Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A new ultrasound technique using fetal nasal bone examination at 11-14 weeks pregnancy improved the accuracy of Down's syndrome screening by increasing sensitivity to 85% and reducing false positives. The study found that fetuses without a nasal bone were 150 times more likely to have trisomy 21 compared to normal fetuses.
A genetic 'thermostat' called LRP5 regulates bone mass during growth and may contribute to normal variation in bone strength. The discovery could lead to new treatments for rare genetic disorders and potentially increase bone density in the general population.
The researchers are studying the otolith - the ear bone of the bluefin tuna - to see why its numbers have been dwindling for 25 years. By analyzing the layering of the otolith, they can determine the age of the fish and its nursery areas.
Researchers found evidence of advanced stone tool technology and symbolic thinking in Africa, challenging the long-held assumption that modern human behavior emerged later. The discovery of 28 bone tools at Blombos Cave suggests that 'behavioral modernity' first evolved in Africa around 35,000 years ago.
A study presented at the American College of Gastroenterology meeting found that Actonel 5mg daily significantly reduced vertebral fracture risk by 70% in patients on chronic glucocorticoid therapy. Patients who received calcium supplementation and vitamin D also experienced significant reductions in bone loss.
Premenopausal women who use oral contraceptives may experience lower bone mineral density compared to those who do not use hormonal birth control. The Canadian Multicentre Osteoporosis Study found a significant correlation between oral contraceptive use and decreased bone mineral density in premenopausal women.
New findings show that Actonel therapy can reduce clinical vertebral fractures in postmenopausal women as early as six months. The data suggests that treatment with Actonel can stop the fracture cascade and improve bone health.
Researchers are developing a compact machine called AMPDXA to precision measure tissue mass, bone density and geometry. This instrument will aid in preventing weakened bones and fractures for astronauts returning to Earth or landing on another planet.
A new study from Massachusetts General Hospital found that medication pamidronate prevented bone loss in men with prostate cancer who received androgen-deprivation therapy. The study showed significant differences in bone mineral density between the treatment and control groups.
Consuming caffeinated carbonated beverages results in small but significant increases in urinary calcium excretion, displacing milk's role as a major source of bone-building calcium. Regular consumption leads to nutrient deficiencies, causing bone loss.
A team of researchers, led by George Cybenko and Sue McGrath, are developing a mobile agent-based system to monitor bone loss in astronauts during extended space missions. The system will analyze data on urinary calcium, diet, exercise, atmospheric conditions, and medical history to provide timely feedback and prevent bone loss.
The AI-powered Author system can generate readable prose, including dialogue and short stories, by analyzing a story plan and applying rules to create grammatically correct sentences. However, it still lacks the ability to discern fact from fiction, which is a significant hurdle before it can be used for hot news reporting.
Researchers at Washington University in St. Louis discovered that blood vessels signal the onset of bone loss in diseases such as rheumatoid arthritis and osteoporosis. The discovery sheds light on how inflamed blood vessels trigger a cascade of events leading to local bone destruction.
A University of Cincinnati doctoral student and her team have found conclusive evidence of burnt animal sacrifice in Bronze Age Greece, supporting details in Homer's 'The Odyssey'. The Pylos bones date back to the 13th century B.C. and provide historical credence to the practice.
A retrospective analysis found that Risedronate reduced nonvertebral fracture risk by 69% at six months, compared to a 54% reduction in risk for patients taking Alendronate. This study suggests that Risedronate is an effective treatment option for osteoporosis prevention and treatment.
A UCSF study found that elderly women who consume a higher amount of animal-based protein compared to vegetable-based protein are at an increased risk of bone loss and hip fractures. The researchers believe this is due to the high acid content in animal products, which can lead to bone dissolution over time.
A recent study published by the Mayo Clinic has found that estrogen plays a crucial role in preventing bone resorption in elderly men. The research suggests that estrogen is essential for maintaining optimal bone metabolism in aging men, and highlights the importance of osteoporosis prevention for this demographic.
A recent Penn study reveals that bone is actively involved in the process of sinus disease, confirming a link between bone involvement and disease spread and chronicity. The study suggests that removal of bony partitions during endoscopic sinus surgery may be crucial for effective treatment.
Researchers have uncovered a crucial interaction between an enzyme and osteoclasts, cells responsible for removing bone in the body. The connection may provide a novel target for future medications to block bone erosion associated with osteoporosis and cancers.
