Articles tagged with Body Weight
A new oral GLP-1 medication, elecoglipron, has been shown to significantly reduce blood glucose levels and bodyweight in adults with type 2 diabetes. The study found that up to 89.6% of participants achieved an HbA1c level of 7%, while 72.3% experienced at least 5% weight reduction.
A study of over 229,000 obese adults without diabetes found that weight loss drugs, such as semaglutide and tirzepatide, were associated with a 41% decrease in the overall risk of developing obesity-related cancers. GLP-1 RAs also showed larger reductions in certain subgroups, including men and gynaecologic cancers.
A study found that adding orfglipron to titrated insulin glargine significantly improved glycemic control and body weight in participants with type 2 diabetes. The treatment did not increase the risk of hypoglycemia, compared to placebo.
A new study published in Nature Medicine finds that semaglutide improves weight loss and metabolic health outcomes in patients who do not respond well to bariatric surgery. Patients taking semaglutide showed significant weight loss from body fat, improved blood sugar levels, and better quality of life.
Researchers at Duke University developed a new approach to deliver GLP-1 medications orally that maintains efficacy without requiring fasting. The technique uses an elastin-like polypeptide-based delivery system that protects the peptide from stomach acid and releases it in the intestines, bypassing the stomach's destructive acids.
Researchers have identified potential mechanisms linked to reduced type 2 diabetes risk in chronic cannabis users. A team led by Nicholas V. DiPatrizio found that specific compounds within cannabis regulate metabolism, leading to significant weight loss and improved glucose regulation in obese mice.
Regular physical activity is essential for mitigating the regain of lost weight after discontinuing GLP-1 medications. Exercise has complementary effects beyond energy balance, including improved insulin sensitivity and increased fat oxidation. Clinicians must develop individualized strategies to improve exercise adherence.
A preclinical study found that mice stopped and restarted GLP-1s gained less weight over time, with a significant decrease in muscle mass. The researchers suggest that clinicians help patients preserve muscle mass while on these medications through exercise or nutrition.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
A new study has found that postmenopausal white women with higher genetic risk of obesity regained weight about two times faster than those with lower genetic risk. Despite this difference, Black women in the study regained weight at a similar rate, regardless of their genetic risk.
A Japanese study examines the long-term effects of COVID-19 lockdowns on individuals with glucose intolerance, revealing a clear divergence in clinical trajectories among those who worsened and improved. Flexible lifestyle adaptation is crucial for restoring metabolic health, suggesting personalized support may improve glycemic control.
A study by Worcester Polytechnic Institute researcher Angela Incollingo Rodriguez found that weighing patients can elevate stress and blood pressure levels. The research suggests that the timing of weight measurement may impact the accuracy of subsequent blood pressure readings. This could lead to more accurate physiological measuremen...
A new study from the University of Eastern Finland and Rutgers University found that waist-to-height ratio predicted the risk of hypertension better than body mass index. Waist-to-height ratio-assessed high fat mass was associated with a 50% increased likelihood of elevated blood pressure and an 82% increased likelihood of hypertension.
A new study found that maintaining a healthy weight from early adulthood is associated with lower risks of premature death from various diseases. Excess weight at 25 years old has lasting effects on mortality risk, independent of subsequent weight changes.
Multiple sclerosis prevalence more than doubled in England's healthcare system over 30 years, while survival rates increased. Lifestyle factors, including tobacco use and socioeconomic deprivation, were significantly associated with mortality.
A concerning rise in adolescent obesity has been found, with overall rates climbing to 15.9% in 2023. Obesity patterns also reveal a decline in weight-loss attempts, with females more likely to attempt weight loss but fewer adolescents reporting efforts in 2023.
A Cleveland Clinic analysis of nearly 8,000 patients found that discontinuing semaglutide and tirzepatide does not lead to significant weight regain in clinical practice. Many patients successfully stabilized their weight after one year through alternative treatments and therapeutic lifestyle interventions.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
Patients who stop taking weight loss drugs like Ozempic and Wegovy experience rapid weight regain of up to 60% within a year, but sustain around 25% of lost weight. Researchers found that individuals may maintain healthier eating habits even after treatment ends.
