Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers found that taking calcium before exercise results in less of a decrease in blood calcium levels and slightly lower parathyroid hormone levels compared to taking it after exercising. This could help maintain stable blood levels during exercise and potentially mitigate bone loss.
Researchers at MIT develop approach to print synthetic materials with fracture behavior similar to natural bone, using computer-optimized designs and 3-D printing. The new material exhibits a fracture resistance of up to 22 times larger than its strongest constituent material.
A clinical study found that insulin resistance is associated with weakened bones and a higher risk of bone fractures. The study, presented at The Endocrine Society's annual meeting, showed that bone strength decreased by 10-14% for every doubling of insulin resistance.
A new study presented at The Endocrine Society's Annual Meeting found that hormone treatment to halt puberty in transgender adolescents is effective and safe, relieving psychological suffering. After cross-sex hormone therapy, bone density caught up, similar to natural puberty, with no long-term harm detected.
A new study found that older patients who know they are at risk of fractures will make positive lifestyle changes, such as exercising and wearing proper shoes, to avoid them. Many participants were confused about the significance of bone density but engaged in daily behavioural strategies to manage their fracture risk.
Scientists at NYU Langone Health have discovered a population of self-renewing stem cells in the nail matrix that depend on Wnt signaling proteins to regenerate bone and tissue. This breakthrough holds promise for therapies to help people regenerate lost limbs, affecting an estimated 1.7 million Americans with amputations.
A new study found that the bacterium NI1060 causes gum disease by triggering a normally protective protein called Nod1 to destroy more bone, not just fight infection. This discovery could lead to personalized therapy for dental patients.
Researchers found reversal cells covering 80% of resorbed bone surfaces that gradually mature into osteoblasts during the reversal phase. Biopsies from postmenopausal patients with osteoporosis showed a high proportion of arrested cells, associated with bone loss.
A new therapy, magnetic resonance image-guided focused ultrasound (MRIgFU) ablation therapy, has significantly reduced pain in 67% of patients with bone cancer. The treatment uses heat to destroy tumors without invasive surgery.
A team of MSU researchers aims to boost astronaut motivation to exercise during long-duration space missions. They will test software featuring computer-generated workout partners to improve adherence and overall health outcomes.
Scientists at Johns Hopkins Medicine discovered that blocking critical bone regulation protein halts OA progression in mice, suggesting a new therapeutic approach to joint replacement surgery. The theory proposes that initial harm to cartilage causes excessive bone growth, leading to disease exacerbation.
A team of scientists analyzed isotopes from the bones and teeth of the first New Zealanders, identifying their likely diet and childhood origins. The study suggests that the first group shared similar diets, while others had highly variable diets reflecting their geographical movements.
A new study found that bone mineral density testing is not routine among men receiving androgen deprivation therapy, but those with primary care physicians are more likely to receive the test. This highlights the importance of primary care physicians in bone care for men with prostate cancer.
Synthetic silicate nanoplatelets induce stem cell differentiation into bone cells, providing a potential therapeutic tool for tissue repair and regeneration. The study's findings offer new insights into the use of bioactive materials in medicine and biotechnology.
Researchers analyzed Hawaiian petrels' ancient and modern remains, finding a drastic shift in diet towards lower-level prey. This change coincides with the growth of industrialized fishing, prompting concerns for other species' fate.
Researchers analyzed Hawaiian petrel bones to determine the impact of industrial fishing on open-ocean food webs. They found a shift in diet from large prey to smaller fish and squid within a century, indicating profound changes in the Pacific's ecosystem.
Researchers have identified a gene mutation that causes a spectrum of disorders affecting the bones and connective tissue, including SEMD-JL1 and Ehlers-Danlos syndrome. The study reveals that B3GALT6 is essential for the development and maintenance of these tissues.
The World Health Organization's FRAX tool has been updated to version 3.8, offering 58 country-specific models for 53 countries and 28 languages. This new release expands the tool's accessibility and functionality, enabling clinicians to make more informed decisions about fracture risk assessment.
Researchers at NYSCF's Research Institute created patient-specific bone substitutes from skin cells to repair large bone defects. The new method uses induced pluripotent stem (iPS) cells, which can become any body cell type, and overcomes previous limitations of bone formation.
A recent study published by the American Academy of Pediatrics found that magnesium intake and absorption are significantly associated with bone density in children. Unlike dietary calcium, which was not significantly linked to bone mineral content or density.
