Articles tagged with Muscles
A Michigan Medicine study found that people with cerebral palsy and spina bifida are prescribed opioids at a rate up to five times higher than those without the conditions. Chronic pain is the most commonly reported symptom among these individuals, raising concerns over addiction and overdose issues.
Researchers from Tianjin Medical University General Hospital review sarcopenic obesity's impact on liver disease, including nonalcoholic fatty liver disease and cirrhosis. The study aims to clarify the pathogenesis of sarcopenic obesity and identify potential therapeutic avenues.
Researchers have discovered that a cancer drug could slow the progress of Duchenne muscular dystrophy in mice by increasing muscle fibre resilience. The findings suggest that the drug may help delay disease progression and improve mobility for patients, potentially serving as an adjunct to emerging gene therapy approaches.
Researchers created a cyborg beetle to study insect flight, using a tiny control backpack and electrodes to stimulate muscles. The study found that the subalar muscle regulates wing rotation angle to adjust body angles and accelerations in free flight, enabling complex maneuvers.
A global team led by Rutgers Cancer Institute of New Jersey has secured $25 million to study cachexia, a debilitating wasting condition responsible for up to 30% of cancer deaths. The team plans to build a deep understanding of what causes cachexia and develop novel treatments.
Researchers at McMaster University found that older adults with Type 1 diabetes are at a higher risk of reduced muscle strength and cardiovascular complications. They discovered abnormally low diastolic blood pressure in these patients, which may indicate early increased cardiovascular disease risk.
Researchers created a new fiber that performs like a muscle actuator, outperforming existing options in efficiency, flexibility, and strain handling. The fibers can be easily made and recycled, opening up potential applications in prosthetic limbs, robotic arms, and self-closing bandages.
Researchers discovered how electric fish evolved electric organs by modifying a sodium channel gene. The finding highlights the potential for this genetic mechanism to contribute to human diseases. By studying electric fish, scientists can gain a better understanding of evolutionary processes and their applications in human health.
Research reveals antibiotics can knock out essential gut bacteria, leading to reduced motivation and endurance in athletes. The study found that high-performance mice were more affected by antibiotic treatment, highlighting the microbiome's impact on exercise behaviors.
Researchers found that the effectiveness of exercise depends on the time of day, with morning exercise reducing belly fat and blood pressure in women, while evening exercise increasing muscular performance. For men, evening exercise lowers blood pressure, burns more fat, and improves heart disease risk.
A new University of California, Irvine-led study identifies sex-specific circuits of muscle signaling to other tissues, highlighting differences in muscle function between males and females. The research sheds light on how muscle functions, such as exercise, promote healthy longevity, metabolism and improve cognition.
A study published in eLife found that high-intensity interval training increases the production of proteins essential for energy metabolism and muscle contractions, as well as alters key metabolic proteins through acetylation. These changes may contribute to improved metabolic health.
Researchers developed size-tunable PEG-grafted copolymers to target muscle tissues by exploiting the blood-muscle barrier. The optimal size range for extravasation was found to be between 11-32 nm, with accumulation in skeletal muscles of Duchenne muscular dystrophy model mice being significantly higher than in normal mice.
Researchers developed a tool to analyze facial movements in common marmosets, finding they have more facial expressions than previously thought. The study suggests that facial expressions may be more ancient and prevalent among social animals.
A systematic review and meta-analysis of compression garment use found no benefit in muscle recovery following exercise. The study suggests that practitioners should reconsider the effectiveness of compression garments as a means to reduce muscle strength loss.
A new clinical study published in Cell Reports Medicine found that daily intake of postbiotic Urolithin A improved muscle strength by 12% in middle-aged adults. The supplement supported the cells' ability to renew their powerplants, the mitochondria, during the aging process.
Exercise strengthens bones, reduces fracture risk, and improves posture in people with osteoporosis. A consensus statement recommends a balanced routine of muscle strengthening exercises on 2-3 days and moderate impact activities on most days.
A study of over 4,000 US high school boys found a strong association between muscle-building exercise and physical fighting, as well as carrying weapons. The research highlights the importance of addressing gender equity and violence among adolescent boys.
A recent study published in Obesity Reviews found that resistance training, in conjunction with a reduced calorie diet, can lead to significant fat mass and muscle loss. This breakthrough highlights the importance of considering non-aerobic exercise options for individuals struggling with obesity.
A new study from Tel Aviv University finds that women aged 55 and over who snore are at significant risk for sleep apnea, which can be fatal. The researchers warn that the phenomenon often occurs during sleep, causing women to be unaware of their condition.
