Research on bone health and repair. Covers bone healing, mineral density, skeletal evolution, and radiopharmaceutical trials.
Researchers have identified Smurf1 as a signaling partner that damages bone in rheumatoid arthritis, guiding the development of new drugs to reverse bone loss. The study also suggests potential applications against osteoporosis by targeting Smurf1 with specific drugs.
Researchers have identified two receptors on the tongue that detect the taste of calcium, which is crucial for building strong bones. This discovery could lead to the development of foods and drinks that are more palatable and easier to consume.
Researchers at Carnegie Mellon University developed hydrogels that promote the growth of pre-osteoblast cells, aiding bone development. These gels interact with growth factors like demineralized bone matrix, providing scaffolding for bone cell proliferation and new tissue formation.
Researchers found that adolescents who consumed 2 or more servings of dairy per day had higher levels of bone mineral content and density. Dairy was also shown to have a combined beneficial effect when paired with other protein sources, leading to increased bone mineral content over 300 grams.
A recent study published in the journal Bone found that higher intakes of calcium significantly improve bone health in children. The study, which pooled data from 21 randomized clinical trials, revealed a substantial increase in total body bone mineral content among children with inadequate calcium consumption.
Researchers found previously reported dinosaur soft tissues were actually bacterial biofilms, created by bacteria that coated the voids once occupied by blood vessels and cells. The discovery challenges the notion of preserved dinosaur tissues still surviving.
After losing a significant amount of weight through calorie restriction, bone turnover remains accelerated, leading to increased fragility. Researchers found that moderate weight loss followed by weight maintenance resulted in persistent elevated bone remodeling markers.
A recent study suggests that excessive weight-bearing activities in children can affect the mechanical properties of developing bones, leading to a higher risk of degenerative skeletal disorders later in life. Researchers found that young boys who participated in regular farming activities had significantly lower bone-damping ability c...
Six-thousand year old Jericho bones excavated by Dr. Kathleen Kenyon will be tested for tuberculosis, leprosy, and malaria to better understand disease development and transmission.
Researchers at NIST have identified a small biomolecule that binds specifically to hydroxyapatite, the key crystal structure of teeth and bones. This new peptide can be used as a nondestructive tag to monitor bone and tooth mineralization.
A mouse study reveals that sex-specific growth hormone secretion patterns mediate gender-associated differences in susceptibility to diseases caused by inappropriate thrombosis. Additionally, research identifies the protein FGF9 as a key player in prostate cancer progression to osteoblastic bone metastases.
USC School of Dentistry researchers found that aspirin can inhibit bone resorption and promote osteoblast formation in mice with osteoporosis. The study's findings suggest that aspirin may be a potential alternative to current treatments for osteoporosis, which affect both men and women.
Researchers are studying two myostatin inhibitors to optimize recovery of injured soldiers, with promising results in muscle regeneration and bone formation. The goal is to develop a stronger, more rapid recovery for victims of traumatic limb injuries.
Researchers discovered that nanostructures enhance bone formation on titanium implants as early as 4 weeks after placement. Modifying the size and distribution of nanostructures at the implant surface may lead to faster and more predictable results.
The ETH Zurich and IBM team developed a breakthrough method that combines density measurements with large-scale mechanical analysis of the inner-bone microstructure. This allows clinicians to detect osteoporotic damage more precisely and adjust surgical plates accordingly.
Researchers have identified a short-acting protein GILZ that may disrupt the fat production pathway, leading to increased bone formation and decreased fat accumulation. Dr. Xingming Shi believes sustained GILZ action could be used to develop targeted therapies for osteoporosis and obesity.
Children with acute osteomyelitis are developing more severe MRSA infections, resulting in longer hospital stays and antibiotic therapy. Researchers found that MRSA infections were associated with higher rates of bone abscesses, muscle inflammation, and the need for surgical drainage.
A new study suggests that an ultrasound exam of the heel may be able to predict if a woman is at heightened risk for fractures due to osteoporosis. The research found that women who were considered higher risk had a significantly lower bone strength, increasing their fracture risk.
The summit concludes that eating a higher protein diet within the recommended range can have health benefits, including a lower risk of type 2 diabetes, metabolic syndrome, cardiovascular diseases, osteoporosis, and sarcopenia. High-quality protein sources like dairy products are particularly beneficial.
Researchers at the University of Granada have developed a method to drastically reduce the wait time for new teeth implants by using growth hormone. The process enables faster bone regeneration and integration with dental implants, improving patients' quality of life.