A phase 3 trial found that orforglipron, a novel GLP-1 receptor agonist pill, leads to greater blood sugar control and weight loss than current oral GLP-1 RA semaglutide in people with type 2 diabetes. Participants taking orforglipron had significantly greater reductions in body weight and blood sugar levels.
A new study found that adding one avocado and a cup of mango to daily meals and snacks for eight weeks improved vascular function among adults with prediabetes, while also reducing diastolic blood pressure. The Avocado-Mango diet showed significant increases in flow-mediated dilation and nutrient-dense nutrients without changes in calo...
A new study finds salcaprozate sodium may have adverse biological effects on the gut and beyond, including shifts in potentially harmful gut bacteria and elevated inflammatory markers. The research highlights an important gap in understanding the long-term impact of repeated SNAC exposure.
A comprehensive scientific review highlights pecans' positive effects on cardiovascular health, including improved lipid metabolism and antioxidant defenses. While findings on blood sugar control are mixed, the review suggests pecans may support better diet quality and satiety.
A new study discovered two previously unidentified fat distribution types associated with extensive gray matter atrophy and accelerated brain aging in men and women. Individuals with 'pancreatic-predominant' and 'skinny fat' profiles showed increased risk of neurological diseases, cognitive decline, and brain health issues.
The W8Buddy study, a major real-world evaluation of digitally delivered specialist weight management pathways, is recruiting 450 participants from 4 Specialist Weight Management Services across England and Wales. The study aims to assess the long-term health benefits and economic impact of digital tools for obesity care.
Research from the University of Warwick finds that teenage girls who manage their bodies through constant dieting and exercise face heightened risks of psychological health issues. By age 20, these young women are more likely to experience anxiety and depression, highlighting the need for a broader approach to mental health support.
Women with a genetic predisposition to higher body mass index are at increased risk of all-cause mortality after breast cancer diagnosis. Targeted lifestyle recommendations can mitigate this risk.
Researchers at Vanderbilt Health found that both weight loss drugs and bariatric surgery induce a moderate loss of lean muscle and substantial reduction in fat, improving body composition in obese patients. This shift is associated with lower mortality risk from obesity-related diseases.
A systematic review finds that stopping weight loss drugs leads to rapid weight regain, reversing heart health markers in under two years. Average monthly weight gain is 0.4kg, with all cardiometabolic risk markers projected to return to pre-treatment levels within 1.4 years.
A new study found that 4.9 million adults in Great Britain have recently used a drug to support weight loss or were interested in using one in the near future. The usage far exceeds NHS England's initial goal of prescribing these drugs to 220,000 people over three years.
A cohort study found higher fine particulate matter (PM2.5) exposure associated with lower birth weight, particularly in early and mid-pregnancy. The study's findings suggest that understanding windows of susceptibility to environmental exposures can inform strategies for limiting exposure during critical periods.
Households taking GLP-1 medications reduce grocery spending by an average of 5.3%, while spending at fast-food restaurants and coffee shops also decrease. Ultra-processed foods see significant declines, whereas yogurt, fresh fruit, and meat snacks experience modest increases.
Researchers identified a specific type of gut bacteria, Turicibacter, that promotes metabolic health and reduces weight gain in mice. The bacterium produces fatty molecules that are absorbed by the small intestine, improving ceramide levels and preventing excessive weight gain.
A study found that reducing body fat percentage improves long-distance running and cross-country skiing performance, but converting body fat into muscle tissue is a more effective way for female athletes to optimize their body composition. Training and dietary habits that promote muscle growth outweigh the benefits of weight loss.
A recent study suggests that adverse childhood experiences may increase the risk of obesity in Latinx and Hispanic youths. The study found that promoting resiliency-focused skills may help improve pediatric weight trajectories among these populations, potentially mitigating the impact of adverse experiences on health outcomes.
A national study led by Curtin University found that Australian's location significantly affects their body weight. The research tracked individuals across 14 years and discovered that people tend to adapt to the typical weight profile of their new community., Local food environments, walkability, and access to green space are key fact...
