Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers created fully biodegradable silk scaffolds with high-compressive strength, mimicking native bone features. The composite materials enhanced human mesenchymal stem cell differentiation and improved bone remodeling.
Researchers have discovered evidence of humans consuming elephant meat and bone marrow in the Middle Palaeolithic site of Preresa, Madrid. The findings, published in the Journal of Archaeological Science, suggest that the practice was not as common as previously thought due to the difficulty of extracting marrow from bones.
Researchers at the University of Delaware have identified a protein called endoglin that regulates the creation of fat cells. By decreasing the amount of this protein on the surface of cells, it may be possible to force fat cells to transform into other cell types, potentially leading to new treatments for osteoporosis and obesity.
Researchers found vitamin D can promote bone density loss while maintaining normal serum calcium levels. The study suggests vitamin D supplements may not be effective in preventing fractures in elderly patients, and high doses could even increase fracture risk.
Researchers found vitamin D can stimulate bone cells to remove calcium from bones, potentially leading to density loss and increased fracture risk. This discovery may explain conflicting results of clinical trials examining the effects of vitamin D supplements on preventing fractures in elderly patients.
A Tulane research team found that applying high levels of oxygen to a severed bone facilitates bone regrowth, particularly when applied at the right time. This discovery may one day benefit injured soldiers, diabetics, and other accident victims with partial limb regeneration.
Fiber intake among the global population is extremely low, posing serious long-term public health implications. New research supports the role of soluble corn fiber in enhancing calcium absorption in adolescents, promoting gut fermentation, and improving digestion, while also addressing challenges related to bloating and tolerance.
Researchers investigated non-emergent musculoskeletal injuries in soldiers returning from combat, finding that nearly 19% required orthopaedic consultations. Another study estimated the incidence of symptomatic venous thromboembolism after elective knee arthroscopy, revealing a relatively low risk for complications.
Researchers investigate gum disease in young and old mice and find a drop in Del-1 levels is associated with increased gum disease. Understanding the effects of Del-1 on the immune system could lead to new treatments or prevention strategies for gum disease.
Researchers found bands of fast and slow growth in Edmontosaurus fossils, indicating periodic seasonal stresses. The study suggests these dinosaurs adapted to Arctic conditions by living year-round, rather than migrating to warmer regions.
Researchers studying human origins face uncertainty due to lack of agreement on interpreting marks on fossil bones. Creating standards for analyzing Pliocene bones is crucial to determine when early hominids began using tools, a fundamental step in human evolution.
A Canadian Journal of Surgery study reveals that only 13 out of 14,000 cancer patients with bone metastases receive orthopedic care annually. This under-referral may contribute to poor outcomes and high mortality rates, emphasizing the need for timely surgical consultations.
Researchers at Brown University have discovered a new signaling molecule, Gbb38, that plays a crucial role in tissue formation in flies. The study suggests possible links to human developmental disorders, such as cleft lip and palate, and may lead to improved therapeutics for bone repair and reconstruction.
The International Osteoporosis Foundation (IOF) and the European Calcified Tissue Society (ECTS) have published a guidance document outlining management strategies to prevent bone loss and related fractures in high-risk patients. The guidelines provide a framework for developing national assessment and treatment guidelines, emphasizing...
Long-term oral glucocorticoid therapy is associated with a significant risk of bone loss and fractures, particularly in older adults and those with higher doses. To mitigate this risk, patients should take preventive measures such as maintaining adequate calcium and protein intake, exercising regularly, and getting enough vitamin D.
The grant will support research on the relationships between body composition, muscle and bone strength. Dr Edwards' project aims to clarify uncertainties with regard to these relationships and assess their impact on fracture risk.
Scientists analyze bones from 80 sailors buried in Royal Naval Hospitals to reveal their diet was mainly salt beef, sea biscuits, and beer; a 'naval average' diet was consistent across theaters
A phase III clinical trial found that the combination of everolimus and exemestane improved bone strength and reduced the chance of cancer spreading in the bone. The treatment also showed a lower rate of further tumour growth and more difficult metastases to occur.
René Rizzoli receives the award for his major scientific contributions to osteoporosis research and advocacy. He is recognized for both his clinical achievements and long-term impact as an educator and advocate in the field.
Researchers are developing a computerized model to predict the force necessary to create fractures and the location of fractures with high accuracy. This will help clinicians make more informed decisions when assessing injuries sustained by young children.
