Articles tagged with Bones
A phase I clinical trial found that ex vivo cultured cord blood stem cells showed improved engraftment rates and earlier hematopoietic recovery in patients with hematological malignancies. The study also developed a murine model of Ewing's sarcoma, revealing tumor origins in embryonic osteochondrogenic progenitors.
Researchers propose that domestic dogs assisted early humans in killing mammoths, explaining the sudden appearance of massive mammoth kill sites. The hypothesis suggests that dogs' hunting skills and ability to guard carcasses increased human success rates.
Researchers will use the ForceShoe to measure exercise loads and ground reaction forces, aiming to understand how joint forces differ between Earth-based exercises and those in microgravity. The goal is to recommend optimal exercise regimens for safe bone and muscle strength maintenance during spaceflight.
A University of Pennsylvania team has identified a promising new target for gum disease treatment: the complement component C3. Treating monkeys with a C3 inhibitor successfully prevented periodontitis-related inflammation and bone loss, suggesting this could be a promising drug option for humans.
Researchers use NMR spectroscopy to enrich a mouse's carbon isotopes, enabling the growth of biological tissue in the lab. The technique has huge potential for scientific and medical breakthroughs, including replacing heart valves.
Scientists have made significant breakthroughs with pluripotent stem cell therapy in monkeys, producing new bone tissue and minimizing the risk of tumors. The study uses autologous iPSCs derived from individual monkeys' skin cells, eliminating the need for immune suppression drugs.
A nearly complete human skeleton found in a cave in Mexico has provided new insights into the ancestry of early Americans. The discovery, which dates back at least 12,000 years, shows that modern Native Americans are genetically related to an ancient population that migrated from Beringia.
A newly discovered fish, Kryptoglanis shajii, has a unique combination of characteristics that set it apart from other catfishes. The fish's bone structure shows modified shapes and changes in certain bones, giving it a bulldog-like snout and conical teeth.
Researchers used synchrotron-imaging to examine 150-million-year-old predatory dinosaur bones, discovering that many healed injuries were not fatal to humans. The study sheds light on the chemical signatures of bone healing and remodelling strategies in extinct vertebrates.
Scientists at Harvard's Wyss Institute have created a bone marrow-on-a-chip device that replicates the complex structure and function of living bone marrow. The device has passed initial tests, including a drug-testing capability that protected the engineered marrow from radiation.
The University of Michigan has launched a new online repository of fossils, featuring high-definition 3-D models of prehistoric creatures. The digital showcase allows users to manipulate and examine the fossils in detail, providing a valuable resource for researchers and sparking interest in young scientists.
Researchers have identified a new approach to treating brittle bone disease by targeting excessive activity of transforming growth factor beta, a signaling protein in the bone matrix. This novel treatment strategy shows promise for personalized and effective management of the condition, potentially applicable to osteoporosis as well.
A new computational model simulates bone metastasis of prostate cancer and accurately predicts the impact of potential therapies on cancer cells and normal cells of the bone. The model was validated by comparing its predictions with tumor growth rates in mice, and identified critical players and events in the process of bone metastasis.
Researchers at Columbia University successfully grew fully functional human cartilage from adult human stem cells, marking a significant breakthrough in tissue engineering. The developed cartilage exhibits physiologic architecture and strength, with potential applications in repairing cartilage defects or reconstructing complex tissues.
New research suggests that mango consumption may reduce inflammation in ulcerative colitis and promote bone health in ovariectomized mice. Mango polyphenolics also showed potential in modifying microbiota and short chain fatty acid production in rats with DSS-induced colitis.
A recent study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that the World Health Organization's Fracture Risk Assessment Tool (FRAX) underestimates the true dangers for people who are younger than 65 or have been treated for a single broken bone. The study used the Canadian BMI-FRAX form of...
A new study reveals that women with wider hips are more likely to have multiple sexual partners and engage in one-night stands. Hip width, rather than waist-to-hip ratio, is found to be a key predictor of a woman's sexual behavior.
A Cornell study published in Eating Behaviors found that children aged 6-10 who ate whole foods like drumsticks and apples were twice as likely to disobey adults and exhibit aggressive behavior compared to those eating cut-up foods. The researchers suggest cutting food can help reduce rowdy behavior at mealtime.
A new analysis of cougar teeth found significant variation in dietary habits among the species, suggesting a more generalized approach that allowed them to survive the Pleistocene mass extinction. This contrasts with the more finicky diets of extinct cousins like saber-tooth cats and American lions.
Researchers have identified a new syndrome called osteosarcopenic obesity, which combines the deterioration of bone density and muscle mass with obesity. This can lead to a higher risk of falls and breaking bones, particularly in older women.
