A new study suggests that semaglutide reduces heart disease risk beyond just weight loss, but the exact mechanism is unclear. The study analyzed data from a clinical trial of semaglutide, which found that patients taking the drug had a 20% lower risk of heart disease, but only half of this reduction could be explained by changes in kno...
Researchers at Harrington Discovery Institute have identified a biological mechanism that may explain why obesity relapse occurs and how it is passed down through generations. They found that obesity creates a lasting biological change in fat cells that keeps the hunger hormone asprosin elevated, even after weight loss, and that this s...
Digital behavioral infrastructure leverages digital health apps to drive medication persistence, side-effect mitigation, and durable weight loss. The 'habit window' hypothesis proposes building healthy behaviors during medication's peak efficacy window.
Weight loss injections can impact reproductive health, and a new study provides evidence-based guidelines for families and health professionals. The guidelines recommend that incretin-based medication therapy should not be deliberately continued throughout pregnancy, but women who used the injections without realizing they were pregnan...
A recent study identified three distinct BMI trajectories among people with type 2 diabetes, with stable, increasing, and decreasing trajectories associated with different comorbidities and healthcare service use. Increasing BMI was linked to a clustering of chronic diseases, while weight loss was not always indicative of better health...
A new study reveals that support from spouses and friends is crucial for successful weight loss, differing from current public health approaches. This research emphasizes the need for tailored lifestyle practices that consider individual experiences.
A new study identified why men struggle with weight loss, finding traditional diet programs are often perceived as too restrictive and female-focused. Support from spouses and incorporating sport or physical activity may be key to successful weight-loss initiatives tailored for men.
Researchers found that dietary tryptophan supplementation can prevent sepsis by enhancing macrophage bacterial defense through GPR37 activation, which increases phagocytic ability against bacteria. IPyA, a key metabolic product, directly binds to GPR37 on macrophages, activating RAC1/CDC42 and increasing phagocytosis.
A 6-month study of 5132 MyNetDiary users found that consistent food-tracking, even with fewer than 2 days per week, is associated with better weight loss outcomes. Users who tracked food 6-7 days per week lost an average of 11.33% of their body weight, while those who tracked only 2-3 days per week lost 7.35%.
Researchers developed a system using a 3D time-of-flight camera to measure frozen skipjack tuna, capturing dense 3D point-cloud data for accurate body size and weight estimation. The combination of 3D imaging and machine learning analysis yielded accurate noncontact estimates of fish body weight.
A new molecular compound, TOFA, identified by UC Berkeley scientists, helps cells burn extra energy with no change in food intake or exercise, improving insulin sensitivity and glucose control. The treatment, which works by increasing energy expenditure, shows promise in mouse models and may be used in combination with GLP-1 medications.
A new trial will assess whether Semaglutide reduces alcohol consumption in people with alcohol use disorder, obesity, and liver disease. The four-year CURB project aims to explore the potential benefits of the weight loss drug in treating alcohol-related liver disease and obesity.
Adults who continued to eat pork while participating in a 6-month digital weight management program lost a clinically significant 5.3% of starting body weight and improved their overall diet quality scores by 4.3 points. This study challenges the notion that pork is automatically off-limits within a healthier eating plan.
A new study published in JACC suggests that waist circumference and waist-to-hip ratio provide critical information about cardiovascular risk, even among people with a normal BMI. Individuals with elevated central adiposity were associated with higher risks for most outcomes, regardless of their weight status.
A cohort study found associations between perinatal factors and changes in brain maturation among adolescents. The study used conditional-longitudinal models to assess individual growth trajectories and mental health symptoms.
Researchers found that people with well-controlled HIV have more fibrosis in their fat tissues, leading to insulin resistance and type 2 diabetes. The study also identified a blood marker of scarred fat, which may help predict metabolic future for individuals with HIV.
Adults with type 2 diabetes have a high risk of fragility fractures, but new research found GLP-1 receptor agonists reduce this risk by 21% compared to DPP-4 inhibitors. The largest reductions occurred in hip, femur, and spine fractures.
Researchers identified endotrophin as a biological marker that rises and falls with changes in body fat, reflecting changes in metabolic health. The study suggests endotrophin could serve as a valuable biomarker and therapeutic target for reducing obesity-related health risks.
Researchers from Pennington Biomedical will present findings on organoid models, GLP-1 therapies, and early-life nutrition. The center's broad research portfolio is represented at the annual meeting of the American Society for Nutrition.