A new study by UNC Chapel Hill researchers found that pregnant women with low calcium intake have higher levels of lead in their bloodstream due to rapid bone turnover. Calcium consumption can minimize this effect, but the study also suggests that even low-level exposure may pose health risks.
Researchers found that alcohol feeding impaired osteoblast function and led to increased bone turnover, contributing to bone fragility. In contrast, mice lacking the interleukin-6 (IL-6) gene had better maintained bone mass and reduced fractures.
A new study has found that osteoporosis doubles the risk of fractures in nursing home residents, particularly those with better mobility. Researchers discovered that 80% of women in the study had osteoporosis and that low bone mineral density increased fracture rates.
A new polymer material could revolutionize treatment of broken bones by speeding up healing and reducing the need for invasive surgery. The biodegradable material is designed to degrade like a bar of soap, allowing for a gradual transfer of load from the degrading polymer to the healing bone.
M. David Francis, an Ohio-based physical biochemist, received a national award from the American Chemical Society for his pioneering work on fluoride additives in toothpaste and pharmaceuticals.
Canadian researchers developed a method to steer proteins to bone, where they can accumulate and help build bone mass. Additional research is needed to determine the effectiveness of these proteins in growing bone tissue.
Researchers found similarities in bone structure among coelurosaurs, suggesting birds evolved from a group of dinosaurs. The study also sheds light on the debate over dinosaur metabolic rates, finding irregular collagen fiber bundles similar to those in modern birds.
A study by Oregon State University researchers found that 46% of adult white-tailed ptarmigan in a 10,000-square kilometer area of south-central Colorado have cadmium accumulations in their kidneys above the toxic threshold. Cadmium toxicity causes kidney and liver dysfunction, brittle bones, and affects reproduction and survival.
Researchers found that high-resolution ultrasound images can detect completely torn rotator cuff tendons with high accuracy. US is also a more patient-friendly option compared to MRI, taking less than 15 minutes and costing only one-fourth as much.
Researchers have discovered a metal wire with 'memory' that can help compress broken bones, leading to quicker healing times and better fusion of the bone. The alloy, Nitinol, resists loosening even after being absorbed by the bone, applying consistent pressure to promote proper healing.
A study published in AIDS found an association between osteopenia and protease inhibitors, a class of medications used to treat HIV/AIDS. Researchers discovered that patients taking these medications were more likely to develop low bone-mineral density, which can lead to fractures.
A study published in the American Journal of Clinical Nutrition found that high vitamin K intake was associated with lower incidence of hip fractures in elderly participants, while no correlation was found with bone mineral density or apo-E genotype. Researchers analyzed data from the Framingham Heart Study and discovered a significant...
A new study from the University of California, San Francisco, suggests that stimulating blood vessel growth with VEGF may help repair stubbornly non-healing fractures. Researchers found that injecting VEGF into broken mouse legs promoted bone growth and increased expression of genes necessary for osteoblast formation.
Researchers discovered a novel pathway controlling bone formation and density through the brain's hypothalamus, where leptin acts as a natural bone inhibitor. This finding offers potential treatment approaches for osteoporosis by manipulating the leptin pathway.
Scientists have documented reversible bone shrinkage in Galapagos iguanas during El Niño years. The reptiles adapt by shrinking to reach an optimal body size for survival, with significant increases in survival rate and efficiency. Researchers now seek the underlying mechanisms behind this remarkable adaptation.
Researchers at Princess Margaret Hospital and AMGEN identify the role of T cells in bone destruction characteristic of many inflammatory diseases. The study reveals that T cells produce a substance that triggers bone loss, leading to severe osteoporosis and joint damage.
A new nutrition intervention program aims to improve eating habits and increase calcium consumption in healthy children, potentially reducing the risk of osteoporosis and bone-related health issues later in life. The program will test whether behavioral modification and education can lead to long-lasting changes in diet.
Researchers are tracking 5,700 men to determine the relationship between bone mass, structure, and lifestyle with fracture risk in men. The study aims to provide knowledge for designing prevention and treatment approaches for male osteoporosis.
Researchers at the University at Buffalo have found that melatonin speeds up bone formation and increases production of bone matrix proteins, suggesting a potential link to osteoporosis prevention. The study used mouse and rat cells to demonstrate the role of melatonin in promoting bone growth.
Biologists at Washington University in St. Louis have discovered that lower estrogen levels allow cytokines to bind to bone cell surfaces, leading to bone destruction. Estrogen replacement therapy may be able to prevent this by increasing decoy receptor proteins, which inhibit cytokine binding.