Dr. Jonathan D. Adachi has been awarded the IOF Olof Johnell Science Award for his internationally recognized contributions to osteoporosis research, including epidemiological studies and clinical trials. He is also a prominent advocate for osteoporosis prevention and treatment.
A Norwegian study found that higher screen time was associated with lower bone mineral density in boys, while girls who spent more time on computers had higher BMD than their peers. The findings suggest that sedentary lifestyles during adolescence can impact bone health and increase the risk of osteoporosis.
New research from Wake Forest Baptist Medical Center suggests that physicians are ordering vitamin D deficiency screening tests for preventive care purposes. The study found that the number of diagnoses for vitamin D deficiency rapidly increased from 2007 to 2010, with older patients and females more likely to be diagnosed.
A new study led by Penn Dental Medicine researchers has reversed bone loss and inflammation in patients with leukocyte adhesion deficiency, a rare immune disorder. The breakthrough discovery identifies IL-17 as the key driver of periodontitis and bone loss in these patients.
Citrate, a natural cell by-product, is mixed with water to create a fluid trapped between bone crystals, allowing flexibility and absorbing pressure. Without citrate, crystals fuse together, becoming brittle and prone to shattering.
The new material exhibits a high stability to weight ratio, surpassing that of steel and aluminum. It is produced through 3D laser lithography and has potential applications in insulation, shock absorption, and chemical industry filters.
Researchers developed polymorphonuclear leukocyte-derived novel pro-resolving medicines (NPRMs) to deliver a lipoxin A4 analog to the site of surgery, controlling inflammation and promoting tissue and bone growth. The mini-pig model revealed significant pocket depth reductions and new bone formation in NPRM+LXA4-treated sites.
Researchers at the University of Illinois Chicago have developed a computerized treadmill program to prevent falls in older adults. Studies show that people can be trained not to fall, with adaptations retained for up to 12 months. The training is safe even for those with reduced bone density or osteoporosis.
Researchers have identified genetic markers of original Polynesian chickens, tracing early movements and trading patterns across the Pacific. The study also found that these lineages survived on isolated Pacific islands despite European introduction.
Obese children are more likely to suffer from distal radius fractures and experience complications related to healing. Surgical pinning at the onset of fracture may ensure faster and more effective healing for these patients.
The distraction osteogenesis technique successfully increased the length of the maxilla by an average of 6.4 millimeters in seven adolescent to young adult patients with cleft lip and palate deformities. This approach showed benefits over standard surgical methods, with significantly less bone regression after follow-up.
Researchers developed an MRI that can visualize bone and soft tissue despite the presence of metal screws, allowing for earlier detection of osteonecrosis. The study found that 80% of patients had decreased blood flow to the injured area and osteonecrosis in the femoral head.
Researchers found that biomarkers for bone formation and resorption predict outcomes for men with castration-resistant prostate cancer. Elevated markers also identify patients who respond to investigational drug atrasentan, enabling clinicians to match treatments and track effectiveness.
Researchers analyzed bone collagen of 49 adults from 3000-year-old skeletons to reveal the Lapita people's diet, which included reef fish, marine turtles, and free-range pigs. The study provides new insights into the socio-cultural elements of their society.
A new meta-analysis by IOF-IFCC found moderate but significant associations between bone turnover markers s-CTX and s-PINP, and risk of future fractures. The study confirms the clinical performance of these markers for fracture risk prediction in untreated individuals.
Researchers have developed silk-based screws and plates that can potentially improve bone remodeling following injury and eliminate the need for surgical removal. The devices were tested in laboratory rats and showed promising results, suggesting they could spare patients from complications associated with metal implants.
Research published in the Journal of Clinical Investigation reveals that DLC1 suppresses breast cancer bone metastasis by inhibiting PTHLH production and regulating TGF-\u00b1 signaling. Clinical samples also show a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.
A large-scale investigation reveals that Early British farmers prioritized dairy products and abandoned fishing, adopting a new diet around 6,000 years ago. The study suggests that the hazardous North Atlantic waters made fish an unsuitable food source until new technologies arrived.
A team of researchers is working to improve the outcome of surgical repairs for large rotator cuff tears in older patients by studying the natural attachment of tendon to bone. They plan to use advanced imaging methods and mechanical testing to understand how the natural tendon-to-bone insertion works and what goes wrong in healing.
MIT researchers create a microfluidic platform that mimics the spread of breast cancer cells into a bonelike environment. The study found that certain molecules, such as CXCL5 and CXCR2, may encourage cancer cell metastasis, potentially leading to new targets for cancer therapy.
