Articles tagged with Bones
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Researchers at the Academy of Finland have developed a new, laser-based ultrasound technique to accurately assess osteoporosis. This method uses photo-acoustic methods to produce an ultrasound pulse that propagates along the bone, providing a more accurate measurement than current X-ray methods.
A study found that catch-up growth with different diets and resveratrol intervention can improve bone status. Re-feeding with normal chow showed a greater degree of improvement in mineral density than high-fat diet, while resveratrol had protective effects on bone health.
A study of 6,712 preadolescent and adolescent girls found that higher vitamin D intake was associated with a lower risk of developing stress fractures. In contrast, dairy and calcium intakes were unrelated to the risk of stress fractures.
Osteoporosis experts advocate for shorter intervals between DXA scans for high-risk women, patients with low bone mineral density, and those receiving osteoporosis medication. This approach can prevent debilitating fractures and reduce healthcare costs.
Researchers at Linköping University have developed a new method for stronger dental implants by using a drug coating that allows titanium screws to adhere to the bone better and faster. After six months, 15 out of 16 patients showed significantly improved fixation of their treated implants.
Researchers analyzed metal-on-metal hip replacement studies for negative outcomes, finding no bias in results from authors with disclosed conflicts. Despite a trend towards increasingly negative study results over time, the findings support the AAOS's disclosure requirements and peer review process.
A new study presented at the American Academy of Orthopaedic Surgeons meeting found that obese children are 74 percent more likely to sustain a fracture of the growth plate. The study looked at 224 children and found that those with a higher BMI were more likely to experience low-energy impact injuries.
A study reveals that hatchery-raised fish are replacing wild salmon in the river, masking a decline in wild populations. The researchers used ear bones to detect chemical signatures from hatchery feed, finding that only 10% of spawning fish were naturally produced.
A study published by the American Academy of Orthopaedic Surgeons found that excessive sporting activities can lead to a higher risk of surgical revision in patients with hip resurfacing. Patients with lower Impact Scores had better survival rates and lower revision risks, highlighting the importance of limiting physical activity.
Researchers at UT Southwestern Medical Center found that fibroblast growth factor 21 (FGF21) causes significant and rapid bone loss in mice, promoting fat cell growth but inhibiting bone cells. The study suggests a potential tradeoff between the anti-obesity benefits of FGF21 and its risk of osteoporosis.
Researchers have developed modular growth factors that can stimulate bone and blood vessel growth in sheep, showing promise for treating orthopedic injuries and defects. The approach uses flexible proteins to activate specific signaling pathways, reducing the risk of unwanted side effects like cancer.
Researchers show that spider web durability relies on compensating for damage and stress responses of individual strands. Spider webs sacrifice local areas to prevent failure, a strategy unlike other biological materials.
Researchers identified a genetic variation in the RBMS3 gene that increases the risk of osteonecrosis of the jaw (ONJ) in patients taking bisphosphonates. A genetic screening test could help determine safe treatment options, reducing the need for medication discontinuation or invasive dental procedures.
Researchers at URMC discovered a link between leukemia cells and bone formation, finding that leukemia alters the balance of osteoblast and osteoclast activity. The study suggests that targeting osteoclasts could be a potential treatment strategy for leukemia.
Researchers at Wayne State University are investigating the role of c-kit in bone metastasis of prostate cancer. They aim to understand how factors from the bone stimulate the production of c-kit and its ligand in prostate cancer cells, facilitating their growth and survival.
The study found that long, thin teeth and delicate dentition were associated with thicker forelimbs, suggesting an evolutionary trade-off between the two traits. This convergence of traits suggests that these prehistoric predators may have relied on their forelimbs to catch and kill prey without fracturing their fangs.
A new study found that prehistoric predators with large canines had beefier arm bones, a combination seen in sabertooth cats and other extinct mammals. The researchers discovered this pattern through the analysis of fossilized arm bones and teeth, finding convergence across multiple species.
Research at Pompeii counters previous theories that tombs were abandoned due to garbage, suggesting people continued to maintain burial spaces alongside public areas. The ancient city's casual treatment of waste is also revealed, with trash found in homes, streets, and alleys.
Researchers propose that manganese is essential for calcium absorption and its depletion may lead to osteoporosis. The study suggests a link between manganese deficiency and conditions like Alzheimer's and Parkinson's disease, highlighting the importance of maintaining bone health in relation to brain function.
A simple physician notification system improves postfracture care for osteoporotic patients, increasing bone mineral density tests by 13% and pharmacologic treatment initiation by 5%. Researchers suggest additional strategies may be more effective in combination.
