Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers found that postmenopausal women on bisphosphonate therapies for osteoporosis had abnormal dental plaque levels, which could endanger the jawbone. The study recommends more frequent dental checkups, including deep periodontal cleanings, to control dental plaque and prevent bone loss.
Professor Gerard Karsenty is awarded the first Herbert A. Fleisch ESCEO-IOF Medal for his pioneering work in understanding skeletal development and physiology. The medal recognizes his outstanding achievements in basic bone science, including identifying Runx2 as a master gene of osteoblast differentiation.
Scientists have identified NOTCH2 as the causative gene for Hajdu-Cheney syndrome, a rare disorder characterized by progressive bone loss and osteoporosis. The study provides vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition.
A study of 143 overweight adolescents found those with risk factors like insulin resistance and low HDL cholesterol have less bone mass than their peers. The study suggests that increasing vigorous physical activity can help improve bone mass and reduce the risk of diabetes and heart disease.
Researchers have found a bone-creating protein that can improve dental implant success when used to augment the maxillary sinus. The protein, BMP, induces superior bone quality and improves chances for successful implants compared to conventional bone grafting.
The iPrEx study found daily oral Truvada effective in preventing HIV infection in gay and bisexual men and transgender women. Researchers also discovered small but significant decreases in bone mineral density among those taking Truvada compared to a placebo.
Scientists discovered an 11,500-year-old Paleoindian house in central Alaska with a cremated child skeleton. The findings provide a unique glimpse into the domestic life of the region's early people, including women and children. The child was around three years old and died before being cremated in a pit within the house.
A phase 3 study shows that denosumab delays and prevents bone events in men with castration-resistant prostate cancer, improving outcomes compared to zoledronic acid. Denosumab reduces the risk of bone fractures and other complications by inhibiting osteoclast activity.
Researchers found that osteocalcin produced in bone enhances testosterone production in testes, supporting sperm survival. This discovery links the skeleton to male fertility and may provide insights into unexplained infertility cases.
A team of BGU researchers has created a unique calcium supplement form that provides higher biological absorption and retention rates. The supplement, derived from unstable calcium carbonate, showed significant benefits in laboratory animals, with improved blood and bone absorption rates.
Researchers found that osteocalcin enhances testosterone production, leading to improved sperm count and reproductive success in male mice. The study suggests that low osteocalcin levels may contribute to male infertility in humans.
Researchers view the knee as a complex organ to develop more effective treatments for osteoarthritis. The exhibit explores degenerative knee arthritis as a failure of multiple tissue systems.
Two large studies on osteonecrosis of the jaw (ONJ) published in the IADR/AADR Journal of Dental Research investigate risk factors and prevalence. The studies found that bisphosphonate use is strongly associated with ONJ, and patients with oral bisphosphonates are 15.5 times more likely to have ONJ.
A new anti-microbial collar is being designed to prevent bacterial infections associated with broken bones, reducing infection rates by up to 85%. The device aims to kill bacteria before they can spread, and could reduce NHS costs by avoiding complications.
A Princeton University research team has unraveled the mystery of how breast cancer tumors take root in the bone. The discovery highlights a specific protein called Jagged1 that sends destructive signals to cells, disrupting normal bone growth and paving the way for potential drug therapies.
Researchers have discovered Largazole's potential to stimulate bone growth and repair damaged bones. The compound blocks the body's natural bone resorption process, offering new hope for treating bone diseases.
Researchers found that breast cancer treatment contributes to weakened bones in middle-aged women, leading to hip fractures. Six breast cancer survivors were studied over a year, showing difficulty with daily activities despite not having osteoporosis.
Researchers found that people taking bisphosphonates lived longer than those without osteoporosis and even gained an extra five years of life. The study, published in the Journal of Clinical Endocrinology and Metabolism, suggests a possible link between bone health and toxic metal release.
A new FDA-approved drug, Sodium Fluoride F18, has been approved for use in bone scans, providing a safer alternative to the radioactive tracer Technetium-99m. The drug offers improved images using PET imaging, enabling better and earlier detection of bone metastases in cancer patients.
Researchers found that early puberty is associated with greater bone mass, while later puberty results in less, increasing the risk of fracture. This discovery has significant implications for adolescence growth and development, highlighting the importance of timing in shaping adult bone health.
Researchers used advanced X-ray technology to compare shoulder motion before and after surgery in 22 patients. While patient satisfaction is high, the data suggest that long-term shoulder strength and dynamic joint stability may not be fully restored in every patient.