A University of Pittsburgh-led study has found a specific gene, APOE-4, to be associated with an increased risk of hip and wrist fractures in women over 65. The researchers discovered that women carrying the APOE-4 allele were twice as likely to suffer these fractures compared to those without the allele.
A new study published in the American Journal of Clinical Nutrition suggests that lifelong dietary intakes of potassium, magnesium and fruit and vegetables are determinants of bone mineral density in elderly men and women. Eating fruits and vegetables can help prevent osteoporosis by neutralizing acidity and maintaining bone health.
Researchers have identified three compounds that can stimulate new bone growth in animals, including synthetic chemicals and a natural product. These small molecule compounds are relatively inexpensive, stable, and can be easily modified or formulated, potentially leading to the first osteoporosis treatment to stimulate new bone growth.
Researchers found two embryonic genes essential for fetal bone formation also play a crucial role in adult fracture repair. The study's findings shed light on the molecular mechanisms of bone healing and have the potential to develop targeted, injection-based therapies.
The new Plasma Atomisation Technology (PAT) process creates spherical titanium powders for coatings on implants, encouraging natural bone growth. The technique also allows for thin films and intricate components in pacemakers, resulting in high-quality products with reduced contaminants.
Temple University Hospital has introduced the internal jaw distraction device DynaForm, which helps regrow destroyed bone and correct facial deformities. The device is less cumbersome than traditional methods and can be used as an alternative to painful extraction for severe tooth crowding.
A new study will investigate whether intensive gymnastics training at a young age leads to negative dietary issues and affect future health in children between 4-8 years old. The research aims to explore the psychological effect of gymnastics on young girls' eating habits and potential risk for eating disorders.
Researchers have developed a new coating technique called Surface Induced Mineralization (SIM) that facilitates bone growth around implants, potentially extending their lifespan. The water-based process incorporates growth factors to promote new bone cells, addressing a common issue with implants becoming loose after 10 years.
A new study published in the Annals of Internal Medicine has found that warfarin, a commonly used blood thinner for older women, does not weaken their bones. The study, which tracked over 6,000 post-menopausal women for two years, found no significant difference in bone thinning or fractures between warfarin users and non-users.
Researchers have successfully replicated human bone disorder McCune-Albright syndrome in mice using a novel animal model. The model utilizes a combination of normal and mutant stromal cells, which are mixed together before transplantation into immune-compromised mice.
A study of 228 diseased heart valves found organized, hard-bone tissue in 30 valves, suggesting an active process of calcification. The discovery could lead to the development of treatments to prevent or treat heart-valve disease and provide insights into rare disorders like fibrodysplasia ossificans progressiva.
Researchers uncover evidence of complex behaviors, symbolic thinking, and problem-solving among early humans in southern China. Large mammal remains show signs of human intervention, such as burning and cutting marks, suggesting a deliberate process of collection and use.
A study of 290 hospital patients found that nearly 60% had vitamin D deficiency, with severe cases common among those without known risk factors. The researchers highlight the importance of screening and treating low vitamin D levels to prevent bone-related issues and fractures.
Researchers found that high concentrations of nitric oxide in osteoclasts prevent excessive bone resorption, a process linked to diseases like osteoporosis. This discovery may lead to new strategies for preventing bone loss and potentially treating inflammatory conditions.
A review of 20 published trials found that combining estrogen replacement with at least 1200 mg calcium daily preserves better bone health than using either treatment alone. This review suggests a combination therapy approach to managing osteoporosis in postmenopausal women.
A study by Purdue University researchers found that adolescent girls aged 12-15 require 1,300 milligrams of calcium per day to achieve maximum bone growth. The new recommendation aims to address the fact that nine out of ten teenage girls do not meet the current daily intake of four cups of dairy products.
A long-term epidemiological study found a strong association between high bone mass and increased risk of breast cancer. Women with higher bone mass had 3.5 times the risk of developing postmenopausal breast cancer compared to those in the lowest quartile.
A new hormonal drug combination allows post-menopausal women to get the benefits of estrogen without experiencing menses-like bleeding. The therapy significantly increases bone mineral density and improves blood cholesterol levels.
Researchers at Penn State's Applied Research Laboratory develop a 'roadmap' for applying machine sensor technology to human health. The technology could enable constant surveillance of bone cracks and heart activity, alerting physicians to intervene before it's too late.