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How does the brain interpret taste?

Researchers aim to understand how neurons receive signals for taste and touch sensations, exploring potential emotional correlations. The study will investigate the organization of brain circuits supporting these intersections, with implications for health and disease.

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Sensory cells taste cerebrospinal fluid to fight brain infections

Researchers discovered that sensory cells in the spinal cord's central canal can detect bacteria in cerebrospinal fluid and trigger an inflammatory response to fight brain infections. These 'taste' receptors recognize bitter substances, such as those from Streptococcus pneumoniae, and increase cytokine production to combat pathogens.

How the brain encodes warm and cool

Researchers identify 'thermal cortex' in posterior insular cortex of mice brains, finding specific cold-responding neurons for warmth and vice versa. The discovery sheds light on temperature perception and may help understand complex surface structures and brain diseases.

When bugs swipe left

Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.

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A multifaceted sensation

Scientists found that neurons actually fall silent above a certain level, with the most sensitive ones dropping off first. This finding challenges the long-held assumption that neurons plateau in activity above odor concentrations, and suggests a more complex encoding of smells at different levels.

The genes of the sixth sense

Scientists have identified genes that enable proprioception, a crucial sense for coordinated movement and balance. The discovery could lead to better understanding of neurological disorders such as spinal cord injuries, scoliosis, and hip dysplasia, ultimately enabling the development of novel therapies.

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Stem cells may help replace lost sensory neurons

Researchers discovered stem cells in mouse dorsal root ganglia (DRG) with the potential to regenerate lost sensory neurons and glia. These cells, known as satellite glia, can become activated and generate new glia and, to a lesser extent, neurons after injury.

Mapping the path from smell to perception

Scientists have created an extensive new map of the brain's olfactory circuits, revealing a complex system that processes different aspects of odor information. The map suggests the existence of parallel neural circuits dedicated to assessing smell identity, pleasantness, and origin, offering new insights into olfactory processing.

Too much motivation affects our decision-making

A team from UNIGE and EPFL discovered that too much or too little motivation can blur sensory information and affect decision-making. In a state of hyper-motivation, rodents performed poorly, while moderate motivation led to optimal choice. These results open up new perspectives in learning methods.

Why are sounds not perceived under anesthesia?

Scientists discovered a novel neural mechanism that accompanies unconsciousness, masking sensory inputs with spontaneous activity. The auditory cortex's response to sounds is indistinguishable from its own internal activity under anesthesia.

Sniffing out the brain’s smelling power

Researchers at Cold Spring Harbor Laboratory discovered that tufted cells in the olfactory bulb are better at recognizing smells than mitral cells. This finding sheds light on how the brain processes sensory information, including smell intensity and identity.

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Nerves on the spot

Sensory neurons in human skin have been found to regulate melanocytes, influencing pigmentation and cell survival. The study identified a protein called RGMB as a key factor promoting melanocyte survival and darkness.

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How visual information travels from the retina to the midbrain

Researchers used Neuropixels probes to measure the activity of synaptically connected retinal and midbrain neurons, revealing a mosaic-like neural connection. The study provides new insights into visual processing and strengthens our understanding of blindsight.

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A sensory mystery

A team of researchers at Harvard Medical School has made new strides in understanding the basic biology of internal organ sensing, revealing spatial maps of neurons in the brain stem responding to feedback from internal organs. The study found that inhibition within the brain plays a key role in selectively responding to organs.

Scripps Research scientists eavesdrop on communication between fat and brain

Researchers have identified a stream of messages between fat tissue and the brain, revealing a previously unknown pathway for adipose tissue to communicate with the brain. The discovery suggests that sensory neurons play a crucial role in regulating fat metabolism and may hold potential for treating obesity and metabolic diseases.

Why heat makes us sleepy

Researchers at Northwestern University found that a thermometer-like brain circuit promotes midday siestas on hot days. The study, which used fruit flies as a model organism, identified absolute heat receptors in fly heads, leading to increased midday sleep in flies and potentially humans.

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New study reveals where memory fragments are stored

A new study found that individual details of a memory are parsed and stored elsewhere, in the prefrontal cortex. This separation ensures that exposure to any cue is sufficient to activate the prefrontal cortex for recall of the whole memory.

Scripps Research scientists identify sensor underlying mechanical itch

Researchers at Scripps Research have identified a protein in sensory nerves that detects mechanical itch, which could lead to better drug treatments for chronic itch conditions. The discovery was made by Ardem Patapoutian and his team, who found that PIEZO1 is expressed in two types of sensory neurons implicated in chemical itch.

How the brain interprets motion while in motion

Researchers at the University of Rochester have discovered a novel neural mechanism involved in causal inference that helps the brain detect object motion during self-motion. This discovery may have applications in designing artificial intelligence devices and developing treatments for brain disorders such as autism and schizophrenia.

Olfactory neurons adapt to the surrounding environment

Researchers at UNIGE found that olfactory neurons change their identity based on expressed receptors and past experiences. The study reveals a wide range of identities among these neurons, which adapt rapidly to different levels of stimulation.

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Rhythmical deep sleep

Scientists used fMRI to detect burst-suppression events in anesthetized animals and found its spatial distribution varies between primates and rodents. This phenomenon is linked to the brain's sensory areas, with certain regions showing resistance to anesthesia-induced suppression.