Researchers from Harvard University found that teenage athletes with hormone disorders may experience amenorrhea, leading to infertility and early bone density loss. Ghrelin levels were higher in amenorrheic girls than non-athletes, suggesting a link between energy deficit and menstrual irregularities.
Older adults experience increased bone loss, but antiresorptive medications can attenuate this process. Researchers found that even in women aged 50-54, bone loss was only 1.3% per year.
A new study has shown that adding nanoparticles to porous materials can lead to denser bone tissue. Researchers found that the nanoparticles increased bone ingrowth by threefold after 12 weeks compared to a biodegradable plastic scaffold alone. The study paves the way for further research into tissue engineering and bone regeneration.
A new study found that low hand bone mineral density is a significant predictor of mortality in rheumatoid arthritis (RA) patients. Bone mineral density measured by digital X-ray radiogrammetry was as effective as established means like radiographic damage and functional disability in predicting mortality.
A four-year study found that adults who took a daily calcium supplement experienced significantly fewer bone fractures than those who received a placebo. Maintaining calcium intake is crucial to sustain benefits, but the effects disappeared after four years.
Paleontologists have discovered fossilized burrows of tetrapods in Antarctica, dating back to the Early Triassic epoch. The burrows were created when sand poured into animal dens and hardened, preserving track marks and scratch marks from the animals' initial excavation.
A new study published in Pediatrics found that 80% of pediatric patients with low bone density had vitamin D insufficiency. Vitamin D deficiency can contribute to low bone mass and worsen underlying metabolic bone disease if left untreated, according to the study's lead author.
A global study found significant differences in the standard of care for osteoporosis across Europe, North America, and Australia. Women in Europe reported lower use of bone-saving drugs and fewer bone density tests than those in other regions, highlighting the need for improved regional comparisons.
Researchers have found that delaying gum tissue closure improves outcomes for cleft palate patients. The study, led by Dr. Damir Matic, involved 136 children and found that closing the cleft at 8-9 years old prior to canine tooth eruption leads to better facial growth and reduces damage.
The International Osteoporosis Foundation is urging EU countries to continue seeking government recognition and action to address the growing burden of osteoporosis. Despite progress in management, important care gaps remain, including limited access to bone mineral density machines and evidence-based treatments.
A landmark observational study is tracking the management of osteoporosis in 60,000 postmenopausal women from around the world. The Global Longitudinal Registry of Osteoporosis in Women (GLOW) aims to improve diagnosis and treatment standards, with data collected over five years.
Preliminary study results show testosterone administration reduces bone turnover, with potential protective effects on existing bone mass. Testosterone replacement therapy may benefit older men with low-to-normal testosterone concentrations.
A newly discovered biological clock controls many metabolic functions and determines life span, operating on shorter time intervals for small mammals like rats and longer ones for larger animals like chimpanzees. The discovery was made by NYU dental professor Dr. Timothy Bromage while observing incremental growth lines in tooth enamel.
Researchers have successfully developed bioengineered dental tissues resembling naturally formed teeth, including dentin, enamel, pulp, and periodontal ligament. The novel mineralized tissue interface formation demonstrates the therapeutic potential for regenerating tooth and bone from autologous stem cells.
Researchers found that Bonelike-coated dental implants promoted extensive new bone formation and attachment, improving incorporation into the jaw. One implant was removed due to poor positioning, allowing for detailed analysis of the coating's effects.
A new surgical technique, osteoprogenitor cellular grafting, has been used to treat steroid-induced osteonecrosis of the knee in three young patients. The procedure involves transplanting cellular material from the pelvic area into the knee, resulting in nearly normal activity and knee function with no complications.
Analysis of ancient Hadropithecus stenognathus hand bones reveals a novel joint configuration on the little finger, differing from other primates. The discovery highlights the diversity of lemurs that existed over 2,000 years ago.
The use of a rigid endoscope during removal of an impacted foreign body is an effective and safe treatment alternative for esophageal perforation. Non-operative management is not recommended in the presence of neck and mediastinum abscesses, necessitating surgical suture and drainage.
A new technique called Scan and Solve uses 3-D data analysis to predict stress points in objects like Michelangelo's David and human bones. The approach could aid engineers in developing protections for heavily used components, such as ancient artifacts and implants.
A fossilized giant rhino bone found in Anatolia reveals animal migrations between Europe and Asia during the Oligocene epoch. The discovery confirms that Anatolia was not geographically isolated, but rather connected to continental Asia by an isthmus.
