Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers at Clemson University will develop an animal model to study bone loss caused by radiation therapy, which could lead to the development of therapies for cancer survivors. The study also examines the effect of space radiation on bone loss for astronauts, a growing concern for future space missions.
Researchers developed a new near-infrared contrast agent that selectively marks hydroxyapatite crystals, allowing for the detection of malignant tissue. The swine trials demonstrated the effectiveness of real-time NIR fluorescence images in image-guided surgery.
Researchers discovered that specialized sugars are predominantly responsible for bone's characteristic toughness and stiffness, challenging previous beliefs about collagen's role. This finding could lead to new treatments for osteoporosis and other bone disorders by targeting sugar molecules.
A recent study found that cheap and moderately priced running shoes provide similar cushioning impact and comfort as expensive trainers. Plantar pressure measurements showed no significant differences among the shoes, regardless of brand or price.
A study by ANZAC Research Institute suggests that a calcium deficiency can increase the likelihood of advanced breast cancer targeting bones. Dietary calcium intake could help prevent this spread and serve as an adjuvant treatment during therapy.
A recent study published in Science confirms that Homo floresiensis, also known as the 'hobbit', is a distinct human species. The research focuses on the unique wrist bones of the hobbit, which show striking similarities to those of African apes and early hominins.
A recent study led by the University of Pittsburgh Graduate School of Public Health found that low vitamin D levels are associated with a higher risk of hip fractures in women. The study analyzed data from 400 women who experienced hip fractures and found that those with lower vitamin D levels had a 77% increased risk.
Yu aims to overcome limitations in current bone grafting procedures by developing biodegradable polymeric 3D scaffolds with optimal porosity and surface area, enabling nutrient transport and cell penetration for successful repair of large bone defects.
Researchers at Brown University have developed a new material that enhances bone growth on orthopaedic implants, increasing the success rate of joint replacements and other implants. The new material, created by applying carbon nanotubes to anodized titanium, encourages bone cells to grow faster and produce more calcium.
Researchers found that reactive oxygen stimulates dendritic cells to up-regulate the immune antigen CD80, leading to T cell activation and increased TNF production. This causes excessive destruction of bone via osteoclasts.
Rutgers researchers found that osteopontin-dependent changes in thymus and spleen lead to organ atrophy in mice stressed under simulated weightlessness. This study demonstrates the critical role of OPN in human diseases such as cancer, multiple sclerosis, and autoimmune responses.
New research from MIT reveals a unified explanation for bone's toughness, incorporating several previously proposed theories. The study finds that bone's atomistic structure plays a crucial role in a toughening mechanism that allows it to tolerate small cracks and maintain its strength.
Researchers discovered a novel molecular pathway involved in bone healing and found that lithium can activate it, but only when treatment is given after the fracture occurs. The study showed accelerated bone healing in mice with activated '-catenin signaling pathway.
Patients treated with bisphosphonates are at higher risk of jaw bone deterioration or infection. The use of intravenous bisphosphonates has been associated with osteonecrosis of the jaw or facial bones, a condition caused by poor blood supply to the area.
Bisphosphonates may cause osteonecrosis of the jaws in patients taking these medications. Women should inform their dentists if they take bisphosphonates to reduce risk. Meanwhile, Burning Mouth Syndrome can be caused by xerostomia, and treatment depends on the patient's condition.
Women with diabetes experienced a decline in death rates, but at a cost: their bone density and endometrial thickness may have increased. In contrast, a study on soy products found that genistein supplements boosted bone mineral density and improved markers of bone metabolism.
A study published in PLOS Medicine found that men who participate in sports or vigorous physical activity are less likely to suffer from osteoporotic fractures. The researchers analyzed data from over 2,000 men and found that those with higher levels of physical activity had a significantly lower risk of fractures. By taking exercise, ...
Researchers have identified a gene, TGBF1, that contributes to otosclerosis, the single most common cause of hearing loss among white adults. The study found that a specific variant of this gene is protective against the disease.
A phase 2 trial found that denosumab reduced the progression of bone erosion in patients with rheumatoid arthritis. The treatment group experienced significant reductions in erosion scores, even as early as six months, compared to the control group.
A study of postmenopausal women has found that infection with four known gum-disease-causing bacteria is associated with more severe oral bone loss. The two most prevalent pathogens were P. gingivalis and T. forsythensis, found in 15.1% and 37.9% of the participants.
