Articles tagged with Nerve Tissue
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A new chemical compound named '1938' has been identified that can stimulate nerve regeneration after injury and protect cardiac tissue from damage. The compound activates the PI3K signalling pathway and has shown increased neuron growth in nerve cells and improved recovery in animal models.
Researchers developed a new metric to analyze the relationship between nerve density and oral cancer progression. Normalized nerve density was found to be associated with poor survival rates for patients with tongue cancer, highlighting its potential as a tool for identifying aggressive tumors.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new high-speed two-photon microscope was developed with an unprecedented line scanning frequency of 400 kHz, achieving up to 10,000 frames per second. This allowed for precise observations of complex biological processes in living tissues, including calcium signal propagation and blood flow measurements.
A study by IMBA researchers links muscle degeneration to a deficiency in the enzyme PCYT2, essential for lipid synthesis. PCYT2 depletion affects mitochondrial function and muscle energetics, highlighting the importance of lipid balance in muscle health.
A world-first study from the University of South Australia is providing valuable insights into how young people understand chronic pain, potentially helping thousands of sufferers to better manage their symptoms and long-term wellbeing. Researchers found that young people tend to make sense of chronic pain by explaining it as a softwar...
Scientists have developed a new technique using tissue-embedded nanoelectronic devices to study the functional maturation of stem-cell derived heart tissues. The research found that co-culturing stem-cell-derived cardiomyocytes with endothelial cells enables faster and more efficient maturation, with significant implications for engine...
Researchers created adaptive optical phantoms by combining multiple pigments to mimic target tissue's optical properties, successfully validating them in extensive experiments. The new platform enables broader band spectra for emerging hybrid modalities and novel instruments.
Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.
A new study has identified distinct patterns of circular RNA expression in human ALS muscle tissue, which display disease-specific gradients and could inform about neuromuscular molecular programs in ALS. The research reveals that specific circRNAs are elevated in ALS muscle biopsies but reduced in spinal cord samples from ALS patients.
Researchers have developed an innovative amputated human limb model to evaluate molecularly targeted fluorescent probes for human tissues. The model allows for controlled testing of imaging agents with zero risk to patients, improving the accuracy and safety of surgical procedures.
Researchers at UCSF's Cell Design Institute engineered cells with customized adhesion molecules to form complex multicellular ensembles in predictable ways. The discovery represents a major step toward building tissues and organs through regenerative medicine.
A study published in BMJ Open found that adolescents with hypermobile joints are at a higher risk of developing depression and anxiety. Researchers discovered that psychiatric symptoms were more severe among hypermobile participants, highlighting the need for targeted support and treatment.
Researchers discovered that ant pupae secrete a fluid that is consumed by both adults and larvae, highlighting the interconnectedness of different developmental stages within an ant colony. The fluid, derived from molting, is rich in nutrients and psychoactive substances, essential for larval growth and adult metabolism.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
Researchers at Indiana University School of Medicine developed a minimally invasive nanochip device that can reprogram tissue function by delivering specific genes. The technology has shown promise as a treatment for traumatic muscle loss, with improved muscle function observed in rats following volumetric muscle loss.
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
Researchers at the University of Tokyo have made a groundbreaking discovery about the development of the visual system in mice. By studying the neural networks in cortical and thalamic regions, they found that parallel pathways from the retinas form earlier than connections within cortical areas, challenging current understanding of co...
Researchers developed a low-cost 3D model of the brain to study SARS-CoV-2's neurological effects. The adapted virus replicates 30 times more efficiently in astrocytes than neurons, highlighting the importance of these cells in central nervous system infection.
Oregon State University scientists have created a hydrogel-based technology that helps surgeons identify nerves during procedures, reducing the risk of nerve damage. The innovation uses pluronics, polymers with FDA approval, to create a fluorescent probe that selectively labels tissues within the surgical field.
Researchers have developed a new tool to visualize leukocytes in the brain vasculature during in vivo two-photon laser scanning microscopy. The tool uses a fluorescent antibody targeting CD45, a ubiquitously expressed protein on white blood cells, allowing for tracking of circulating leukocytes over time and space.