Repeatedly losing and gaining weight accelerates muscle loss in middle-aged people, as found in new UC San Francisco research. The study analyzed MRI scans of 1,433 participants and found that those with fluctuating weights lost nearly four times as much thigh muscle over four years.
A pooled analysis of two randomized trials found that decreasing sleep by just 1.5 hours each night was associated with increases in body weight, waist circumference, and sedentary time in adults with elevated cardiometabolic risk. The findings highlight the importance of discussing sleep duration at health care visits.
A review of research on repeated weight loss and regain suggests that yo-yo dieting is not necessarily as harmful as often portrayed. The benefits of weight loss can outweigh the potential risks of later weight regain, with several large studies showing that obesity itself is a primary driver of metabolic disease risk.
The study found that gestational exposure to 10 classes of priority chemicals was associated with differences in gestational age at birth and lower birth weight-for-gestational age z scores. Reducing exposure to these chemicals could promote healthy deliveries and better child outcomes.
The NOVO EXPENDITURE trial investigates the effects of a hormone-based treatment on weight loss compared to a reduced-calorie diet. Participants will undergo extensive physiological testing, including metabolic chamber sessions and regular weigh-ins, to assess the treatment's impact on energy use and body weight.
A new oral GLP-1 medication, elecoglipron, has been shown to significantly reduce blood glucose levels and bodyweight in adults with type 2 diabetes. The study found that up to 89.6% of participants achieved an HbA1c level of 7%, while 72.3% experienced at least 5% weight reduction.
A study found that adding orfglipron to titrated insulin glargine significantly improved glycemic control and body weight in participants with type 2 diabetes. The treatment did not increase the risk of hypoglycemia, compared to placebo.
A study of over 229,000 obese adults without diabetes found that weight loss drugs, such as semaglutide and tirzepatide, were associated with a 41% decrease in the overall risk of developing obesity-related cancers. GLP-1 RAs also showed larger reductions in certain subgroups, including men and gynaecologic cancers.
A new study published in Nature Medicine finds that semaglutide improves weight loss and metabolic health outcomes in patients who do not respond well to bariatric surgery. Patients taking semaglutide showed significant weight loss from body fat, improved blood sugar levels, and better quality of life.
Researchers at Duke University developed a new approach to deliver GLP-1 medications orally that maintains efficacy without requiring fasting. The technique uses an elastin-like polypeptide-based delivery system that protects the peptide from stomach acid and releases it in the intestines, bypassing the stomach's destructive acids.
A comparative study found that endoscopic sleeve gastroplasty (ESG) is associated with significantly greater short-term weight loss than oral semaglutide. Patients undergoing ESG achieved a mean total body weight loss of 12.7%, compared to 8.7% in those receiving semaglutide.
Research by Dr. Hanim Diktas at Pennington Biomedical Research Center shows that combining GLP-1 receptor agonists with behavioral intervention leads to a greater reduction in 'food noise', a persistent thought about food disrupting daily life and healthy behaviors. The study found significant decreases in food noise for participants u...
Researchers have identified potential mechanisms linked to reduced type 2 diabetes risk in chronic cannabis users. A team led by Nicholas V. DiPatrizio found that specific compounds within cannabis regulate metabolism, leading to significant weight loss and improved glucose regulation in obese mice.
A recent study found that a 10-week nutrition and body image intervention program improved eating behaviors, physical activity, and body image among women undergoing substance use treatment. The program also reduced disordered eating behaviors and weight-related concerns.
SourceElsevier·JournalJournal of Nutrition Education and Behavior·TypeExperimental study·DateMay 7, 2026
A study by the University of Gothenburg reveals that changes in gut bacteria composition after bariatric surgery are strongly associated with improved glucose metabolism and insulin release. Patients with type 2 diabetes who achieved improved glycemic control exhibited greater microbial gene richness and enhanced fermentation processes.
Regular physical activity is essential for mitigating the regain of lost weight after discontinuing GLP-1 medications. Exercise has complementary effects beyond energy balance, including improved insulin sensitivity and increased fat oxidation. Clinicians must develop individualized strategies to improve exercise adherence.
A preclinical study found that mice stopped and restarted GLP-1s gained less weight over time, with a significant decrease in muscle mass. The researchers suggest that clinicians help patients preserve muscle mass while on these medications through exercise or nutrition.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
A Japanese study examines the long-term effects of COVID-19 lockdowns on individuals with glucose intolerance, revealing a clear divergence in clinical trajectories among those who worsened and improved. Flexible lifestyle adaptation is crucial for restoring metabolic health, suggesting personalized support may improve glycemic control.
