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Preventing heart cells from turning to bone

Researchers at Gladstone Institutes have discovered a chain of events that cause healthy valves to become bone-like. They identified three key genes that are altered in calcific aortic valve disease (CAVD) and found a potential therapeutic target by manipulating their activity, pointing to novel treatments for the condition.

SourceGladstone Institutes·JournalCell·DateMar 12, 2015

You are when you eat

A new study by researchers at San Diego State University found that limiting fruit flies' eating hours can prevent aging- and diet-related heart problems. Flies on a time-restricted feeding schedule slept better, didn't gain as much weight and had healthier hearts than those that ate anytime.

SourceSan Diego State University·JournalScience·DateMar 12, 2015

Optimistic people have healthier hearts, study finds

A study found that optimistic individuals have significantly better blood sugar and total cholesterol levels, are more physically active, and have healthier body mass indexes. They were also less likely to smoke and had a stronger association with cardiovascular health when socio-demographic characteristics were factored in.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalHealth Behavior and Policy Review·DateJan 9, 2015

Lifestyle the key to gap in cardiac patient outcomes

Researchers at the University of Adelaide found that patients who managed their lifestyle factors were five times more likely to have long-term survival without any further heart arrhythmia. The intensive risk factor management program improved arrhythmia-free survival rates from 18% to 87% after five years.

SourceUniversity of Adelaide·JournalJournal of the American College of Cardiology·DateDec 10, 2014

For cardiac arrest, epinephrine may do more harm than good

A study published in the Journal of the American College of Cardiology found that administering epinephrine to patients in cardiac arrest may increase the likelihood of death or brain damage. The research analyzed hospital records for over 1,500 patients and showed that those who received higher doses of epinephrine had a worse outcome.

SourceAmerican College of Cardiology·JournalJournal of the American College of Cardiology·DateDec 1, 2014

Study finds most older adults qualify for statin therapy under new cholesterol guidelines

The American College of Cardiology and American Heart Association guidelines now recommend statin therapy for individuals with an elevated estimated risk of a heart attack or stroke in the next 10 years. A study found that 97% of adults aged 66-75 qualify for statin therapy, with 100% of men in this age group being eligible.

SourceMinneapolis Heart Institute Foundation·JournalJAMA Internal Medicine·DateNov 24, 2014

Bad marriage, broken heart?

A new study from Michigan State University finds that bad marriages are associated with a higher risk of heart disease in older adults, particularly women. The study analyzed data from over 1,200 couples and found that negative marital quality had a greater impact on cardiovascular health than positive quality.

SourceMichigan State University·JournalJournal of Health and Social Behavior·DateNov 19, 2014

Novel basic science tip sheet

Researchers found that a diet rich in plant-based flavonoids can help regulate the body's immune system response to fine particles in polluted air, potentially reducing the risk of heart disease. Additionally, a low-cost vaccine targeting PCSK9 has been shown to safely lower bad cholesterol levels in animal studies.