A University of Missouri expert analyzed the pelvis fragments of an early hominid fossil, revealing insights into the evolution of modern great apes. The study suggests that the ape's wider pelvis indicates greater lateral balance and stability, while its distinct finger bones indicate a different evolutionary path than initially thought.
Bone-melting acid secreted by Osedax worms dissolves whale bones to access collagen and lipids, a process similar to how mammals repair and remodel bone. The symbiotic relationship between the worms and bacteria involved in this process is still not fully understood.
A new study by McGill University confirms that a daily dose of 400 IU vitamin D is sufficient for infants under 1 year of age. The research followed 132 infants and found no additional benefits from higher doses.
Researchers at the University of Illinois developed equations to calculate phosphorus and calcium concentrations in meat and bone meal. The study found that ash content is a reliable indicator of Ca and P concentrations, allowing producers to estimate mineral levels without harming pig growth.
Research finds that palliative radiotherapy significantly improves the quality of life for elderly patients with painful bone metastases. The treatment, which involves a single fraction of radiotherapy, has been shown to be effective in all age groups, including those over 75, despite some variability in response.
Dr. Margaret Gourlay's study defined appropriate bone density screening intervals for older women, reducing the need for frequent tests and targeting those at higher risk of osteoporosis. The research has been instrumental in shaping clinical practice guidelines, benefiting human health and welfare.
Professor Socrates Papapoulos has made significant contributions to advancing osteoporosis research and advocacy worldwide. He is a renowned researcher at the Leiden University Medical Center and IOF Board member, with over 300 publications and several awards.
Professor Diez-Perez has advanced understanding of osteoporosis through original scientific contributions, including epidemiology and clinical care. He is recognized for promoting medical innovation and improving patient outcomes.
Professor Maria Luisa Brandi was awarded the prestigious ESCEO-IOF Servier Pierre D. Delmas Prize for her major scientific contributions to bone and mineral diseases. She is a renowned researcher with numerous patents and publications, recognized nationally and internationally.
A recent study found that zoledronic acid, a common osteoporosis drug, not only slows bone loss but also increases levels of sclerostin, a biomarker that inhibits bone formation. This suggests that combination treatments may be needed to effectively treat osteoporosis and increase bone mass.
Dr. Mary Bouxsein has been recognized with the ESCEO-IOF Herbert Fleisch Medal for her outstanding contributions to understanding skeletal fragility through biomechanics. Her work focuses on predicting fracture risk using novel non-invasive imaging techniques.
The European Union faces a significant burden of osteoporosis, with 22 million women and 5.5 million men affected. The annual economic cost of new and prior fragility fractures is €37 billion, with costs expected to increase by 25% by 2025.
Researchers found microwave ablation (MWA) therapy cut pain in half for patients with bone and soft-tissue tumors, lasting up to 15 months. MWA was faster than radiofrequency ablation, with less risk of complications.
A study found that growth hormone therapy can help reverse growth problems in children with kidney failure by increasing bone turnover. However, treatment may not benefit overall bone health and may interrupt the relationship between bone turnover and parathyroid hormone markers.
Researchers at UPV/EHU have created a biodegradable polymer/bioglass composite system that can help mend broken bones. The addition of bioglass to the polymer improves its mechanical properties, but it also reduces thermal stability, which could lead to degradation and harm to cells.
Researchers used hormone levels to estimate when a woman will have her final menstrual period, providing a way to gauge menopause-related bone loss. The study found that levels of estradiol and follicle stimulating hormone can predict the timeline for menopause.
A recent study by the American Academy of Orthopaedic Surgeons found that smoking significantly increases the risk of nonunion in fractures involving long bones. The average time to fracture healing is also longer for smokers compared to nonsmokers, highlighting the negative impact of smoking on bone health.
Scientists at King's College London found that the middle ear cavity is formed by two different tissue types, one of which is less efficient at clearing debris and more susceptible to infection. This 'evolutionary glitch' may be the reason why some children are more prone to developing chronic ear problems like glue ear.
A study by University of Pennsylvania researchers found that younger mice exhibit a more robust healing response compared to older mice. The team identified the Notch signaling pathway as critical to fracture healing, with reduced baseline activity in geriatric MSCs.
A recent study found that current and past smokers have a higher risk of hip replacement failure compared to non-smokers. The study, which reviewed records of total hip replacement patients between 2007 and 2009, found a significant correlation between smoking and increased revision rates.
