Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers have created a material for bone grafts that attracts stem cells and growth factors to promote bone regrowth and integration. The synthetic graft heals similarly to natural bone implants in animal tests, suggesting potential as a replacement for traditional grafts.
A 3-year study found no significant positive effect of soy isoflavones on preventing bone loss in postmenopausal women. However, a moderate dose of 120mg showed a modest benefit when combined with lifestyle factors.
A statistical analysis of chemicals found in walleye ear bones reveals that almost all Maumee-spawned walleyes were hatched there, but only two-thirds of Sandusky-spawned walleyes originated from the same river. This study helps wildlife officials determine which rivers are at risk of overfishing.
Researchers identify neogenin as a crucial protein in skeletal development, which can disrupt cartilage and bone formation if mutated. This finding offers new insight into treating osteoarthritis and provides potential therapeutic targets.
Researchers at Columbia University Medical Center discovered that bone resorption plays a crucial role in regulating blood sugar levels. The study suggests that stimulating the release of insulin and improving glucose uptake in cells could be a new target for type 2 diabetes treatment.
Two new studies reveal a key molecular link between bone remodeling and metabolism, finding that osteocalcin levels are tied to insulin resistance and glucose intolerance. Osteocalcin treatment improves symptoms in mice with diabetes-like conditions.
A new study by Johns Hopkins researchers found that insulin is required for normal bone development and may provide a link between bone health and metabolic diseases like diabetes. The study suggests that insulin action in bone provides a critical signal that links metabolism and metabolic disease with bone health.
Children with celiac disease are at risk for poor bone health, but adding vitamins K and D to their diets can reduce this risk. Incorporating physical activity into daily routines also boosts bone strength and Vitamin D intake through outdoor exercise.
Researchers have discovered that bone cells' spindly extensions can sense mechanical stimulation, signaling the release of bone-growth factors. This breakthrough could lead to therapies for osteoporosis and bone loss associated with aging.
A comprehensive Argentinean epidemiological study found that one out of three women aged 50 or over suffers from osteoporosis, with a prevalence of vertebral fractures in 16% of women aged 50 or older. The study estimated annual costs of hip fractures and vertebral fractures to exceed $250 million USD per year.
Researchers at Loyola University Health System found long-lasting disruptions in hundreds of genes involved in bone formation in rats exposed to binge drinking. The study suggests that lifestyle-related damage done during young adulthood may have repercussions lasting decades.
Researchers found that men with high-risk prostate cancer lose significantly less bone mineral content as they age compared to healthy men. The study, published in BJUI, suggests a possible link between prostate cancer and bone health, which could lead to new prevention strategies.
A University of Leicester archaeologist has discovered a bone belonging to a late 19th-century tortoise from Stafford Castle, providing the earliest archaeological evidence for pet tortoises. This find sheds light on the changing attitudes towards family pets in British society during the late 19th century.
A new study from Purdue University found that higher protein intake can lead to weight loss in postmenopausal women, but also increases the risk of bone mineral density loss. Researchers analyzed data from two controlled diet studies and found that older women who consumed more protein through meat sources experienced faster bone loss ...
Researchers at Sanford-Burnham Medical Research Institute created a new mouse model of multiple hereditary exostoses, a rare childhood disease characterized by abnormal bone growths. The study reveals the molecular basis of the disease and provides a tool to screen new treatments.
A large population-based study found that individuals treated with vitamin A analogues do not have an increased risk of fractures. The research, published in Archives of Dermatology, analyzed data from two nationwide registers and found no association between retinoid use and fracture risk at any skeletal site.
A new study from North Carolina State University found that calcium-deficient piglets developed fat cells instead of bone-forming cells, potentially leading to lifelong bone health issues. The researchers plan to investigate the effects of early life calcium deficiency on bone density and strength in a longer-term study.
A 150-million-year-old 'Dinobird' fossil has been found to contain remnants of the animal's original chemistry, including phosphorous and sulfur in its feathers. The discovery could revolutionize the field of palaeontology by providing a new avenue for learning about long-extinct creatures.
The IOF-Servier Young Investigator Research Grant was awarded to two young researchers, Dr. Frank DeVries and Dr. Davide Ruffoni, for their innovative projects on osteoporosis. The grant aims to estimate the risk of fracture in patients with bariatric surgery and understand the mechanisms of implant integration in osteoporotic bone.
The International Osteoporosis Foundation recommends optimal vitamin D status through serum 25OHD levels and effective sun exposure. Vitamin D deficiency is associated with decreased muscle strength, increased risk of falls and osteoporotic fractures.
