Articles tagged with Bones
A new study recruiting up to 2,000 people from the remote Isles of Orkney aims to discover genes that predispose individuals to osteoporosis. The research will utilize a unique population isolated from the UK mainland, allowing for easier tracking and identification of genetic factors.
The Mayo Clinic team has developed a consensus statement recommending the use of pamidronate over zoledronic acid for starting therapy, and stopping or reducing bisphosphonates after two years for safe management of multiple myeloma. The guidelines aim to minimize adverse reactions while maintaining effective bone disease prevention.
The study compared MDCT and digital radiography in orthopedic patients, finding that 63% were concordant, while 37% showed discordant results. MDCT was underestimation or overestimation in some cases, highlighting its potential value in bone healing evaluation.
Researchers reveal that glucocorticoids, commonly used for inflammatory disorders, can cause osteoporosis by delaying osteoclast death and suppressing bone formation. Prolonged GC use affects bone health in mice with normal and disrupted GC receptors.
Cortisone has been found to weaken bones by targeting osteoclasts, which dismantle old bone. Researchers may now be able to develop therapeutic targets to prevent cortisone's damaging side effects on bone.
A new MRI data-acquisition technique developed at the University of Wisconsin-Madison enables clinics to image more patients with osteoarthritis-related knee problems in a shorter time. The technique delivers precise 3D images, allowing for better diagnosis and treatment options.
Researchers have found that protein-coated dental implants can induce bone formation and promote tissue regeneration. In laboratory tests, the protein-induced bone growth nearly completely regenerates lost tissue around teeth.
A study published by the American Physiological Society found that a single therapeutic dose of radiation can cause up to 39% spongy bone loss in mice, reducing their weight-bearing connections by 64%. This has significant implications for astronauts on long space missions and patients receiving radiation therapy.
A new study published in European Journal of Nutrition found that soy germ isoflavones supplementation decreased bone loss in postmenopausal women. The study used SoyLife&Reg; EXTRA and showed a dose-dependent effect on reducing bone loss in non-obese women.
Researchers have identified a protein in mice that regulates bone formation, finding that augmented osteoblast activity leads to elevated bone mass. The discovery could lead to new treatments for osteoporosis by targeting the Shn3 and WWP1 proteins.
The inner walls of bones serve as sites for both bone breakdown and reconstruction, with osteoclasts playing a crucial role in releasing hematopoietic stem cells. This process is essential for maintaining balance in the body's response to injury or inflammation, and may have implications for bone marrow transplant techniques.
The number of hip fractures worldwide is projected to rise from 1.7 million in 1990 to 6.3 million in 2050, with estimated annual costs reaching $131.5 billion globally and $30 billion in the EU.
Significant studies presented at the World Congress on Osteoporosis highlight the importance of calcium, vitamin D, and protein in building bones, as well as the impact of space travel, obesity, and smoking on bone health. The congress also emphasized the need for improved screening and treatment options for osteoporosis patients.
Researchers found that slightly increasing NFATc1 activity leads to massive bone accumulation in mice, suggesting potential new targets for treating osteoporosis. The study's findings may enable the development of drugs that promote bone formation without causing undesirable side effects.
A new study reveals that dietary calcium is more beneficial than supplements alone for building strong bones. Vitamin D supplements only reduce fracture risk when combined with sufficient calcium levels. Meanwhile, research suggests high protein intake promotes bone health.
Researchers have introduced a new technique combining SPECT and spiral CT for improved bone scanning, shortening diagnostic time and clarifying findings. The technology has been shown to enhance the specificity of bone scintigraphy and reduce CT radiation exposure.
Seven young researchers from six countries have been awarded the IOF-Novartis Young Scholars' Award for outstanding contributions to osteoporosis research. The award aims to support and encourage careers in osteoporosis research, a field that has seen significant progress in understanding and treating this debilitating disease.
The 2nd IOF Women Leaders Roundtable emphasizes the need for global awareness and action on osteoporosis. The participants urge individuals to engage in bone-friendly lifestyles and healthcare professionals to improve their knowledge about osteoporosis, while governments are encouraged to recognize it as a health priority.
Research suggests that infant bone growth and maternal vitamin D levels during pregnancy have a significant impact on future fracture risk. Children born to mothers with lower vitamin D levels tend to have weaker bones, while higher levels may improve bone density.
A new study reveals a growing osteoporosis crisis in Latin America, with higher prevalence rates than expected. The study's findings highlight the need for increased attention and funding from governments to address this growing health issue. In contrast, North American diagnosis and treatment of osteoporosis are influenced by socioeco...