A wooden statue of a king, believed to be female pharaoh Hatshepsut, was found along with an offering chapel and remains of over 80 animal mummies. The discovery provides insight into ritual activity associated with the great gods and challenges previous understanding of pharaonic representation.
Researchers at the Academy of Finland have developed a new, laser-based ultrasound technique to accurately assess osteoporosis. This method uses photo-acoustic methods to produce an ultrasound pulse that propagates along the bone, providing a more accurate measurement than current X-ray methods.
A study found that catch-up growth with different diets and resveratrol intervention can improve bone status. Re-feeding with normal chow showed a greater degree of improvement in mineral density than high-fat diet, while resveratrol had protective effects on bone health.
A study of 6,712 preadolescent and adolescent girls found that higher vitamin D intake was associated with a lower risk of developing stress fractures. In contrast, dairy and calcium intakes were unrelated to the risk of stress fractures.
Researchers at Linköping University have developed a new method for stronger dental implants by using a drug coating that allows titanium screws to adhere to the bone better and faster. After six months, 15 out of 16 patients showed significantly improved fixation of their treated implants.
Osteoporosis experts advocate for shorter intervals between DXA scans for high-risk women, patients with low bone mineral density, and those receiving osteoporosis medication. This approach can prevent debilitating fractures and reduce healthcare costs.
Researchers analyzed metal-on-metal hip replacement studies for negative outcomes, finding no bias in results from authors with disclosed conflicts. Despite a trend towards increasingly negative study results over time, the findings support the AAOS's disclosure requirements and peer review process.
A study reveals that hatchery-raised fish are replacing wild salmon in the river, masking a decline in wild populations. The researchers used ear bones to detect chemical signatures from hatchery feed, finding that only 10% of spawning fish were naturally produced.
A study published by the American Academy of Orthopaedic Surgeons found that excessive sporting activities can lead to a higher risk of surgical revision in patients with hip resurfacing. Patients with lower Impact Scores had better survival rates and lower revision risks, highlighting the importance of limiting physical activity.
A new study presented at the American Academy of Orthopaedic Surgeons meeting found that obese children are 74 percent more likely to sustain a fracture of the growth plate. The study looked at 224 children and found that those with a higher BMI were more likely to experience low-energy impact injuries.
Researchers have developed modular growth factors that can stimulate bone and blood vessel growth in sheep, showing promise for treating orthopedic injuries and defects. The approach uses flexible proteins to activate specific signaling pathways, reducing the risk of unwanted side effects like cancer.
Researchers at UT Southwestern Medical Center found that fibroblast growth factor 21 (FGF21) causes significant and rapid bone loss in mice, promoting fat cell growth but inhibiting bone cells. The study suggests a potential tradeoff between the anti-obesity benefits of FGF21 and its risk of osteoporosis.
Researchers show that spider web durability relies on compensating for damage and stress responses of individual strands. Spider webs sacrifice local areas to prevent failure, a strategy unlike other biological materials.
Researchers at URMC discovered a link between leukemia cells and bone formation, finding that leukemia alters the balance of osteoblast and osteoclast activity. The study suggests that targeting osteoclasts could be a potential treatment strategy for leukemia.
Researchers identified a genetic variation in the RBMS3 gene that increases the risk of osteonecrosis of the jaw (ONJ) in patients taking bisphosphonates. A genetic screening test could help determine safe treatment options, reducing the need for medication discontinuation or invasive dental procedures.
Researchers at Wayne State University are investigating the role of c-kit in bone metastasis of prostate cancer. They aim to understand how factors from the bone stimulate the production of c-kit and its ligand in prostate cancer cells, facilitating their growth and survival.
A new study found that prehistoric predators with large canines had beefier arm bones, a combination seen in sabertooth cats and other extinct mammals. The researchers discovered this pattern through the analysis of fossilized arm bones and teeth, finding convergence across multiple species.
Research at Pompeii counters previous theories that tombs were abandoned due to garbage, suggesting people continued to maintain burial spaces alongside public areas. The ancient city's casual treatment of waste is also revealed, with trash found in homes, streets, and alleys.
The study found that long, thin teeth and delicate dentition were associated with thicker forelimbs, suggesting an evolutionary trade-off between the two traits. This convergence of traits suggests that these prehistoric predators may have relied on their forelimbs to catch and kill prey without fracturing their fangs.
Researchers propose that manganese is essential for calcium absorption and its depletion may lead to osteoporosis. The study suggests a link between manganese deficiency and conditions like Alzheimer's and Parkinson's disease, highlighting the importance of maintaining bone health in relation to brain function.
