Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers have discovered evidence of woolly mammoth survival in Britain until around 14,000 years ago, challenging conventional beliefs about their extinction. The findings, published in the Geological Journal, suggest that climate change may be a likely explanation for their disappearance.
A new study found that combining rosiglitazone with metformin reverses the negative impact on bone healing caused by rosiglitazone. This beneficial effect was observed in an experimental rat model, where metformin improved bone formation and density compared to rosiglitazone treatment alone.
A new study found that bariatric surgery nearly doubles the expected risk of fractures, especially hand and foot fractures, in patients who underwent weight loss surgery to treat medically complicated obesity. The researchers analyzed data from 97 patients with an average age of 44 years and found a total of 31 fractures after surgery.
A 700,000-year-old fossil bone bed in California has been found to be a record of normal life and death, rather than a catastrophic event. The bone bed, which features shark teeth and seal bones, was formed under unusual climatic conditions that kept sediment at bay.
Recent studies on mud transport, Appalachian promontories, Pisco valley drainage basins, and Eocene Arctic forests shed light on geological processes. The findings suggest that abiogenic methane emissions may be more prevalent than thought and reveal clues about ancient life in the High Arctic.
A £4M funding award will support a multidisciplinary study combining stem cell science and tissue engineering to develop new treatments for bone fractures and orthopaedic problems. The research aims to improve our understanding of skeletal cell activity, scaffold development, and environmental factors that affect tissue regeneration.
Researchers have identified a potential new focus for treating osteoporosis and periodontitis by inhibiting nuclear factor-kB, a master protein controlling inflammation and immunity. This balance is crucial in bone formation and resorption.
Scientists at Eindhoven University of Technology have made a groundbreaking discovery in biomineralization, the process that forms bones, teeth, and shells. They were able to capture three-dimensional images of nanoparticles using the world's most modern electron microscope, revealing the earliest stages of this complex process.
MDC researchers have elucidated a molecular mechanism that regulates the equilibrium between bone formation and bone resorption. They found that two different forms of a gene switch – LAP and LIP – determine this process. The study suggests that an imbalance in the ratio between these two isoforms may play a role in osteoporosis.
A recent study published in the Journal of Periodontology found that marginal bone remodeling occurs between implant placement and prosthesis placement. After a five-year follow-up, minimal mean bone change was observed, indicating dental implants can be an effective tooth replacement option.
A new study provides clear protocols for clinicians to follow, updating fracture risk algorithms and creating simple tables to guide doctors. The findings suggest that repeat bone density measurements can help prognosis of fracture in patients at risk due to age and other factors.
MIT engineers have developed a new tissue scaffold that can stimulate bone and cartilage growth when transplanted into joints. The technology has shown promise in small defects and could offer a more effective, less expensive, and easier alternative to current treatments for sports injuries and arthritis.
Researchers studied 243 wounded Marines to identify risk factors for heterotopic ossification, a condition where bone forms in soft tissues. The study found that age, traumatic brain injury, amputation, and multiple injuries are key contributors to the development of this abnormal bone growth.
A study published in the Journal of Bone and Joint Surgery found that 96 percent of cementless metal components remained securely fixed in place after 20 years. The implants showed promise, especially for younger patients, but wear-related problems were more common among those under 60.
A Purdue University study shows that dairy promotes better bone growth and strength compared to calcium carbonate, with bones of rats fed nonfat dry milk being longer, wider, more dense and stronger. The study found a strong effect of having dairy as a calcium source followed by periods of inadequate calcium.
New research suggests that dinosaur bones from the Ojo Alamo Sandstone may date from after the extinction event, and could indicate that some species survived for up to half a million years. The study uses chemical investigations and evidence of rock age to support the hypothesis.
Researchers at Uppsala University and colleagues analyze fossil upper arm bones from ancient vertebrates, revealing two distinct life histories. Ichthyostega, a more terrestrial animal, undergoes significant changes in limb shape and muscle attachments as it grows, while Acanthostega remains aquatic with less dramatic transformations.
A recent study published in Osteoporosis International found that the bone density of vegan Buddhist nuns was identical to that of non-vegetarian women, despite lower protein and calcium intakes. The researchers noted that fruits and vegetables may have positive effects on bone health.
Scientists at Boston University discovered Resolvins, a new family of biologically active products of omega-3 fatty acids with therapeutic potential. These compounds have been shown to resolve periodontal inflammation and regenerate tissues in experimental gum disease models.
Professor Juliet Compston has received the IBMS John G. Haddad, Jr. Award for her significant contributions to clinical research in bone and mineral metabolism. Her work focuses on metabolic bone disease, osteoporosis, and the effects of glucocorticoids on bone health.
