Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers identified a strategy to target human breast cancer stem cells by blocking the protein CXCR1. The approach selectively depleted cancer stem cells in mice xenotransplanted with human breast cancer cells, leading to reduced tumor growth and metastasis. This finding provides hope for women with breast cancer.
Researchers have discovered changes in the collagen component of bone that directly relate to bone health. The study uses atomic force microscopy to measure key features of collagen fibrils and found that normal bone contains a distribution of collagen fibril spacings, whereas diseased bone has a different spacing distribution.
Australian scientists have discovered that the brain plays a crucial role in regulating bone formation, fine-tuning the process based on energy availability. The neural network controlling appetite and energy also influences bone density, with starvation reducing bone creation and overeating increasing it.
Researchers unveil fossil skeleton 'Ardi,' a 4.4 million-year-old hominid species that changes our understanding of human evolution. Led by Dr. C. Owen Lovejoy, the team presents groundbreaking findings in 11 papers published in Science.
A DNA study has identified the earliest known case of leprosy in a 1st-century shrouded man found in a Jerusalem tomb. The analysis reveals that this individual likely died from tuberculosis, challenging the historical association between leprosy and social exclusion.
Scientists unveil the story of a 4.5 million-year-old whale, shedding light on fossilization and taphonomic processes. The study provides insights into the ecological phases associated with whales in the past.
Researchers used DNA samples from frozen dirt to revise the history of woolly mammoths and ancient horses in North America. The analysis shows that these animals survived until at least 10,000 years ago, contradicting previous extinction theories based on fossil bones.
Researchers have discovered that tendons initiate bone ridge outgrowth through BMP4 secretion and muscle activity promotes further growth, highlighting the importance of tendon-bone interactions
Current UK guidelines limit postmenopausal women's treatment options due to bone mass T-score criteria. Alternative therapies are available but often require stricter conditions.
A team of researchers at the University of Houston has created a process to grow real human bone in tissue culture, allowing them to investigate how bones form and grow. The technology has potential applications in preventing bone loss in astronauts and patients with spinal cord injuries.
Researchers explored how changes in water content affect bone's structure and dynamics, revealing dynamical structural changes in collagen. The study's success enables future research into atomic-level behaviors of bone under different conditions.
Researchers find that the RANK protein and its ligand regulate the body's fever response, helping to fight infection. Female mice lacking RANK in the brain have increased body temperatures compared to males, with a link to sex hormones and reproductive biology.
A team of scientists has discovered how fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder, develops at a cellular level. The mutation that causes FOP mistakenly activates a cascade of biochemical events in soft tissues, leading to extra bone growth.
Researchers have discovered that ancient penguin DNA can significantly challenge the accuracy of traditional genetic aging measurements, suggesting that many specimens may be up to 600% younger than reported. This finding has major implications for our understanding of evolutionary rates and the history of evolution.
Researchers have discovered up to 15 species of boneworms in Monterey Bay, which feed on dead whales and exhibit unique life cycles. The worms' ability to adapt to different environments and find food sources has led scientists to estimate their evolutionary origins, suggesting they may date back to the time of dinosaurs.
A large-scale meta-analysis has found a clear connection between depression and reduced bone density, increasing the risk of osteoporosis. The study, conducted by Hebrew University researchers, reveals that young women are particularly at risk, especially those with clinical depression.
A Kaiser Permanente study found that aggressively managing patients at risk for osteoporosis can reduce the hip fracture rate by 25%. The study, which followed 650,000 men and women over 50 years old, found a 38% drop in hip fractures and prevented 970 hip fractures in 2007.
Scientists copy natural glue secreted by sandcastle worm to create new medical adhesive for repairing shattered bones. The synthetic glue is based on complex coacervates, ideal but unused method for making injectable adhesives.
Researchers at Boston University School of Medicine found that weekly and biweekly vitamin D2 doses effectively treat and prevent vitamin D deficiency. The study shows significant increases in 25-hydroxyvitamin D (25(OH)D) levels after treatment, with no reported toxicity risks.
Researchers at Tel Aviv University have developed a biologically active scaffold made from soluble fibers that can help replace lost or missing bone. The technology, which has shown promise in animal models, could also be used to regenerate other types of human tissues, including muscle, arteries, and skin.
