Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
A Swedish study shows that implementing Fracture Liaison Services can prevent a significant number of fractures, saving lives and reducing healthcare costs. The model predicts a reduction in fractures by 50% among patients identified with bone mineral testing, resulting in 19 quality-adjusted life years saved.
A recent study found that over one-third of Division I college athletes have low vitamin D levels, with male and darker-skinned athletes at greatest risk. The study suggests that correcting these levels may improve performance and reduce injury risk through modifications to diet, sunlight exposure, and supplementation.
A study by the University of Adelaide reveals that black bream in the Coorong estuary employ a 'bet-hedging' strategy to survive, migrating between locations based on water and food availability. This adaptation helps the species resist climate change and human impacts.
A new hand-held instrument called OsteoProbe measures the bone material strength index (BMSi), which predicts bone fracture risk. The device is more sensitive than standard measurement techniques and can detect changes in cortical bone indentation following treatment with osteoporosis therapies.
Researchers at Children's Hospital Los Angeles have identified a new role for VEGFA in the metastasis of neuroblastoma. The study found that an increase in bone deposition occurs when NB cells metastasize to the bone, driven by VEGFA, leading to increased bone resorption and severe bone loss.
A new study has identified protein modification needed to treat IBMPFD, a rare and deadly genetic disorder. The researchers found that changing the p47 protein could lead to proper cellular functions in cells with mutated p97, opening the door for potential treatments or prevention.
A new study found that gastric bypass surgery in adolescents significantly improved bone density, which returned to normal levels within two years. The results suggest that obesity surgery may have favorable effects on the adolescent skeleton.
A new study has uncovered seven different species of crocodiles co-existing in the same place and time, filling gaps in understanding the Amazon's rich biodiversity. The research suggests that a peak in mollusk diversity was correlated with the rise of 'durophagous' crocodiles, which went extinct when the mega-wetlands transformed.
Researchers tracked over 2,500 Newark children to chart the progression of localized aggressive periodontitis, a genetic disease affecting 2% of African-American adolescents. The study aims to pinpoint biological markers in saliva that can predict bone loss and identify affected teeth.
Researchers report a breakthrough in treating hypophosphatasia, a fatal genetic bone disease, by combining bone marrow transplants with mesenchymal stem cell transplants. The treatment has shown promising results in improving bone mineralization and survival rates for infants with severe hypophosphatasia.
Recent research suggests sleep apnea impacts bone metabolism through sleep duration and quality disruptions. Daily rhythms play a crucial role in maintaining normal bone health.
A study found that people with recurrent kidney stones have more calcification in their arteries, increasing their risk for heart disease. Additionally, kidney stone formers tend to have less dense bones, elevating their risk for osteoporosis.
Researchers at the Max Planck Institute discovered that removing water from collagen fibers dramatically increases their tensile forces, generating up to 300 times more force than human muscles. This finding suggests a more active role for collagen in living organisms and opens new possibilities for developing novel materials.
Researchers found that Australopithecus africanus, a 3-2 million-year-old species from South Africa, had a human-like trabecular bone pattern in the hand bones consistent with forceful opposition of the thumb and fingers. This suggests that early humans used their hands to exert precision and power, similar to modern humans.
Early human ancestors, such as Australopithecus africanus, used human-like hand postures for forceful precision and power gripping 3-2 million years ago. This discovery supports archaeological evidence for stone tool use among fossil australopiths.
Researchers found evidence of arboreality playing a key role in primate evolution, suggesting subtle changes allowed for easier navigation and better access to food in the trees. The discovery challenges traditional textbook illustrations and provides the oldest fossil evidence to date for this concept.
Researchers at Columbia University Irving Medical Center have discovered a stem cell capable of regenerating both bone and cartilage. The discovery, published in the journal Cell, suggests that this stem cell could be exploited to treat osteoarthritis and osteoporosis. Further study is needed to determine if this technology can be appl...
New research from the University of Surrey found that potassium salts improve bone health by reducing bone resorption. The study showed a significant decrease in bone resorption and an increase in bone strength, potentially preventing osteoporosis.
A recent study published in Psychosomatic Medicine found that women with good life satisfaction had higher bone density and lower rates of osteoporosis compared to those with poor life satisfaction. Life satisfaction was positively associated with bone health, even after controlling for other risk factors.
Researchers at the University of Cincinnati and Boston University explored the decline of ancient civilization using modern biology techniques. They found that soil formation after abandonment led to poor preservation of historic remains, including the survival of thicker cattle bones.
