Articles tagged with Muscles
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A study by IMBA researchers links muscle degeneration to a deficiency in the enzyme PCYT2, essential for lipid synthesis. PCYT2 depletion affects mitochondrial function and muscle energetics, highlighting the importance of lipid balance in muscle health.
Researchers developed the first wearable sensor for monitoring muscle atrophy, a condition typically caused by degenerative disease or aging. The sensor can measure small-scale volume changes in overall limb size and monitor muscle loss of up to 51%. This technology has the potential to create less burden on patients and improve treatm...
New research directly measures human muscle contractile properties, revealing that extrapolating animal data to humans based on size is inaccurate. The study finds that human muscle fiber-specific tension is 24% smaller than traditionally used in small mammals.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
Researchers found that COVID-19 survivors with persistent symptoms were more likely to be sedentary, especially those experiencing breathlessness and fatigue. The study, supported by FAPESP, included 614 participants who were analyzed for physical activity and lifestyle habits.
A protein complex formed of HuR and YB1 is crucial for messenger RNA stability during muscle-fiber formation. Further research could help scientists influence protein synthesis and develop novel therapeutics for muscle-related pathologies.
A study by the University of Missouri found that older adults who completed an eight-week resistance training program maintained long-term exercise habits and increased their physical energy despite COVID-19 restrictions. The Stay Strong, Stay Healthy program improved participants' sleep, balance, flexibility, and self-confidence in da...
Researchers at Martin-Luther-Universität Halle-Wittenberg have found a new treatment for ADCY5-related dyskinesia using the asthma drug theophylline. The treatment has been shown to reduce symptoms and improve quality of life in affected individuals.
Researchers found that gut microbes drive the production of regulatory T cells, which act as immune healers that repair muscle injury. These cells were previously thought to be only produced in the gut, but now it's clear they also play a role in healing damaged livers.
A new study found that eccentric contractions prove most effective in preventing muscle wasting and damage after immobilization. Strengthening the unaffected arm through weightlifting also counteracted muscle atrophy, with a stronger cross-education effect observed for eccentric contractions.
A multidisciplinary team developed a physiologically accurate model of octopus arm muscles, providing insight into biological and design challenges. The model enables energy-shaping control, simplifying arm control design and enabling life-like motion in soft robots.
Automated AI body composition tools achieved high technical adequacy rates (97.8-99.1%) in a large sample of external abdominal CT scans. The results support the generalizability and potential for widespread adoption of these tools, which can help build trust among radiologists and physicians.
Researchers found that strengthening hip abductor muscles can provide effective compensation for weaknesses in knee extensor muscles, leading to improved mobility in people with below-the-knee amputations. The study tested the hypothesis in eight military personnel who had undergone a lower limb amputation and showed promising results.
Researchers created adaptive optical phantoms by combining multiple pigments to mimic target tissue's optical properties, successfully validating them in extensive experiments. The new platform enables broader band spectra for emerging hybrid modalities and novel instruments.
A recent study published in JHEP Reports found that individuals with low thigh muscle volume and high muscle fat infiltration had an increased mortality risk. The researchers also discovered that poor muscle health was not associated with a worsened prognosis in people with fatty liver disease.
A recent study from the University of Toronto found that greater screen time is associated with more symptoms of muscle dysmorphia among Canadian young people. The researchers analyzed data from over 2,500 adolescents and young adults and found that social media use, texting, TV watching, and video chatting were linked to muscle dysmor...
Researchers create 'Lego-like' BIND interface to assemble stretchable devices with excellent mechanical and electrical performance. The interface allows for easy connection of modules, enabling the development of highly functional wearable devices or soft robots.
Research found combining Kegel exercises before resistance training improves pelvic floor strength and reduces urinary leakage. Over 8% of incontinent women no longer experienced urinary leakage after performing resistance training.
A study found that competition preparation temporarily reduces resting energy expenditure in physique athletes, primarily due to reduced energy intake and lower levels of thyroid hormone T3. This reduction can complicate weight loss and make it difficult for athletes to compete.
