Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A new type of biocompatible glass with dual porosity has been developed to mimic the vital functions of bone, facilitating vascularization and cell adhesion. The glass has successfully tested in laboratory experiments and is being further investigated for its potential to stimulate bone regeneration.
Researchers find that organic molecules control the rate of crystal growth, allowing for the tuning of growth rates. The study's findings provide a new understanding of how proteins and biomolecules influence crystal formation.
Researchers found that exercising young rats reduced their risk of bone fractures later in life, demonstrating the importance of childhood exercise for future bone health. The study suggests that short periods of exercise during growth can stimulate bone development and lead to stronger bones.
Long-term Fosrenol treatment improves bone formation and reduces phosphorus levels in CKD stage 5 patients, according to a two-year study. The reformulated tablets also demonstrate efficacy as monotherapy for controlling serum phosphorus levels.
Researchers at Max Planck Institute found that bone stretches more than its fibers and mineral composition, allowing it to sustain large strains without breaking. The hierarchical structure of bone leads to a hierarchical deformation, with soft layers absorbing most of the strain, protecting the mineral phase from excessive loads.
A recent University of Colorado at Boulder study reveals that Paranthropus robustus had a diverse diet including fruits, nuts, sedges, and possibly animals, casting doubt on the idea that its extinction was linked to its eating habits. The findings suggest alternative explanations for the species' demise.
Researchers at Max Planck Institute and ESRF study bone deformation using X-rays, revealing a hierarchical structure that allows bones to sustain large strains without breaking. The findings provide new insight into the design principles behind healthy bone fracture resistance.
New analysis of 30,000-year-old Romanian fossils reveals a mix of human and Neandertal features, challenging the hypothesis that Neandertals were simply replaced by modern humans in Europe around 35,000 years ago. The study also shows that these early humans lacked full anatomical adaptations for hunting with spears.
A US study finds no link between rock climbing and increased osteoarthritis risk, despite increased bone density in climbers' fingers and hands. Climbing style intensity is a significant predictor of bone strength, with bouldering and sport climbing styles correlating with stronger bones.
A newly identified gene mutation in the CRTAP gene helps explain a subset of osteogenesis imperfecta (OI) cases, where bones break easily due to abnormal collagen protein modification. The finding may also offer clues to as-yet-undescribed connective tissue diseases and provide insight into collagen formation.
A team of researchers has identified a new genetic mutation responsible for osteogenesis imperfecta (OI), a condition that makes bones more likely to break. The study found that mutations in the CRTAP gene reduce the ability of a protein involved in collagen formation, leading to weaker bone and increased risk of fracture.
Researchers found PLC-gamma-2 crucial for normal osteoclast development and function in mice with rheumatoid arthritis (RA). The protein also regulates B cell differentiation, suggesting a potential therapeutic target for controlling joint destruction and bone erosion.
Researchers at the University of Rochester Medical Center have received a $7.8 million grant to develop new treatments for bone fractures and arthritis. The team will explore ways to predict who is likely to suffer from osteoarthritis after injury and create targeted drug therapies to prevent it.
Researchers found a positive association between periodontal disease and coronary heart disease, particularly in individuals under 60 with significant alveolar bone loss. The study suggests that chronic infections and inflammatory responses from periodontal disease may contribute to the development of atherosclerosis.
New research suggests that skeletal microdamage resulting from bisphosphonate treatment may be maximal during the first year of treatment and not continue to accumulate with longer periods of treatment. The study found no increase in vertebral microcracks after 3 years of alendronate treatment compared to those treated for 1 year.
Researchers have discovered that the Black-Bone Silky Fowl has significantly higher carnosine levels than other chicken breeds, which may contribute to its long-standing use in traditional Chinese medicine. The study found that carnosine makes up 0.45% of the muscle tissue in Black-Bones, compared to 0.22% in White Plymouth Rocks.
A study on liver transplant patients found that those with low bone density before transplant showed significant improvement afterwards. Bone loss immediately following transplant was common and several risk factors were identified, including PSC, younger age at transplant, and smoking.
A new study questions the use of estrens as estrogen-like molecules for treating osteoporosis. Estrens improved bone strength in mice, but also caused adverse effects on reproductive organs and human breast cancer cells. Further clinical trials are needed to determine their safety.
A human study confirms that immune cells play a destructive role in periodontal disease. Researchers found that B cells and T cells produce RANKL, which induces osteoclasts and leads to bone loss.
A new study recruiting up to 2,000 people from the remote Isles of Orkney aims to discover genes that predispose individuals to osteoporosis. The research will utilize a unique population isolated from the UK mainland, allowing for easier tracking and identification of genetic factors.