Researchers have found that light-based therapies such as photobiomodulation and photodynamics can effectively treat a range of post-COVID complications, including muscle and joint damage. The studies, conducted in Brazil, utilized laser irradiation, negative pressure, and other technologies to improve symptoms and promote healing.
Researchers discovered that neurons carrying a mutation in the Nf1 gene are hyperexcitable and suppressing this hyperactivity with lamotrigine stops tumor growth in mice. The study provides an explanation for why some people with NF1 lack optic gliomas or neurofibromas, highlighting the critical role of neurons in tumor biology.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
A recent Cornell University study reveals that white-tailed deer can shed and transmit the COVID-19 virus for up to five days following infection. The virus replicates in the deer's respiratory tract, lymphoid tissues, and central nervous system, making them a potential reservoir for the virus in nature.
A novel system to control protein aggregation in a model of Parkinson’s disease suggests that aggregation of alpha-synuclein plays a critical role in disrupting neuronal homeostasis and triggering neurodegeneration. Light treatment led to formation of Lewy body-like aggregates, neurodegeneration, and Parkinson-like motor deficits in mice.
A new study from the University of Cambridge has developed an implant coating that incorporates the anti-inflammatory drug MCC950, reducing the 'foreign body reaction' to implants. This reduction allows for improved nerve regeneration and potentially transforms long-term implant treatment for serious disability or illness.
A University of Houston researcher has identified potential biomarkers for neuropsychiatric symptoms of lupus, which include CSF Lipocalin-2, M-CSF, IgM, and complement C3. Elevated levels of these proteins in cerebrospinal fluid may indicate a diagnosis of NPSLE.
Research finds a strong association between retinal age and real age, with large gaps associated with increased mortality risk. The 'retinal age gap' could be used as a screening tool to predict mortality risk, particularly for non-cardiovascular causes.
Researchers at Mount Sinai Hospital are testing a novel light therapy to slow Alzheimer's debilitating effects, aiming to improve both cognition and sleep. The treatment involves flashing pulses of light designed to enhance electrical brain waves and reset the sleep-wake cycle.
Researchers develop tiny tumbling robots called MANiACs that can climb slopes and move against fluid flow in the body, delivering substances to neural tissue. The study finds these robots have potential for controlled local delivery in neural diseases, offering targeted treatment with improved efficacy and reduced side effects.
A new study published in Chemical Senses found that patients who had their wisdom teeth extracted showed improved tasting abilities decades after surgery. The study challenges the notion that removal of wisdom teeth has only negative effects on taste and represents a significant finding in the field.
A team of scientists has identified serum cytokine concentrations as a quick and affordable means of classifying the severity of spinal cord injury in patients. The study aims to provide personalized healthcare decisions and accelerate research into spinal cord injury, with potential applications in developing countries.
A recent study has identified potential risk factors for chemotherapy-induced peripheral neuropathy (CIPN), including age, body mass index (BMI), and low haemoglobin levels. Patients who are older, overweight, or have lower red blood cell counts may be more at risk of developing debilitating nerve damage following chemotherapy.
A Northwestern University study shows how advanced imaging technology can pinpoint the cause of nerve damage in COVID-19 patients. The imaging techniques include ultra-high-resolution ultrasound and MR neurography, which help localize where the problem is and assess the severity of nerve damage.
A phase 1 trial involving 12 children with relapsed neuroblastoma found CAR T cells effective against tumors without damaging nerve tissue. The treatment showed signs of antitumor immunity in some patients and may be further modified to boost persistence within tumors.
Researchers at the University of South Carolina have identified a biological trigger that promotes quicker nerve regeneration. The discovery highlights the importance of protein phosphorylation and Casein kinase 2-alpha (CK2α) in breaking down stress granules, allowing nerves to regrow faster.
A new study from Northwestern University finds that COVID-19 patients on ventilators are at risk of permanent nerve damage due to prone positioning. The study reveals that 12% to 15% of the most severely ill patients have experienced such injuries.
Researchers developed a neural network to assess stored blood quality, achieving 76.7% agreement with experts in identifying damaged red blood cells. The network outperformed expert predictions when trained using only storage duration.
A new study reveals that persistent genital arousal disorder (PGAD) is caused by altered nerve firing and spinal cord damage, which can be treated with neurological interventions. The study found that 80% of patients benefited from treatments targeting the affected nerves and areas.