A combination of aerobic, strength, flexibility, and balance exercises alongside personalized nutritional counselling reduced mobility disability by 22% over three years. The intervention also improved physical performance and reduced muscle loss in older adults.
A study from Edith Cowan University reveals that electrical stimulation on specific nerves and relaxation techniques can reduce neural amplification in the spinal cord, which may help alleviate involuntary muscle spasms. These methods could provide a non-pharmacological alternative to current treatment options.
Researchers mapped neural networks in marmoset and macaque monkeys to find that multiple areas in the frontal lobe control vocalization, contradicting a long-held view. This discovery could lead to a better understanding of speech disorders such as stuttering and apraxia.
A Brazilian study analyzing data from 3,875 elderly men and women found that weak muscles combined with abdominal obesity can indicate an early sign of functional decline. The study suggests that monitoring simple actions such as sitting down, standing up, walking short distances may help identify this condition.
Scientists discover that activating TAK1 in skeletal muscle promotes muscle growth and prevents atrophy, with implications for treating conditions like cancer, COPD, and genetic diseases. The research also highlights the importance of maintaining healthy neuromuscular junctions.
A study published in eLife has identified genetic variants linked to age-related mobility changes. The research suggests that variations in a mitochondrial enzyme may contribute to the loss of strength and mobility as people age. The findings have important implications for understanding age-related muscle health.
Researchers at the University of Cincinnati are searching for the ideal exosuit design to reduce muscle load and prevent work-related musculoskeletal disorders. The study found that commercially available exosuits have limitations, with the Auxivo LiftSuit being stiff and uncomfortable during prolonged wear.
A new study suggests that glucose-lowering medications can restore aerobic exercise capacity in people with high blood sugar. The research, published in the journal Diabetes, found that combining a medication like canagliflozin with exercise training may improve exercise response in individuals with diabetes.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
A study published in the Journal of Cachexia, Sarcopenia and Muscle found that BAM15 improves health outcomes for aged mice with obesity by preventing muscle loss and increasing energy expenditure. The compound helped mice lose fat, gain strength and increase physical activity.
Researchers discovered that dogs have faster muscle fibers than wolves, enabling greater facial mobility and effective communication with humans. The study also found an additional mimetic muscle contributing to the 'puppy-dog eye' expression in dogs.
A new study from Northwestern University found that once-weekly prednisone treatment improved exercise endurance, increased lean body mass, and reduced weight in obese mice. The treatment also promoted nutrient uptake into muscles and increased adiponectin levels, a hormone that helps protect against diabetes and insulin resistance.
A study found that strength training activates androgen receptors to protect against muscle pain in mice. Resistance training also alleviated pain only in male mice, while females did not show similar benefits. The findings suggest exercise may be a useful treatment for chronic musculoskeletal pain.
A study has discovered that using a strategically-timed pull from a waist belt can help individuals walk more efficiently, reducing metabolic cost by as much as half. This approach uses biomechanical testing to optimize the timing of assistance, which was found to be most effective during a brief window between steps.
Researchers at Kobe University discover that immobilization induces loss of muscle mass by disrupting calcium levels and triggering the KLF15-IL-6 pathway. This finding may lead to the development of a treatment for muscle loss, known as sarcopenia, which affects aging societies.
Researchers at the University of Maine used zebrafish to test the effectiveness of neuromuscular electrical stimulation (NMES) on muscle strength and structure. The study found that only one NMES regimen, endurance neuromuscular stimulation (eNMES), improved muscle health when combined with an antioxidant and a specific receptor.
A novel bed net treated with chlorfenapyr has been shown to significantly reduce malaria infection in children, with a 43% decrease in the first year and 37% decrease in the second year. The study found that the bed net reduced clinical episodes of malaria by 44% over two years.
Researchers from IRB Barcelona have discovered that damaged mitochondria accumulation triggers inflammatory processes leading to muscle atrophy. Correcting mitochondrial function through increased BNIP3 levels can mitigate inflammation and muscle loss, offering potential tools for promoting healthy ageing.
A retrospective cohort study found that shoulder injuries occurred in fewer than 1 in 10,000 patients who received intramuscular vaccinations administered in the deltoid muscle. Researchers also identified risk factors for developing shoulder conditions, including advanced age, female sex, and receiving pneumococcal conjugate vaccine.
A team of researchers found that re-activating the Piezo1 protein allows muscle stem cells to repair broken down muscles in mice with Duchenne muscular dystrophy. The study opens doors for potential molecular-level treatments to slow or halt disease progression.