Researchers have made significant discoveries in musculoskeletal health, including bio-enhanced ACL repair and the diagnosis of posterolateral knee injuries. The new approaches aim to stimulate healing and regeneration, reduce future injury-related osteoarthritis, and improve patient outcomes.
A study by the ZEUS group found no significant difference in the incidence of bone metastases between patients receiving zoledronic acid and those on standard treatment. The 50-month study suggested that zoledronic acid may not be effective in preventing hormone therapy-induced bone loss in high-risk prostate cancer patients.
A large observational study found no significant association between maternal vitamin D levels and children's bone mineral content, suggesting that UK guidelines for vitamin D supplementation during pregnancy may be overstated.
A new study elucidates the reproductive strategy of bone-eating worms, shedding light on their postembryonic development and sexual maturation. The researchers observed the duration of the larval stage, male dwarfism, and rapid female spawning, enabling effective reproduction in a food-rich but isolated habitat.
Researchers at Tel Aviv University found a clear genetic connection between fat and bone mass, which can impact body composition and overall health. The discovery highlights the importance of considering both factors in treatment plans to avoid negative side effects.
Researchers have found that a signaling molecule called SDF-1 helps stem cells survive in the low-oxygen environment of bone marrow by activating autophagy, a survival pathway. However, with age or disease, SDF-1's role shifts, reducing stem cell survival and increasing the likelihood of fat cell formation.
Researchers at Brigham Young University found that runners who transition too quickly to minimalist shoes suffer an increased risk of injury. The study suggests a slower and more gradual transition over a longer duration is necessary to minimize the risk of injuries.
A new UCLA study reveals that primary hyperparathyroidism is the leading cause of high blood-calcium levels, affecting mainly women and the elderly, particularly African American women over 50. The condition can lead to bone loss, depression, fatigue, and increased risk of osteoporosis and fractures.
Scientists at McGill University and the Federal University of Sao Paulo have identified osteopontin as a key player in X-linked hypophosphatemia (XLH), a rare bone disease characterized by soft bones and tooth abnormalities. This discovery may lead to the development of an enzyme-replacement therapy to treat XLH patients.
Polymer implants coated with a bioactive film can bond better with surrounding bone and tissues, reducing complications. The new technique uses microwaves to apply a hydroxyapatite layer that dissolves slowly, promoting stable bonding.
Scientists at Michigan State University found that a natural probiotic supplement can enhance bone density in male mice, but not female mice. The study suggests a possible new treatment for osteoporosis without the risks of traditional medications.
Researchers at Penn Vet have identified a new pathway for stimulating bone growth using the protein Jagged-1. This discovery has the potential to treat bone fractures and improve outcomes for patients with rare metabolic conditions like Alagille syndrome.
Emerging cancer drugs targeting tumor cells may also stimulate osteoclasts to tear down bone, increasing the risk of tumor spread. Researchers recommend closely monitoring patients' bone health when taking these drugs.
Scientists at the University of Southampton have created a method to generate bone cells on nanoscale surfaces, opening up new opportunities for bone repair therapies. The research used human embryonic stem cells cultured on plastic materials with nanotopographical patterns, without chemical enhancement.
Artificial bone created using stem cells and lightweight plastic can heal shattered limbs by encouraging real bone growth. The implant's honeycomb structure allows blood to flow through it, supporting the attachment of patient-derived stem cells.
A new kind of pterosaur, Eurazhdarcho langendorfensis, has been identified by scientists from the Transylvanian Museum Society, University of Southampton, and Museau Nacional. The fossilized bones are approximately 68 million years old and belong to the azhdarchids group.
Researchers analyzed 48 studies on second trimester markers and found that most single markers have only a small effect on modifying the odds for Down's syndrome. However, some markers such as dilated brain ventricles, increased neck thickness, and absent nose bone significantly increase the risk by three- to four-fold.
Researchers discovered a calcified ovarian teratoma in a Roman-age skeleton, shedding light on the presence of this tumour in antiquity. The tumour contained four anomalous teeth and a small bone fragment, providing valuable information for the study of ancient diseases.
A recent study using dental microwear texture analysis found no evidence of increased starvation in saber-tooth cats before their extinction. Instead, the research suggests that these great cats and American lions were well-fed and actively hunted prey, challenging popular theories on megafaunal extinction.
A new analysis suggests that saber-toothed cats and American lions didn't drastically change their diet near extinction due to scarcity. Instead, they likely consumed carcass bones regularly, contradicting the idea that food shortage was a main reason for their extinction.