Aging and bone mineral density
Older adults experience increased bone loss, but antiresorptive medications can attenuate this process. Researchers found that even in women aged 50-54, bone loss was only 1.3% per year.
Bones
Articles tagged with Bones
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Nanoparticles aid bone growth
A new study has shown that adding nanoparticles to porous materials can lead to denser bone tissue. Researchers found that the nanoparticles increased bone ingrowth by threefold after 12 weeks compared to a biodegradable plastic scaffold alone. The study paves the way for further research into tissue engineering and bone regeneration.
Hand bone mineral density is an effective predictor of mortality in rheumatoid arthritis
A new study found that low hand bone mineral density is a significant predictor of mortality in rheumatoid arthritis (RA) patients. Bone mineral density measured by digital X-ray radiogrammetry was as effective as established means like radiographic damage and functional disability in predicting mortality.
Prevent a bone break, drink milk to boost calcium
A four-year study found that adults who took a daily calcium supplement experienced significantly fewer bone fractures than those who received a placebo. Maintaining calcium intake is crucial to sustain benefits, but the effects disappeared after four years.
Scientists find 245-million-year-old burrows of land vertebrates in Antarctica
Paleontologists have discovered fossilized burrows of tetrapods in Antarctica, dating back to the Early Triassic epoch. The burrows were created when sand poured into animal dens and hardened, preserving track marks and scratch marks from the animals' initial excavation.
First study to examine vitamin D insufficiency in pediatric patients with low bone density
A new study published in Pediatrics found that 80% of pediatric patients with low bone density had vitamin D insufficiency. Vitamin D deficiency can contribute to low bone mass and worsen underlying metabolic bone disease if left untreated, according to the study's lead author.
Global study reveals differences in standard of care for osteoporosis across the world
A global study found significant differences in the standard of care for osteoporosis across Europe, North America, and Australia. Women in Europe reported lower use of bone-saving drugs and fewer bone density tests than those in other regions, highlighting the need for improved regional comparisons.
Research shows timing improves cleft palate surgery
Researchers have found that delaying gum tissue closure improves outcomes for cleft palate patients. The study, led by Dr. Damir Matic, involved 136 children and found that closing the cleft at 8-9 years old prior to canine tooth eruption leads to better facial growth and reduces damage.
IOF calls for concerted support for second EU osteoporosis audit
The International Osteoporosis Foundation is urging EU countries to continue seeking government recognition and action to address the growing burden of osteoporosis. Despite progress in management, important care gaps remain, including limited access to bone mineral density machines and evidence-based treatments.
Landmark observational study aims to improve osteoporosis care standards worldwide
A landmark observational study is tracking the management of osteoporosis in 60,000 postmenopausal women from around the world. The Global Longitudinal Registry of Osteoporosis in Women (GLOW) aims to improve diagnosis and treatment standards, with data collected over five years.
Testosterone replacement theraphy beneficial in men 60 and older
Preliminary study results show testosterone administration reduces bone turnover, with potential protective effects on existing bone mass. Testosterone replacement therapy may benefit older men with low-to-normal testosterone concentrations.
NYU dental professor discovers biological clock
A newly discovered biological clock controls many metabolic functions and determines life span, operating on shorter time intervals for small mammals like rats and longer ones for larger animals like chimpanzees. The discovery was made by NYU dental professor Dr. Timothy Bromage while observing incremental growth lines in tooth enamel.
Reconstructing mandibular defects with bioengineered tooth and bone
Researchers have successfully developed bioengineered dental tissues resembling naturally formed teeth, including dentin, enamel, pulp, and periodontal ligament. The novel mineralized tissue interface formation demonstrates the therapeutic potential for regenerating tooth and bone from autologous stem cells.
Crowning glory
Researchers found that Bonelike-coated dental implants promoted extensive new bone formation and attachment, improving incorporation into the jaw. One implant was removed due to poor positioning, allowing for detailed analysis of the coating's effects.
Young patients with knee disorder get active after new Stanford surgical procedure
A new surgical technique, osteoprogenitor cellular grafting, has been used to treat steroid-induced osteonecrosis of the knee in three young patients. The procedure involves transplanting cellular material from the pelvic area into the knee, resulting in nearly normal activity and knee function with no complications.