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
A doctor warns of critical treatment gaps in eating disorders, highlighting the dangers of ignoring physical warning signs and behavioral indicators. Dr. Jennifer Gaudiani advocates for integrated medical and psychological care to address the urgent need for effective treatment.
A new medication called DR10624 has shown promising results in reducing high triglyceride levels by over 60% in patients with severe hypertriglyceridemia. The treatment also improved cholesterol and liver health, offering a potential alternative for managing this condition.
A new study found that combining GLP-1 receptor agonist medications with healthy lifestyle habits significantly reduces the risk of major adverse cardiovascular events, including heart attacks and strokes. The research suggests that adopting multiple healthy behaviors can lower cardiovascular risk even further.
Three new Cochrane reviews found GLP-1 drugs result in clinically meaningful weight loss, but evidence on longer-term outcomes and side effects is limited. The wider use of these drugs should consider social and commercial determinants to avoid deepening existing health inequities.
A new study found that fitness and calorie counting apps can lead to negative emotions such as shame, disappointment, and demotivation among users. The researchers called for a more holistic approach focusing on wellbeing rather than rigid calorie counting and exercise quantification.
A new Cochrane review found that immediate skin-to-skin contact between newborns and their mothers significantly improves exclusive breastfeeding rates, optimal body temperature, breathing, and heart rate. The review suggests that skin-to-skin contact should be the global standard of care for all babies after birth.
A recent study published in Integrative and Comparative Biology found that bonnethead sharks' skin undergoes significant changes as they mature, with younger sharks having fewer ridges on their denticles. These changes likely improve swimming performance and protect the skin from predators or injuries.
A repeated cross-sectional study shows that cardiometabolic risk factors in Spanish children have improved over the last 30 years, with decreases in excess weight, lipid parameters, and blood pressure. The study provides valuable insights into the evolution of cardiometabolic risk in children.
A new study by Florida Atlantic University researchers found that heat does not significantly affect the cognitive ability of sea turtle hatchlings. However, higher incubation temperatures negatively impact their physical traits, including shorter incubation durations, lower hatching success, and more frequent scute anomalies. The stud...
A new study published in JAMA Network Open shows that regular phone support after losing weight is crucial for maintaining weight loss. Participants who received monthly phone calls maintained an average of 8% weight loss from their starting weight, with about 60% keeping off at least 5% of their initial weight.
A systematic review and meta-analysis of 18 trials found GLP-1 RAs significantly improved glycemic and weight outcomes in children and adolescents with type 2 diabetes or obesity. However, gastrointestinal adverse effects warrant attention in long-term management.
Researchers at Penn State found that weight fluctuations and changes can lead to faster cognitive decline in older adults. The study analyzed data from 4,304 participants and showed that those with greater variability in weight experienced more rapid cognitive declines.
A cohort study shows bariatric surgery significantly lowers major metabolic comorbidity risk compared to medical weight management. The procedure is deemed a durable approach for obesity-related risk mitigation.
A landmark clinical trial found that Transcendental Meditation significantly reduced diabetes risk factors and supported weight loss in older Black women at high risk for heart disease. Meditation improved blood sugar control, insulin resistance, cholesterol, and weight.
A new study suggests that being overweight (BMI 25–29.9) may actually be protective in the short term after surgery for older adults, with a 0.8% 30-day all-cause mortality rate compared to 18.8% for those with normal BMI.
Researchers designed an ideal primary care visit scenario that emphasizes patient-centered communication, respect, and inclusivity. A survey of 250 adults with obesity found that most preferred this approach, citing doctors who listen attentively and treat weight issues sensitively.
A telephone-based weight loss intervention significantly reduced weight in breast cancer patients with overweight and obesity. The study suggests that this intervention may improve disease outcomes, warranting further investigation in future trials.
A new study found that adolescents with higher blood levels of per- and polyfluoroalkyl substances (PFAS) prior to bariatric surgery regained more weight and had greater increases in waist circumference up to five years after surgery. Researchers believe PFAS exposure disrupts endocrine and metabolic processes, leading to weight regain.
A new study suggests that using glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before surgery can help control blood sugar and support weight loss, potentially improving surgical outcomes. The medication was not associated with increased risk in 12 studies reporting postoperative outcomes.