Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A nationwide study found that women taking osteoporosis medications had fewer bone abnormalities and less knee pain associated with osteoarthritis. The research suggests that these medications, primarily alendronate and estrogen, may offer protective benefits for the development of knee OA.
FOSRENOL effectively controls hyperphosphatemia, a leading cause of renal osteodystrophy and bone pain in ESRD patients. Long-term use maintains bone health status without worsening bone status, unlike aluminum-based phosphate binders.
Researchers found that estrogen deficiency triggers the expression of interferon gamma, which stimulates T cell activation and TNF production. Estrogen treatment increases TGFb levels in bone marrow, leading to bone preservation.
A mouse study challenges the idea that a specific gene region is responsible for Down syndrome's characteristic facial features and traits. Researchers found that mice with only two copies of this region still exhibited shorter bones, contradicting previous assumptions.
Researchers at Tufts University found a significant gap in care for fracture patients, with few treated for osteoporosis despite increased risk of re-fracture. The study suggests that primary care physicians play a crucial role in reducing this risk through targeted counseling and medication.
Two studies found that soy-based diets improved cholesterol levels and increased bone mass in monkeys, suggesting a potential benefit for premenopausal women. The research suggests that soy may provide a potent protection against cardiovascular disease and could help maintain bone health after menopause.
Running and jumping exercises are most effective for strengthening bones in children, as they stimulate new bone growth where it is needed. Unlike swimming or biking, these activities do not affect longitudinal growth, making them a recommended choice.
A retrospective study found that low-dose ketamine infusions provided complete relief from CRPS pain for 76% of patients, with 54% remaining pain-free for three months or more. The therapy's effectiveness was linked to its ability to block NMDA-receptor complexes involved in pain processing.
A study by Dr. Massey Beveridge highlights the importance of orthopedic care in developing countries, where road traffic injuries and falls are major causes of disease burden among children. With only 400 surgeons serving 200 million people, access to simple surgical and obstetrical procedures could prevent up to 10% of all deaths.
Researchers are using genetically engineered 'mighty mice' to study the relationship between muscle and bone health. They hope to find a way to build bone and avoid osteoporosis in young people. Early evidence suggests that exercise may not have as much of an impact on bone density as previously thought.
The American Physiological Society (APS) has awarded over $140,000 to minority students pursuing careers in physiology. These Porter Physiology Fellows are conducting innovative research projects that aim to improve our understanding of various physiological processes.
A new study challenges the long-held view that high-dose steroids cause bone loss in children. Researchers found no signs of osteoporosis in 60 steroid-sensitive nephrotic syndrome patients, contradicting previous findings in other childhood diseases treated with steroids. Obesity may actually stimulate bone growth and increase bone mass.
A blood stem cell has been found to give rise to bone in mice, suggesting a potential basis for treatments to repair or restore bone. The study used retroviral integration site analysis to prove that a single type of stem cell can produce two distinct bodily tissues.
Thomas Jefferson University is developing a clinical trial using a bone-targeted agent to treat microscopic bony metastasis in high-risk prostate cancer patients. The trial aims to improve death rates from prostate cancer by combining hormones and radiation with the targeted agent, Quadramet.
Researchers discovered that human stem cells can replenish muscle fibers in mice with Duchene muscular dystrophy, offering a potential treatment. In contrast, elevated cyclic AMP levels halted egg maturation in females, while HIV protease inhibitors impaired osteoclasts leading to bone loss.
A team of archaeologists has uncovered a cooking hearth and bone fragments at Alder Creek Camp in the Tahoe National Forest, providing new evidence to locate the Donner Party camp and settle debates about cannibalism. The discovery includes broken china, bits of jewelry, musket balls, fragments of a wagon, and a chunk of a writing slate.
A large-scale study found that soy protein supplementation with isoflavones had no effect on cognitive function, bone mineral density, or cholesterol levels in postmenopausal women. The authors suggest that the timing of supplementation may be a key factor in determining its efficacy.
A new mouse model study identifies the connection between maternal immune activation and reproductive hormone secretion systems, linking them to pregnancy loss. The researchers found that an inflammatory response caused by activated CD40 receptor led to embryo resorption due to decreased progesterone levels.
The absence of platelet-activating factor receptor in mice with induced menopause leads to improved bone mineral density and volume. Osteoclasts are responsible for PAF's mechanism of action, and inhibiting PAF receptor function reduces bone resorption.
Researchers found that adding texture to implant surfaces increased compatibility with fibroblasts, reducing the risk of dead tissue build-up and infections. The study suggests that textured surfaces could lead to fewer implant replacements and improved patient outcomes.