Archaeologists at Tel Aviv University have uncovered clues about the development of communal meat-cutting habits in early humans. The study, published in the Proceedings of the National Academy of Sciences, reveals that our ancestors shared meat differently than later periods.
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
The study finds that Archaeopteryx grew slowly, taking 970 days to mature, similar to dinosaurs, and its bone growth rate was three times slower than living birds. This challenges the common perception of Archaeopteryx as a bird-like creature.
A study of 166 breast cancer patients found nearly 70% had low vitamin D levels, increasing fracture risk. High-dose supplements improved levels and boosted bone mass, helping mitigate disease symptoms.
A gluten-free diet can rapidly increase bone mineral density in children with celiac disease, leading to complete recovery of bone mineralization. Early diagnosis and a strict gluten-free diet are critical in preventing complications such as reduced bone mineral density and osteoporosis.
Researchers at Duke University have found a new mechanism of bone formation that works without inducing bone breakdown, suggesting a targeted approach to fighting osteoporosis and other degenerative bone diseases. The discovery involves the G-protein coupled receptor (GPCR) pathway and beta-arrestin molecule.
A new study reveals that people with coeliac disease are at risk of developing osteoporosis due to an immune system attack on their bone tissue. Researchers have identified a protein called osteoprotegerin as the target of this attack, leading to rapid bone destruction and severe osteoporosis.
The debut edition of Science Translational Medicine describes a microfluidics device for detecting tiny amounts of estrogen, which could improve breast cancer screening. Researchers have also identified a novel mechanism to protect patients from graft-versus-host disease after bone marrow transplants.
The discovery of Ardipithecus ramidus provides new information on human evolution, suggesting that humans did not evolve from apes but rather that apes evolved from humans. The 4.4 million-year-old skeleton is more informative than the famous 'Lucy' fossil and sheds light on human behavior and anatomy.
Researchers discovered that Tyrannosaurus rex and its relatives had a potentially deadly infectious disease similar to trichomonosis, which causes swollen jaws and holes. The study found evidence of face-biting marks on many specimens and suggests that cannibalism or head-biting may have spread the disease.
Research suggests that diabetes accelerates bone loss and impairs fracture healing due to increased levels of inflammatory molecules like TNF-α. This can lead to delayed bone fracture healing and an increased risk of fractures in diabetics.
The International Osteoporosis Foundation's Health Professional Awareness Grants support innovative projects promoting osteoporosis knowledge among clinicians and allied health professionals. Five grants were awarded to patient societies in Armenia, Austria, Bulgaria, Hungary, and Singapore for their awareness programs targeting health...
The Arthritis Foundation of India Trust has won the prestigious IOF Linda Edwards Memorial Award for its innovative campaigns to raise awareness about osteoporosis. The organization, established in 2002, has been recognized for its efforts to improve bone health and patient care across India.
A recent study published in Cell by Yale School of Medicine researchers identified a novel brain pathway where leptin regulates bone mass and suppresses appetite through serotonin pathways. The findings contradict the prevailing view that leptin primarily acts in the hypothalamus.
Scientists have discovered a potential therapeutic strategy for reversing rheumatoid arthritis and osteoporosis by manipulating the levels of NF-κB p100, a key inhibitory protein. The study found that increasing NF-κB p100 levels can limit bone destruction and inflammation in both diseases.
Researchers found that elephants use two pathways to 'hear' ground-borne vocalizations: somatosensory pathway through feet and trunks, and bone conduction pathway through toenails. This allows them to understand seismic communication over long distances.
Researchers have discovered that space radiation can cause rapid bone loss in mice, which may lead to new treatments for cancer patients and astronauts. The study's findings suggest that existing medications like bisphosphonates could prevent this early loss of bone mass.
Researchers have found that T cells from individuals with X-linked lymphoproliferative disease (XLP) are resistant to cell death triggered by repeated stimulation of a cell surface protein complex, leading to uncontrolled expansion upon infection. Additionally, a molecular regulatory network controlled by the protein SPDEF governs alle...
The Bcl-xL protein prevents bone breakdown by negatively regulating the bone-resorbing activity of osteoclasts. In mice, Bcl-xL promotes osteoclast survival and decreases extracellular matrix production, leading to increased osteoclast-mediated bone resorption.
Researchers found that bone lead levels were associated with a higher risk of death from all causes and cardiovascular disease. The study suggests that bone lead may be a better biomarker for cumulative exposure to lead, leading to important public health implications.
