Articles tagged with Nerve Tissue
A new NIH-funded center, co-led by UT San Antonio School of Dentistry, aims to accelerate evidence-based dental care by exploring pulpotomy as an alternative to root canal procedures. The center will develop, implement, and evaluate a national training platform to improve clinical practice.
A new drug patch is being developed to promote the repair of damaged myelin sheaths in multiple sclerosis patients. The patch, which delivers a low dose of theophylline, is being tested in a Phase I clinical trial for its safety and tolerability.
Researchers at University of Texas MD Anderson Cancer Center found that BRAF plays a key role in developing and maintaining chronic nerve pain caused by nerve damage. Using BRAF inhibitors reduced pain sensitivity in preclinical models, suggesting therapeutic potential for treating chronic nerve pain.
A landmark study identifies new genetic risk factors associated with fibromyalgia syndrome, pointing to a neurological origin of the disorder. The research found substantial overlap between fibromyalgia and other conditions, suggesting shared biological mechanisms that may benefit from targeted therapies.
Researchers compared two prevalent MS models to identify specific scenarios where one model is better suited for studying myelin loss and regeneration. The study analyzed preclinical models alongside human MS tissue samples, revealing genetic changes and insights into disease progression.
Researchers at CUNY ASRC have uncovered a metabolic switch that influences the formation of myelinating cells, helping shape brain development. The study reveals that glucose levels act as a signal directing behavior during development and can be harnessed to protect myelin in the developing brain and promote repair in disease states.
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
Researchers have developed a new device that can record and stimulate activity across the entire surface of miniature, lab-grown human brain-like tissues, enabling whole-network mapping and manipulation. This breakthrough could improve our understanding of brain development, function, and disease.
A study published in PNAS reveals that peripheral neuropathy can reduce macrophage immune cells' ability to clear dead cells through efferocytosis, leading to chronic pain. Restoring this process may offer a new therapeutic strategy to prevent inflammatory signaling and improve nerve repair.
Researchers at Tulane University discovered a new nerve cell signaling mechanism that can turn on pain signaling after injury, potentially leading to safer treatments. The discovery of enzyme vertebrate lonesome kinase (VLK) offers a new way to influence cell behavior and could simplify drug development.
A new Northwestern University study reveals how a key disease protein, TDP-43, drives overactive nerve cells in ALS and FTD. The findings highlight a promising new drug that can fix this error and restore balance to neurons.
A recent study found that preserving just one centimeter of corpus callosum fibers is enough to maintain information exchange between the two brain hemispheres, preventing neurological symptoms. The research challenged long-held assumptions about the relationships between brain structure and function.
Researchers used ultraflexible probes to track neurons in the visual cortex of mice for 15 consecutive days, revealing that millisecond rhythms explain how the brain maintains a stable picture of the world. The findings provide new insights for brain-computer interfaces, sensory prostheses and therapies for neurological disease.
Researchers found that cancer cells break down nerve protective covers, triggering chronic inflammation and immune exhaustion, making treatment resistant. Targeting the nerve injury pathway can reverse this resistance and improve treatment response.
Researchers found that the primary somatosensory cortex, responsible for processing sensory information, has a layered structure that ages differently. The middle and upper layers remain stable or even thicken with age, while the lower layers show age-related degeneration, providing evidence for neuroplasticity.
Laminin-411 protein and its derived peptide A4G47 exhibit pro-myelinating activity in oligodendrocytes, promoting myelin sheath formation. This discovery advances understanding of myelin sheath formation and potential applications for treating demyelinating diseases.
A new drug developed by UNM researchers enables surgeons to better see nerves during surgery, improving safety and efficiency. The Phase 3 trial is currently underway and aims to assess whether the imaging agent improves overall surgical outcomes.
Scientists at Tufts University have developed a three-dimensional model to study the regeneration of nerve tissue in the nose, revealing that dormant stem cells play a key role in preserving the sense of smell. The research found that these stem cells actively support the generation of new olfactory neurons.
A new technique using focused sound waves and microbubbles has shown great promise in treating debilitating brain lesions called cerebral cavernous malformations. The approach has halted the growth of lesions almost entirely, offering a potential paradigm shift in treatment.
