Musculoskeletal System
Articles tagged with Musculoskeletal System
A simple 30-second sit-to-stand test that can predict how well you age
A simple 30-second sit-to-stand test can estimate muscle power and identify individuals at higher risk of hospitalization and mortality. The test revealed a strong association between low muscle power and increased risks of falls, fractures, hospitalizations, and mortality in older adults.
Blocking TGF-β signaling may strengthen efficacy of osteoporosis therapy
Hidden muscle fat poses danger to heart, metabolism
Researchers used MRI to analyze muscle composition in 11,348 participants and found that higher intermuscular fat and lower muscle mass were associated with increased cardiometabolic risk factors. Lean muscle mass was only protective against these risks in men, while women's muscle mass declined after age 40.
Researchers identify the ‘organizer’ cells that build bone marrow
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
Mapping the hidden triggers of jaw joint arthritis at the cellular level
A study mapped early molecular and cellular changes in the jaw joint that may trigger temporomandibular joint osteoarthritis. The research found structural and molecular changes in joint tissues, including inflammation, fibrosis, and metabolic shifts. Single-cell sequencing revealed diverse cell populations interacting within the synov...
Scientists reveal the secrets behind the penguin waddle and underwater “flight”
Researchers uncovered previously unknown features in the limb musculature of the macaroni penguin that help explain its efficient movement on land and underwater. The study found modified key wing muscles and a unique configuration of shoulder muscles giving penguins an 'underwater flying' wing stroke.
Not just snoring: Obstructive sleep apnea damages muscles
A new study reveals a significant link between obstructive sleep apnea and skeletal muscle quality, indicating an increased risk of muscle deterioration with aging. Researchers found that people with obstructive sleep apnea have lower skeletal muscle density and a higher skeletal muscle index than those without the condition.
Why the Nordic hamstring exercise protects against injury
Research shows that nine weeks of Nordic hamstring exercise training increases eccentric knee flexor strength and allows participants to control the exercise through a greater range of motion. The study found that muscle fibers can stretch to longer lengths during exercise without overstretching, reducing injury risk.
University of Cincinnati enrolls first patients in clinical trial for prosthetic joint infections
A new clinical trial at the University of Cincinnati is testing a peptide solution to treat prosthetic joint infections after total knee replacement. The trial aims to reduce the need for repeat surgeries and expand the treatment window beyond two weeks.
Doubt cast on effectiveness of widely used ‘KT-tape’ for joint/muscle pain + mobility
Research suggests that Kinesio taping (KT tape) may reduce pain intensity in the immediate and short term, but evidence for long-term benefits and its use in various musculoskeletal conditions is inconclusive. The majority of systematic reviews found inconsistent findings, and potential skin irritation remains a concern.
Uncovering the molecular mechanisms that drive cartilage-to-bone transition
Researchers developed in vitro and in vivo models to track cartilage-to-bone transition, identifying key signaling pathways and transcription factors involved. The study found that some cartilage cells can transition into bone-like cells, challenging the traditional view of bone cell origin.
Overlooked brainstem pathway controls human hands
A new study identifies a previously unknown brainstem pathway controlling hand and arm movements, revealing a multi-stage pathway integrating signals from the cortex, brainstem, and spinal networks. This finding may lead to new therapies for stroke rehabilitation, providing additional targets for neuromodulation treatments.
NYU Langone orthopedic surgeons present latest clinical findings and research at AAOS 2026
Researchers at NYU Langone Orthopedics present new study on ACL reconstruction in athletes over 50, finding physiological age determines treatment. They also develop an AI chatbot to answer pre- and postoperative questions, improving patient engagement and education.
Do muscles remember being weak?
New research reveals that skeletal muscle retains a 'molecular memory' of repeated disuse, which differs between young and old muscles. Younger muscles show resilience, while older muscles become increasingly susceptible to atrophy. The study provides insights into how muscle responds to inactivity and its potential for recovery.
Key proteins found to drive abnormal bone growth after injury
A study reveals that two key proteins, TSP1 and TSP2, play a central role in shaping the healing environment after injury, leading to abnormal bone growth. The findings suggest targeting these proteins may reduce harmful bone formation without interfering with healthy development.