A team of researchers led by the University of Pittsburgh School of Medicine has confirmed that a gene from the measles virus plays a key role in the development of Paget's disease of bone. The study found that osteoclasts in affected patients express a viral protein, leading to characteristic bone lesions and increased risk of fracture.
Scientists use atom-probe tomography to map millions of individual atoms in a sea creature's tooth, revealing organic/inorganic interfaces. This breakthrough opens up possibilities for tracking fluoride in teeth and cancer, osteoporosis drugs in bone, and designing new materials with improved properties.
A new species of pterosaur, Gwawinapterus beardi, has been discovered on Hornby Island off Vancouver Island in British Columbia. The fossil, dated to 70 million years ago, features small teeth and a wing span of approximately 3 metres.
Studies found that most anti-epileptic drugs increase the risk of non-traumatic fractures in individuals aged 50 and older. Anti-epileptic drugs are associated with greater bone density loss, particularly in post-menopausal women. The study identified phenytoin and carbamazepine as the most significant contributors to this increased risk.
The IOF and IFCC have identified research priorities and recommended specific bone turnover markers (s-PINP and s-CTX) as reference analytes for clinical and observational studies. Standardized protocols would greatly increase the clinical and research potential of BTMs, improving patient management and treatment adherence.
Experts flag vitamin D deficiency as a major concern in the region, with severe deficiency across India and Pakistan. Interactive maps tracking vitamin D levels by region are being developed to identify problem areas and stimulate research studies.
Denosumab was found to delay the time to first skeletal-related event by 18% and the time to first and subsequent event by 22%, while overall survival and disease progression were similar between groups. The treatment also showed a lower rate of jaw osteonecrosis compared to zoledronic acid.
Researchers at Tel Aviv University have created a new computer method to measure mechanical stress in fat cells, which can help control the amount of fat produced by these cells. The study has direct applications in weight loss programs, treating bedsores, and managing chronic diabetes.
Researchers have identified a potential solution for preventing osteoporosis using potassium citrate supplements. Additionally, waist circumference measurements in children may be a better predictor of heart disease risk than body mass index. Early urine tests can also predict pregnancy complications such as pre-eclampsia.
A recent study found that bone density remained stable for three years in patients who took a drug holiday from bisphosphonates, a popular class of osteoporosis drugs. The researchers recommend taking drug holidays after four to five years, but the study suggests that this duration may be longer, potentially up to three years.
Research identifies a key mechanism in bone formation after resorption, revealing the importance of TGF-?1 and skeletal stem cell recruitment. The study suggests that using PTH before antiresorptive drugs could be an effective therapy for osteoporosis treatment.
A new surgical procedure using Kryptonite superglue has improved the recovery of heart patients after open-chest surgery, accelerating healing and reducing complications. The adhesive allows for new bone growth, enabling patients to breathe deeply without powerful painkillers.
Researchers at UMass Medical School have developed FlexBone, a synthetic bone material with bone-like properties, to replace traditional bone transplants. The material facilitates tissue repair by absorbing proteins from the surrounding tissue, accelerating healing, and delivering growth factors.
Research highlights include colorful connections in the brain, disease-detecting lights for osteoporosis monitoring, and direct laser cooling of molecules. New techniques like Raman spectroscopy and two-photon microscopy are also being showcased.
A team of researchers has discovered that lubricin, a synovial fluid glycoprotein, reduces wear to bone cartilage. This discovery has significant implications for the treatment of osteoarthritis, the most common form of joint disease.
A study by the University of Michigan found that teriparatide, a drug marketed for osteoporosis, can also heal bone wounds in gum disease patients. The treatment showed a 29% improvement in bone-level measurements on x-rays, compared to a 3% improvement in the placebo group.
A new study found that Vitamin D deficiency is associated with a higher rate of abnormal bone density and osteoporosis in IBD patients. The study, which included 161 patients, revealed that nearly half of those with IBD under age 50 had reduced bone density.
A new study found that women aged 67 and older with normal bone mineral density scores may not need re-screening in 10 years. The researchers calculated estimated times for 10 percent of the women to transition to osteoporosis, finding that it would take about 16 years for this group to develop osteoporosis.
Materials scientists from Jena University have created a cellulose implant that can trigger the regeneration of cartilage produced naturally in the body. The implant, which consists of a sponge-like structure with two different surfaces, is designed to adhere to bone and stimulate cartilage growth.