Researchers from the University of Maine have found evidence suggesting that changes in Peruvian fisheries occurred centuries before modern fishing practices. The study used archaeological data from ancient fish processing sites and correlated these shifts with El Nino climate patterns.
A study by UT Southwestern Medical Center researchers found that patients who broke bones in traumatic accidents often experience Post-traumatic Stress Disorder (PTSD), with almost 51% of civilian orthopaedic trauma patients displaying symptoms. The more severe the injury, the higher the likelihood of PTSD.
Researchers analyzed data from 149,524 postmenopausal women to identify predictors of bone fractures. Women with low T scores or previous fractures were found to be at increased risk, highlighting the need for targeted interventions.
Exercise has been shown to improve physical fitness, lower back pain, and cholesterol levels in early postmenopausal women. After 26 months, the exercise group experienced significant increases in physical fitness and reductions in bone loss compared to the control group.
A study found that MDCT was more accurate than plain film in detecting bone loss near the prosthesis (100% vs 67%) and fractures (100% vs 94%). MDCT also showed improved detection of loose components (61% vs 54%). The study suggests MDCT should be performed for patients with questionable x-rays or those needing surgery.
A recent study of 413 pediatric knee MRI exams found that bone bruises in adolescents frequently occur without accompanying injuries to the menisci, ligaments, or cartilage. This discovery could lead to more conservative treatment approaches and reduced anxiety for patients and families.
Researchers at Rice University have developed a biodegradable implant that can release growth factors to stimulate bone growth in critical-size defects, aiding the body's natural regeneration process. This innovative approach aims to provide patients with their own tissue and eliminate risks associated with existing treatments.
The study reveals that oysters' immune blood cells contain rhombohedral-shaped crystals used to form shell. The research aims to understand biomineralization for potential breakthroughs in medical and material sciences.
Researchers at Purdue University have discovered self-assembling nanotubes that attach better to titanium-coated implants than uncoated ones, promoting new cell growth and potentially leading to longer-lasting artificial joints. The nanotubes offer promise in biomedical applications and could be tailored for specific parts of the body.
Researchers have discovered the remains of a 9,500-year-old human-cat burial on Cyprus, providing the oldest known evidence of cat taming. The find, published in Science journal, suggests that humans may have begun taming wild cats earlier than previously thought, around 11,000 years ago.
A study led by Michigan State University scientists found that lyophilization does not improve the safety of bones and tissues for transplantation, contradicting current clinical beliefs. The researchers tested five samples each of infected bone and tissue through lyophilization and found that the virus survived the process.
A new study reveals that children under 10 are at risk for sustaining multiple injuries, with boys being 10% more likely to seek medical attention than girls. The study also found that certain ages are more susceptible to specific types of injuries, such as burns and poisoning between the ages of one and three.
Dr. Soskolne has made significant contributions to scientific literature in the fields of oral pathology, bone physiology, and the pathogenesis of periodontal diseases. He developed an organ-culture model for studying bone remodeling, which has been used extensively to study bone physiology.
A Rice bioengineer has won the 'Create the Future' design contest with a device that uses acoustic waves to measure bone structural integrity. The OsteoSonic TM system offers advantages over existing radiological diagnostics and is currently undergoing testing.
A team of scientists at Stanford University re-analyzed the DNA samples from the alleged Romanov remains, finding significant discrepancies that challenge previous conclusions. The researchers argue that the original genetic tests were flawed due to contamination or degradation, which led to inaccurate results.
Type I diabetics experience bone loss due to insufficient amylin production, which reduces osteoclast cell activity. Amylin injection or pathway activation may help correct this issue and alleviate osteoporosis.
A Baylor College of Medicine study reveals that the hormone amylin inhibits bone loss and resorption. Mice without amylin have less bone mass due to increased bone destruction, suggesting a potential therapeutic avenue for preventing osteoporosis in Type 1 diabetes patients.
Scientists give mice with damaged kidneys injections of BMP-7 to prevent adynamic bone disorder, a condition causing weakening and distortion of bones. The treatment is shown to be effective in normalizing bone cell counts and structures.
A study monitored sun exposure, diet and blood levels of vitamin D in 23 teenage girls from ages 10 to 13 years old. The results showed that almost half of the Bangor area girls had insufficient levels of vitamin D in their blood, with 17% having low levels in September.
A study published in Science has identified the Alox15 gene as a potential human therapeutic target for osteoporosis risk. The gene's over-activity leads to reduced bone density and increased risk of osteoporosis, but inhibitors of the gene's enzyme can improve bone mass and strength.