A significant decline in US vitamin D levels has been reported, with serious consequences including increased cancer and heart disease risks. The study suggests that higher doses of vitamin D supplementation may be necessary to address this growing epidemic.
The study suggests that humans were experimenting with agriculture by cultivating local grains, rather than adopting from southern rice-farming areas. The findings provide insight into the origins of agriculture in northern China.
A study published by the American Academy of Neurology found that people with osteoporosis are three times more likely to experience vertigo than those without. Researchers discovered a strong link between low bone density and an increased risk of inner ear disorders, which can cause dizziness.
Dr. Roger Zebazé's project will investigate the structural causes of childhood fractures, aiming to understand bone fragility and devise preventative measures. The IOF-Servier Young Investigator Research Grant provides €40,000 support for innovative osteoporosis research.
Professor Jean-Yves Reginster, a renowned researcher and former IOF General Secretary, has been honored with the Pierre Delmas Award. He is being recognized for his significant contributions to the advancement of osteoporosis research.
Professor Ego Seeman received the IOF Medal of Achievement for his outstanding scientific contributions to osteoporosis research. The award recognizes individuals who have significantly advanced the field of osteoporosis through their original and outstanding work.
A recent study at the University of Pennsylvania School of Medicine reveals that immature cells in blood vessels deep within skeletal muscle orchestrate aberrant bone formation. Cells from the inflammatory response to injury trigger skeleton-stimulating proteins to transform muscle tissue into bone.
Studies reveal that PICK1 protein plays a crucial role in acrosome formation, and its deficiency leads to low sperm count and abnormal sperm movement in male mice. This discovery may shed new light on the human disorder of globozoospermia, which affects male fertility.
Researchers developed a cell-permeable inhibitor of the mouse protein RANK, which blocks osteoclast formation and function, preventing bone destruction. The compound protected against bone loss in two mouse models, suggesting similar drugs may be beneficial for individuals with diseases involving bone destruction.
A new therapeutic target has been identified for osteosarcoma, a type of bone cancer that affects about 30% of patients despite existing treatments. The protein interleukin-11 receptor alpha (IL-11Ra) is highly expressed in primary osteosarcoma and lung metastases from these tumors.
Researchers have confirmed the identities of the two missing Romanov children murdered in 1918 using DNA analysis. The study used mitochondrial and nuclear DNA to link the remains to Empress Alexandra and Crown Prince Alexei, resolving a 90-year-old mystery. Genetic connections were established through maternal and paternal lineages.
The new ultrasound technology, SCAN, uses non-invasive imaging to assess bone quality and predict fracture risk. It also assists in healing fractures by stimulating bone regeneration, making it a cost-effective and accessible tool for healthcare providers.
A new surgical procedure called OCRPRC (OsteoChondral Resurfacing in Proximal Row Carpectomy) offers a promising alternative to traditional treatments for wrist arthritis. By reducing inflammation and improving cartilage status, the procedure aims to restore wrist function and alleviate pain.
A multi-centre study found that osteoblast cell injections accelerated fracture healing, with increased bone growth and no significant patient complications. The treatment is considered a safe and effective alternative to traditional methods, allowing for faster recovery without surgery.
A new study reveals that the chemical mediator sphingosine-1-phosphate plays a crucial role in maintaining bone balance. Researchers found that mice with functional S1P receptors had denser bones than those without, suggesting a potential target for treating bone-resorptive disorders.
A study published in PNAS found that the facial structure of an ancient human relative was adapted for cracking open hard nuts and seeds. The team used finite element analysis and comparative methods to challenge the long-standing hypothesis about Australopithecus africanus' diet.
Researchers at Rush University Medical Center found that a cementless metal cup design remained fixed in place in 95% of hip revision cases after 20 years. The device's bone-in-growth surface allows for long-term stability and durability, reducing the need for repeat surgeries.
A new study suggests that a twist on old medical technology could save limbs by treating infections in soldiers with compound bone fractures. Colistin-laced bone cement may prevent the spread of deadly A. baumannii infections, which are widespread among US troops in Afghanistan.
Researchers discovered that aging causes a dramatic drop in COX-2 enzyme levels, leading to reduced stem cell differentiation into cartilage and decreased bone formation. The study found that manipulating the COX-2 pathway with experimental drugs can rescue healing ability lost with age.
A Texas state dinosaur is facing a name change after research revealed it was misidentified as Pleurocoelus. The new species, Paluxysaurus jonesi, was discovered by Southern Methodist University scientist Peter Rose, who studied sauropod bones in central Texas.
