Articles tagged with Intestines
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Researchers at the University of Helsinki discovered a new mechanism by which nutrient adaptation influences intestinal stem cell function and ageing. Intermittent fasting has been shown to benefit intestinal stem cells by preserving their flexible regulation, which is essential for differentiation.
A new consortium, co-led by Florian Rieder, MD, and Vipul Jairath, MD, will create clinical care pathways toward drug development and improve disease management for patients with Crohn's disease and permanent ileostomy. The EndO-trial Consortium aims to develop effective drugs and measure treatment outcomes using patient-reported outco...
A Learning Health System model is being developed to increase organ donation and reduce disparities in access to transplantation. The project, led by Hennepin Healthcare Research Institute, will use data tools to track progress and improve equity in organ donation across the US.
A recent study published in Nature reveals that mitochondrial dysfunction disrupts dietary lipid processing in enterocytes, leading to abnormal fat accumulation and impaired nutrient delivery. The findings provide new insights into the gastrointestinal symptoms of mitochondrial disease and may lead to novel therapeutic approaches.
A new study reveals a multi-drug resistant strain of E.coli, MDR ST131, can outcompete and displace other strains in the human gut. The research provides evidence that certain types of E.coli are more prone to developing antibiotic resistance, posing significant health risks.
A novel biomaterial developed at the Federal University of São Paulo can deliver medication directly to the gastrointestinal tract of fish, enhancing the efficacy of conventional drugs. The material is administered orally in powder form and has shown high penetration into epithelial cells without cytotoxic effects.
Researchers at UC Riverside have discovered a new cell type in the thymus that is similar to M cells found in the gut and airways. The newly discovered cells are like gatekeepers, acting as antigen-delivery cells for the immune system in organs such as the intestine and lung.
A new study found that antibiotics promote the growth of antibiotic-resistant bacteria in the gut by providing extra nutrients, allowing these 'bad' bacteria to multiply. The research suggests that targeting beneficial bacteria can help restrict the growth of resistant bacteria, paving the way for microbiome therapeutics treatments.
HSE biologists explain how coronavirus evolves from Wuhan variant to Omicron, highlighting the crucial role of microRNA molecules in the process. The study found that substitutions in the viral genome disrupted microRNA binding regions, leading to the emergence of more contagious and resilient strains.
Researchers found that ethanol metabolism can produce toxic substances damaging the gut, leading to leaky gut, dysbiosis and increased cancer risk. The study aims to better understand the mechanisms of alcohol-associated bowel disease and its relationship with liver disease.
A new study has identified thousands of shared genetic variants between patients with irritable bowel syndrome (IBS) and psychiatric disorders such as bipolar disorder, schizophrenia, depression, and anxiety. This discovery provides a new understanding of the brain-gut axis and holds promise for developing effective treatments for IBS.
Researchers at the University of Gothenburg have developed a new strategy for producing oxygen-tolerant probiotics, including Faecalibacterium prausnitzii, which can improve glucose control. The combination of bacteria increased biomass and butyrate production, making it safe for human consumption.
Research shows that a diet rich in soluble fiber like inulin can renew intestinal epithelial cells and improve intestinal health. The study found that gut microbiota plays a key role in this process.
A new study reveals that breast milk contains a unique set of antibodies passed from mom to baby, which can vary significantly between mothers. This variability may explain why some infants develop life-threatening diseases like NEC, while others do not.
New studies show cow colostrum can reduce infant formula use and strengthen mother's milk in premature babies, providing essential nutrients like amino acids. Researchers hope to optimize cow colostrum product for critical first few weeks after birth.
Researchers found that centenarians have a diverse gut virome with high microbial diversity associated with a healthy gut microbiome. The study suggests that intestinal bacteria and bacterial viruses may work together to promote healthy lifespan.
Researchers discovered that certain bacterial species, including lactic acid bacteria, correlate with high levels of Candida yeasts in the gut microbiome. This suggests a complex interaction between these microorganisms, where lactic acid bacteria may favor Candida proliferation while making the fungus less virulent.
A study published in Microorganisms shows that melatonin can aggravate Crohn's disease and ulcerative colitis by disrupting the balance of gut microbiota. The hormone, commonly used to improve sleep, had negative effects on bowel inflammation in laboratory mice, depending on their microbiota profile.
CARMN is a long noncoding RNA that regulates contractility in both blood vessels and the gastrointestinal tract. Without CARMN, mice cannot survive due to impaired GI tract contraction, leading to conditions like intestinal pseudo-obstruction.