Researchers found evidence of donkey domestication around 5,000 years ago in Egypt, with skeletal remains showing joint wear and signs of load carrying. The study suggests that the process of domestication may be slower and more complicated than previously thought.
A toxic pollutant found in cigarette smoke, benzo(a)pyrene (BaP), has been shown to slow bone healing by interfering with the process of stem cells becoming cartilage cells. This delay can lead to chronic pain and disability.
Researchers used CT and MRI scans to detect bone erosions in RA wrists, finding that CT was more sensitive, but with limitations. The study validates the use of Outcome Measures in Rheumatology (OMERACT) scores for erosion assessment.
Researchers from Boston University School of Medicine found that previtamin D3 production varies depending on skin type and weather conditions. Vitamin D deficiency is common worldwide, with increased risk of cancers and autoimmune diseases associated with higher altitudes.
Researchers are developing a new approach to treat conditions like osteoarthritis and trauma injuries using patient-derived stem cells. The 'bioactive scaffold' protects the stem cells, simulating their growth into bone or cartilage in the affected area.
A study of over 7,000 patients found that bisphosphonate therapy for osteoporosis has little to no effect on the risk of bone necrosis. However, clinicians face significant challenges in treating bone necrosis when it presents itself in patients.
A recent MUHC study reveals that cystic fibrosis-related bone problems are an additional pathology stemming from the Cftr gene mutation, not a side effect of treatment. The study found that mice with the mutation have lower bone mineral density and mass than control mice, without pancreatic insufficiency or steroid treatment.
Researchers at Columbia University have developed a novel porous structure that facilitates the delivery of bioactive cues, accelerating host tissue integration and new bone growth. This controlled-release approach reduces the need for high drug doses, offering a promising solution for orthopedic and dental implants.
A study published in the Journal of Clinical Investigation found that a medication used to treat bone marrow cancer improves bone density in a mouse model of osteoporosis by activating mesenchymal stem cells. This breakthrough could lead to new treatments for osteoporosis and other degenerative conditions.
Researchers discovered that the antitumor drug bortezomib can specifically target mesenchymal stem cells, leading to enhanced bone regeneration in mice. Bortezomib treatment increased bone formation in normal mice and recovered bone loss in mice with induced osteoporosis.
A new study by Naofumi Mukaida and colleagues found that TNF-alpha antagonist reduces inflammation-induced colon cancer in mice, suggesting a potential treatment for ulcerative colitis patients. Additionally, research on mesenchymal stem cells showed that the antitumor drug bortezomib can target these cells and promote bone cell-specif...
A University of British Columbia study found that popular osteoporosis drugs like Actonel, Didrocal, and Fosamax nearly triple the risk of developing bone necrosis. Researchers also discovered that this condition primarily affects shoulders, knees, and hips.
Researchers found that oral osteoporosis medications appear to reduce the risk of jaw degradation in patients. The study analyzed medical claims data from over 714,000 individuals and showed a protective association between oral bisphosphonates and adverse bone outcomes.
Bone skates were an early means of human-powered transport, with a recent study supporting their origins in Southern Finland. The use of bone skates limited energy consumption by 10% in winter, but only slightly in other North European countries.
A study by Children's Hospital of The King's Daughters found that dads break or fracture the bones of their children far more often than moms. The abuse can be horrific, with one case involving 31 broken or fractured bones.
Researchers found a significant relationship between bone mineral density and fracture risk, regardless of trauma severity. Women who experienced high-trauma fractures were at increased risk for future fractures.
A University of Georgia study published in the American Journal of Clinical Nutrition found that obesity may be bad for bone health in young women. The research used advanced three-dimensional bone scans on 115 women aged 18-19 and found that obese participants had weaker bones by 8-9% compared to those with normal body fat.
Researchers have found that a new estrogen-derived drug, 2-methoxyestradiol (meth-oxy-es-tra-di-ol), effectively targets breast cancer cells, prevents their spread to bone, and protects against osteolysis. This discovery has significant implications for the treatment of breast cancer.
Mayo Clinic researchers found that 2ME2 can effectively target breast cancer cells, prevent the spread of breast cancer to bone and protect bone from osteolysis. The study's findings suggest that 2ME2 could be a new therapy in treating advanced breast cancer.
Prostate cancer patients undergoing hormone therapy who walked five times a week maintained or gained bone density, while those who didn't exercise lost more than two percent of their bone density. A nurse-directed home-based walking program improved physical function and managed symptoms during radiation and hormone treatment.