Articles tagged with Muscles
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A study found that a daily supplement of urolithin A improved muscle function and reduced inflammation in older adults. The supplement, produced by gut bacteria, was shown to stimulate mitophagy, a process that recycles damaged mitochondria.
A prospective observational study found that preoperative shear wave elastography (SWE) can predict successful rotator cuff repair. SWE-derived elasticity was higher in patients with insufficient repair, and the elasticity ratio independently predicted insufficient repair.
An international team led by the University of Ottawa has published findings on the importance of the enzyme GCN5 in maintaining muscle integrity. The study discovered that GCN5 plays a crucial role in boosting the expression of key structural proteins, notably dystrophin.
A new study reconstructs the limb muscles of Thecodontosaurus, a small to medium-sized two-legged dinosaur that roamed the UK during the Triassic period. The research suggests that Thecodontosaurus was agile and used its forelimbs to grasp objects, contrasting with its later relatives.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Researchers at Penn State will investigate ways to stimulate muscle growth by increasing ribosome production. Their goal is to find molecular targets that can be used to promote muscle growth without exercise or drugs. This study aims to prevent muscle loss due to aging, cancer, and other chronic diseases.
Researchers have found that blocking mineralocorticoid receptors, a key factor in bone health, may help protect against bone loss and osteoporosis. This new target is thought to be more effective than previously believed logical targets, such as reducing glucocorticoid receptor activity.
A new wearable sensor has been developed using MXene nanomaterials that can detect changes in pH levels in sweat, which correlate with muscle fatigue. The device measures electrical resistance patterns in response to mechanical stress and pH changes.
Researchers found that brain activity in children with arthrogryposis is different from healthy controls, with increased motor neuron activity and less precise movements. Non-invasive brain stimulation may be a possible rehabilitation strategy to help them start movements.
Researchers have identified IRE1 and XBP1 proteins as crucial for skeletal muscle regeneration after injury and in Duchenne Muscular Dystrophy. The study's findings pave the way for drug development to treat genetic and acquired muscle disorders.
A new muscle layer has been discovered on the jaw, contradicting traditional anatomy descriptions. The masseter muscle was found to have an additional third layer, which is involved in stabilizing the lower jaw and pulling it backwards.
Contrary to previous research, some Covid patients exhibit increased muscle mass, particularly those with a strong immune response, while others experience significant muscle wastage. This study suggests that immune response to Covid may exacerbate muscle damage, potentially impacting recovery and quality of life.
Researchers found that standard shopping carts, which activate triceps muscles, may constrain buying and result in missed sales. In contrast, alternative cart designs with parallel handles activate biceps muscles, leading to increased purchasing and spending.
The study found that exercise induces expression of long noncoding RNA CYTOR, which enhances myogenic differentiation and improves muscle morphology and function in aged muscles. CYTOR also re-configures chromatin accessibility at binding sites of other genes, shedding light on its mechanisms.
A new study reveals that extracellular vesicles deliver genetic instructions for the longevity protein Klotho to muscle cells, which declines with age. This finding suggests that EVs could be developed into novel therapies for healing damaged muscle tissue and improving functional recovery in older individuals.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
Researchers found that some individuals with probable sarcopenia can improve after five years, suggesting the condition is modifiable. Factors such as physical activity and cognitive function are associated with improved outcomes.
Researchers discover changes in muscle torque recovery can predict maximum voluntary strength gains but not delayed-onset muscle soreness. The study's findings offer a promising approach to assessing muscle damage symptoms after exercise.
A team of researchers led by Guy Genin and Stavros Thomopoulos found a previously unknown fibrous architecture in the shoulder joint, revealing new features of the attachment system. The discovery sheds light on how the rotator cuff functions and why repairs fail frequently.
Research from Harvard University reveals that physical activity later in life shifts energy towards mechanisms that extend health, reducing chronic illnesses. The study highlights the importance of staying physically active as we age to allocate energy to physiological processes that slow down deterioration.
Researchers discovered that chemotherapy drugs can affect protein synthesis in muscle cells, even at low doses. This finding has significant implications for cancer treatment and exercise rehabilitation programs, suggesting that even non-oxidative stress effects of chemotherapy should be considered.