Intermittent fasting produces mild to moderate weight loss and improves cardiometabolic risk factors, comparable to traditional calorie-restricted diets. The review also dispels myths about intermittent fasting, including the misconception that it leads to weakness and decreased concentration.
A research team at the Advanced Science Research Center has identified peptidoglycan as the most powerful actuator material. The new water-responsive muscles can quickly expand and contract in response to water absorption and evaporation, enabling rapid actuation of micro and macro structures.
Researchers have introduced a new mRNA delivery method to treat muscular dystrophy, which has already proven successful in mice. The method uses messenger RNA to correct genetic defects and has shown promise in clinical trials.
The International Lipid Expert Panel recommends a step-by-step approach to diagnosing and managing muscle symptoms caused by statins. The 'nocebo/drucebo' effect, where patients experience side effects due to expectation, affects up to 70% of diagnosed statin intolerance cases.
A study by Dr. Ryoichi Ema found that eccentric cycling has higher neuromuscular activation of the rectus femoris muscle and can be performed with less effort. This suggests that eccentric cycling exercise is beneficial for improving athletic performance and preventing muscle damage.
A recent study found that sleep bruxism can lead to temporomandibular joint disorders due to increased mechanical loading. The research discovered that specific combinations of tooth shape and location during grinding significantly impact the risk of TMJ problems.
A multicenter study validates the accuracy and reliability of NS-RADS for classifying and grading peripheral neuropathies, with high interrater agreement across different reader experience levels. The study shows promising results for routine practice, suggesting NS-RADS as a standardized guideline for reporting peripheral neuropathies.
Researchers at Tohoku University developed a new lab-based system to grow human muscle cells that contract vigorously. They found that muscle cells from patients with sporadic inclusion body mitosis (sIBM) have similar muscular properties to healthy humans but exhibit altered responses to exercise.
A joint team of Kaunas University of Technology, Lithuania researchers, and JSC Abili created a prototype of an office chair that activates deep muscles and improves trunk stabilisation. This innovation aims to prevent musculoskeletal disorders caused by prolonged sitting, common among sedentary workers.
A pooled data analysis found that between 30 and 60 minutes of muscle strengthening activity per week is associated with a 10-17% lower risk of death from any cause. The J-shaped curve showed no conclusive evidence that more than an hour of this activity reduces the risk further.
Researchers at the University of Leeds discovered that deactivating the Piezo1 protein, a blood flow sensor, reduces muscle capillary density and restricts blood flow to muscles. This results in reduced exercise capability and increased risk of disease, highlighting the crucial link between physical activity and physical performance.
Researchers at HKUST discovered a protein called CPEB1 that drives skeletal muscle stem cell activation to repair damaged muscle. The study reveals discordance between SC proteome and transcriptome during activation, showing post-transcriptional regulation.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
Researchers discovered a crucial RNA strand called CYTOR that helps build muscle mass, and found it decreases with age. Gene therapy stimulated CYTOR production, leading to increased fast-twitch muscle fibers and improved muscle function in humans and mice.
Researchers from the Max Planck Institute have obtained the first high-resolution 3D image of the muscle protein nebulin using electron cryo-tomography. The structure reveals that each nebulin repeat binds with an actin subunit, acting as a ruler to dictate filament length and interacting with neighboring actin subunits to stabilize it.
A study in mice reveals how the Kdm6b gene influences motor neuron development into subtypes with distinct synaptic targets. The research, led by biologists at the University at Buffalo, founds that Kdm6b works cooperatively with proteins Isl1-Lhx3 to diversify motor neurons.
Researchers have solved atomic-level structures of the muscle-type nicotinic acetylcholine receptor, a crucial step in understanding its function. The new findings could lead to breakthroughs in treating neurological disorders such as congenital myasthenic syndrome and myasthenia gravis.
A new study found that statin intolerance is over-estimated, affecting only 6-10% of patients worldwide. Researchers identified risk factors for statin intolerance, including age, sex, ethnicity, and medical conditions.
Researchers discovered two simple physical maneuvers to effectively reduce blood pressure drops and alleviate symptoms of IOH in young women. Lower body muscle preactivation (thighs) and tensing improved cardiac output and stroke volume, respectively, leading to a reduction in symptoms upon standing.
A new study reveals that animals use cheap tissues like chitin to build their weapons, allowing them to deceive opponents and gain advantages in battles. This tactic is used by species such as snapping shrimps and fiddler crabs, which can exaggerate their size and strength through clever deception.