Blocking pain at the source: Hormone therapy rewires nerve signals in aging spines
Researchers found that hormone treatment reduces abnormal nerve invasion and improves chronic back pain by limiting nerve growth inside damaged spinal tissue. The study suggests that parathyroid hormone can reverse the process by activating natural signals.
Why some broken bones fail to heal: scientists reveal a critical molecular trigger
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
Blocking a cancer-related pathway helps reduce spine deformities due to genetic disorder, finds new study
Researchers identify bone-forming cells as driver of scoliosis caused by NF1. Blocking RAS-MAPK signaling pathway with medications halts progression of spinal deformity in genetically engineered mouse model.
Orthopedics can play critical role in identifying intimate partner violence
A study highlights the opportunity for orthopedic surgeons to identify patients who have experienced intimate partner violence (IPV), with only 0.3% of referrals compared to 29% from emergency departments. Orthopedic teams can educate and empower patients, providing timely life-saving referrals.
New study finds where you live affects recovery after a hip fracture
A new study published in JAMA Network Open found that older adults living in economically disadvantaged neighborhoods spend significantly fewer days at home after a hip fracture. The researchers analyzed Medicare data and found that people in the most deprived areas spent about 23 fewer days at home compared to those in less disadvanta...
Cartilaginous cells regulate growth and blood vessel formation in bones
Researchers discovered subtypes of chondrocytes that transform into bone-building cells, regulating bone growth and vascularization. The study found that these cells secrete Thbs4 to induce blood vessel formation, shedding insights for treating defective angiogenesis.
Avoidable cancellation of knee replacement operations costs NHS millions and increases waiting times
A new study reveals thousands of NHS knee replacement operations are cancelled annually for avoidable reasons, costing millions and prolonging waiting times. Lack of available beds and medical ineligibility were the most common causes, with many cancellations avoidable with advance planning.
Exercise and L-BAIBA supplement boost muscle and bone health in aging mice
Researchers found that combining L-BAIBA supplementation with voluntary wheel running exercise enhances musculoskeletal properties in middle-aged male mice. The study showed significant improvements in muscle strength, bone density, and reduced bone marrow fat.
Understanding jaw growth: Key gene axis controls postnatal condyle development
Researchers investigated the role of PLAGL1 in postnatal condyle development and found that it regulates osteogenesis through the IGF2 pathway. The study reveals a critical driver of jaw bone formation, offering opportunities for therapeutic exploration and a deeper understanding of craniofacial biology.
Hip or shoulder? Location matters in bone marrow for joint repair
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Mount Sinai study highlights sex-based pelvic differences’ effect on spinal screw, rod placement during surgical procedures
The study found that males have a narrower pelvis, resulting in a more medial starting point for S2AI screws and poorer rod alignment. Researchers aim to tailor treatment to patients' specific anatomy to improve surgical efficiency and outcomes.
Artificial protein mimicking elastin aids tissue regeneration
Researchers developed a novel biomaterial called elastin domain-derived protein (EDDP) that overcomes natural elastin limitations. EDDP promotes cell adhesion and growth, aiding tissue regeneration in damaged tissues like heart valves, blood vessels, or torn ligaments.
The aging blueprint: Understanding the cellular mechanisms of skeletal aging
Aging cells disrupt bone renewal and repair processes, leading to weak bones and joint degeneration. Cellular senescence and inflammation are major drivers of skeletal decline, while senolytics and emerging therapies offer promising new paths for treatment.
Mount Sinai returns as official hospital and medical services provider of the US Open Tennis Championships
Mount Sinai will provide orthopedics, sports medicine, emergency medicine, and musculoskeletal radiology services to world's top tennis stars. The institution has partnered with the USTA for 13 years, promoting health and wellness, preventing injuries, and catering to diverse populations.
Genetically engineered mouse model provides insights on genetic bone disorders
Researchers developed a genetically modified mouse model to study osteogenesis imperfecta (OI), a rare genetic bone disorder. The study found that the Sp7 R342C mutation affects bone mineral density, trabecular bone volume fraction, and cortical porosity, leading to impaired bone remodeling.