Researchers found that androgen deprivation therapy is associated with structural decay of cortical and trabecular bone in men with prostate cancer. The study used virtual bone biopsies to assess bone microarchitecture and found a link between testosterone deficiency and increased fracture risk.
A new nutritional supplement containing S-equol has been shown to reduce moderate to severe hot flashes, muscle and joint pain, and improve bone density in postmenopausal women. The supplement also lowers 'bad' LDL-cholesterol levels and is considered safe for long-term use.
A study published in the Journal of Bone and Joint Surgery found that 43% of patients undergoing orthopaedic surgery have insufficient vitamin D levels. Vitamin D is essential for bone growth and absorption of calcium. Patients are advised to screen for low levels before surgery, as deficiency may negatively impact patient outcomes.
A new soy-based natural S-equol supplement reduced the frequency of moderate to severe hot flashes and muscle and joint pain in postmenopausal U.S. women. The study found that lower doses of Natural S-equol significantly improved symptoms, with no clinically significant adverse effects.
A new species of dinosaur, Sarahsaurus, discovered in Arizona suggests that dinosaurs did not spread globally by overpowering other species but instead took advantage of a natural catastrophe. The fossil, which lived around 190 million years ago, shows that sauropodomorphs started out small and later evolved to large size.
Researchers at Hebrew University discover a group of substances in the body controlling bone density, leading to development of a new osteoporosis drug. Oleoyl serine increases bone density in both healthy and osteoporotic mice, offering a promising approach to reversing bone loss.
A $1.76 million study at Rensselaer Polytechnic Institute investigates the role of two proteins, osteocalcin and osteopontin, in bone fractures over time. The research aims to develop new methods of diagnosing osteoporosis and treating related bone diseases.
Spanish researchers have discovered a genetic link between the 677C>T variant and osteoporotic vertebral fractures in post-menopausal women. This finding highlights the importance of genetic analysis in identifying individuals at high risk for bone-related illnesses.
A novel nano-CT imaging technique enables researchers to visualize the nano-structure of bone samples with high precision. This allows for better understanding of structural changes related to osteoporosis and development of new therapeutic approaches.
A new study shows that bone-anchored leg prostheses significantly improve function and quality of life for younger amputees. The treatment, developed over 20 years, involves attaching prostheses directly to the bone using a titanium implant.
Researchers have found a new potential treatment target for bone disease osteomyelitis by interrupting the bacterial death signal that instructs bone cells to die. Blocking this signal could prevent or treat painful bone infections resistant to antibiotics.
Researchers developed models to investigate non-healing bone fractures, suggesting cell transplantation as a potential treatment. The study used an animal model and mathematical modeling to demonstrate the effectiveness of this approach.
Researchers will explore fundamental questions about bone health and the immune system in a microgravity environment. The NIH is funding experiments on osteoporosis, immune response suppression, and excessive alcohol use.
Researchers have identified a critical regulatory switch in mesenchymal stem cell lineage allocation, which could lead to the development of new treatments for obesity and osteoporosis. The 'Sprouty' protein has been shown to regulate body fat and bone mass, with potential applications for weight loss and bone density improvement.
The discovery of Balaur bondoc, a large theropod dinosaur from Late Cretaceous Europe, reveals an animal with advanced adaptations and fused bones. Its presence indicates that the region had intermittent faunal connections with the mainland up to the end of the Cretaceous period.
A University of Illinois professor has developed a nutritious salmon baby food for toddlers, citing the importance of omega-3 fatty acids for brain development and preventing coronary artery disease. The product's taste was found to be mild and appealing to parents, with an encouraging sensory panel response.
A new study reveals that ancient alligators and giant tortoises lived on Ellesmere Island above the Arctic Circle despite six months of darkness, with average temperatures ranging from 66-68°F (19-20°C). The research provides insights into past and future biodiversity in the High Arctic as climate change impacts the region.
A study of 140 overweight children found that those with signs of poor blood sugar regulation had less bone mass, a measure of bone strength. Higher abdominal fat was linked to lower bone mass and more body fat overall was associated with higher bone mass.
A study found that valproate reduces collagen production by almost 60% and osteonectin levels by 28% in SMA cells, contributing to bone loss in these patients.
Researchers at Stevens Institute of Technology have developed a novel biomimetic approach using nanofibers to reconstruct intricate bone tissue, focusing on engineering cortical bone. The team aims to create robust platforms for complex tissue structures, with potential applications in reconstructive and transplant surgery.