Researchers found that the loss of elephant bones at Gesher Benot Ya'aqov site may have imposed significant nutritional stress on Homo erectus. This led to a shift towards hunting smaller prey, which is evident in the physical appearance of modern humans and suggests their emergence in the Middle East 400,000 years ago.
A new study from the University of Gothenburg found that dental X-rays can predict who is at risk of fractures. The research used data from a long-running Prospective Population Study of Women in Gothenburg and showed that people with sparse bone structure in their jaw are more likely to experience fractures, particularly as they age.
A calorie-restricted diet high in protein from dairy foods and low in carbs, combined with daily exercise, improves bone health in overweight women. Dairy-based protein supports calcium and vitamin D levels, reducing markers of bone loss.
Researchers at Washington State University have successfully created a bone-like material and structure that can be used in orthopedic procedures, dental work, and to deliver medicine for treating osteoporosis. The material was produced using a 3D printer and has shown promising results in both in vitro and in vivo tests.
Research suggests that sauropod dinosaurs used hollow osteoderms to store minerals needed for their huge skeletons and laying large egg clutches. The study also found that these "skin bones" became more important mineral stores as the animals grew.
A new study reveals that the recipient's immune system, specifically T-cells, alternately discourages and encourages stem cells to regrow bone and tissue. Administering regulatory T-cells or anti-inflammatory drugs like aspirin increases the rate of bone growth and defect repair.
Research finds that exposure to PCB 126 affects turtles' growth, leading to lower bone density, thinner eggshells, and softer shells. The study provides insights into the environmental impact of PCBs on humans.
A clinical trial found that denosumab treatment increases bone-metastasis-free survival by an average of four months in men with prostate cancer. The drug targets the bone microenvironment to prevent tumor spread.
A study published in The Lancet shows denosumab can delay time to bone metastasis in men with castration-resistant prostate cancer. Denosumab significantly increases bone-metastasis-free survival by over four months compared to placebo, with improved outcomes also seen in delayed first bone metastasis.
Research found that higher CHADS2 scores are associated with increased risks of stroke, systemic embolism, and major bleeding in A-Fib patients taking oral anticoagulants. Additionally, a study on warfarin patients suggests a 12-week monitoring interval is non-inferior to the current four-week schedule.
A study found that consuming dairy foods and higher protein resulted in improved markers of bone formation and reduced markers of bone degradation in overweight premenopausal women. The study showed that a diet with a high proportion of dairy foods and higher than recommended protein intake was associated with improved bone health.
Women under 50 with rheumatoid arthritis are more likely to break bones than their counterparts, according to a Mayo Clinic study. Researchers found that even in younger patients, the condition increases fracture risk, particularly in women.
A piece of jawbone excavated from a prehistoric cave in England is the earliest evidence for modern humans in Europe, dating back to 44,000-41,000 years old. The discovery confirms the coexistence of Neanderthals and anatomically modern humans during the last Ice Age.
Research shows that repeated administrations of radionuclide therapy with 188Re-HEDP improve overall survival rates, reducing pain in prostate cancer patients with hormone-refractory bone metastases. The study found significant increases in post-treatment survival for patients receiving two or three therapies.
Researchers at the University of Texas Health Science Center have discovered that old stem cells can be rejuvenated by being placed in a young microenvironment. This could lead to personal stem cell banks treating age-related diseases, with the potential for regular rescue and infusion.
Six young investigators from the Middle East received prestigious grants for their top-ranking research abstracts presented at the IOF Regionals – 1st Middle-East & Africa Osteoporosis Meeting. The awards aim to encourage bone research among young researchers worldwide.
A three-step strategy for healthy bones and strong muscles is promoted by the International Osteoporosis Foundation, involving vitamin D intake, adequate calcium and protein in diet, and daily weight-bearing and muscle strengthening exercise. These components work together to optimize bone health and reduce falls and fractures in seniors.
A new study has found that zoledronic acid can prevent and treat bone loss in postmenopausal breast cancer patients taking aromatase inhibitors. The five-year study showed significant increases in bone density when the drug was administered upfront, but also found that initiating treatment even after bone loss developed was beneficial.
Researchers at IRCM identified a new gene modulating bone mass and potentially leading to osteoporosis. This breakthrough may help identify individuals with a greater predisposition to the disease.
Researchers successfully grafted deciduous canine teeth and dental pulp stem cells into parent canines, demonstrating bone regeneration after four weeks. The study found increased immunosuppressive activity of these stem cells, paving the way for potential clinical applications in allogenic in vivo stem cell transplantation.