The Mayo Clinic team has developed a consensus statement recommending the use of pamidronate over zoledronic acid for starting therapy, and stopping or reducing bisphosphonates after two years for safe management of multiple myeloma. The guidelines aim to minimize adverse reactions while maintaining effective bone disease prevention.
The study compared MDCT and digital radiography in orthopedic patients, finding that 63% were concordant, while 37% showed discordant results. MDCT was underestimation or overestimation in some cases, highlighting its potential value in bone healing evaluation.
Cortisone has been found to weaken bones by targeting osteoclasts, which dismantle old bone. Researchers may now be able to develop therapeutic targets to prevent cortisone's damaging side effects on bone.
Researchers reveal that glucocorticoids, commonly used for inflammatory disorders, can cause osteoporosis by delaying osteoclast death and suppressing bone formation. Prolonged GC use affects bone health in mice with normal and disrupted GC receptors.
A new MRI data-acquisition technique developed at the University of Wisconsin-Madison enables clinics to image more patients with osteoarthritis-related knee problems in a shorter time. The technique delivers precise 3D images, allowing for better diagnosis and treatment options.
Researchers have found that protein-coated dental implants can induce bone formation and promote tissue regeneration. In laboratory tests, the protein-induced bone growth nearly completely regenerates lost tissue around teeth.
A study published by the American Physiological Society found that a single therapeutic dose of radiation can cause up to 39% spongy bone loss in mice, reducing their weight-bearing connections by 64%. This has significant implications for astronauts on long space missions and patients receiving radiation therapy.
A new study published in European Journal of Nutrition found that soy germ isoflavones supplementation decreased bone loss in postmenopausal women. The study used SoyLife&Reg; EXTRA and showed a dose-dependent effect on reducing bone loss in non-obese women.
Researchers have identified a protein in mice that regulates bone formation, finding that augmented osteoblast activity leads to elevated bone mass. The discovery could lead to new treatments for osteoporosis by targeting the Shn3 and WWP1 proteins.
The inner walls of bones serve as sites for both bone breakdown and reconstruction, with osteoclasts playing a crucial role in releasing hematopoietic stem cells. This process is essential for maintaining balance in the body's response to injury or inflammation, and may have implications for bone marrow transplant techniques.
The number of hip fractures worldwide is projected to rise from 1.7 million in 1990 to 6.3 million in 2050, with estimated annual costs reaching $131.5 billion globally and $30 billion in the EU.
Significant studies presented at the World Congress on Osteoporosis highlight the importance of calcium, vitamin D, and protein in building bones, as well as the impact of space travel, obesity, and smoking on bone health. The congress also emphasized the need for improved screening and treatment options for osteoporosis patients.
Researchers found that slightly increasing NFATc1 activity leads to massive bone accumulation in mice, suggesting potential new targets for treating osteoporosis. The study's findings may enable the development of drugs that promote bone formation without causing undesirable side effects.
A new study reveals that dietary calcium is more beneficial than supplements alone for building strong bones. Vitamin D supplements only reduce fracture risk when combined with sufficient calcium levels. Meanwhile, research suggests high protein intake promotes bone health.
Researchers have introduced a new technique combining SPECT and spiral CT for improved bone scanning, shortening diagnostic time and clarifying findings. The technology has been shown to enhance the specificity of bone scintigraphy and reduce CT radiation exposure.
Seven young researchers from six countries have been awarded the IOF-Novartis Young Scholars' Award for outstanding contributions to osteoporosis research. The award aims to support and encourage careers in osteoporosis research, a field that has seen significant progress in understanding and treating this debilitating disease.
The 2nd IOF Women Leaders Roundtable emphasizes the need for global awareness and action on osteoporosis. The participants urge individuals to engage in bone-friendly lifestyles and healthcare professionals to improve their knowledge about osteoporosis, while governments are encouraged to recognize it as a health priority.
Research suggests that infant bone growth and maternal vitamin D levels during pregnancy have a significant impact on future fracture risk. Children born to mothers with lower vitamin D levels tend to have weaker bones, while higher levels may improve bone density.
A new study reveals a growing osteoporosis crisis in Latin America, with higher prevalence rates than expected. The study's findings highlight the need for increased attention and funding from governments to address this growing health issue. In contrast, North American diagnosis and treatment of osteoporosis are influenced by socioeco...
A recent USF Health study published in Osteoporosis International found that low-carbohydrate diets do not increase bone loss. Patients on the diet lost significant weight without compromising their bone health. The study's lead author notes potential limitations, but emphasizes the benefits of a balanced approach to weight management.