Ancient lemur's little finger poses mystery
Analysis of ancient Hadropithecus stenognathus hand bones reveals a novel joint configuration on the little finger, differing from other primates. The discovery highlights the diversity of lemurs that existed over 2,000 years ago.
What should we do when esophageal perforation occurs?
The use of a rigid endoscope during removal of an impacted foreign body is an effective and safe treatment alternative for esophageal perforation. Non-operative management is not recommended in the presence of neck and mediastinum abscesses, necessitating surgical suture and drainage.
Tell them where it hurts
A new technique called Scan and Solve uses 3-D data analysis to predict stress points in objects like Michelangelo's David and human bones. The approach could aid engineers in developing protections for heavily used components, such as ancient artifacts and implants.
A fossilized giant rhino bone questions the isolation of Anatolia, 25 million years ago
A fossilized giant rhino bone found in Anatolia reveals animal migrations between Europe and Asia during the Oligocene epoch. The discovery confirms that Anatolia was not geographically isolated, but rather connected to continental Asia by an isthmus.
Domestication of the donkey
Researchers found evidence of donkey domestication around 5,000 years ago in Egypt, with skeletal remains showing joint wear and signs of load carrying. The study suggests that the process of domestication may be slower and more complicated than previously thought.
Toxins in cigarette smoke prevent stem cells from becoming cartilage
A toxic pollutant found in cigarette smoke, benzo(a)pyrene (BaP), has been shown to slow bone healing by interfering with the process of stem cells becoming cartilage cells. This delay can lead to chronic pain and disability.
Detecting bone erosion in arthritic wrists
Researchers used CT and MRI scans to detect bone erosions in RA wrists, finding that CT was more sensitive, but with limitations. The study validates the use of Outcome Measures in Rheumatology (OMERACT) scores for erosion assessment.
Study shows effects of vitamin D and skin's physiology
Researchers from Boston University School of Medicine found that previtamin D3 production varies depending on skin type and weather conditions. Vitamin D deficiency is common worldwide, with increased risk of cancers and autoimmune diseases associated with higher altitudes.
Scientists move towards stem cell therapy trials to mend shattered bones
Researchers are developing a new approach to treat conditions like osteoarthritis and trauma injuries using patient-derived stem cells. The 'bioactive scaffold' protects the stem cells, simulating their growth into bone or cartilage in the affected area.
Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined
A study of over 7,000 patients found that bisphosphonate therapy for osteoporosis has little to no effect on the risk of bone necrosis. However, clinicians face significant challenges in treating bone necrosis when it presents itself in patients.
Bone complications due to cystic fibrosis have a genetic cause, according to an MUHC study
A recent MUHC study reveals that cystic fibrosis-related bone problems are an additional pathology stemming from the Cftr gene mutation, not a side effect of treatment. The study found that mice with the mutation have lower bone mineral density and mass than control mice, without pancreatic insufficiency or steroid treatment.
Porous structures help boost integration of host tissue with implants, study finds
Researchers at Columbia University have developed a novel porous structure that facilitates the delivery of bioactive cues, accelerating host tissue integration and new bone growth. This controlled-release approach reduces the need for high drug doses, offering a promising solution for orthopedic and dental implants.
Turning on adult stem cells may help repair bone
A study published in the Journal of Clinical Investigation found that a medication used to treat bone marrow cancer improves bone density in a mouse model of osteoporosis by activating mesenchymal stem cells. This breakthrough could lead to new treatments for osteoporosis and other degenerative conditions.
Building stronger bones, 1 stem cell at a time
Researchers discovered that the antitumor drug bortezomib can specifically target mesenchymal stem cells, leading to enhanced bone regeneration in mice. Bortezomib treatment increased bone formation in normal mice and recovered bone loss in mice with induced osteoporosis.
JCI table of contents: Jan. 24, 2008
A new study by Naofumi Mukaida and colleagues found that TNF-alpha antagonist reduces inflammation-induced colon cancer in mice, suggesting a potential treatment for ulcerative colitis patients. Additionally, research on mesenchymal stem cells showed that the antitumor drug bortezomib can target these cells and promote bone cell-specif...