Researchers at the University of Illinois developed soft robotic devices driven by neuromuscular tissue stimulated by light, enabling biobots to swim and walk autonomously. The new generation of two-tailed bots uses skeletal muscle tissue and optogenetic neurons for propulsion.
Researchers studied tau protein accumulation after a single traumatic brain injury (TBI) in 32 individuals and found increased deposition of tau associated with poorer memory and cognitive performance. Higher tau levels were also linked to more severe neurodegeneration and damage to the brain's white matter.
Researchers at Tampere University found voltage-gated sodium channels in epithelial tissue of the eye, which are involved in renewal of sensory cells and phagocytosis process in retinal pigment epithelium. This discovery reveals new insight on functioning of the eye and retinal diseases.
A new analysis of a 16th-century drawing reveals that Leonardo da Vinci's right hand was affected by ulnar palsy, rather than stroke. The study suggests that the artist's hand impairment may have been caused by traumatic nerve damage, leading to incomplete paintings and limited motor function.
A new study suggests that regular vitamin B12 screening in metformin-treated type-2 diabetes patients can reduce the risk of irreversible nerve damage. The study found that nearly 70% of patients were not being checked for vitamin B12 levels, despite a link to peripheral nerve damage.
Inhalant abuse is a growing concern among teens, particularly those from disadvantaged backgrounds, with up to 125 deaths per year in the US. Deodorant spray contains butane, which can be toxic when inhaled.
A recent study published in Nature Immunology found that B cell accumulation triggers nervous system damage in MS patients. The presence of myeloid-derived suppressor cells (MDSCs) regulates the number of B cells, and their absence leads to inflammation and tissue damage.
Researchers at UConn have created a tiny neuro-controller that can precisely control the movement of cyborg cockroaches. The system, which includes an inertial measurement unit and real-time feedback, enables operators to steer the insect in desired directions.
Researchers have developed a new ALS therapy that extends survival and reverses signs of neuromuscular damage in mice and rats with SOD1 mutations. The investigational drug, an antisense oligonucleotide, has shown impressive effects in preclinical trials.
A new method tracks mechanisms causing nerve cell damage in the heart, a previously unappreciated area affected by Parkinson's disease. The research has implications for testing therapies and exploring causes of fatigue, fainting, and falling.
Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
Researchers at Brandeis University have engineered soft materials with embedded chemical networks that mimic the behavior of neural tissue, paving the way for autonomous soft robotics and dual sensors. The breakthrough material may also lead to artificial skins and exoskeletons.
A study by the University of Nottingham found that current injection methods in UK dairy cattle can damage the sciatic nerve, particularly in cows with low body condition scores. Researchers recommend injecting cattle in the neck or choosing a more lateral location when using the gluteal region to minimize the risk of nerve injury.
A study by Progetto Vita found that 93% of patients treated with an onsite AED survived cardiac arrest, compared to just 9% without an AED. The presence of an AED significantly reduced response times and improved survival rates.
Scientists explore gene therapy for injured peripheral nerves, aiming to improve functional recovery after microsurgical repair. The approach involves modifying a directional cue for nerve cells to promote fast regeneration and functional recovery.
A new study from Case Western Reserve University School of Medicine suggests that replenishing cytokine molecules could repair diabetic nerve damage. Diabetic mice showed low levels of specific cytokines that hindered activation of reparative genes, leading to poor circulation and muscle weakness.
A global study analyzed six clinical trials with over 12,800 patients, finding that 3 months of chemotherapy was nearly as effective as 6 months in patients with lower recurrence risk and caused fewer side effects. The study suggests a new standard for personalized chemotherapy in colon cancer.
Scientists have shown how diesel exhaust particles directly affect the lungs to initiate symptoms such as a tightening of airways and cough. The study found that chemicals on the surface of diesel exhaust particles stimulate nerves in the lungs, leading to respiratory reflexes.
Researchers have synthesized and evaluated three novel aldose reductase inhibitors, showcasing a spirobenzopyran scaffold that inhibits the target enzyme without affecting ARL1. These results suggest a promising tool for developing effective ARIs to treat diabetic complications.