Researchers found that SXR inhibits VDR-mediated CYP24 activity in mice, contradicting previous studies. In humans, rifampicin treatment increases CYP3A4 expression but has no effect on CYP24 expression, suggesting a complex regulatory mechanism.
Research reveals a previously unknown role for histamine receptors in asthma, suggesting that blocking these receptors could alleviate symptoms. Additionally, a novel peptide inhibitor has been discovered to prevent bone loss in osteoporosis by targeting the RANK/TNF pathway.
Research reveals cartilage cells can die outside the direct impact zone due to leukocyte-mediated damage. Anti-CD18 antibodies and desferoxamine show promise in blocking this process.
A study of 1,460 elderly women found that calcium supplementation did not reduce the risk of osteoporotic fractures overall, but compliance was key. Women who took 80% or more of their daily pills had a lower risk of fractures and improved bone test results.
Researchers find that high FSH levels are necessary for bone loss in postmenopausal women, suggesting an alternative approach to prevent osteoporosis. The study reveals a direct link between pituitary-derived hormones and bone remodeling, revising the understanding of pituitary hormone physiology.
COX-2 inhibitors increase myocardial infarction and stroke risk due to suppression of prostacyclin and PGE2. Inhibiting microsomal PGE synthase-1 may offer anti-inflammatory effects without cardiovascular consequences, suggesting a potential alternative therapeutic option.
A new three-year project is investigating the earliest development of sea fisheries in Northern Europe, with a focus on the critical period between 950AD and 1050AD. Researchers are analyzing fish bones from archaeological sites across the region to understand the impact of intensive sea fishing on medieval trading patterns.
The International Osteoporosis Foundation (IOF) has partnered with Tetra Pak to support World Osteoporosis Day. The partnership aims to empower women and men to take responsibility for their bone health. World Osteoporosis Day, celebrated on October 20, highlights the importance of healthy food and nutrition in building strong bones.
Dr. Teitelbaum's research reveals that blocking integrin receptors on osteoclasts can prevent bone loss in osteoporosis and rheumatoid arthritis, offering new drug targets. Additionally, his work has shed light on the effects of protease inhibitors on osteoclasts in HIV/AIDS patients.
UCR researchers successfully grew bone cells on a scaffold of carbon nanotubes, which can be used to treat bone defects and improve dental implants. The non-treated and electrically-neutral nanotubes emerged as the best scaffolds for bone growth.
A study found that higher-than-normal levels of IL-1-beta in saliva are associated with increased bone loss. Osteonectin levels inversely correlate with bone loss, suggesting this marker may measure periodontal health. The researchers hope to develop a biomarker test for early detection and monitoring.
Researchers found that administration of a bisphosphonate called zoledronic acid every three months significantly increased bone density in men with advanced prostate cancer. The study supports guidelines for monitoring bone density and initiating treatment to prevent fractures.
Researchers are developing nanotechnology approaches for oral health diagnosis and treatment, including precise drug delivery using dendrimers and PEBBLES-probes. These systems aim to increase the effectiveness of anti-cancer drugs and control mineral composition in bone tissue.
Researchers are using advanced techniques to analyze ancient proteins in fossils, providing insights into prehistoric life, diet, and relationships. By studying these molecular remnants, scientists can reconstruct the history of life on Earth and gain a deeper understanding of dinosaurs.
University of Utah archaeologist Jack M. Broughton's study of ancient Native American bird bones reveals that California wasn't always abundant in wildlife as settlers arrived. Indigenous people hunted some species to local extinction, and wildlife returned after European diseases decimated Indian populations.
The Female Athlete Triad combines disordered eating, absent menstrual periods, and bone loss, particularly affecting elite athletes struggling with eating disorders. The International Olympic Committee's new position statement prioritizes athlete health over performance.
A randomized controlled trial found that robot-assisted surgery improved the accuracy of knee replacement operations, with all robotically assisted cases lining up bones to within two degrees of planned position. The study also showed no additional side effects and quicker recovery times.
A recent study found that older women are more susceptible to hip fractures, with over half experiencing significant decline in functioning. Unfortunately, many women in this age group do not undergo bone density screenings, which can help prevent fractures through osteoporosis therapy.
Researchers discover that crystal clusters in fossil bones can preserve ancient DNA, which is better preserved and contains longer fragments than untreated ground bone. This method holds promise for yielding more authentic results in the analysis of ancient DNA.
Scientists at Berkeley Lab create porous scaffolding-like material that mimics nacre's structure, exhibiting four times greater strength than current materials. The composite could foster bone tissue regeneration and improve artificial joints.