Cincinnati Children's scientists have successfully grown functional human intestinal organoids that mimic key development stages of the human fetus. These lab-grown tissues accurately replicate the formation of specific cell types and tissue structures, providing a valuable resource for studying fetal intestine development and potentia...
A new study has discovered significant variation in the anatomy of the human digestive system, with pronounced differences found between healthy individuals. This finding has implications for understanding the role of digestive tract anatomy in affecting human health and providing potential insights into medical diagnoses.
A new study creates an experimental combo vaccine by adding a key protein from norovirus to a harmless strain of rotavirus, generating antibodies against both viruses. Mice produced neutralizing antibodies in response to the vaccine.
A new study published in Metabolism reveals that the hormone neurotensin is released in greater amounts by people who successfully maintain weight loss after a low-calorie diet. This suggests that neurotensin may play a key role in regulating appetite and weight management.
A UC Riverside-led study found that reduced PTPN2 activity in intestinal epithelial cells leads to decreased Paneth cell antimicrobial peptide production, disrupting the gut microbiota and increasing E. coli. This loss can serve as a marker of IBD disease.
Researchers found that a combination of IL-22 and IL-1R inhibitors could be a promising treatment for inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The study suggests that targeting both pathways may lead to more effective treatment outcomes.
The study reveals that more than 70% of patients developed urinary tract infections caused by endogenous E. coli strains from their own gut microbiota. The researchers also found that non-lactose-fermenting E. coli strains, less common in other countries, were present in the gut microbiota of some patients.
Researchers have discovered that Yersinia pseudotuberculosis triggers the formation of granulomas in the intestines to control bacterial infections. Monocytes play a crucial role in recruiting neutrophils and launching the formation of these immune cells, which help combat the infection.
Researchers at Mayo Clinic found that a dissolvable plug delivering stem cells can heal single-tract fistulas in patients with Crohn's disease. The treatment has shown durable results with minimal side effects, offering hope for patients with refractory perianal fistulas.
A recent study published in Genome Medicine found that intestinal bacteria play a crucial role in multiple sclerosis. The research revealed two types of health-promoting bacteria that can reduce an over-reactive immune system and may help alleviate symptoms.
A husband-and-wife research team at UC Riverside found a simpler gene network is involved in specifying the gut in nematodes related to Caenorhabditis elegans. The discovery was made possible by the COVID-19 pandemic, which freed up time for the researchers to explore their question of how nematodes develop their gut.
Researchers from Tokyo Medical and Dental University developed a new approach to grow human intestinal mini-organs in the lab. They used cell culture plates and bioreactors to create robust and healthy intestine-like tissues that can be transplanted into mice, demonstrating the potential for regenerative medicine applications.
A new theory proposes that irritable bowel syndrome (IBS) may be caused by the body's inability to manage gravity. The hypothesis suggests that gravity can compress the spine, decrease flexibility, and cause organs to shift downward, leading to IBS symptoms.
A new deep learning model using conditional generative adversarial networks (cGANs) has been developed to diagnose bowel ischemia. The model achieved an accuracy of over 93% in segmenting ischemic intestine images, surpassing current subjective methods.
Researchers have created a chemical tag that can be added to drugs, allowing them to enter blood circulation via the intestines. The tag, called EPP6, is a neutral peptide that can deliver drugs orally, potentially replacing injections for diabetes and cancer patients.
A new study by Weill Cornell Medicine investigators finds that Enterococcus faecalis enhances its protective outer layer to resist natural immune defenses and antibiotics. The research suggests possible new ways to target these bacterial infections.
Researchers at UCalgary have discovered a potential new treatment for fibrosis, a condition that causes thickening of the gut wall and life-threatening blockage in people with Crohn's disease and ulcerative colitis. The study suggests that drugs targeting specific sensors may prevent inflammation-associated gut blockage.
A study published in Nature identifies the central functions of group 2 innate lymphoid cells (ILC2s), which play a crucial role in combating parasitic diseases and promoting mucus production. The researchers found that ILC2s are essential for immune response and cannot be replaced without compromising its effectiveness.
Researchers discovered a link between reduced protein synthesis and Feingold syndrome type 1, a rare genetic disorder. The study suggests that a nutritional supplement may help reverse this decrease, potentially alleviating intestinal symptoms in patients with the condition.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
Researchers at the University of Toledo found that consumption of highly refined fiber may increase liver cancer risk in some individuals, particularly those with a silent vascular deformity. The study discovered that high concentrations of bile acids caused by a portosystemic shunt led to the development of liver cancer.