‘Bone-ified muscles’ could be robots’ next flex
Researchers have developed soft artificial muscles that provide the performance and mechanical properties required for building robotic musculoskeletal systems. The new muscles can be battery-powered, enabling robots to move more naturally and safely in unstructured environments.
New aging clock predicts early risk of muscle loss in older adults
A new study introduces a novel muscular clock, MAA, which measures how quickly an individual's muscles are aging compared to their actual age. The research found that about 25% of healthy middle-aged and older adults experience accelerated muscle aging, increasing the risk of sarcopenia.
Rice University scientists discover way to engineer stronger soft devices through smarter silicone bonding
Researchers develop predictive framework that connects silicone curing conditions with adhesion strength, enabling dramatic improvements in performance for molded and 3D-printed elastomer components. The 'reaction coordinate' metric allows precise tracking of the degree of curing, even under variable thermal conditions.
Survey finds Americans choose short term relief for neck and back pain
A survey from the Orlando Health Spine Center found that Americans often opt for short-term relief methods such as rest (44%), over-the-counter pain relievers (42%), and hot/cold therapies (29%) when dealing with neck and back pain. In contrast, only 5% consider surgery as a top option for pain relief.
Decoding the prognostic power of muscle strength in cirrhosis management
Research review finds handgrip strength is a reliable predictor of cirrhosis complications and outcomes, including malnutrition, muscle loss, cognitive impairment, hepatic encephalopathy, and mortality. Regular HGS assessments can inform timely personalized interventions to enhance patient quality of life.
Efficient elastic tissues may hold the secrets to Olympic success
New research identifies 'general motor skills' as crucial for world-class performance across various athletic disciplines. World-class experts show fewer inefficiencies in elastic tissue motions compared to regional-level and novice competitors.
Mount Sinai implements Own the Bone® program for fragility fracture patients
The Mount Sinai Hospital has implemented the American Orthopaedic Association’s Own the Bone program to improve patient care for fragility fracture patients. The program offers a fracture liaison service to document and track individualized care, and incorporates 10 prevention measures to improve patient outcomes.
Emergency department data show rise in hospitalizations due to pediatric clavicular fractures
The study found a statistically significant increase in hospital admissions due to pediatric clavicular fractures over the 10-year period, suggesting an increase in severity of those injuries. This calls for better injury prevention and management strategies for doctors, parents, and patients.
National data shows post-pandemic rise in head and shoulder injuries for youth hockey players
A Mount Sinai study found a post-pandemic increase in head and shoulder injuries among female and male youth hockey players, with higher rates of hospitalizations and fractures. The research highlights the importance of safer equipment standards, injury prevention strategies, and education to protect young athletes.
New study reveals how RUNX2 regulates skull development
Researchers uncover how RUNX2 regulates cranial base growth by controlling chondrocyte differentiation, proliferation, and organization. The study provides fundamental insights into the complex interplay between RUNX2 and FGFR3, shedding light on novel therapeutic targets for craniofacial defects.
Aging disrupts osteocyte networks and bone structure, with greater impact in males
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Women with low muscle mass have a worse prognosis in breast cancer treatment
A study by researchers at the University of São Paulo found that women with low muscle mass have a significantly lower survival rate than those with normal muscle mass. Muscle mass is crucial for patients undergoing cancer treatment, and low levels can predict adverse outcomes, including mortality.
Nationally recognized emergency radiologist Tarek Hanna, MD, named new chair of Diagnostic Radiology & Nuclear Medicine at the University of Maryland School of Medicine
Dr. Tarek Hanna joins UMSOM from Emory University School of Medicine with expertise in emergency and trauma imaging, clinical operations optimization, and faculty development. He will advance clinical excellence and expand radiology services across central Maryland.
Making connections: A three-dimensional visualization of musculoskeletal development
Scientists have successfully visualized how musculoskeletal components are integrated into the functional locomotor system during embryonic development. The study uses a novel fluorescent mouse model combined with high-resolution imaging techniques to provide new insights into the complex process of locomotor system development.