Researchers at Cornell University have launched scMuscle, a large single-cell database that provides a comprehensive picture of the dynamics of muscle repair. The database houses transcriptomic data from approximately 365,000 cells involved in muscle injury across various ages and experimental conditions.
Researchers developed a technology that accurately detects lies by analyzing facial muscle contractions, achieving a success rate of 73%. The study identified two distinct groups of 'liars' based on cheek muscle and eyebrow activation, with potential implications for real-life deception detection.
A new study found that hot flashes are less common in women with sarcopenia, and are positively associated with paraspinal muscle mass. The research highlights the need for further studies to understand the relationships between menopause symptoms, body composition, and aging.
A Baylor University researcher led a study comparing pinniped craniofacial musculature and its potential role in aquatic feeding, revealing unique adaptations in suction- and biting-specialist species. The study provides foundational data for further research on pinnipeds and their evolution of functional morphology.
Researchers found that reactivating memories during sleep improves motor skills by enhancing learning of new motor tasks. The study showed participants performed better without sound cues after a nap, indicating improved memory recall and muscle activation.
Scientists have identified a previously unknown species of ground sloth, Parocnus dominicanus, from fossils found in the Dominican Republic. The species was smaller than its tree-dwelling cousins and had anatomical differences that may have allowed it to occupy lowland areas.
Researchers developed a powered exoskeleton that provides extra energy for walking, reducing the strain on amputee muscles. The device was tested by six individuals with above-knee amputations, showing a 15.6% improvement in metabolic rate and allowing users to walk for extended periods.
A Harvard study found that massage therapy using mechanotherapy rapidly clears immune cells from severely injured muscles, enhancing regeneration. The treatment also removed inflammatory cytokines, leading to greater repair and strength recovery in injured muscles.
Researchers have created a human disease model of FCMD using stem cells from a patient, which successfully mimicked the disorder's brain defects. The study found that a small compound called Mannan-007 can restore αDG glycosylation and reduce FCMD-related defects.
Researchers at Tel Aviv University discovered seahorses can move their head up to catch prey at incredible speeds, facilitated by a powerful flow of water and spring-like mechanism. This study sheds light on the ecology of seahorses, revealing that longer noses enable stronger suction currents for catching smaller prey.
A study published in Cell Metabolism identified a protein called neurturin as crucial for muscle health, improving metabolic rates, motor function and exercise capacity. Mice genetically modified to produce more neurturin had increased resistance to degeneration in neurons associated with ALS.
Researchers developed a wearable, biocompatible, and low-cost biosensor that measures electromyography signals in muscles. The sensor uses a gold-silver nanocomposite printed onto fabric, providing a comfortable and effective way to track muscle activity.
A new study found that a healthy gut microbiome is essential for skeletal muscles to grow after exercise. Researchers used mice with antibiotics to disrupt the microbiome, showing reduced muscle growth compared to healthy mice. The findings support previous studies linking the gut microbiome to muscle health.
Skeletal muscle secretes a molecule that regulates around 35% of liver functions, with the remaining basal functions independent of muscle activity. Ageing alters this communication, leading to non-optimal functions and accelerated ageing.
A new UNSW Sydney-led study suggests that strength training can lead to significant weight loss, with participants losing an average of 1.4% of their total body fat after a five-month program. The study analyzed existing evidence and found that this level of fat loss is comparable to cardio-based exercise.
A Brazilian-UK study found that older individuals with both abdominal fat and muscle weakness experience a significant loss of gait speed over eight years. This decline can lead to difficulty walking and increased risk of falls, impacting independence. Researchers urge health workers to measure abdominal fat and muscle strength to pred...
Researchers at UTHealth found that exoskeleton-assisted rehabilitation can be beneficial for stroke survivors, correcting impaired walking patterns and increasing motor coordination. The study used the Ekso 1.1 exoskeleton to guide patients with chronic post-stroke hemiplegia or hemiparesis in a 10-15 session training program over thre...
Researchers at Washington University in St. Louis have developed a method to produce synthetic muscle protein using microbes, which can be spun into fibers with exceptional toughness and strength. The resulting material has potential biomedical applications, such as sutures and tissue engineering.
A research study is being conducted to understand muscle fatigue in older adults, with a focus on its effects on mobility and daily activities. The study aims to develop a new metric called fatigability to assess an individual's change in performance and perceived effort in response to standardized activity.