Researchers found that modern human skeletons have significantly lower bone density than other animals and even ancient ancestors. The decrease is especially pronounced in lower limbs, suggesting a link to humans' shift from foraging to agricultural lifestyles.
Researchers found that non-model fish, the spotted gar, shares genetic machinery with mammals for building autopod structures. This study provides regulatory support for an ancient origin of Hox expression responsible for building tetrapod limbs.
Researchers have found a new species of Osedax bone worms with females containing harems of tiny dwarf males. The largest male is tens of thousands times larger than its relatives and has evolved to consume bones on its own.
Washington State University researchers are working on a five-year NIH grant project to develop new bone-like coating materials that will allow titanium-based implants to integrate better into the body. The goal is to improve implant success rates, particularly for younger patients and those undergoing revision surgeries.
A study found that prescriptions for bisphosphonates remain low even among men at high risk of fractures on androgen deprivation therapy. The study suggests limited awareness among clinicians about optimal bone health management, particularly in men with prior osteoporosis or fragility fracture.
Researchers discovered a subset of cartilage-making cells that replicate themselves and drive bone growth, offering new hope for children with facial deformities. The findings could lead to the development of new treatments for corrective facial surgery in children.
The Snowmastodon Project Science Volume provides a new benchmark for understanding climate change in the American West, revealing dramatic ecosystems changes in response to climate shifts. The nearly continuous 85,000-year time span of the site offers the best-known record of life and climate at high elevation anywhere in North America.
The Endocrine Society suggests a single dose of IV zoldedronate as the first-choice treatment for Paget's disease. This option can put the condition into remission for up to six years, making it a preferred choice over oral medications with gastrointestinal side effects.
A research project has been awarded for its innovative approach to stopping bone destruction and tooth loss in severe gum disease. The study aims to re-programme the immune system to fight bacteria without damaging healthy tissue, thereby halting bone destruction before it advances.
Researchers are developing AI-powered software to automatically outline bones in X-ray images, a system that can already identify hips and will now be adapted to map out knees and hands. The goal is to reduce the workload of human researchers and enable faster diagnosis for patients with conditions like arthritis.
A new study found that younger postmenopausal women with normal bone density are at a very low risk of fractures. Without osteoporosis, it took an average of 11 years for just 1% to sustain a vertebral fracture and 3% to sustain a major osteoporotic fracture.
A new study shows a novel molecular imaging drug is effective in detecting early prostate cancer in soft tissue, lymph nodes, and bone. The drug, Tc-99m MIP-1404, has favorable pharmacokinetics and biodistribution, representing a breakthrough in prostate cancer imaging.
A study found that older men are three times less likely than women to undergo osteoporosis screening and treatment after a broken wrist. This disparity increases the risk of future bone breaks and related complications in men, who already have twice the mortality rate of women following a hip fracture.
A new study reveals a dietary supplement, KoACT, outperforms calcium and vitamin D in preventing bone loss. Women in early menopause experience rapid bone loss, making this finding crucial for their health.
A new study from Beth Israel Deaconess Medical Center found that men with osteoporosis-related fractures are under-screened for bone density testing and treatment. The research highlights the importance of evaluating and treating older men for osteoporosis, as fracture rates among men are expected to increase dramatically by 2050.
The International Osteoporosis Foundation has published a succinct slide deck highlighting 60 original scientific abstracts presented at the ASBMR meeting in September 2014. The slide kit provides clinically focused research on various aspects of bone health, including osteoporosis treatment and new strategies.
A study on newborn mice reveals a previously unknown mechanism involving bone growth and muscle contraction that rapidly realigns fractured arm bones. This finding could lead to alternative approaches for treating fractures in adults, improving treatment outcomes by reducing side effects like muscle atrophy.
A long-term study shows that KoACT, a unique patented calcium collagen product, reduces bone loss and builds new bone in post-menopausal women. The study found significant improvements in bone health compared to calcium and vitamin D supplementation.
Paleontologists uncover fatal stab wound in allosaur's pubis bone, suggesting stegosaurs wielded their tails as deadly weapons. The discovery challenges conventional views of stegosaurs as lumbering plant-eaters, highlighting their impressive dexterity and fighting skills.
A new study published in Radiology found that teenage baseball pitchers who throw more than 100 pitches per week are at risk for acromial apophysiolysis, a condition characterized by incomplete fusion and tenderness at the acromion. The study also found that these pitchers are more likely to develop rotator cuff tears later in life.