A simple physician notification system improves postfracture care for osteoporotic patients, increasing bone mineral density tests by 13% and pharmacologic treatment initiation by 5%. Researchers suggest additional strategies may be more effective in combination.
Researchers found that the loss of elephant bones at Gesher Benot Ya'aqov site may have imposed significant nutritional stress on Homo erectus. This led to a shift towards hunting smaller prey, which is evident in the physical appearance of modern humans and suggests their emergence in the Middle East 400,000 years ago.
A new study from the University of Gothenburg found that dental X-rays can predict who is at risk of fractures. The research used data from a long-running Prospective Population Study of Women in Gothenburg and showed that people with sparse bone structure in their jaw are more likely to experience fractures, particularly as they age.
A calorie-restricted diet high in protein from dairy foods and low in carbs, combined with daily exercise, improves bone health in overweight women. Dairy-based protein supports calcium and vitamin D levels, reducing markers of bone loss.
Researchers at Washington State University have successfully created a bone-like material and structure that can be used in orthopedic procedures, dental work, and to deliver medicine for treating osteoporosis. The material was produced using a 3D printer and has shown promising results in both in vitro and in vivo tests.
Research suggests that sauropod dinosaurs used hollow osteoderms to store minerals needed for their huge skeletons and laying large egg clutches. The study also found that these "skin bones" became more important mineral stores as the animals grew.
A new study reveals that the recipient's immune system, specifically T-cells, alternately discourages and encourages stem cells to regrow bone and tissue. Administering regulatory T-cells or anti-inflammatory drugs like aspirin increases the rate of bone growth and defect repair.
Research finds that exposure to PCB 126 affects turtles' growth, leading to lower bone density, thinner eggshells, and softer shells. The study provides insights into the environmental impact of PCBs on humans.
A study published in The Lancet shows denosumab can delay time to bone metastasis in men with castration-resistant prostate cancer. Denosumab significantly increases bone-metastasis-free survival by over four months compared to placebo, with improved outcomes also seen in delayed first bone metastasis.
A clinical trial found that denosumab treatment increases bone-metastasis-free survival by an average of four months in men with prostate cancer. The drug targets the bone microenvironment to prevent tumor spread.
Research found that higher CHADS2 scores are associated with increased risks of stroke, systemic embolism, and major bleeding in A-Fib patients taking oral anticoagulants. Additionally, a study on warfarin patients suggests a 12-week monitoring interval is non-inferior to the current four-week schedule.
A study found that consuming dairy foods and higher protein resulted in improved markers of bone formation and reduced markers of bone degradation in overweight premenopausal women. The study showed that a diet with a high proportion of dairy foods and higher than recommended protein intake was associated with improved bone health.
Women under 50 with rheumatoid arthritis are more likely to break bones than their counterparts, according to a Mayo Clinic study. Researchers found that even in younger patients, the condition increases fracture risk, particularly in women.
A piece of jawbone excavated from a prehistoric cave in England is the earliest evidence for modern humans in Europe, dating back to 44,000-41,000 years old. The discovery confirms the coexistence of Neanderthals and anatomically modern humans during the last Ice Age.
Research shows that repeated administrations of radionuclide therapy with 188Re-HEDP improve overall survival rates, reducing pain in prostate cancer patients with hormone-refractory bone metastases. The study found significant increases in post-treatment survival for patients receiving two or three therapies.
Researchers at the University of Texas Health Science Center have discovered that old stem cells can be rejuvenated by being placed in a young microenvironment. This could lead to personal stem cell banks treating age-related diseases, with the potential for regular rescue and infusion.
Six young investigators from the Middle East received prestigious grants for their top-ranking research abstracts presented at the IOF Regionals – 1st Middle-East & Africa Osteoporosis Meeting. The awards aim to encourage bone research among young researchers worldwide.
A three-step strategy for healthy bones and strong muscles is promoted by the International Osteoporosis Foundation, involving vitamin D intake, adequate calcium and protein in diet, and daily weight-bearing and muscle strengthening exercise. These components work together to optimize bone health and reduce falls and fractures in seniors.
A new study has found that zoledronic acid can prevent and treat bone loss in postmenopausal breast cancer patients taking aromatase inhibitors. The five-year study showed significant increases in bone density when the drug was administered upfront, but also found that initiating treatment even after bone loss developed was beneficial.
Researchers at IRCM identified a new gene modulating bone mass and potentially leading to osteoporosis. This breakthrough may help identify individuals with a greater predisposition to the disease.