Popular osteoporosis drugs triple risk of bone necrosis
A University of British Columbia study found that popular osteoporosis drugs like Actonel, Didrocal, and Fosamax nearly triple the risk of developing bone necrosis. Researchers also discovered that this condition primarily affects shoulders, knees, and hips.
Oral osteoporosis meds appear to reduce the risk of jaw degradation
Researchers found that oral osteoporosis medications appear to reduce the risk of jaw degradation in patients. The study analyzed medical claims data from over 714,000 individuals and showed a protective association between oral bisphosphonates and adverse bone outcomes.
Where and why humans made skates out of animal bones
Bone skates were an early means of human-powered transport, with a recent study supporting their origins in Southern Finland. The use of bone skates limited energy consumption by 10% in winter, but only slightly in other North European countries.
Dads break bones of children more often than moms
A study by Children's Hospital of The King's Daughters found that dads break or fracture the bones of their children far more often than moms. The abuse can be horrific, with one case involving 31 broken or fractured bones.
High-trauma fractures in older men and women linked to osteoporosis
Researchers found a significant relationship between bone mineral density and fracture risk, regardless of trauma severity. Women who experienced high-trauma fractures were at increased risk for future fractures.
Study suggests link between obesity, poor bone health
A University of Georgia study published in the American Journal of Clinical Nutrition found that obesity may be bad for bone health in young women. The research used advanced three-dimensional bone scans on 115 women aged 18-19 and found that obese participants had weaker bones by 8-9% compared to those with normal body fat.
Study shows drug effective in treating, preventing breast cancer
Researchers have found that a new estrogen-derived drug, 2-methoxyestradiol (meth-oxy-es-tra-di-ol), effectively targets breast cancer cells, prevents their spread to bone, and protects against osteolysis. This discovery has significant implications for the treatment of breast cancer.
Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer
Mayo Clinic researchers found that 2ME2 can effectively target breast cancer cells, prevent the spread of breast cancer to bone and protect bone from osteolysis. The study's findings suggest that 2ME2 could be a new therapy in treating advanced breast cancer.
Walking prevents bone loss caused from prostate cancer treatment
Prostate cancer patients undergoing hormone therapy who walked five times a week maintained or gained bone density, while those who didn't exercise lost more than two percent of their bone density. A nurse-directed home-based walking program improved physical function and managed symptoms during radiation and hormone treatment.
Clemson awarded $2M to study radiation-induced bone loss
Researchers at Clemson University will develop an animal model to study bone loss caused by radiation therapy, which could lead to the development of therapies for cancer survivors. The study also examines the effect of space radiation on bone loss for astronauts, a growing concern for future space missions.
Contrast agent trials in swine
Researchers developed a new near-infrared contrast agent that selectively marks hydroxyapatite crystals, allowing for the detection of malignant tissue. The swine trials demonstrated the effectiveness of real-time NIR fluorescence images in image-guided surgery.
New research on structure of bones raises questions for treatment of osteoporosis
Researchers discovered that specialized sugars are predominantly responsible for bone's characteristic toughness and stiffness, challenging previous beliefs about collagen's role. This finding could lead to new treatments for osteoporosis and other bone disorders by targeting sugar molecules.
Expensive trainers are a waste of money
A recent study found that cheap and moderately priced running shoes provide similar cushioning impact and comfort as expensive trainers. Plantar pressure measurements showed no significant differences among the shoes, regardless of brand or price.
Dietary calcium could possibly prevent the spread of breast cancer to bone
A study by ANZAC Research Institute suggests that a calcium deficiency can increase the likelihood of advanced breast cancer targeting bones. Dietary calcium intake could help prevent this spread and serve as an adjuvant treatment during therapy.
New research sheds light on 'hobbit'
A recent study published in Science confirms that Homo floresiensis, also known as the 'hobbit', is a distinct human species. The research focuses on the unique wrist bones of the hobbit, which show striking similarities to those of African apes and early hominins.
