Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Immediate weight-bearing pressure can lead to fibrous tissue formation instead of normal bone, hindering implant performance. Bioengineers aim to determine the ideal loading amount and timing to prevent this issue and increase the success rate of implants.
A clinical trial found that oral sodium clodronate reduced the risk of symptomatic bone progression by 21% and mortality by 20% compared to placebo, but with limited statistically significant results due to small population size. However, side effects were common, particularly in older patients.
Researchers discover that estrogen deficiency triggers immune system activation, leading to increased T cell proliferation and bone loss. This finding could lead to the development of new drugs that prevent postmenopausal bone loss without affecting reproductive organs.
A boy was diagnosed with acquired osteopetrosis after being given high doses of bisphosphonates to treat weak, painful bones. The condition results from excessive bone formation and can lead to fractures., Researchers emphasize the importance of carefully monitoring medications like bisphosphonates, especially in children.
Researchers highlight the growing concern of male osteoporosis, emphasizing genetic predispositions and secondary risk factors such as alcohol consumption and malnutrition. Dr. Rosen recommends early bone density testing for men over 55 with unexplained height loss or fracture history to identify potential treatment options.
Researchers develop scaffold that enables bone marrow cells to grow naturally without growth factors, promoting dense new bone growth. The technology has shown promising results in animal studies, with strong new bone replacing the scaffold in just eight weeks.
Researchers at U-M examined the effects of aging and menopause on bone health and found that natural estrogen withdrawal after menopause causes more significant bone loss. The study suggests that hormone replacement therapy may not be necessary for all middle-aged women with regular menstrual cycles.
A 7-year study shows Actonel significantly reduces vertebral fracture incidence, with annualized rates of 4.7%, 5.2%, and 3.8% for the treatment group, respectively. Adverse events were similar to those in patients taking placebo during the first 5 years.
Researchers have developed a new lentiviral vaccine that can induce robust immune responses in mice, offering a promising candidate for cancer therapy. Additionally, studies suggest that newborns may have a mature and functional immune response to infections, raising questions about neonatal vaccination strategies.
A Mayo Clinic case report reveals that long-term minocycline users are at risk of developing dental staining, causing blackish-blue appearance of the gums. The study emphasizes the need for collaboration between medical and dental professionals to ensure proper oral health management.
A recent study evaluated the medical costs of osteoporosis therapies and found that patients taking weekly Fosamax had lower GI-related medical costs compared to those taking daily or weekly doses. The analysis, conducted with a large medical claims database, also revealed that treating patients with a weekly dose of Fosamax versus a d...
Researchers found that there exists a critical nanometer size where mineral particles in biocomposites become insensitive to flaws, maintaining strength equivalent to a perfect crystal despite inherent defects. This phenomenon suggests that the engineering concept of stress concentration at flaws is no longer valid for nanoscale design.
A 12-month study comparing FOSRENOL and calcium carbonate found that FOSRENOL led to a 'considerably better outcome' on bone histology, with halved rates of patients with osteomalacia, adynamic bone disease, or hyperparathyroidism. This contrasts with the calcium carbonate group, which showed an increase in these conditions.
A study published in the Journal of Vascular Interventional Radiology suggests that percutaneous radiofrequency ablation can be an effective treatment for osteoid osteomas, with all eight patients achieving complete pain relief. The use of CT fluoroscopy enhanced imaging guidance improved precision and success rates.
A recent study shows that whole body PET scans are twice as sensitive as CT scans in detecting breast cancer spread, with a higher accuracy rate of 93% compared to 46%. This breakthrough technology also offers less radiation exposure to patients, making it a more efficient and safer option.
A study found that mice genetically engineered to lack a molecule called Stem Cell Antigen-1 (Sca-1) experienced normal bone development but exhibited decreased bone mass and brittle bones as they aged. The researchers believe that defective maintenance of stem cells may contribute to age-related osteoporosis in humans.
Rice University researchers aim to develop new, noninvasive treatment options for damaged cartilage by using patient's own bone marrow cells to grow more cartilage. The goal is to create a biodegradable scaffold that promotes cartilage formation and avoids problems associated with current therapies like allografting.
Scientists have discovered fossilized evidence of a dinosaur, Majungatholus, that regularly consumed members of its own species. The discovery expands our understanding of dinosaur relationships and provides insight into the animal kingdom's common practice of cannibalism.
A study of wild black bears found that they recover from bone loss caused by inactivity through a mechanism involving increased bone formation during remobilization. This suggests that hibernating bears may minimize bone loss and completely recover lost bone, providing potential insights for treating osteoporosis.
Researchers evaluated 83 children with repeated short courses of oral glucocorticoids and found no detectable cumulative negative effect on bone formation. The study also showed no impact on the children's weight or height.