A recent USF Health study published in Osteoporosis International found that low-carbohydrate diets do not increase bone loss. Patients on the diet lost significant weight without compromising their bone health. The study's lead author notes potential limitations, but emphasizes the benefits of a balanced approach to weight management.
Researchers found that SXR inhibits VDR-mediated CYP24 activity in mice, contradicting previous studies. In humans, rifampicin treatment increases CYP3A4 expression but has no effect on CYP24 expression, suggesting a complex regulatory mechanism.
Research reveals a previously unknown role for histamine receptors in asthma, suggesting that blocking these receptors could alleviate symptoms. Additionally, a novel peptide inhibitor has been discovered to prevent bone loss in osteoporosis by targeting the RANK/TNF pathway.
Research reveals cartilage cells can die outside the direct impact zone due to leukocyte-mediated damage. Anti-CD18 antibodies and desferoxamine show promise in blocking this process.
A study of 1,460 elderly women found that calcium supplementation did not reduce the risk of osteoporotic fractures overall, but compliance was key. Women who took 80% or more of their daily pills had a lower risk of fractures and improved bone test results.
Researchers find that high FSH levels are necessary for bone loss in postmenopausal women, suggesting an alternative approach to prevent osteoporosis. The study reveals a direct link between pituitary-derived hormones and bone remodeling, revising the understanding of pituitary hormone physiology.
COX-2 inhibitors increase myocardial infarction and stroke risk due to suppression of prostacyclin and PGE2. Inhibiting microsomal PGE synthase-1 may offer anti-inflammatory effects without cardiovascular consequences, suggesting a potential alternative therapeutic option.
A new three-year project is investigating the earliest development of sea fisheries in Northern Europe, with a focus on the critical period between 950AD and 1050AD. Researchers are analyzing fish bones from archaeological sites across the region to understand the impact of intensive sea fishing on medieval trading patterns.
The International Osteoporosis Foundation (IOF) has partnered with Tetra Pak to support World Osteoporosis Day. The partnership aims to empower women and men to take responsibility for their bone health. World Osteoporosis Day, celebrated on October 20, highlights the importance of healthy food and nutrition in building strong bones.
Dr. Teitelbaum's research reveals that blocking integrin receptors on osteoclasts can prevent bone loss in osteoporosis and rheumatoid arthritis, offering new drug targets. Additionally, his work has shed light on the effects of protease inhibitors on osteoclasts in HIV/AIDS patients.
UCR researchers successfully grew bone cells on a scaffold of carbon nanotubes, which can be used to treat bone defects and improve dental implants. The non-treated and electrically-neutral nanotubes emerged as the best scaffolds for bone growth.
A study found that higher-than-normal levels of IL-1-beta in saliva are associated with increased bone loss. Osteonectin levels inversely correlate with bone loss, suggesting this marker may measure periodontal health. The researchers hope to develop a biomarker test for early detection and monitoring.
Researchers found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density in men with advanced prostate cancer. The study supports guidelines for monitoring bone density and initiating treatment to prevent fractures.
Researchers are developing nanotechnology approaches for oral health diagnosis and treatment, including precise drug delivery using dendrimers and PEBBLES-probes. These systems aim to increase the effectiveness of anti-cancer drugs and control mineral composition in bone tissue.
Researchers are using advanced techniques to analyze ancient proteins in fossils, providing insights into prehistoric life, diet, and relationships. By studying these molecular remnants, scientists can reconstruct the history of life on Earth and gain a deeper understanding of dinosaurs.
University of Utah archaeologist Jack M. Broughton's study of ancient Native American bird bones reveals that California wasn't always abundant in wildlife as settlers arrived. Indigenous people hunted some species to local extinction, and wildlife returned after European diseases decimated Indian populations.
The Female Athlete Triad combines disordered eating, absent menstrual periods, and bone loss, particularly affecting elite athletes struggling with eating disorders. The International Olympic Committee's new position statement prioritizes athlete health over performance.
A randomized controlled trial found that robot-assisted surgery improved the accuracy of knee replacement operations, with all robotically assisted cases lining up bones to within two degrees of planned position. The study also showed no additional side effects and quicker recovery times.
A recent study found that older women are more susceptible to hip fractures, with over half experiencing significant decline in functioning. Unfortunately, many women in this age group do not undergo bone density screenings, which can help prevent fractures through osteoporosis therapy.
Researchers discover that crystal clusters in fossil bones can preserve ancient DNA, which is better preserved and contains longer fragments than untreated ground bone. This method holds promise for yielding more authentic results in the analysis of ancient DNA.