A study published in Science finds that gut rotation is regulated by two waves of Pitx2 expression, triggered by mechanical cues and a latent TGF-beta sensor. This discovery sheds light on the mechanisms of organ formation and has implications for understanding birth defects such as intestinal malrotation.
A new study led by Marc Veldhoen found that tissue resident white blood cells use glucose as an energy source and have a faster metabolism than circulating lymphocytes. This discovery highlights the importance of having a balanced diet for a healthy immune response.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
A new study from Duke University suggests that consuming more fiber can lead to improved gut health, regardless of the specific supplement used. Participants who had been eating the least amount of fiber before the study showed the greatest benefit from supplements.
Research found that acidic activated charcoal from Shinshu Ina's specialty Akamatsu tree suppresses weight gain due to a high-fat diet by increasing bile acid, cholesterol, triglyceride, and fatty acid excretion. No damage to the gastrointestinal mucosa or lungs was observed.
A team of researchers created an in vitro human model of environmental enteric dysfunction (EED) using the Human Organ Chip technology. The EED Chips recapitulate features of EED found in biopsies from human patients, including inflammation and intestinal barrier dysfunction. The study sheds light on the complex interplay between malnu...
Researchers at Leibniz-HKI found that lactic acid bacteria nourish intestinal cells, promoting bacterial growth and adapting Candida's metabolism to make it less infectious. This balance restores a healthy state and prevents fungal infections.
Researchers found that fecal transplants restored intestinal function and reduced inflammation in mice lacking the antimicrobial compound catestatin. The study suggests that changes in gut microbial composition are responsible for the inflammatory response.
In a mouse model, stromal cells developed before weaning age promote the maturation of the intestinal barrier by forming a specialized niche. Absence of these cells induces defect in postnatal growth and increases susceptibility to intestinal inflammatory diseases.
A study from the University of Birmingham and National Institutes of Health found that antibiotics can lead to fungal infections by disrupting the gut's immune system. Using immune-boosting drugs alongside antibiotics may reduce health risks associated with these complex infections.
Research reveals that imbalances in the intestine's viral community may promote inflammatory bowel disease. Viruses in a normal intestine have anti-inflammatory effects, whereas those from inflamed intestines provoke inflammation. This study provides a missing functional link between the virome and human health.
A recent report by the International Society of Microbiota confirms a bidirectional interplay between gut microbiota and various organs, highlighting the crucial role of microbiota in disease pathogenesis. The report also explores therapeutic strategies for manipulating gut microbiota to prevent and treat disorders.
Researchers at Brigham and Women's Hospital discovered a tissue-modifying molecule that can target intestinal stem cells and signal them to create Paneth cells, a rare but important cell type. This could represent a new therapeutic pathway for diseases such as inflammatory bowel disease and graft-versus-host disease.
Researchers have identified how IL-36 cytokines instruct proinflammatory CD4+ T cells to accumulate in the inflamed intestine, worsening disease. This discovery offers fresh insights into targeting these proteins as a new therapeutic option for childhood IBD patients.
Researchers at the University of Copenhagen have made a groundbreaking discovery that could phase out medications derived from pig intestines. The team has successfully created a synthetic alternative to heparin in a laboratory setting, using cell factories, similar to insulin production.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
A preclinical study by Weill Cornell Medicine researchers reveals that a specific group of fungi residing in the intestines can protect against intestinal injury and influence social behavior in mice. The findings suggest a novel signaling system connecting fungi in the gut to their host's cells, including immune cells and neurons.
Researchers at Karolinska Institutet used spatial transcriptomics to create a map of gene expression in the mouse colon, gaining new insights into inflammatory bowel disease. The study's findings suggest that the colon is divided into more segments than previously thought and could lead to the development of new treatments.
Scientists from Tokyo Medical and Dental University have developed a protocol to transplant 3D cellular structures called organoids into the colon to repair damaged intestinal tissue. This approach shows promise as a quick, reproducible, and minimally invasive method for treating ulcerative colitis.
Research in C. elegans reveals that intestinal stress signals can control oocyte chromosome stability, influencing egg quality control and heritable euploidy. This study opens new possibilities for eliminating environmental influences and preventing malformations.