Two studies suggest that periodontal diseases are a threat to women of all ages. Women taking oral contraceptive pills are more likely to experience gingival bleeding and deeper periodontal pockets. Periodontal bacteria are also linked to bone loss in postmenopausal women, highlighting the importance of good oral health throughout life.
A new species of long-necked, gliding reptile has been identified from CT scans of fossilized bones. The Mecistrotrachelos apeoros had curved feet, suggesting it lived in trees and exhibited gliding behavior.
Researchers develop an exercise program using rowing and strength training to address physical changes caused by microgravity. The program also includes a potassium-magnesium-citrate supplement to prevent kidney stones. Studies show that the regimen preserves cardiac size and function, muscle mass, and bone mineralization.
Research suggests that young women are at risk for bone loss if they follow extreme diets and engage in rigorous exercise. Women may need to consume more calories to support bone health, as low energy availability can impair bone formation.
Researchers found that percutaneous ethanol injection (PEI) significantly reduces tumor volume and alleviates symptoms in patients with radioiodine-ineffective bone metastasis from thyroid cancer. PEI's effectiveness was also linked to improved quality of life for selected patients.
Researchers use archaeology, biochemistry, and ecology to study the behavior and ecology of northern fur seals over 1,500 years. They find evidence of reproductive behavior in prehistoric populations that differs from modern populations.
Scientists found a new species of sea anemone, Anthosactis pearseae, living on the carcass of a dead whale 1.8 miles below sea level. The anemone is small and white, with roughly uniform tentacle length, and may provide clues about human impact on deep-sea ecosystems.
Researchers found that bat flight is distinct from bird flight, particularly at small scales, due to its collapsible membrane and twisting wing path, generating different wakes and lift during the upstroke.
A University at Buffalo study finds that IL-17, a primary cause of bone destruction in autoimmune diseases like rheumatoid arthritis, protects bones from infectious pathogens in the oral cavity. Researchers discovered that blocking IL-17's receptor increases susceptibility to periodontal disease.
A Cornell University study found that graduate students ate 27% less chicken wings when they could see leftover bones accumulating on their table, compared to tables where food was cleared. The study suggests using environmental cues like empty glasses or bottles to curb overeating and overdrinking at social gatherings.
A study published by the American Academy of Periodontology found that subjects with periodontitis exposed to secondhand smoke experienced greater bone loss than those not exposed. This highlights the devastating effects of secondhand smoke on oral health, emphasizing the importance of smoke-free environments.
A 40,000-year-old human skeleton found in China suggests that modern humans may have migrated to the region via multiple routes rather than a single 'out of Africa' event. The discovery provides valuable insights into the emergence of modern humans in eastern Asia.
Researchers discovered a new cell type in pythons that degrades bone, allowing for efficient calcium absorption from prey.
Researchers at the Weizmann Institute of Science have discovered that the impermeable ring formed by osteoclasts is composed of individual podosomes held together by protein filaments. This unique structure allows the cells to confine bone-eating acids and enzymes, enabling efficient bone digestion.
Dutch researchers have developed a DNA layer that improves attachment, recovery, and immune response to body implants. The coating, patented by Jeroen van den Beucken, approximates the body's natural material, reducing inflammation and immune responses.
Researchers at the University at Buffalo have discovered that estradiol helps maintain bone density by stopping the activation of caspase-3, an enzyme involved in osteoblast apoptosis. This finding suggests that estrogens may prevent both bone loss and fractures through anti-apoptotic effects on bone cells.
Karin Vargervik is being recognized for her extensive work on experimental and clinical issues related to bone formation and remodeling. Her research has focused on craniofacial growth, development, and malocclusions, with a particular emphasis on etiological factors.
Dr. David Mooney is recognized for his groundbreaking work on tissue engineering and tissue regeneration, including blood vessel and bone regeneration. He will receive the IADR Isaac Schour Memorial Award, a prestigious honor acknowledging outstanding scientific contributions in the field.
A two-year study found that the drug risedronate reduced hip fractures in people with Parkinson disease by three times compared to placebo. Risedronate also increased bone mineral density and decreased biomarkers for bone loss, effectively controlling osteoporosis progression.
Research suggests that genetic variations in MMP1 and vitamin D synthesis genes are associated with a higher risk of complications after hip replacement surgery. Patients with specific genetic variations were more likely to experience aseptic loosening and deep infection.