A new branch of mammals closely related to modern horses, rhinos, and tapirs has been identified through the discovery of ancient bones from India and Pakistan. These animals spent a considerable amount of time near water, similar to modern rhinos and tapirs, and were likely large and lumbering.
Researchers create a fluorescent tag that identifies bone-producing cells in human fat, yielding more than twice the yield of potential bone-makers compared to another method. The extracted cells produce significant amounts of bone matrix and show promise for regenerative therapies.
A new study reveals that preosteoclasts, a previously overlooked group of cells, play a crucial role in maintaining bone health. The discovery explains the success of an experimental osteoporosis drug and opens up new avenues for research into designing future studies.
Researchers have made a breakthrough in understanding how birds evolved from dinosaurs by studying fossil and developmental data, revealing the fusion of two bones to form a semilunate bone. The study clarifies the identity of wrist bones in both groups, shedding light on the evolutionary reversal of a lost bone.
Paleontologists discover a tooth embedded in a rauisuchid's bone, showing phytosaurs targeted both aquatic and terrestrial prey. The find provides evidence for the interaction between these two top predators on land and sea, forcing a reevaluation of ancient ecosystems.
Researchers have identified a potential method to interrupt abnormal bone growth, commonly known as heterotopic ossification (HO), in burn patients. Using an anti-inflammatory treatment called apyrase, the study found that HO can be reduced by breaking down ATP, a primary energy source for cells.
Researchers redesigned a molecule to control immune cell activity, changing its target and altering the effects of its signal. This new approach may let scientists selectively block the bad signals that cause or contribute to disease, enhancing good signals that defend against cancer and infections.
Researchers discovered that GILZ protein can reduce bone loss and inflammation associated with arthritis, potentially replacing synthetic glucocorticoids as a treatment option. The study used mice bred with overexpressed tumor necrosis factor alpha and GILZ to demonstrate the protein's protective effects.
Researchers at the University of Granada found that hyperproteic diets can maintain better bone properties than normoproteic diets. Soy protein supplements were shown to be more beneficial, increasing calcium content in bones by up to 7%.
Raloxifene increases bone toughness by altering the physical properties of the bone matrix, rather than just suppressing bone loss or altering cellular activity. This novel mechanism provides a new class of osteoporosis treatments that target bone's intrinsic strength.
The FASEB MARC Program has announced the travel award recipients for the 2014 ASBMR annual meeting, promoting diversity in bone and mineral research. The program aims to increase the number of underrepresented groups engaged in biomedical research, with this year's awards totaling $3,200.
Research suggests that comprehensive fitness and nutrition regimens can minimize bone and joint health decline and maintain overall physical health in seniors. The study recommends individualized exercise programs with resistance, endurance, flexibility, and balance training, as well as proper nutrition to optimize performance.
A new study sheds light on the diversity and distribution of toothless 'dragon' pterosaurs from the Azhdarchidae family. The research reveals these flying giants inhabited various environments, particularly near large lakes and rivers.
A UK study found that smoking during pregnancy affects grandkids' growth, with paternal grandmother's smoke increasing daughters' height and both sexes' bone mass. Maternal grandmother's smoke, however, linked to sons' increased weight and muscle mass during adolescence.
Researchers have discovered an enzyme therapy that improves bone growth, mineralization, and strength in a mouse model of neurofibromatosis type-1. The treatment, asfotase-alpha, reduces fractures by clearing accumulated pyrophosphate, a strong inhibitor of bone mineralization.
Researchers have made a breakthrough in evaluating long bone fractures using ultrasound, providing a new method for monitoring healing. The study found that the amplitude of ultrasonic guided waves can quantify fracture degree and depth, offering a non-invasive diagnostic tool.
Researchers from ASU and Mayo Clinic developed a method using calcium isotope analysis to detect early bone loss in multiple myeloma patients. This technique could help tailor therapies to protect bones and monitor disease progression.
Researchers found a systematic connection between FMD, bone abnormalities, and TGF-beta pathway activation. The study suggests that FMD may not be limited to arteries and is a systemic disease with altered TGF-β expression.
Researchers found that microRNA-124 significantly increases β-III tubulin and microtubule-associated protein-2 expression in BMSCs, promoting neuronal differentiation. Transplantation of miR-124-transfected BMSCs into spinal cord injury models improves motor function.
Research found that one in three female triathletes suffer from urinary incontinence, bowel incontinence, or pelvic organ prolapse. High-impact sports like triathlon training can lead to decreased energy, menstrual irregularities, and abnormal bone density due to inadequate nutrition.