A team of paleontologists, geochemists, and physicists used X-ray technology to analyze the Thermopolis Archaeopteryx fossil, revealing half a dozen chemical elements that were part of the living animal itself. The study confirms that feathers in the fossil are actual fossilized feathers containing phosphorus and sulfur.
A team of researchers from the University of Bonn has confirmed that Magyarosaurus dacus was a dwarf sauropod dinosaur, contrary to earlier theories that it was just a juvenile. The study reveals that dinosaurs on islands underwent the same ecological and evolutionary processes as modern mammals.
A new study published in the Journal of Bone and Joint Surgery found that statin use post-operative reduces the need for revision surgery after total hip replacement. Statins have been associated with improved bone metabolism, anti-inflammatory effects, and prognosis after infections, which may improve THR outcomes.
Researchers identified three genes involved in regulating bone repair rate, explaining why Paget's disease occurs. The discovery could lead to a screening test for early detection and preventative treatment.
Recent evidence suggests that bones and muscles are interconnected, releasing signals to affect each other's function or disease state. The discovery could lead to novel therapies for age-related muscle and bone disorders, which cost the US $14 billion annually.
Research suggests that low to moderate alcohol consumption has no negative effects on bone health or circulating levels of vitamin D in postmenopausal women. The study also found that moderate alcohol intake does not affect markers influencing alcohol metabolism.
Researchers found that higher levels of follicle-stimulating hormone (FSH) decrease bone mineral density by increasing cytokines, leading to bone breakdown. Exercise has been shown to retain greater bone density in women who engage in more than 180 minutes of physical activity per week.
Research suggests that optimal vitamin D levels are associated with better physical function in seniors, which can improve their overall quality of life. The study found that participants with higher circulating 25-hydroxyvitamin D had better physical function, including improved walking ability and balance.
Researchers found that increased follicle-stimulating hormone (FSH) levels correspond to lower bone density in postmenopausal women. FSH stimulates the production of cytokines, such as interleukin-1 beta, which activate osteoclasts and lead to bone loss.
Researchers from North Carolina State University found that very early calcium nutrition can impact long-term skeletal health. The study involved piglets fed a calcium-rich or deficient diet during infancy, resulting in marked differences in bone density and strength. This suggests that early nutritional programming may predispose indi...
A recent international study on osteoporosis in women has found that most postmenopausal women are not aware of their actual risk of debilitating bone breaks. The study, which involved over 60,000 women aged 55 and older in 10 countries, highlights the need for public education about osteoporosis risk factors and treatment.
Researchers identified signaling mechanisms used by primary cilia to regulate bone cells' capacity to sense fluid flow. The discovery opens the door to developing drugs that mimic exercise benefits for osteoporosis patients. Primary cilia play a crucial role in detecting mechanical loads, such as exercise, and triggering new bone growth.
Researchers have created a new type of tissue and bone scaffolding polymer that addresses long-standing limitations in grafting materials. The smart polymer combines tissue-like properties and strength, and can be reshaped to fit complex injury sites before surgery.
A new study found that a patient's pre-surgical health classification, as determined by the American Society of Anesthesiologists (ASA), is a leading indicator of how well they will fare after hip fracture surgery. Medical complications were more common in patients with ASA class 3 and 4, highlighting the need for close medical managem...
Vitamin D deficiency is linked to obesity, heart disease, depression, diabetes, and fibromyalgia. Dr. Michael F. Holick's book outlines a 3-step strategy to attain optimal Vitamin D levels.
Researchers found that zoledronic acid decreased detectable tumour cells in women with locally advanced breast cancer, particularly after 3 months of treatment. The study suggests zoledronic acid's potential to alter the microenvironment making it less favourable for cancer cells.
A new study led by LSU researcher Mandi Lopez aims to improve treatment of broken bones in horses. Adult equine stem cells have shown promise in repairing bone injuries, but little research has been done on the best combinations of stem cells and carriers.
A new study has discovered that the 'vegetable lamb' plant contains substances with promise as treatments for osteoporosis. The plant's compounds blocked the formation of bone-destroying osteoclasts in up to 97% of laboratory cultures without harming other cells.
Researchers have pinpointed a key molecular player to control mesenchymal stem cell development, which could lead to new therapies for bone and cartilage diseases. The study found that activating the Notch pathway can delay the development of these cells, potentially making them more useful for treating conditions like osteoporosis.
Researchers are using thermography and endoscopy to examine the contents of a 1,000-pound lead coffin found in an ancient Italian city without breaking it. The discovery is significant due to its rarity, with only a handful of examples from this time period existing in Italy.