Researchers from the University of Washington and Southern Methodist University conclude that climate change, not humans, was responsible for the extinction of Pleistocene mammals in the New World. The study found no evidence linking Clovis people to the extinctions, contradicting previous 'overkill' hypothesis.
Researchers use bio-ferrography to capture tiny particles in synovial fluid, enabling the creation of a diagnostic atlas for orthopedic surgeons. The atlas will help identify potential problems with implants prior to revision surgery.
Researchers used titanium mesh and bone marrow cells to promote new bone growth in rats, achieving better results with fibronectin-coated mesh and a flow perfusion system. The study presents an alternative method for treating bone defects and highlights the potential for improving cell growth and bone mineralization.
Actonel significantly reduced fracture risk in high-risk postmenopausal women, with a 62% reduction seen at one year. The medication was found to be effective in reducing spinal fractures in patients over 70 years old and those with low hip BMD.
Researchers found no difference in life expectancy between single- and multiple-fraction radiotherapy for painful bone metastases. Single-fraction radiotherapy is more cost-effective, with a lower treatment cost of $2,438 compared to $3,311 for multiple-fraction radiotherapy.
Researchers have discovered that bone formation in a regenerated forelimb combines elements of embryonic development and adult wound healing. MicroCT imaging reveals that bone formation does not occur in the same order as previously thought, but rather follows a pattern similar to normal fracture recovery.
Research reveals that mice without the calcitonin gene exhibit greater bone mass and formation, suggesting a novel function for this hormone. This discovery opens up new avenues for preventing bone loss associated with estrogen deficiency.
Researchers discovered that calcitonin knockout mice have greater bone mass and increased bone formation, suggesting a novel function for the calcitonin gene product. This finding has implications for preventing bone loss associated with estrogen deficiency, potentially leading to new treatments for post-menopausal osteoporosis.
A study published in Nicotine & Tobacco Research found that postmenopausal women who quit or cut back on smoking experienced a significant drop in SHBG and NTx levels, two proteins linked to bone loss. This discovery may help explain how smoking contributes to osteoporosis in this demographic.
Researchers have discovered that angiopoietin-1 can restore faulty blood vessel architecture in mice by promoting sprouting, survival, and stability of new vessels. This study highlights the importance of pericytes in maintaining normal vessel stability and may lead to new treatments for diseases like diabetic retinopathy.
Recent studies have found that hospitalists provide better patient outcomes in terms of reduced costs, shorter hospital stays, and lower short-term mortality rates compared to non-hospitalist physicians. The benefits of hospitalist care became evident only after the second year of both studies, highlighting the importance of experience...
Engineers mimic nature's solution to a classic problem in aerospace engineering by recreating part of a horse bone's unique structure. The biomimetic plate pushes stresses away from holes, resulting in increased strength and reduced weight.
Researchers discover two compounds that inhibit parathyroid hormone-related protein production in human breast cancer cells, reducing metastatic bone breakdown and calcium levels. The findings suggest a novel therapeutic approach to treating bone metastasis and hypercalcemia in breast cancer patients.
Researchers have identified two compounds that inhibit PTHrP production, reducing metastatic bone breakdown and tumor burden. The findings suggest potential therapeutic benefits for treating both bone metastasis and hypercalcemia in breast cancer patients.
Postmenopausal women taking glucocorticoids are at a significantly increased risk of spinal fractures, with nearly six-fold higher odds compared to those not using the medication. Long-term use for chronic diseases can lead to glucocorticoid-induced osteoporosis (GIO), which increases the risk of fracture.
A new study published in the journal Science suggests that estren, a synthetic compound, can build bone and improve bone density and strength without affecting reproductive organs. The findings may indicate a potential alternative to standard hormone replacement therapy for treating osteoporosis in both men and women.
Researchers at Rice University have developed a technique to create a porous, 3D bony matrix similar to natural bone. The method uses flowing fluids to provide mechanical stimulation, resulting in thicker and more developed mineralized bone compared to static samples.
The USPSTF recommends that physicians routinely screen women over 65 for osteoporosis, a thinning of the bones that can lead to bone fracture. Women at higher than average risk should begin screening at age 60. Early nephrologist care is associated with better outcomes for kidney disease patients, particularly those with African-Americ...
Children who avoided drinking milk in early life have low dietary calcium intakes and poor bone health, including significantly smaller bones and a higher incidence of fractures. The study highlights the importance of increasing calcium intake in growing skeletons to mitigate these effects.
Researchers at Johns Hopkins University have successfully created cartilage-like tissue using adult stem cells in a minimally invasive procedure. The technique involves injecting a fluid filled with stem cells and nutrients into damaged tissue, where it hardens into a stable gel that can be replaced by new bone or cartilage.
