Articles tagged with Musculoskeletal System
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
The UMass Lowell-led team aims to understand how proteins affect biting function in animals, with potential applications in treating diseases like muscular dystrophy. The research will involve studying molecular properties of myosin, a fibrous motor protein, and its impact on muscle force and velocity.
Researchers developed a digital health system approach to enhance clinical decision-making for low-back pain sufferers. The system combines self-reported pain measures with precise motion-sensing data, revealing functional improvements only after six months of surgery.
A new study found evidence that multituberculates, an extinct group of mammals, likely reproduced in a placental-like manner. This discovery questions the long-held idea that marsupials were less advanced than placentals in terms of reproductive strategy.
A recent study published in Annals of Internal Medicine found that patients who underwent spinal anesthesia for hip fracture surgery experienced more pain and were more likely to use prescription painkillers compared to those who received general anesthesia. The researchers hope to improve pain care by increasing the use of peripheral ...
A study published in Frontiers in Nutrition found that malnutrition contributes to sarcopenia in hemodialysis patients, characterized by muscle mass, strength, and function losses. The Nutrition Risk Index (NRI) is a simple and convenient metric developed in Japan, which shows significant relationships between NRI score and sarcopenia,...
Researchers compared SARS-CoV-2 antibody titers after Pfizer-BioNTech and Moderna COVID-19 vaccines in immunosuppressed patients. The study found differing antibody responses among these individuals, who have decreased immune responses to standard vaccines.
Researchers at Kobe University discover that immobilization induces loss of muscle mass by disrupting calcium levels and triggering the KLF15-IL-6 pathway. This finding may lead to the development of a treatment for muscle loss, known as sarcopenia, which affects aging societies.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Dysfunction in mitochondrial respiration leads to imbalanced extracellular matrix (ECM) and tissue organization in cartilage. Research discovered the respiratory chain plays a key role in maintaining ECM balance.