A mathematical model developed by researchers at the University of Cambridge can predict the optimum exercise regime for building muscle. The model takes into account individual physiology and optimizes exercise regimes based on user input, promising to maximize athletes' potential.
A deep learning tool for sarcopenia assessment on CT scans shows similar utility in predicting hip fractures and death at both L1 and L3 vertebral levels. Muscle attenuation measurements performed better than muscle area assessments, likely due to the inclusion of intramuscular fat.
New research from the University of Arkansas finds that prior training can accelerate muscle growth and response even after extended idleness. Previously trained muscles in mice responded with more sensitivity and grew more rapidly than previously untrained muscles, thanks to epigenetic changes in DNA.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
A new study developed a wearable technology-based method to assess myoclonus symptoms in the home environment. The method, which measures electrical neuromuscular function and movement, correlates well with assessments performed by experienced physicians.
A new clinical trial will test a simple breathing exercise for adults with obstructive sleep apnea and hypertension. The study aims to reduce blood pressure and improve cardiovascular health through inspiratory muscle training.
A recent study found that a muscle protein called CaMKII improves strength, endurance, and fitness in young animals, but also contributes to an evolutionary tradeoff: increased susceptibility to age-related diseases. The research suggests that future therapies targeting CaMKII could stave off diseases of old age.
Scientists at the University of Copenhagen have discovered that exercise can alter the structure of our DNA, specifically the enhancers that regulate gene expression. This epigenetic rewiring may be responsible for the beneficial effects of physical activity on human health.
A compassionate-use study released in STEM CELLS Translational Medicine found significant improvement in body muscles with mesenchymal stem cells derived from Wharton's jelly, a substance in the umbilical cord. The treatment resulted in improved muscle strength and function without serious side effects.
Researchers at UMD developed a supplement that improves pig muscle growth, which could lead to increased sustainability in the pork industry. The study also explored potential applications in human health, including improved immune function and reduced inflammation.
The FDA has approved Octagam 10% for treating adult dermatomyositis, a rare immune-mediated inflammatory disease. The approval is based on positive results of the ProDERM study, which showed significant improvement in patient response to treatment.
Researchers found that consuming protein at breakfast increases skeletal muscle growth and function in humans, as seen in a study of women aged 65 and above. The study's findings suggest that the timing of protein intake is crucial for maintaining skeletal muscle health, with early morning consumption being particularly beneficial.
Texas A&M researchers found that sea otters' muscles use thermogenic leak to generate heat, allowing them to thrive in cold water. This finding explains how otters maintain their high metabolic rate and survive in marine environments.
NRF2 helps keep muscles from weakening in low gravity by regulating oxidative stress. In mice, NRF2 deficiency accelerates fast-twitch fiber type transition and changes energy metabolism during space flight.
A systematic review and meta-analysis found that muscle relaxants have a small effect on reducing pain intensity in the short term, but this effect is not clinically meaningful. The use of muscle relaxants may also increase the risk of side effects such as dizziness and nausea.
Researchers at Kumamoto University discovered that muscles and satellite cells retain positional memory from fetal life, based on the expression pattern of the homeobox (Hox) gene cluster. This finding is expected to provide insights into the pathogenesis of muscle diseases and develop regenerative medicine.
Dr. Brian Clark, Ohio University professor, has received a five-year, nearly $3 million NIH grant to investigate age-related changes in motor neuron excitability. The study will examine the role of motor neurons in health and disease, with potential implications for developing interventions to improve physical function in older adults.
A mutation in the C9orf72 gene may disrupt communication between motor neurons and muscles in ALS patients, leading to motor disorders, muscle atrophy, and mortality. The study reveals that the loss of function induced by the mutation affects synaptic transmission and protein TDP-43's location within the cell.
A study published in iScience has identified dozens of muscle proteins with decreased quantities in individuals with prediabetes and type 2 diabetes. The findings highlight the significance of mitochondrial energy metabolism in the progression from prediabetes to type 2 diabetes.
Researchers at Northwestern University and Shirley Ryan AbilityLab have discovered that muscles lose sarcomeres -- their smallest building blocks -- after a stroke. This loss results in shorter muscle fibers and tighter muscles, making it harder for patients to regain function.