A new study has found that postmenopausal white women with higher genetic risk of obesity regained weight about two times faster than those with lower genetic risk. Despite this difference, Black women in the study regained weight at a similar rate, regardless of their genetic risk.
A study by Worcester Polytechnic Institute researcher Angela Incollingo Rodriguez found that weighing patients can elevate stress and blood pressure levels. The research suggests that the timing of weight measurement may impact the accuracy of subsequent blood pressure readings. This could lead to more accurate physiological measuremen...
A new study from the University of Eastern Finland and Rutgers University found that waist-to-height ratio predicted the risk of hypertension better than body mass index. Waist-to-height ratio-assessed high fat mass was associated with a 50% increased likelihood of elevated blood pressure and an 82% increased likelihood of hypertension.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Multiple sclerosis prevalence more than doubled in England's healthcare system over 30 years, while survival rates increased. Lifestyle factors, including tobacco use and socioeconomic deprivation, were significantly associated with mortality.
A concerning rise in adolescent obesity has been found, with overall rates climbing to 15.9% in 2023. Obesity patterns also reveal a decline in weight-loss attempts, with females more likely to attempt weight loss but fewer adolescents reporting efforts in 2023.
A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide does not lead to significant weight regain in clinical practice. Many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
Patients who stop taking weight loss drugs like Ozempic and Wegovy experience rapid weight regain of up to 60% within a year, but sustain around 25% of lost weight. Researchers found that individuals may maintain healthier eating habits even after treatment ends.
A phase 3 trial found that orforglipron, a novel GLP-1 receptor agonist pill, leads to greater blood sugar control and weight loss than current oral GLP-1 RA semaglutide in people with type 2 diabetes. Participants taking orforglipron had significantly greater reductions in body weight and blood sugar levels.
A new study found that adding one avocado and a cup of mango to daily meals and snacks for eight weeks improved vascular function among adults with prediabetes, while also reducing diastolic blood pressure. The Avocado-Mango diet showed significant increases in flow-mediated dilation and nutrient-dense nutrients without changes in calo...
A new study finds salcaprozate sodium may have adverse biological effects on the gut and beyond, including shifts in potentially harmful gut bacteria and elevated inflammatory markers. The research highlights an important gap in understanding the long-term impact of repeated SNAC exposure.
A comprehensive scientific review highlights pecans' positive effects on cardiovascular health, including improved lipid metabolism and antioxidant defenses. While findings on blood sugar control are mixed, the review suggests pecans may support better diet quality and satiety.
A new study discovered two previously unidentified fat distribution types associated with extensive gray matter atrophy and accelerated brain aging in men and women. Individuals with 'pancreatic-predominant' and 'skinny fat' profiles showed increased risk of neurological diseases, cognitive decline, and brain health issues.
The W8Buddy study, a major real-world evaluation of digitally delivered specialist weight management pathways, is recruiting 450 participants from 4 Specialist Weight Management Services across England and Wales. The study aims to assess the long-term health benefits and economic impact of digital tools for obesity care.
Research from the University of Warwick finds that teenage girls who manage their bodies through constant dieting and exercise face heightened risks of psychological health issues. By age 20, these young women are more likely to experience anxiety and depression, highlighting the need for a broader approach to mental health support.
Women with a genetic predisposition to higher body mass index are at increased risk of all-cause mortality after breast cancer diagnosis. Targeted lifestyle recommendations can mitigate this risk.
Researchers at Vanderbilt Health found that both weight loss drugs and bariatric surgery induce a moderate loss of lean muscle and substantial reduction in fat, improving body composition in obese patients. This shift is associated with lower mortality risk from obesity-related diseases.
A new study found that 4.9 million adults in Great Britain have recently used a drug to support weight loss or were interested in using one in the near future. The usage far exceeds NHS England's initial goal of prescribing these drugs to 220,000 people over three years.
A systematic review finds that stopping weight loss drugs leads to rapid weight regain, reversing heart health markers in under two years. Average monthly weight gain is 0.4kg, with all cardiometabolic risk markers projected to return to pre-treatment levels within 1.4 years.
A cohort study found higher fine particulate matter (PM2.5) exposure associated with lower birth weight, particularly in early and mid-pregnancy. The study's findings suggest that understanding windows of susceptibility to environmental exposures can inform strategies for limiting exposure during critical periods.
Households taking GLP-1 medications reduce grocery spending by an average of 5.3%, while spending at fast-food restaurants and coffee shops also decrease. Ultra-processed foods see significant declines, whereas yogurt, fresh fruit, and meat snacks experience modest increases.