A recent study by Kaiser Permanente found that women aged 65-69 who break a hip are five times more likely to die within a year than those who don't. The study also discovered that for women aged 70-79, a hip fracture doubles the risk of dying, while for those aged 80 and older in excellent health, it nearly triples. These findings hig...
A new trial shows that a single dose of the drug ibandronate is as effective in controlling pain from prostate cancer bone metastases as a single dose of radiotherapy. The study found no long-term difference in pain relief between the two treatments.
Researchers have developed a new bone-targeting drug that can delay the onset of metastases in hormone-resistant prostate cancer patients. The study showed that denosumab prolonged bone metastasis-free survival significantly compared to placebo, improving patient quality of life.
A Phase III trial of Radium-223 Chloride has shown improved survival rates among patients with bone metastases from advanced prostate cancer. The study found that patients taking radium-223 had a 30% lower rate of death compared to those receiving placebo.
A recent study found that the ultrasonic bone aspirator can be a useful tool for cosmetic rhinoplasty, allowing precise removal of bone without damaging surrounding soft tissue. The device showed a positive safety profile and early results warranting further investigation and use.
A Phase III trial demonstrated that the oral recombinant salmon calcitonin tablet OSTORA achieved superior efficacy to nasal calcitonin while showing equivalent safety. This offers a promising new treatment option for postmenopausal osteoporosis patients who have limited options due to side effects or poor tolerance.
A University of Oklahoma graduate student has received the EPA's STAR Fellowship Award to develop a low-cost method for removing fluoride from drinking water in rural Ethiopian communities. Her research aims to address severe overexposure to fluoride, which can cause bone damage and tooth discoloration.
A new study from Mount Sinai School of Medicine reveals that thyroid-stimulating hormone (TSH) directly influences bone growth, contrary to its usual thyroid functions. The findings suggest TSH may be a novel method for addressing bone production and could lead to innovative treatments for osteoporosis.
New research at NIST finds that controlling stem cell shape can induce specific types of cells, offering a simpler and cheaper alternative to biochemical supplements. The study compared five scaffold designs and found that only one, nanofiber scaffolds, successfully directed stem cells into bone-like structures.
Researchers describe the earliest complete fossil hominin hand post-dating stone tools, Australopithecus sediba's hand. The study reveals that it used its hand for arboreal locomotion but also showed human-like precision grips, a prerequisite for tool-making.
Eight young investigators from Australia, China, India, and Japan received IOF Young Investigator Awards for their exceptional work on bone health. The award winners presented their research at the joint Asia-Pacific Osteoporosis and Bone Meeting & ANZBMS Annual Meeting.
Research led by McMaster University found that exercise triggers mesenchymal stem cells to become bone instead of fat, leading to improved blood production and overall health. This finding suggests a new potential for exercise as a non-medicinal treatment for blood-related disorders.
Research reveals age-related degradation of bone's intrinsic and extrinsic toughness. Biological aging increases collagen cross-linking, osteonal density, and micro cracking, compromising fracture resistance.
Researchers develop salubrinal to treat weakened and broken bones by strengthening protein-producing machinery. Studies show accelerated healing in as little as a week, with potential for FDA approval.
A Wayne State researcher has discovered an antibiotic that can prevent and treat aseptic loosening, a condition where surrounding bones disintegrate after prosthetic joint surgery. The antibiotic, erythromycin, can be administered directly at the site of bone breakdown, reducing side effects associated with long-term oral use.
Researchers found that curcumin can suppress inflammation in tendon diseases, potentially reducing reliance on NSAIDs. This natural compound could be used to treat tendinitis and other inflammatory conditions.
Researchers at Johns Hopkins University discovered that the shape of jaw bones in human populations is influenced by both genetic and environmental factors. The study used archaeological jaw bones from two different regions to determine how much of the mandible's shape is plastic, a response to diet, and how much is genetic.
Researchers at Montana State University have discovered that dog-sized dinosaurs that lived in the Antarctic Circle had bone tissue very similar to those living elsewhere on the planet. This finding may help explain how dinosaurs were able to dominate the Earth for 160 million years.
The FRAX tool has been validated in 11 independent cohorts covering over 1 million patient years, providing empirical evidence to guide intervention. However, clinicians should be aware of the tool's limitations, including exclusion of certain risk factors and failure to account for variations in fracture rates within countries.
A recent study published in the Journal of Dental Research investigated the link between bone fluoride levels and osteosarcoma risk. The research found no significant association between the two, contradicting previous controversies over fluoride's potential role in increasing osteosarcoma risk.