Articles tagged with Bile
A traditional herbal remedy has been found to improve bilirubin clearance in neonates, offering a potential complement to Western pharmaceutical treatments. The discovery involves the activation of the nuclear receptor CAR by an herbal tea, highlighting the intersection of Eastern and Western medical practices.
A University of Minnesota study has found that tauroursodeoxycholic acid (TUDCA) significantly reduces injury associated with hemorrhagic strokes in rats. The bile acid crosses the blood-brain barrier and induces survival pathways while inhibiting destructive ones, leading to a 50% decrease in lesion volume.
Two new genes, Abcg5 and Abcg8, play a critical role in cholesterol secretion into the bile, essential for maintaining cholesterol homeostasis. Disrupting these genes can lead to increased plasma levels of cholesterol and plant sterols, associated with premature heart disease.
Researchers discovered that tauroursodeoxycholic acid (TUDCA) can cross the blood-brain barrier and reduce apoptosis in mice with the HD gene, improving neurological cell function. The bile acid's anti-apoptotic qualities may also have potential for treating other chronic neurodegenerative conditions.
Researchers discovered that guggulsterone blocks the FXR receptor, regulating cholesterol metabolism. The study suggests that guggulsterone could lead to new drugs to control cholesterol levels and potentially treat hyperlipidemia.
The NIH/Office of the Director's panel endorses ERCP for diagnosing suspected ampullary cancers and treating conditions like symptomatic gallstone disease, but emphasizes caution due to potential complications such as pancreatitis.
Researchers reexamine the process of reverse cholesterol transport, a critical mechanism for removing excess cholesterol from peripheral tissues. The study reveals that this process may have both protective and detrimental effects on cardiovascular health.
Researchers at UT Southwestern Medical Center have discovered a nuclear receptor, FXR, that controls bile acids and cholesterol production. The finding has important implications for developing drugs to control dietary cholesterol in humans.
Researchers have developed a system to detect the formation of gallstones by monitoring the interactions between cholesterol and lecithin in artificial bile. The technique may help identify key enzymes that speed up or slow down gallstone growth, leading to new treatments for cardiovascular ailments and genetic disorders.