Important genetic origin of our senses identified

A study by researchers at the University of Innsbruck discovered that the Cranial Sensory Ganglia in vertebrates shares a common genetic origin with Bipolar Tail Neurons found in tunicates. This finding suggests that Hmx, a gene conserved across evolution, played a crucial role in the formation of highly specialized sensory organs.

Triggering cellular apoptosis by optical targeting

Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.

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The algebra of neurons

Researchers at Max Planck Institute for Biological Intelligence discovered how a specific type of neuron can multiply two incoming signals in fruit flies. This finding provides insight into the algebra of neurons, which underlies various brain processes such as sound localization and visual motion detection.

Exploring the signals that underlie learning

Researchers found that the primary somatosensory cortex, traditionally thought to be a basic sensory center, plays a deeper role in decision-making and facilitates flexible behavior with experience. The study suggests an expanded role for this brain area in adaptive strategies.

Untangling mixed (neural) signals

Researchers at the University of Pittsburgh have discovered how 'polyglot' neurons encode and decode sensorimotor chatter, enabling the differentiation between motor and sensory signals. This breakthrough has vital applications in brain-computer interfaces and neuroprosthetics, where accurate decoding is crucial.

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A Map for the sense of smell

Scientists have identified a peripheral mechanism that allows fruit flies to quickly assess complex odors without costly synaptic computation. The fly's olfactory receptor neurons communicate through electrical interactions, enabling an energy-saving way to process meaningful odor blends.

The ‘surprisingly simple’ arithmetic of smell

A team of researchers at Washington University in St. Louis used machine learning to understand how locusts can consistently recognize smells despite environmental factors, finding that combining the activity of ON and OFF neurons provides a simple yet effective solution.

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Switching in the brain: A fresh perspective

A transdisciplinary research team at Göttingen Campus has found a new perspective on the rhythmic processes in the brain. They discovered that adapting interneurons can switch between very slow rhythms and fast rhythms, challenging previous assumptions about their function.

Learning and protecting itself: how the brain adapts

Researchers at the University of Göttingen studied how blocking certain enzymes affects brain adaptability in healthy and diseased mice. In healthy mice, inhibiting these enzymes blocked neuronal plasticity, while in stroke-affected mice, it restored lost plasticity.

Which side is which?: How the brain perceives borders

Researchers at Salk Institute discovered that neurons deep in the brain's cortex process information from borders first, then send clues back to upstream areas. This supports the importance of the 'feedback' pathway for deciphering borders.

Feast or forage: Study finds circuit that helps a brain decide

Researchers discovered a brain circuit that enables C. elegans worms to switch between foraging and feasting behaviors based on sensory information. The circuit involves a key neuron called AIA, which integrates food odor signals to influence the behavior.

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Reading the mind of a worm

Researchers used a machine-learning algorithm to identify differences in how the brain responds to various chemicals, including salt and benzaldehyde. The study provides insight into how brains process information and may help understand sensory processing disorders.

The goal in mind

Researchers found that future goals are represented by a pattern of neural activity resembling previous visits, and this activity can re-emerge upon decision to target a location. The orbitofrontal cortex plays a key role in representing future goals during navigation.

Drug helps sensory neurons regrow in the mouse central nervous system

Researchers at WashU Medicine identified a drug that helps sensory neurons regrow after spinal cord injury. The drug, fenofibrate, activated support cells and improved recovery by about twice as much as a placebo. This finding offers potential for repurposing an FDA-approved compound to restore sensory function.

Unraveling the mystery of touch

A new study reveals that sensitive skin surfaces are overrepresented in the brain due to stronger connections between sensory neurons and brain stem neurons. This mechanism may explain why certain body parts, like hands and lips, are more sensitive than others.

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Neurons in visual cortex of the brain ‘drift’ over time

Researchers at Washington University found that neurons in the primary visual cortex exhibit 'drift' over time, changing their responses to the same stimulus even without learning or experience. This discovery challenges the notion of stable neural activity in sensory cortices.

Genetic program protects neurons from degeneration

Researchers at the University of Bonn identified a genetic program in fruit flies that controls neuron development and protection. The program, which involves the WNK gene, has similar functions in humans and may hold the key to understanding and treating neurodegenerative diseases.

Neurons that respond to touch are less picky than expected

A new study from Northwestern University found that primary touch-sensitive neurons respond to multiple types of touch and varying degrees. Researchers developed a comprehensive technique to stimulate rats' whiskers in three dimensions while recording brain activity, revealing that these neurons communicate touch in a more complex manner.

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Researchers discover how hunger boosts learning about food in mice

Researchers used genetically engineered mice to study the AgRP hunger neurons, finding that fasting activates these cells, while food cues inhibit their activity. The team discovered that the aversive feeling caused by hunger enhances learning, making dieting difficult due to this persistent sensation.

Scientists discover a new class of memory cells in the brain

Researchers have identified a population of neurons in the brain's temporal pole region that collectively remembers familiar faces, including those of loved ones. This discovery sheds new light on how our brains process and remember faces, with potential implications for understanding conditions like prosopagnosia.