Research uses bacteria to produce biofilm layers containing biopolymers that act as strong adhesives, resulting in better mechanical strength and surface coverage. The biocoating method could lead to improved bone implant materials with enhanced properties.
Researchers at Columbia University Medical Center have identified a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. The discovery reveals that leptin acts on serotonin in the brain stem, increasing appetite and bone mass.
New research from Purdue University raises concerns about estrogen supplements claiming to improve bone health in postmenopausal women. While some plant-derived isoflavones show modest effects, many supplements lack efficacy or are less effective than current treatments for osteoporosis.
Scientists discovered that downregulation of IRF-8 gene increases production of osteoclasts responsible for bone breakdown. The study found that IRF-8 suppresses osteoclast activity and inhibits NFATc1 protein function, potentially leading to new therapeutic approaches.
Researchers identify a link between high cholesterol and osteoporosis, with the immune system playing a key role in bone loss. The study found that oxidized LDL triggers an immune response, leading to excessive bone damage.
A study published in PLOS Medicine found that adults born with very low birth weight have significantly lower bone mineral density compared to their term-born peers. This increased risk of osteoporosis in adulthood highlights the importance of monitoring and addressing this issue for individuals born preterm.
A new UCLA study reveals the immune system plays a crucial role in bone loss, with high cholesterol levels contributing to the disease. The research identifies a new approach for treating osteoporosis using immune-based therapies.
Researchers have copied the sandcastle worm's natural glue to create a synthetic adhesive for repairing bones, which could revolutionize fracture treatment. The new adhesive is biocompatible and twice as strong as the natural glue it mimics.
A recent study found that the type 1 cannabinoid receptor is key to bone development and osteoporosis. Cannabis may reduce bone strength in young people but protect against osteoporosis in older age.
Researchers found that early human hunters in central Israel between 400,000 and 250,000 years ago were skilled at big-game hunting like later stone-age hunters, but shared meat differently. The earlier humans were less efficient and specialized when it comes to carving flesh from their prey.
A recent review suggests that limb-sparing surgery does not provide a significant benefit to patients with bone and soft tissue sarcomas. The study found that early and late complications are more common with limb-sparing surgery, but some advantages were seen for higher surgical sites in the lower limb, such as the hip.
Research suggests humans and African apes have distinct wrist bone features that indicate independent evolution of knuckle-walking behavior in two separate lineages. A study examining juvenile and adult wrist bones found key features associated with knuckle walking present in 96% of chimpanzees, but only 6% of gorillas.
A new study re-examining Tyrannosaurus rex remains has confirmed the presence of proteins from blood and bone, tendons, or cartilage, resolving a long-standing controversy over detectable biochemical remnants. The analysis also found evidence of substances typical of bird-like bones, which were previously disputed.
Researchers found that freshwater fish like largemouth bass, which feed primarily on fish, have remained relatively unchanged over time. Once they evolved the optimal size and shape for catching fish, natural selection kept them in an evolutionary holding pattern.
A new study reveals that specialized blood cells have bone-forming potential and can contribute to abnormal bone growth in rare genetic disorders like fibrodysplasia ossificans progressiva. This discovery has significant implications for understanding FOP and other conditions where bone forms outside the skeleton.
Two matrix metalloproteinase (MMP) proteins contribute to bone metastasis in advanced breast cancer by degrading extracellular matrix and stimulating osteoclast activity. This discovery supports therapeutic targeting of MMP1 and ADAMTS1, potentially mitigating bone complications in advanced metastatic breast cancers.
The study aims to reduce bone damage and fractures in laying hens by providing omega-3 supplemented diets. Researchers will house 16 flocks of 1,500 hens each in identical free-range systems to compare the effects of high and standard omega-3 diets.
A UAB study reveals the human protein TGF beta-1 plays a crucial role in balancing bone resorption and formation. The discovery could lead to better bone-building therapies and new osteoporosis drugs, offering hope for patients with bone diseases.
Prof. Noam Eliaz's electrochemical coating process improves implant functionality, longevity, and integration into the body. The new coating reduces materials failure by 33% and has potential to spur new bone growth.
Researchers at Scripps Institution of Oceanography found that high CO2 levels in water lead to abnormally large ear bones in fish, a vital structure for sensing orientation and acceleration. The study suggests potential implications for the survival and behavior of affected fish.