A study by Dr. Kimberly O'Brien found that adolescent pregnancy compromises a girl's ability to reach optimal bone growth, potentially leading to osteoporosis. Girls who consumed more calcium during pregnancy showed less bone loss when tested post-partum.
A study published in Journal of Bone and Mineral Research found that repetitive work tasks can cause pathological overloading of upper extremity bones in rats. The researchers observed tissue damage and inflammation within 3-6 weeks, suggesting the potential for early intervention to prevent further harm.
Researchers at Purdue University have created a new type of metal alloy with nanometer-scale bumps that can stimulate the body to regrow bone and other tissues. This technology has the potential to improve artificial body parts, such as hip replacements, by reducing the rate of rejection and failure.
Researchers found that an anti-platelet drug, ML464, blocked bone metastases and reduced new tumor development in mice. The study provides a promising start to exploring the use of anti-platelet drugs as potential therapies for breast and prostate cancer.
Researchers successfully used gene-modified dendritic cells to induce apoptosis in collagen-specific T cells, reducing arthritis incidence and severity. Additionally, stem cell factor was found to drive hepatocyte proliferation after liver resection, while VLA-1 expression is crucial for T cell memory of previously encountered antigens.
Researchers on the Old English Dictionary project found a heavy preponderance of 'for' compounds and the phrase 'to be on fire,' which originated in an Old English quotation. The study highlights the importance of understanding language as a conveyor of culture, revealing insights into social, political, and intellectual institutions.
Researchers at the University of Rochester Medical Center have identified a key role for bone-forming osteoblasts in controlling the expansion of blood-forming stem cells. The discovery could lead to new treatments for bone marrow-transplant patients, who often face challenges due to limited stem cell availability.
UMHS researchers found poor bone quality in rats with high-dose radiation, suggesting new therapies to improve human treatment. The study uses a rat model to analyze the success and failure of distraction osteogenesis in irradiated cancer patients.
Research reveals that bone cement containing antibiotics can effectively control bacterial growth in the immediate vicinity of the implant, but this effectiveness is short-lived. After just a few weeks, the concentration of antibiotics decreases, making it less effective against bacteria.
Rensselaer Polytechnic Institute researchers are awarded a $2.6 million NIH grant to develop engineered bone tissue that can promote faster and stronger bone healing, potentially treating bone injuries, hip replacements, and arthritis.
A study published in Radiology found that MRI can accurately detect bone invasion by soft-tissue sarcomas, with a sensitivity and specificity of 100% and 93%, respectively. This accuracy enables radiologists to confidently evaluate MR results for bone involvement, previously reserved for soft tissue involvement.
A large-scale study from Massachusetts General Hospital finds radiofrequency ablation (RFA) to be the most effective treatment for osteoid osteoma, a type of benign bone tumor. RFA offers a high success rate and low complication rate, making it an attractive alternative to traditional surgery and medication.
A study of fossil records at Grotte XVI found that Neanderthals and Cro-Magnon both hunted a wide variety of game, including reindeer and red deer. The researchers also discovered a sharp drop in cave bear numbers from Neanderthal to Cro-Magnon times, suggesting competition for living space may have led to their extinction.
A new study found that Actonel maintained the size of calcium-based mineral crystals and the integrity of collagen structure over five years, preserving bone quality. This is significant because osteoporosis therapies should aim to reduce fracture risk, not just treat symptoms.
A major axis within bone cells regulates bone production and loss, providing a potential new target for treating debilitating osteoporosis. Local regulation of bone mass is now believed to occur primarily in the bone, not in the brain as previously thought.
A new study found that combining osteoporosis medications, parathyroid hormone and bisphosphonates, does not provide additional benefits to patients. The trial of 238 postmenopausal women showed no significant improvement in bone density or anabolic effects when both drugs were used together.
A recent study found a dramatic increase in wrist fractures among children under 35 over three decades, with rising physical activity and declining milk consumption contributing to the trend. The research suggests that early-life dietary habits may impact bone development and increase fracture risk later in life.
Researchers at Columbia University discovered that D-beta-hydroxybutyrate restores impaired brain function and protects against neurodegeneration in mice with Parkinson's disease. The study supports a critical role for mitochondrial defects in the progression of the disease.
The overproduction of noggin during aging may result in impaired bone building and function, leading to net bone loss. Researchers suggest that recombinant BMP2 may prove useful in reversing age-related bone loss.
A study conducted at the University of Melbourne found that smoking is significantly linked to osteoporosis in women, particularly after menopause. Continuing high exposure to tobacco and greater sensitivity to smoking-induced bone loss are possible explanations for this link.