The CombPlex technology developed at Weizmann Institute allows for the simultaneous imaging and quantification of nearly two dozen proteins within individual cells. This breakthrough enables researchers to measure lots of proteins at the same time, crucial for understanding tissue function and disease processes.
A new study presents a proof-of-concept leptomeningeal neural organoid (LMNO) fusion model to study meninges-brain signaling. The co-culture system of neural organoids fused with fetal leptomeninges from mice demonstrates stability and interface characteristics.
A new surgical technique called NeuroSAFE has been shown to preserve erectile function in men with prostate cancer, with 39% of patients experiencing no or mild dysfunction after treatment. This is compared to 23% of those who received standard surgery.
Developing heart cells use filopodia to probe and grab onto potential partners, seeking stability through energy equilibrium. The model predicts how cells match and rearrange, mirroring real embryo outcomes.
A recent report in The Journal of Craniofacial Surgery highlights the importance of anatomical factors in minimizing risks and optimizing outcomes of facial thread lifting. The report outlines techniques such as reticular cutis gathering and pinching to enhance procedural safety and results.
An international research team developed a user-friendly software method called Segment Anything for Microscopy, which can precisely segment images of tissues, cells, and similar structures. The new model improved performance for cell segmentation, enabling researchers to automate tasks that previously took weeks of manual effort.
Researchers at Johannes Gutenberg University Mainz have discovered that histone deacetylase 8 (HDCA8) inhibits the conversion of Schwann cells into their repair phenotype, slowing down peripheral nervous system recovery. Removing HDAC8 accelerates regeneration and restores sensory function.
Researchers at Penn State developed a novel, living biomaterial that mimics biological tissues and extracellular matrices. The material exhibits self-healing properties and strain-stiffening behavior, enabling precise control of mechanical properties.
Researchers at FAU's Schmidt College of Medicine will explore the use of genetically engineered cells to treat degenerative diseases, with a focus on understanding how hypoxic conditions drive cellular transformation. The study aims to identify novel pathways controlling this process and develop strategies for engineering more complex ...
Researchers developed an AI model that analyzes electrocardiogram (ECG) data to predict biological age and potential cognitive decline. The study, based on UK Biobank data, found a link between higher ECG-age and poorer cognitive performance.
A pooled data analysis found that cancer chemotherapy is linked to persistent severe peripheral nerve pain for around 4 in every 10 patients, with platinum-based drugs and taxanes associated with the highest rates of painful neuropathy. The study analyzed data from 77 eligible studies involving 10,962 participants from 28 countries.
The Wake Forest Institute for Regenerative Medicine is part of a major undertaking to bring together experts from around the country to develop vision-restoring whole eye transplants. The project, valued at up to $56 million, aims to overcome technical, biological, and immunological hurdles in whole eye transplant.
Researchers used STOC-T to visualize retinal microcirculation in real-time, providing insights into the mechanisms of retinal function. The study offers a groundbreaking opportunity for precise monitoring of hemodynamic changes in the retina, enabling early detection and treatment of diseases such as Alzheimer's and Parkinson's.
Researchers develop non-genetic optoelectronic biointerfaces for targeted stimulation and monitoring of cells, tissues, and organs. The technology offers precise control over biological processes with increased spatial resolution and reduced invasiveness.
Researchers developed a new imaging technique using fluorescence-guided surgery to enhance visibility of tumors and nerves during head and neck cancer surgery. The technique uses two near-infrared fluorophores, one for tumors and another for facial nerves, allowing for clear differentiation between cancerous tissues and nerves.
Researchers have discovered a gene called NANOG that can improve nerve regrowth and re-establish innervation in damaged muscles after traumatic nerve injuries. This discovery has significant potential to help mitigate long-term disability for people with debilitating nerve injuries.
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
The ISSCR 2025 Annual Meeting will bring together stem cell scientists from diverse backgrounds to share knowledge and collaborate on innovative research. Scientists can submit abstracts by January 21, 2025, for oral presentations and qualify for awards.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.
A recent study by Harvard University researchers compares the effectiveness of one-photon (1P) versus two-photon (2P) voltage imaging in neural circuits. The study found that 2P excitation requires approximately 10,000 times more illumination power per cell compared to 1P excitation, posing significant challenges for 2P voltage imaging.