Low vitamin D linked to higher risk of hip fracture
A recent study led by the University of Pittsburgh Graduate School of Public Health found that low vitamin D levels are associated with a higher risk of hip fractures in women. The study analyzed data from 400 women who experienced hip fractures and found that those with lower vitamin D levels had a 77% increased risk.
Yu receives research funding from the Wallace H. Coulter Foundation
Yu aims to overcome limitations in current bone grafting procedures by developing biodegradable polymeric 3D scaffolds with optimal porosity and surface area, enabling nutrient transport and cell penetration for successful repair of large bone defects.
Bone-growing nanomaterial could improve orthopaedic implants
Researchers at Brown University have developed a new material that enhances bone growth on orthopaedic implants, increasing the success rate of joint replacements and other implants. The new material, created by applying carbon nanotubes to anodized titanium, encourages bone cells to grow faster and produce more calcium.
Scientists learn role of oxidative stress in estrogen-related bone loss
Researchers found that reactive oxygen stimulates dendritic cells to up-regulate the immune antigen CD80, leading to T cell activation and increased TNF production. This causes excessive destruction of bone via osteoclasts.
Mice stressed in simulated weightlessness show organ atrophy
Rutgers researchers found that osteopontin-dependent changes in thymus and spleen lead to organ atrophy in mice stressed under simulated weightlessness. This study demonstrates the critical role of OPN in human diseases such as cancer, multiple sclerosis, and autoimmune responses.
MIT probes secret to bone's strength
New research from MIT reveals a unified explanation for bone's toughness, incorporating several previously proposed theories. The study finds that bone's atomistic structure plays a crucial role in a toughening mechanism that allows it to tolerate small cracks and maintain its strength.
Lithium and bone healing
Researchers discovered a novel molecular pathway involved in bone healing and found that lithium can activate it, but only when treatment is given after the fracture occurs. The study showed accelerated bone healing in mice with activated '-catenin signaling pathway.
Bisphosphonate treatment is associated with jaw bone problems
Patients treated with bisphosphonates are at higher risk of jaw bone deterioration or infection. The use of intravenous bisphosphonates has been associated with osteonecrosis of the jaw or facial bones, a condition caused by poor blood supply to the area.
Down in the mouth?
Bisphosphonates may cause osteonecrosis of the jaws in patients taking these medications. Women should inform their dentists if they take bisphosphonates to reduce risk. Meanwhile, Burning Mouth Syndrome can be caused by xerostomia, and treatment depends on the patient's condition.
Tip sheet Annals of Internal Medicine, June 19, 2007
Women with diabetes experienced a decline in death rates, but at a cost: their bone density and endometrial thickness may have increased. In contrast, a study on soy products found that genistein supplements boosted bone mineral density and improved markers of bone metabolism.
Preventing fractures in men -- Making the most of limited flu vaccine stocks
A study published in PLOS Medicine found that men who participate in sports or vigorous physical activity are less likely to suffer from osteoporotic fractures. The researchers analyzed data from over 2,000 men and found that those with higher levels of physical activity had a significantly lower risk of fractures. By taking exercise, ...
Gene responsible for common hearing loss identified for first time
Researchers have identified a gene, TGBF1, that contributes to otosclerosis, the single most common cause of hearing loss among white adults. The study found that a specific variant of this gene is protective against the disease.
Bone erosion reduced by denosumab in phase 2 trial
A phase 2 trial found that denosumab reduced the progression of bone erosion in patients with rheumatoid arthritis. The treatment group experienced significant reductions in erosion scores, even as early as six months, compared to the control group.
Gum disease in postmenopausal women linked to oral bone loss
A study of postmenopausal women has found that infection with four known gum-disease-causing bacteria is associated with more severe oral bone loss. The two most prevalent pathogens were P. gingivalis and T. forsythensis, found in 15.1% and 37.9% of the participants.
Periodontal diseases are blind to age
Two studies suggest that periodontal diseases are a threat to women of all ages. Women taking oral contraceptive pills are more likely to experience gingival bleeding and deeper periodontal pockets. Periodontal bacteria are also linked to bone loss in postmenopausal women, highlighting the importance of good oral health throughout life.