Pennington Biomedical welcomes Dr. Stefan Pasiakos as Director of the Center for Human Performance Optimization
Dr. Pasiakos joins Pennington Biomedical to lead research on muscle physiology, nutrition, neuroscience, and technology to optimize human performance in extreme conditions. His expertise strengthens capabilities for U.S. Military resilience, spaceflight bioenergetics, and elite athlete development.
To walk, you only need fins (and maybe a sense of adventure)
Researchers studied the anatomy of mudskippers to understand their adaptations to life on land. They found that the fish's muscles in the pectoral fins are bigger and that some bone-connecting tendons were replaced by fascia tissue, providing stability and strength for walking.
People who are ‘double jointed’ may be at heightened risk of long COVID
A case-control study found that individuals with joint hypermobility were 30% more likely to not fully recover from COVID-19 infection and experience persistent fatigue associated with long COVID. The study, published in BMJ Public Health, also identified other underlying health conditions as risk factors for developing long COVID.
School-age girls with obesity are more likely to experience joint and muscle pain
Research by Queen Mary University of London found that girls with obesity are 1.7 times more likely than those with a healthy weight to have at least one GP consultation for musculoskeletal symptoms or diagnosis in childhood. Knee pain was the most common symptom reported, and researchers hope their findings will raise awareness about ...
No clear link between weather and common muscle and joint symptoms
Researchers found no clear link between weather conditions and muscle and joint pain, debunking a long-standing medical myth. High temperatures, low humidity, and dehydration may increase the risk of gout flares.
Pusan National University's breakthrough in muscle regeneration: Nanotech scaffolding supports tissue growth
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
New NIH-funded center could soon reduce the need for pharmaceutical trials on animals
The University of Rochester is establishing a new NIH-funded center focused on developing FDA-qualified drug development tools related to barrier functions in disease. Researchers will create microphysiological systems with ultrathin membranes of human cells, aiming to reduce animal trials and improve drug efficacy.
Fruit, nectar, bugs and blood: How bat teeth and jaws evolved for a diverse dinnertime
Researchers studied over 100 noctilionoid bat species, finding that different dietary types drove modifications in tooth number, size, shape, and position. For instance, fruit-eating bats have shorter jaws with reduced middle premolars, while nectar-feeders have longer jaws with room for more teeth.
Commonly used muscle-building dietary supplements are under regulated in Canada
A recent policy analysis highlights gaps in Canadian regulation of muscle-building dietary supplements, including whey protein and creatine monohydrate. The lack of consistent manufacturing site and product safety testing poses significant health risks to young people.
New study reveals the most common form of arthritis, osteoarthritis, affects 15% of the global population over the age of 30
A new study projects nearly 1 billion people will be living with osteoarthritis, the most common form of arthritis, by 2050. Currently, 15% of individuals aged 30 and older experience osteoarthritis, with obesity being a major risk factor.
Successful mentorship program in Latin America leads to more Fracture Liaison Services, finds new review
A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
UCLA-led research suggests no difference in health outcomes, care costs for patients treated by traditional MDs or osteopaths
A recent study published in Annals of Internal Medicine found that elderly hospitalized patients treated by physicians with MD or DO degrees had virtually identical mortality rates, readmissions, length of stay, and healthcare spending. The results suggest high-quality care regardless of the physician's educational background.
Patients with rheumatic and musculoskeletal conditions vulnerable to long term opioid use
Researchers warn that patients with rheumatic and musculoskeletal conditions are vulnerable to long term opioid use. The study found that up to 1 in 3 patients with rheumatoid arthritis or fibromyalgia may be at risk of transitioning to long term opioid use, highlighting the need for vigilance in practice prescribing.
Association between depression and physical conditions requiring hospitalization
The study found that endocrine, musculoskeletal, and vascular diseases were the most common causes of hospitalization in individuals with depression. Depression is considered a potential target for preventing both physical and mental health issues.
Fishermen-developed “banger bar” helps reduce risk of injury on crab boats, OSU study finds
A study by Oregon State University found that a metal bar installed on the crab-sorting table can reduce the strain on fishermen's bodies and prevent injuries. The researchers tested different banger bar configurations and found that higher bars and triangular bars were the most effective in reducing muscle activity and joint moment.