Researchers created mice lacking SHIP gene to understand how bone forms and breaks down in diseases like JPD. The study reveals that mice with deficient SHIP develop osteoclasts similar to those found in humans with JPD, leading to severely osteoporotic conditions.
A new study finds that low-carbohydrate, high-protein diets may increase the risk of developing kidney stones and raising bone loss. Researchers observed a significant decrease in urinary citrate levels and an increase in acid excretion in subjects following these diets.
A genetic mutation in the NOG gene causes autosomal dominant stapes ankylosis, a rare hearing loss syndrome with similar symptoms to otosclerosis. The syndrome is characterized by skeletal abnormalities and may require different treatment options.
Researchers found two Navajo patients missing the osteoprotegerin gene, leading to a rare bone disorder characterized by fast bone formation and breakdown. The study provides a genetic cause for Juvenile Paget's Disease (JPD) and sheds light on bone metabolism control.
The ACP-ASIM published 'Osteoporosis' guide provides the latest scientific evidence on osteoporosis and essential information on its origins and progress. It addresses every facet of osteoporosis, a common disease that can be identified through non-invasive tests and treated with new effective drugs to reduce fractures.
Women with irregular periods are at increased risk of developing osteoporosis later in life, according to a recent study. The research found that nearly all women with premature ovarian failure reported changes in their menstrual cycle, highlighting the importance of early evaluation and treatment.
A study by UCSF found that consuming excessive salt increases calcium loss, while a potassium supplement helps maintain bone density. Potassium-rich foods like bananas and spinach can be beneficial for preventing osteoporosis in postmenopausal women.
Young women with anorexia nervosa exhibit varying reactions to bone density results, with some finding motivation for recovery later in their course. The timing of the measurement seemed to be a key factor in these responses.
A recent study published in JCI Journals reveals a significant connection between the brain and bone health, with implications for osteoporosis treatment. The findings suggest that certain neurological factors contribute to the development of bone disorders, opening up new avenues for therapy.
A high-protein diet supplemented with calcium and vitamin D was found to increase bone mineral density in older adults. The study showed that higher protein intake, particularly in combination with adequate calcium levels, can promote bone health and reduce the risk of fractures.
A long-term follow-up study of over 800 postmenopausal women found that stopping hormone replacement therapy resumes bone loss at a rate similar to those who never took the drugs. The study showed that while bone mass increased in the first 36 months after starting hormone replacement therapy, there was little gain after that.
Excavations at Kostenki in Russia reveal that anatomically modern humans were developing new technologies for survival in the cold region around 30,000 to 40,000 years ago. The discoveries include bone and ivory needles with eyelets, as well as trapping techniques for obtaining furs.
A randomized study by Tufts University researchers found that high protein diets combined with sufficient calcium intake can improve bone mass density in older adults. The study suggests that adequate calcium is crucial to mitigate the negative effects of protein on bone health.
Researchers at Johns Hopkins Medicine have developed a novel imaging technique to detect tiny tumors that cause a rare bone disorder. The method, which uses radioactive pentetreotide to identify tumor locations, has correctly pinpointed tumors in five of seven patients with oncogenic osteomalacia.
A diagnostic scan called capromab pendetide immunoscintigraphy can detect recurrent disease if it is localized to the area of prior prostate surgery or has spread to other parts of the body. The study found that this imaging tool is more sensitive than CT and bone scans in identifying the site and extent of disease recurrence.
A Mayo Clinic study has confirmed the effectiveness of samarium as a treatment option for osteosarcoma, with 24 of 30 patients experiencing a good to excellent response. The radioactive drug targets tumors in the bone, killing off cancer cells and reducing side effects associated with chemotherapy.
Scientists at Johns Hopkins have identified GNAS1 as the gene responsible for progressive osseus heteroplasia (POH), a disease causing rice-size bone fragments to form under the skin and inside organs. The discovery may lead to new treatments blocking problem-causing bone fragments and potentially treating other bone problems like oste...
Researchers have identified matrix metalloproteinases as a key player in the spread of prostate cancer to the bone, offering a new target for treatment. Additionally, a genetic marker may be useful in predicting survival rates for patients with diffuse large B-cell lymphoma, while oral contraceptive use has been found to reduce ovarian...
A study is underway to test the effectiveness of zoledronate, a bisphosphonate medication, in preventing bone loss in spinal cord injury patients. The results could also have implications for astronauts on long-duration space missions, where bone loss is a significant concern.
Researchers create self-assembled nanofibers resembling collagen fibrils in real bone, enabling mineralization and promoting cell attachment. The synthetic nanofibers offer potential applications in bone fractures, tissue regeneration, and electronics.