The study found that domesticated camels arrived in the southern Levant, including Israel, around the 9th century BCE. This challenges the biblical account and highlights a significant turning point in Israel's engagement with the world.
Bariatric surgery is the most effective treatment for both obesity and type 2 diabetes, offering substantial benefits in terms of weight loss, metabolic status, and quality of life. In people with type 2 diabetes, bariatric surgery can reverse complications and improve end-organ health, including pancreatic, renal, retinal, peripheral ...
Researchers at University of Oregon gain insight into bone regeneration in zebra fish, finding two molecular pathways that work together to replace lost bones. Understanding these mechanisms could support the design of regenerative therapies for humans.
Researchers developed antibiotic-containing microspheres to prevent implant-associated bone infections. The study found that coated implants prevented infection in 100% of specimens, while uncoated ones showed a 64% infection rate.
A Penn State College of Medicine researcher developed an automated system that identifies high-risk osteoporosis patients and encourages follow-up treatment to prevent future fractures. The system resulted in a 60% follow-up rate among those who received letters, compared to 14% of those who did not receive letters.
A new statistical model has been developed to isolate ancient DNA from fossils contaminated with modern-day DNA. This method allows for the recovery of complete mitochondrial genomes from Neandertal and anatomically modern human bones, enabling scientists to study these individuals in detail.
A large population-based study published in Annals of the Rheumatic Diseases found that hormone replacement therapy (HRT) taken regularly after knee or hip replacement reduces the risk of repeat surgery by around 40%. The research also showed that taking HRT for 12 months or more after surgery further decreases the risk, with those rec...
Researchers developed a method to harden bones by growing aragonite on their surfaces, making them 50-70% sturdier. This technique has wide implications for preserving valuable remains and restoring cultural clues.
A recent study at Mayo Clinic suggests that certain types of fractures in children may be linked to lower bone strength and a higher risk of osteoporotic fractures later in life. The study found that children with mild-trauma distal forearm fractures had weaker bones compared to those with moderate trauma or no fractures.
Researchers at UC Davis have developed a new MRI technique called Active-MRI that captures the movement of the wrist in real-time. This allows for more accurate diagnosis of conditions such as wrist instability, which can be misaligned and cause chronic pain and osteoarthritis.
Researchers at the Stowers Institute for Medical Research have developed the first genetic model of syngnathia, a rare congenital disorder characterized by fused upper and lower jaws. The study sheds light on the molecular mechanisms underlying the defect, which affects regions such as the head, heart, or gut.
A 1.4 million-year-old fossil hand bone from East Africa has revealed a modern human-like hand anatomy, bridging the evolutionary gap between humans and their nonhuman primate ancestors. The discovery indicates that early humans possessed dexterous hands capable of precise tool use.
Researchers found evidence of cat domestication in ancient China, tracing it back to farmers 5,300 years ago. The study analyzed bones from excavated sites and discovered that cats were attracted to rodents and other small animals in farming villages.
A 13-year study confirms that Neanderthals in western Europe intentionally buried their dead, revealing a relatively sophisticated cognitive capacity. The discovery reduces the behavioral distance between Neanderthals and modern humans.
Five young investigators from China, Chinese Taipei, Hong Kong, Malaysia, and Pakistan received the IOF Young Investigator Awards for outstanding bone health research. The awards recognize the top-scoring abstracts presented at the 4th Asia-Pacific Osteoporosis Meeting.
A team of researchers, including a scientist from Case Western Reserve University, have announced the discovery of a new species of fossil horse from 4.4 million-year-old deposits in Ethiopia. The newly named Eurygnathohippus woldegabrieli had three-toed hooves and grazed grasslands and shrubby woods.
A new report by the International Osteoporosis Foundation warns that Hong Kong's rapidly ageing population will lead to a significant increase in hip fractures, resulting in severe disability and early deaths. The report recommends prioritizing osteoporosis treatment and prevention to mitigate this growing health problem.
The Asia-Pacific region will see a dramatic rise in osteoporosis and related fractures by 2050, with more than half of hip fractures occurring in Asia. The report highlights the need for immediate action to reduce future costs and disability.
Researchers found that chloroquine treatment increased TRAF3 levels in osteoclast precursor cells, limiting osteoclast generation and bone resorption. The study suggests that therapies targeting TRAF3 may help prevent bone loss in individuals with osteoporosis.
Researchers discovered an association between oncometabolite 2-hydroxyglutarate (2-HG) levels and DNA methylation patterns with breast cancer prognosis. Chloroquine treatment was found to limit osteoclast generation, suggesting potential therapeutic applications.