Scientists at Nagoya University developed an index to estimate a bird's wing use based on coracoid bone strength and body mass. This new tool sheds light on how ancient birds evolved to fly, including the flapping abilities of extinct species.
Nicotinamide riboside has been found to increase muscle mitochondria, improve gut bacterial composition, and boost NAD+ concentrations in humans. The findings suggest that NR supplementation may be a promising therapeutic option for diseases characterized by muscle mitochondrial dysfunction and/or gut microbiota imbalance.
Researchers have identified superfast muscles in mouse legs using new technology, opening up possibilities for therapeutic interventions to improve human limb movements. The discovery sheds light on the mechanisms behind fast twitch muscles and fatigue-resistant oxidative muscles.
A new study finds that age-related abdominal fat is associated with lower muscle density, leading to less effective muscle function. This accumulation of visceral adipose tissue may represent a modifiable risk factor for poor musculoskeletal outcomes with aging.
A new study found that Black and Hispanic stroke survivors in the US are less likely to receive treatment for common complications, despite improved overall stroke survival rates. Researchers analyzed electronic health records from 2002 to 2022 and matched patients based on 41 factors to minimize biases.
A new smartphone application called FAST.AI uses machine learning algorithms to recognize facial asymmetry, arm weakness, and speech changes in people experiencing a stroke. The app's accuracy was validated through a study involving nearly 270 patients with acute stroke, showing promise as a tool for prompt individuals to seek care.
Researchers discovered that myosin motor proteins must be activated before muscles can contract, potentially leading to breakthroughs in treating inherited cardiac conditions. This new understanding could lead to medical remedies for diseases like dilated cardiomyopathy and hypertrophic cardiomyopathy.
A study by researchers in Brazil found that loss of muscle mass during COVID-19 hospitalization is associated with the development of persistent symptoms such as weakness, shortness of breath, and fatigue. The study also showed that patients who lost more muscle mass had higher healthcare costs six months after discharge.
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
Concordia researchers analyzed muscle and fat mass data from a large US sample population to find that high levels of fat mass are linked to poorer overall health. While BMI was surprisingly effective in predicting some cardiometabolic outcomes, the study suggests new body-composition phenotypes may be a better predictor.
Researchers studied cavefish metabolism to understand how humans might adapt over long periods of inactivity, finding genetic changes that enable muscle endurance and efficient energy storage. The study suggests potential implications for understanding and mitigating the negative effects of sedentary lifestyles on human health.
Research published in BMJ Open found that carrying excess weight from mid-life onwards increases the risk of physical frailty in older age. The study tracked over 4500 participants and found that obesity and high waist circumference were associated with a higher risk of pre-frailty/frailty, highlighting the importance of maintaining a ...
A new study found that consuming dietary nitrate from beetroot juice significantly increases muscle force while exercising. The researchers discovered a 7% increase in muscle torque production, providing the best evidence to date on the mechanisms behind why dietary nitrate improves human muscle performance.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
Researchers at Hokkaido University developed a hybrid hydrogel combining natural squid tissues with synthetic polymers, exhibiting hierarchical anisotropy and toughness.
A new study by researchers at Florida Atlantic University explored the effects of resistance training on older adults' cellular level. The study found that resistance training did not significantly affect inflammatory proteins or redox balance markers, but showed a significant reduction in a specific protein ratio. This may support the...
Muscle mass and blood pressure are key factors in maintaining healthy arteries, with higher muscle mass and lower blood pressure linked to reduced arterial stiffness. The study found that these associations remain significant even after accounting for age.
A recent study found that adolescent boys and young adult men in Canada experience high levels of muscle dysmorphia symptoms, with one in four at clinical risk. The study highlights disparities among sexual identities and racial/ethnic groups, emphasizing the need for greater awareness and knowledge among healthcare professionals.
Researchers at Kyoto University found that a poor, low-yeast diet causes fruit flies' larvae to grow dendrites in an unexpected way. The hyperarborization phenotype is triggered by a simultaneous deficiency in vitamins, metal ions, and cholesterol, which increases the production of Wingless signaling molecules from body wall muscle.
Ceramides accumulate in aged muscle, impairing its function and affecting functional capacity in older adults. This finding encourages researchers to develop potential pharmaceutical agents to combat sarcopenia and age-related diseases.