Researchers found significant changes in facial bones, particularly the jaw bone, occur with age and contribute to an aging appearance. The study suggests a two-step approach to facial rejuvenation: first restoring structure underneath before performing skin-tightening procedures.
A new model of the human body is being developed to improve radiation treatment accuracy for cancer patients, especially children. The research found that children have a greater percentage of total mineral bone in direct contact with sensitive bone marrow than do adults, leading to higher radiation doses and increased cancer risk.
The World Federation of Chinese Medicine Societies has urged its members not to use tiger bone or other endangered wildlife parts, citing lack of medicinal benefits. The call aims to support tiger conservation and reduce trade in big cat products.
A study by the USDA's Agricultural Research Service found that vitamin D levels are more important than increasing calcium intake for better bone health. The study suggests that correcting low vitamin D levels is key to improving bone mineral density, especially among women with low vitamin D concentrations.
A study by Hospital for Special Surgery found that Forteo can enhance tendon to bone healing, leading to better repair results. The researchers used a rat model to test the effects of Forteo on rotator cuff surgery and achieved promising results, including improved tissue organization and strength.
Dr. Adele Boskey, a renowned researcher in orthopedics, has been awarded the ORS/AOA Alfred R. Shands, Jr. Award for her lifetime contributions to the field. Her research focuses on bone quality and osteoporosis, with a goal of decreasing fracture risk through a deeper understanding of bone biology.
Researchers at Henry Ford Hospital found that long-term shoulder function and strength are not fully restored in every patient after arthroscopic surgical repair of tendon tears. Despite high patient satisfaction rates, the study suggests that surgery may not restore normal shoulder motion, but rather alleviate pain.
Enobia Pharma and McGill University partner to develop innovative treatments for rare genetic disorder hypophosphatasia, which affects calcium-phosphate mineralization. The treatment, enzyme replacement therapy, is currently undergoing clinical testing in several countries.
New research reveals the mechanical properties of footpads vary predictably across animal sizes, with bigger critters requiring stiffer shoes. The study found that larger animals have softer pads on rear feet, which may help them recover energy from each step and enhance propulsion.
Researchers found a surprising connection between ancient caribou bones and a massive volcanic eruption that blanketed the region with ash 1,000 years ago. The study suggests that changes in local wildlife may have been linked to environmental changes caused by the eruption.
Researchers at North Carolina State University developed a metal foam that mimics the elasticity of bone, reducing bone rejection and improving implant strength. The new composite foam has a modulus of elasticity consistent with bone, fostering bone growth and preventing 'stress shielding'.
Researchers at Columbia University Irving Medical Center found that inhibiting serotonin synthesis in the gut effectively cured osteoporosis in mice and rats. The compound, LP533401, prevents bone breakdown while building new bone, offering a potential treatment for millions of osteoporosis sufferers.
Researchers at North Carolina State University developed a smart coating to improve bond between implants and bone, reducing rejection and infection risks. The coating promotes bone growth and releases antimicrobial silver particles to prevent infections.
A Swedish study of over 3,700 grandparents and their grandsons found that men with a male relative who suffered a hip fracture had up to 5% less bone density and 4% smaller bones than those without. This reduction in bone size increases the risk of fractures threefold.
Researchers are launching a human trial of a new osteoporosis drug, PTHrP, which may increase bone density more dramatically with fewer side effects than current treatments. The study aims to compare the efficacy of PTHrP with existing FDA-approved drugs for osteoporosis treatment.
A study published in PNAS found that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation. However, the therapeutic effect is limited by the migration of stem cells away from the injury site, highlighting the need for improved delivery methods.
A new study led by researchers from the University of Granada reveals that climbing time to exhaustion is the sole determinant of high-level sport climber performance. The study analyzed physiological parameters and found no significant differences between expert and elite climbers except in these two areas.
New fossil footprints in Poland push back the origin of tetrapods by 18 million years, forcing a reassessment of their evolution. The discovery suggests that early tetrapods inhabited the marine intertidal zone during the early Middle Devonian period and may have first left water to feed on stranded marine life.
A new study suggests that fat mass is essential for increasing bone size and thickness in girls, particularly during puberty. The research found that excessive reduction of fat mass in girls may increase the risk of osteoporosis later in life. In contrast, lean mass has a stronger impact on bone development in boys.
In a study, oncostatin M was found to promote bone formation by blocking the production of a protein that inhibits bone growth when signaling through leukemia inhibitory factor receptor. This indicates the existence of a pathway for stimulating bone formation independently of bone destruction.