Many dinosaurs had small genomes, with a clear dichotomy between theropod and ornithischian lineages. The researchers found that theropod genomes were smaller than expected, with an average of 8.4% repetitive DNA.
Researchers argue that bone quality is a flawed concept due to lack of precise definition and established measurement methods. The idea was initially proposed as a solution to explain the paradox of osteoporosis, but ultimately relies on increasing whole bone strength rather than targeting specific 'bone quality' features.
Researchers identified a critical molecular pathway in osteosarcoma, finding it also present in cats and dogs. This discovery could lead to advances in palliative care for companion animals with skeletal tumors.
Recent research suggests that humans likely inhabited the Americas before the Clovis People, who have been considered the first inhabitants of the New World. The revised dates for the Clovis time period indicate a shorter duration and overlap with other sites, casting doubt on the Clovis-first model.
A team of Penn State researchers found that plant-derived omega-3 polyunsaturated fatty acids (PUFA) may have a protective effect on bone health. The study, which included a controlled diet with three diets high in PUFA, showed significant decreases in biomarkers of bone resorption.
Researchers have made progress in restoring bone function using bone tissue engineering, which uses stem cells to regenerate bone tissue. This technique has shown success in animal studies and holds promise for clinical applications, but further research is needed to overcome existing challenges.
Researchers are investigating the causes of bone loss in astronauts due to prolonged weightlessness. The study focuses on the role of integrins, which may be key to decreasing bone cell production and preventing fractures.
A recent study suggests that the 'probe to bone' test, used to diagnose bone infections in people with diabetes, may not be as reliable as thought. The test, which feels for bone inside a wound, is only slightly better than chance when used alone.
The new CTX system will enable doctors and scientists to see inside living humans and animals, tracking 3-D skeletal movements with precision. This technology has applications for basic and applied research, including biomechanics, orthopedic surgeries, and injury treatments.
Researchers found that seeing leftover chicken bones on plates led to a 43% increase in eating, while those who ate off clean plates consumed less. The study suggests serving yourself onto a plate and stopping when it's empty can help prevent overeating at Super Bowl parties.
Paleogenetic research requires well-preserved archeological material, but treatment and storage conditions can deteriorate DNA. A new study shows that treating fossils like biological samples during excavation and after improves DNA amplification rates.
A unique clinical study under way at FSU means to find out if daily prunes can help keep the doctor away by reversing bone loss in postmenopausal women. Researchers are expanding treatment options for osteoporosis, a debilitating disease affecting 10 million Americans.
Researchers found that a medication used to reduce toxic side effects of chemotherapy can also increase bone tumor growth in mice. Physicians are advised to closely monitor cancer patients' bone health with regular scans and prescribe medications to prevent bone loss when needed.
A new study published in the Journal of Periodontology found that breastfeeding mothers who consume insufficient Calcium may be at risk for increased bone loss around their teeth and gums. The research emphasizes the importance of a high-Calcium diet during lactation to promote healthy periodontal tissues.
Researchers at NIH have discovered a gene responsible for a previously unexplained, fatal form of Osteogenesis Imperfecta. The CRTAP gene plays a crucial role in collagen production and is found to be nonfunctional in patients with this rare disorder, leading to deformed brittle bones.
Researchers have discovered that mutations in the p62 gene are associated with abnormal bone cell development, but do not cause full-blown Paget disease. Meanwhile, a study found that GIP and GLP1R hormones influence energy levels beyond the pancreas, affecting brain cells, adipose tissue, and body weight.
Researchers have discovered that oxidative stress contributes to neurodegeneration in a Drosophila model of Alzheimer's disease. Additionally, they found that IFN-gamma stimulates osteoclast formation and bone loss, while targeting FoxM1 may limit liver cancer progression.
Men who lose 3 centimeters or more of height as they age are at an increased risk of coronary heart diseases events, cardiovascular disease, respiratory disease, and death. A study of 4,213 men found that substantial height loss is associated with poor eating habits and weight loss, leading to a higher mortality rate.
Researchers at University of Pennsylvania School of Medicine discovered targeting a single gene can inhibit bone decay while stimulating bone formation. This concept may lead to drug treatments for osteoporosis and other bone diseases.
The discovery of Little Foot, an Australopithecus fossil, has been revised to be around 2.2 million years old, pushing it back from earlier estimates of 3-4 million years. The findings suggest that Little Foot is a distant cousin rather than a direct ancestor of humans.