Ancient flying reptiles employed all four limbs for take-off, defying conventional wisdom. The study reveals that pterosaurs had stronger front limbs than legs, allowing them to generate massive power without sacrificing size. This discovery sheds new light on the biology and evolution of these fascinating creatures.
A Montana State University study found that males from three types of dinosaurs were sole care givers for their mate's eggs, possibly having multiple mates. The researchers examined fossil evidence and compared clutch sizes to adult sizes in the dinosaurs and their closest living relatives, birds and crocodiles.
A study by researchers at Joslin Diabetes Center found that nearly three-quarters of youths with type 1 diabetes have insufficient levels of vitamin D, which may lead to bone fragility and increased fracture risk. The study recommends vitamin D supplementation to children with diabetes, especially those with inadequate sun exposure and...
A new study found that increasing alkali content in the diet through fruits and vegetables can counteract acid-induced bone loss. The study discovered bicarbonate has a favorable effect on bone resorption and calcium excretion.
A new methodology developed by Pedro Álvarez Lloret found that exposure to organochlorate pollutants and lead causes bone weakening and fracture in wild birds. The study also reveals that polychloro-biphenyl (PCB) increases bone maturity, making them more fragile.
Researchers at Columbia University discovered that gut serotonin plays a crucial role in bone formation, challenging the long-held belief that the skeleton controls bone growth. The study found that inhibiting serotonin release can increase bone mass and potentially treat osteoporosis.
A study found that 78% of breast cancer patients had at least one other cause of bone loss besides cancer drugs. Vitamin D deficiency was the most common factor, affecting 38% of breast cancer patients compared to 51% of non-cancer patients.
A new study using high-resolution CT scans found that adolescents with mild anorexia exhibit abnormal bone structure, even before significant bone mineral density decreases. The researchers suggest that traditional methods like DXA may not accurately reflect true bone health in these patients.
A new cross-Canada study found that breast and prostate cancer treatment can cause significant bone loss, affecting up to 46,000 people each year. The researchers discovered that medications called bisphosphonates can help combat osteoporosis and fractures in cancer patients.
A study at the University of Alabama at Birmingham has identified a crucial co-receptor in parathyroid hormone signaling that selectively stimulates bone formation. This finding could lead to new osteoporosis drugs and better bone-building therapies by targeting specific cell receptors responsible for calcium uptake from the blood.
The International Osteoporosis Foundation backs the National Osteoporosis Society in criticizing NICE guidance on osteoporosis prevention and treatment. Key concerns include women's access to effective treatments, exclusion of high-risk men, and lack of incorporation of the WHO-supported Fracture Risk Assessment Tool.
The discovery of ancient DNA in 9,000-year-old bones found off the coast of Israel reveals that human tuberculosis is 3,000 years older than previously thought. The study confirms that the human strain of TB evolved before bovine TB and sheds light on its evolution over time.
A study published in JAMA found that using 5-α reductase inhibitors for treating an enlarged prostate does not increase the risk of hip fractures. The research included over 7,000 men who experienced a hip fracture and found no dose-response relationship between medication use and bone health.
A new NASA-funded study from the University of Houston department of health and human performance is examining the ability of sweat patches to detect levels of chemicals that may indicate bone loss. The study aims to develop a micro-fabricated sweat patch that can perform biomarker analysis and provide immediate read-out results.
The discovery of Albertonykus borealis reveals a new species of tiny dinosaur found in Alberta, Canada. This bird-like creature had long and slender legs, stumpy arms, and powerful forelimbs used to tear into logs for termites.
Researchers used a computer simulator to teach surgeons-in-training how to perform craniectomy procedures on cadaveric temporal bone specimens. After two weeks of practice, the researchers found that the trainees could correctly identify pre- and post-simulation bones with high accuracy.
In a six-month study, young adults who followed low-calorie diets with nutritionally sound results experienced weight loss without significant bone loss. However, markers of bone resorption were increased across all groups, while those for formation were decreased in the calorie restriction group.
A study at the University of Michigan found that high-dose calcium supplements can significantly lower lead levels in pregnant women. The researchers analyzed data from 557 women and discovered that those taking calcium supplements had an average reduction of 11% in blood lead levels, with some groups experiencing even greater reductions.
Researchers at Georgia Institute of Technology successfully created artificial bones with a graded interface, allowing them to blend seamlessly into surrounding tissues like tendons. This breakthrough technology has the potential to improve outcomes in ACL surgery and other applications where tissue integration is critical.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that HIV-infected patients have a higher prevalence of fractures compared to non-HIV infected patients. The study analyzed data from over 8,500 HIV-infected patients and more than 2 million non-HIV infected patients, revealing a significant increase in fr...