Scientists at Berkeley Lab create porous scaffolding-like material that mimics nacre's structure, exhibiting four times greater strength than current materials. The composite could foster bone tissue regeneration and improve artificial joints.
Researchers are working on a three-year €2.5 million project to isolate and expand mesenchymal stem cells from cord blood for use in therapies. The goal is to create viable new medical uses for these stem cells, which could be used to repair bone defects and fractures.
Researchers found that genetically engineered muscle-derived stem cells (MDSC-B4) improved cartilage repair in rats, with well-integrated repaired tissue at 8, 12, and 24 weeks after surgery. The study also showed that MDSC-B4 could differentiate into chondrogenic cells depending on the type of medium they grew in.
Researchers have identified vitamin D as a potential target for preventing bone loss and osteoporosis. The study suggests that vitamin D may signal anti-osteoclastogenic action, which could lead to new treatments for this condition.
Researchers have identified a new vitamin D-related compound that inhibits the production of c-Fos protein, which plays a key role in bone breakdown and resorption. In contrast, a nuclear protein called Tlx acts as an oxygen-sensing switch to regulate angiogenesis in retinal astrocytes.
The study reveals that the calcium-sensing receptor is crucial for the proper localization of blood stem cells in the bone marrow. Without this receptor, stem cells are unable to adhere to essential bone proteins and have limited regenerative capabilities.
Researchers analyzed bone fragments at the Donner Family campsite in California's Tahoe National Forest, finding no conclusive evidence of cannibalism. The team discovered domestic and wild animals were consumed, but human bone was not identified.
Research suggests that maternal vitamin D status during pregnancy influences bone growth and risk of osteoporosis in offspring. Studies have found that women who took vitamin D supplements or were exposed to higher levels of sunlight during pregnancy had fewer deficiencies and lower risk of osteoporosis in their children.
Researchers discovered that substances produced in the body called endocannabinoids, which are present in bones and other tissues, help preserve bone density. A new synthetic compound has been developed to activate CB2 receptors, slowing osteoporosis development without psychoactive side effects.
Researchers have discovered that cannabinoid receptors, particularly CB2, play a crucial role in regulating bone density and reducing the risk of osteoporosis. The study found that mice with a specific gene defect exhibit lower bone density, while patients carrying a variant of the CB2 gene have a three-fold higher risk of osteoporosis.
A study of ancient Egyptian remains and art reveals that dwarfs were highly respected and integrated into society. Elite dwarfs held important positions, while ordinary ones specialized in various occupations, suggesting a positive image of short people in ancient Egypt.
A study of over 2,000 older adults found that higher magnesium intake was associated with increased bone density. The recommended daily allowance is significantly lower than the amount most people receive.
Researchers found that plateosaurs adjusted their growth to environmental conditions, growing faster in abundant food and slowing down during scarcity. This discovery challenges the conventional understanding of dinosaur growth, which was previously thought to be similar to modern mammals.
Chronic alcohol abuse can disrupt the balance of bone remodeling, leading to measurable bone loss over a few years. Alcohol-induced bone disease weakens bones and predisposes individuals to increased fracture risk and delayed fracture healing due to decreased osteoblast activity.
The shift in commonly used PTH assay has led to inconsistent results, potentially causing increased parathyroidectomy rates, unnecessary medication use, and adynamic bone disease among dialysis patients. Researchers have developed a more specific assay for PTH to address these concerns.
Researchers at UF have discovered a population of stem cells with characteristics of adult and embryonic stem cells in cultures derived from bone tumor biopsies. These findings suggest that osteosarcoma, a common bone malignancy in children, may be linked to primitive stem cells.
Researchers have confirmed that Gigantopithecus blackii, a gigantic ape weighing up to 1,200 pounds and measuring 10 feet tall, roamed the same region as early humans in southern China. The species is believed to have co-existed with humans during a time of major evolutionary change.
Scientists have developed a laser imaging technique that can assess bone strength more accurately, predicting the likelihood of young women developing osteoporosis in later life. By measuring collagen content, the new Raman spectroscopic technique eliminates the impact of overlying tissues.
Researchers reveal that a mesh-like protein skeleton gives red blood cells their rubbery ability to stretch without breaking, facilitating oxygen diffusion across the membrane. The model also suggests that deformation of the cell can enhance oxygen movement through narrow capillary openings.
The study aims to determine the window of time when smoking delays bone healing and identify ways to prevent it. Researchers hope to develop treatments that speed up healing in persistent smokers and those with bone injuries.