Researchers warn that bio-hybrid robots, which combine living tissue and synthetic components, present novel ethical dilemmas. The technology raises questions about sentience, moral value, and environmental impact, highlighting the need for proper governance and public awareness.
Researchers at Rice University have developed a nanosized sensor that records the electrical activity of spinal neurons in action. The sensor, called spinalNET, can track individual neurons over multiple days, providing valuable insights into the mechanisms controlling movement and sensation in the spinal cord.
Researchers discuss the critical role of the retinal pigmented epithelium in human vision and its susceptibility to aging. The study highlights the importance of understanding molecular and cellular mechanisms driving age-related pathological changes in vision decline.
A longitudinal study has found that tissue bridges in the spinal cord are associated with short- and long-term clinical improvements in patients with cervical spine injuries. The study's models, developed by a team of experts, incorporate tissue bridges for improved prognosis and can be transferred to other patient cohorts.
Researchers have developed a non-invasive optical-acoustic imaging method using short laser pulses to create images of muscle tissue. This breakthrough technology has the potential to improve diagnosis and treatment of spinal muscular atrophy (SMA), a rare genetic disorder causing muscle degeneration.
Researchers at Rice University have developed a novel fabrication process to create aligned peptide nanofiber hydrogels, which can guide cell growth in a desired direction. The study revealed that cells need to be able to 'pull' on the peptide nanofibers to recognize alignment, and excessive rigidity can prevent this.
Researchers have developed a novel rigid endoscope system for visible-to-OTN hyperspectral imaging, enabling non-destructive imaging and visualization of lesions in normal tissues. The system demonstrated high accuracy in classifying molecular vibration information of various targets with an OTN wavelength range.
Researchers have developed a pressure-alternating shoe insole that provides periods of rest to the soft tissues, thereby reducing the risk of diabetic foot ulcers. This innovative technology aims to mitigate the risk of complications from poor circulation and foot sores.
A new study from the University of South Australia explores female experiences with pelvic pain and identifies key concepts for effective pain management. The study found that women value learning about the biological explanation for persistent pain, which can help change outcomes and reduce stigma.
Scientists have uncovered a crucial step in the wound healing process that is disabled in diseases like diabetes and ageing, promoting tissue repair and regeneration. The discovery highlights the importance of sensory neurons in orchestrating the repair and regeneration of tissues.
Scientists discovered a shift in gene regulation by enhancers during embryonic development, showing both 'instructive' and 'permissive' modes of regulation. The study found that developmental stage determines which mode is dominant, allowing for rapid gene expression changes and tissue-specific control systems.
Researchers at Salk Institute uncover a mechanism for repairing damaged nerves during peripheral neuropathy, with protein Mitf playing a key role. The findings have the potential to inspire novel therapeutics that bolster repair function and heal peripheral neuropathy.
Researchers are developing a bioengineered pancreas-like tissue using innovative biomaterials and engineered cells. The goal is to implant these cell-laden scaffolds into patients who need help managing their glucose levels.
Researchers have summarized recent advances in enzyme-activated near-infrared fluorescent probes for non-invasive visualization of enzyme dynamics and disease status. These probes offer high specificity, sensitivity, and biocompatibility, making them valuable assets in biomedical research and healthcare.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
Scientists have developed a way to regulate gene expression in organoids using optogenetics, enabling the observation of cell behavior and development patterns. This breakthrough allows for more accurate reproduction of tissue processes in the petri dish.
Researchers have discovered new insights into microglia-astrocyte communication and its impact on intracerebral hemorrhage, as well as the testicular toxicity of triptolide. Additionally, a study on epicardial cells has identified key gene markers associated with cardiac regenerative therapy strategies.
Researchers at UCSF found a feedback loop between immune protein IL-31 and nerve cells, which dials back nearby inflammation and promotes skin healing. This discovery could lead to new treatments for conditions like eczema, allergies, and asthma by targeting the nervous system's role in regulating the immune response.
A UCLA-led team has discovered the nerve supply that activates brown adipose tissue, a potential key to treating obesity. The study found nerve branches in all eight cadavers dissected, which may lead to using nerves to stimulate BAT activity for weight loss.
Researchers at University of Oxford have developed a miniaturized soft power source that can alter the activity of cultured human nerve cells, paving the way for miniature bio-integrated devices. The device uses internal ion gradients to generate energy, producing a current that persists for over 30 minutes.