Researchers at Aston University discovered that mechanical vibrations can improve balance control and strengthen calf muscles. The study, published in Scientific Reports, suggests that whole-body vibration could be used to reduce falls and hospital bed days in older people.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
Researchers found that exercise induces a cycle of fatigue and recovery in muscles, paralleled by mitochondrial network rebuilding. Long-term training programs improved middle-aged fitness, while AMPK interventions enhanced exercise capacity during aging.
Researchers found that spontaneous movements in newborns and infants develop patterns of muscle interaction, enabling them to perform sequential movements as infants. This study provides insight into the origin of human movement and may lead to earlier diagnosis of developmental disorders.
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
Researchers at Michigan Medicine have developed a new biomarker-based strategy to screen for immune checkpoint inhibitor-induced myocarditis, which can cause muscle damage and liver injury. Early detection of these biomarkers can lead to earlier treatment and improved survival rates.
Researchers at the University of Montreal discovered a key mechanism in muscle regeneration, enabling targeted therapies for diseases like muscular dystrophy. By biasing the conformation of a protein called ELMO2, they improved muscle fusion and regeneration in mouse models.
A team of scientists discovered that ceramides accumulate in muscles during aging, leading to a decline in muscle function. Treating old mice with ceramide blockers prevented age-related loss of muscle mass and improved muscle strength.
Researchers have developed an edible plant-based ink derived from food waste to create cost-effective scaffolds for culturing meat. This innovation could significantly reduce the cost of large-scale cultured meat production, making it more affordable and environmentally friendly.
Researchers identified two components of a fruit fly's flight stabilization system responsible for angular displacement and angular velocity. By studying genetically engineered flies with optogenetics and magnetic perturbation, they found that two muscles control pitch, enabling stable flight.
Astronauts in space can lose up to 20% of muscle mass after two weeks due to microgravity. Researchers are exploring the use of extracellular vesicles, which contain restorative chemicals, to trigger post-exercise recovery without traditional exercise.
Researchers found that vitamin D deficiency increases the risk of dynapenia, an age-associated loss of muscle strength, by 70-78%. Vitamin D supplementation was shown to reduce this risk. The study analyzed data from over 3,000 individuals aged 50 and over, highlighting the importance of vitamin D for maintaining muscle strength.
Scientists have identified genes that enable proprioception, a crucial sense for coordinated movement and balance. The discovery could lead to better understanding of neurological disorders such as spinal cord injuries, scoliosis, and hip dysplasia, ultimately enabling the development of novel therapies.
The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.
A new study from Northwestern University found that vitamin D supplements do not significantly reduce statin-associated muscle symptoms, contradicting previous non-randomized studies. The trial involved 2,083 participants and was the first placebo-controlled, randomized clinical trial to examine this effect.
CSU researchers created the first successful soft robotic gripper capable of manipulating individual droplets of liquid, enabling precise and lossless liquid cleanup work. The innovative device is lightweight, inexpensive, and can be used for hazardous liquid cleanup scenarios.
Albert Almada's laboratory will explore the role of Nicotinamide Adenine Dinucleotide (NAD+) in muscle repair and regeneration. Lower levels of NAD+ may be inactivating stem cell repair, and re-activating it could promote better muscle healing in older animals.
Researchers are exploring how aging affects communication between bone and muscle, finding that imbalance can lead to muscle loss, falls, and bone fractures. They aim to develop novel interventions to restore this balance, potentially treating osteoporosis and sarcopenia.
A new study from Japan investigated the relationship between training volume and strength gain in young men. The researchers found that training volume was positively correlated with strength gain in participants who were classified as low responders.
A new study reveals how cane toads (Rhinella marina) consume prey by using a complex pulley system of cartilage and muscle. The mechanism involves the hyoid plate, which is attached to muscles and loops like a marionette, pulling food backward into the throat.
Researchers developed a new device, MAGENTA, that prevents and supports muscle atrophy recovery. The device stimulates muscles to stretch and contract, triggering key molecular pathways for growth. It has potential applications in treating various diseases such as ALS and MS.