.
New pathways to long-term memory formation
Researchers found a parallel pathway to long-term memory formation that bypasses short-term memory. Blocking short-term memory did not disrupt long-term memory retention.
Review paper: MDMA-assisted therapy could improve neurorehabilitation of injured service members beyond PTSD
A review paper suggests that MDMA-assisted therapy can benefit military personnel with traumatic brain injuries, improving emotional and cognitive challenges. The drug may facilitate social connections, increased self-esteem, and neural plasticity, leading to improved treatment outcomes.
Key brain circuit for female sexual rejection uncovered
A team of scientists has pinpointed a critical neural circuit for female sexual rejection, revealing how the brain integrates signals to shape behavior. The ventromedial hypothalamus, specifically progesterone-sensitive neurons in the anterior VMH, play a crucial role in determining whether a female accepts or rejects mating attempts.
Kessler Foundation scientist to explore effects of transcutaneous spinal stimulation's impact on motor recovery in traumatic brain injury
A four-year study funded by a $2.5 million grant will investigate the impact of spinal cord transcutaneous stimulation combined with gait training on motor recovery in individuals with traumatic brain injury. The research aims to improve clinical treatment strategies and decision-making for improved gait and functional recovery.
Bilingualism makes the brain more efficient, especially when learned at a young age
Researchers found increased whole-brain connectivity in bilingual participants, particularly those who learned their second language early in life. This increased connectivity was stronger between the cerebellum and left frontal cortex, indicating a more efficient brain organization in terms of functional connectivity.
Adding vagus nerve stimulation to training sessions may boost how well sounds are perceived
Researchers found that vagus nerve stimulation can improve sound discrimination in mice, suggesting a potential new approach to treating hearing disorders. The technique may also speed up hearing improvements from cochlear implants, enabling implant recipients to communicate more effectively.
Cognitive deficits from meth and PCP use are generated by a common neurotransmitter switch
Neurobiologists identify shared brain mechanism behind meth and PCP-induced cognitive deficits, finding a reversible switch in neurotransmitters. Reversing this switch restores memory function, offering potential for new treatments.
New tool quantifies cancer’s ability to shape-shift
A new analytical tool called PATH can quantify tumor cell plasticity, which is a key characteristic of cancer that leads to treatment resistance and metastatic spread. Researchers used PATH to analyze tumor samples from animal models and human patients, revealing new details of how tumors exploit plasticity to spread.
$1 million grant to fund research of nerve regeneration in multiple sclerosis patients
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
New study reveals changes in the brain throughout pregnancy
Researchers have created the first map of a human brain over the course of pregnancy, documenting changes in gray and white matter. These findings suggest that the adult brain is capable of undergoing extended periods of neuroplasticity, which may support behavioral adaptations tied to parenting.
Learning like a teenager
Researchers led by Daniela Vallentin successfully rewired zebra finches' brains using optogenetics, expanding their vocal repertoire. The findings have implications for human aging and potential therapies for neurodegenerative diseases and learning impairments.
The brain creates three copies for a single memory
The brain stores multiple copies of a single memory in parallel among different groups of neurons emerging at different stages during embryonic development. These memory copies change with time, with early-born neurons storing long-term persistence and late-born neurons fading over time.
If you yawn, I yawn too: new mechanisms behind imitative behavior revealed
Researchers have uncovered new insights into how the brain regulates imitative behavior, a phenomenon that facilitates interaction and social cohesion. The study used advanced brain stimulation technique to pinpoint the causal role of different circuits in facilitating or inhibiting automatic imitation.
Breakthrough in tremor treatment: Robotic therapy developed by GIST researchers improves daily activities
Researchers at the Gwangju Institute of Science and Technology (GIST) have developed an innovative robotic rehabilitation system called SPINDLE to enhance the strength and dexterity of individuals with tremors. The study revealed significant benefits, including improved motor control, coordination, and neuroplasticity.
People feel more connected to “tweezer-like” bionic tools that don’t resemble human hands
Researchers used virtual reality to test whether humans can feel embodiment toward prosthetic
CU Anschutz researchers offer new understanding of how antidepressants work
Antidepressants, such as SSRIs and SNRIs, work by restoring connections between brain regions, rather than correcting a chemical imbalance. The framework highlights the importance of these medications in alleviating depressive episodes, even if MDD isn't caused by a lack of serotonin.
In the brain at rest, neurons rehearse future experience
A team of researchers from Rice University and the University of Michigan found that some neurons not only replay recent past experiences but also anticipate future experience during sleep. The discovery provides an unprecedented view of how individual neurons in the hippocampus stabilize and tune spatial representations during periods...
Singing repairs the language network of the brain after a cerebrovascular accident
Researchers at the University of Helsinki found that singing repairs the structural language network of the brain after a cerebrovascular accident. Singing also improved tract connectivity and increased grey matter volume in language regions, leading to improved speech production in patients with aphasia.
'Trojan horse' weight loss drug more effective than available therapies
Researchers have developed a new weight loss drug that combines GLP-1 with molecules blocking the NMDA receptor, exploiting its effects on appetite control and neuroplasticity. This approach shows promise for greater weight loss in mice than existing medications.