Articles tagged with Pancreas
Researchers at Purdue University have successfully reversed pancreatic cancer progression in a new model called the acinus, which produces digestive enzymes. The study found that reactivating the PTF1a gene in cancerous cells converted them back into normal cells, revealing a potential path to treating pancreatic cancer.
Researchers developed an experimental device to improve blood sugar control in HI patients. The bihormonal bionic pancreas (BHBP) helps maintain stable glucose levels without human error in calculating doses.
Researchers at Vanderbilt University Medical Center developed a standardized MRI protocol for pancreatic imaging, enabling reproducible measurements across different MRI hardware and software. The study demonstrates potential for incorporating MRI into multisite clinical trials, advancing diabetes research and treatment.
Researchers found that a gene called REST is crucial for boosting insulin-producing cells during early pancreas development. Inactivating this gene increased the number of insulin-producing cells, which were maintained into adulthood in mice.
A new artificial pancreas has been successfully trialled in outpatients with type 2 diabetes, showing improved blood sugar control and reduced risk of low blood sugar levels. The device can automate insulin delivery using digital technology, allowing for more effective management of the condition.
Experts at the University of Birmingham argue that patients with type one diabetes need clear professional guidance to use 'Do-It-Yourself' artificial pancreas systems. The lack of legal, regulatory, or ethical guidance for clinicians has led to doctors being cautious about discussing DIY APS with patients.
A new AI algorithm enabled a fully automated artificial pancreas system to achieve improved glucose control without manual input of meal or exercise information. This breakthrough could lead to more efficient and hassle-free diabetes management.
Researchers at La Jolla Institute for Immunology discovered that even healthy individuals have high numbers of preproinsulin-specific T cells in their pancreas. These cells are believed to be the prime suspects in triggering the autoimmune response that causes type 1 diabetes.
A new study reveals that reversing type 2 diabetes can restore the pancreas to a normal size and shape, improving insulin function. After 2 years of weight loss, responders experienced significant growth in pancreas volume and fat reduction, while non-responders showed no change.
A new artificial pancreas system has been shown to prevent hypoglycemia during and after heavy exercise in people with type 1 diabetes. The study, published in the Journal of Clinical Endocrinology & Metabolism, found that the system performed well and was safe compared to standard therapy.
The Control-IQ system, manufactured by Tandem Diabetes Care, safely and effectively manages blood glucose levels in children with type 1 diabetes. The study found that the artificial pancreas did a better job keeping the children's blood glucose within the target range.
The study found that youth using the artificial pancreas system had significant improvements in blood glucose control, including a 7% improvement during the daytime and a 26% improvement at night. The technology improved overall time-in-range by nearly 11%, translating to more hours per day in a healthy range.
A clinical trial found that a new artificial pancreas system improved blood glucose control in children aged 6-13, achieving 7% daytime improvement and 26% nighttime control. The technology replaces traditional testing and insulin delivery, providing greater convenience and safety.
A new study from La Jolla Institute for Immunology found that blocking nerve signals to the pancreas could stop patients from ever developing type 1 diabetes. The researchers used a mouse model and discovered that blocking sympathetic nerve signals protected mice from beta cell death.
Researchers have developed a therapy using engineered T cells to target and treat type 1 diabetes by restoring balance in the pancreas. The treatment involves genetically engineering a patient's own T cells to function like normal regulatory T cells, which then help suppress the overactive immune response.
A team of McGill University researchers has created an artificial pancreas system that significantly improves glucose control, enhancing quality of life for individuals with type 1 diabetes. The system, which combines insulin and pramlintide, has shown promising results in minimizing glucose highs and lows.
Studies in mice and humans with pancreatitis reveal a link between FGF21 deficiency and the disease. Replacement therapy with FGF21 may reverse conditions in about 24 hours, offering a new treatment strategy for acute pancreatitis.
The FDA has approved an artificial pancreas system that automatically monitors and regulates blood glucose levels in people with type 1 diabetes. The system, developed by the University of Virginia, uses a continuous glucose sensor and insulin pump to provide seamless integration and automatic insulin dose adjustment.
Scientists have observed people developing Type 2 diabetes due to liver fat over-spilling into the pancreas. A study showed that individuals can reverse the condition through diet and weight loss, with nearly nine out of ten participants achieving remission.
A team of scientists from Tokyo University of Science has made a breakthrough in understanding the inflammation mechanism in IgG4-related disease. They found that cytotoxic T lymphocytes (CTLs) and T follicular helper cells (Tfh cells) are necessary for pancreatic inflammation, and propose Janus kinase (JAK) as a suitable therapeutic t...
A multi-center trial found that the artificial pancreas system improved users' blood glucose control throughout the day and overnight, reducing hyperglycemia and hypoglycemia events. The study showed significant benefits of the new system over existing treatments, with no severe hypoglycemia events occurring in either group.
A multicenter randomized clinical trial found that the new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, outperforming existing treatments. The system significantly increased time with target blood glucose levels and showed improvements in other diabetes control measurements.
A research team has created a better way to grow an organoid model of the liver, bile duct and pancreas using human pluripotent stem cells. The resulting organoid bears a striking resemblance to its corresponding organs and demonstrates the potential for personalized modeling in studying organ development and disease.
A new artificial pancreas system improved blood glucose control throughout the day and overnight, reducing time in range for high and low glucose levels. The system also showed improvements in hemoglobin A1c and other measurements related to diabetes control compared to current technology.
A new artificial pancreas system improved participants' blood glucose control throughout the day and overnight, reducing the risk of low blood sugar levels. The system's advanced algorithms and safety features enabled users to achieve near-normal blood sugar levels every morning.
A new artificial pancreas system has been shown to improve blood glucose control throughout the day and overnight, offering a significant advantage over existing treatments for people with type 1 diabetes. The system, which automatically monitors and regulates blood glucose levels, was more effective than traditional therapies in achie...
Researchers at Technical University of Munich have discovered a specific neuroenzyme responsible for analgesics resistance in chronic pancreatitis. The team found that targeting this enzyme, nNOS, with an existing inhibitor reduces pain perception in animal models, offering new hope for pancreatic patients
Researchers created a human pancreas on a chip that can mimic the human pancreas and potentially help find therapeutic measures to manage glucose imbalance in people with cystic fibrosis. The device was used to study CF-related diabetes and type 1/2 diabetes, opening new possibilities for disease research.
Patients with Type 1 diabetes who are obese often face denied pancreas transplantation due to high infection risks. However, robotic pancreas transplantation has shown promising results, reducing blood loss and surgical complications while improving patient outcomes.
Researchers found that mice eating a high-fat diet who fasted every other day had reduced pancreatic fat and lower blood sugar levels. This suggests that intermittent fasting may be a therapeutic approach to prevent type 2 diabetes by reducing fat accumulation in the pancreas.
Researchers discovered a key clue into pancreas development by studying rare patients born without a pancreas. A previously unexpected pathway was identified, confirming its role in human and mouse pancreas formation.
The study shows that Wt1 gene deletion causes deterioration of the pancreas and activates stellate cells, which play a key role in pancreatic cancer progression. The results suggest Wt1 gene is necessary for normal pancreas maintenance and repair after damage.
A new study reveals that the development of progenitor cells depends on protein quantity and interaction with other cells. Cells with high P120ctn expression remain in the central part of the pancreas, while those with low expression migrate to the peripheral area, where they acquire their final fate.
Researchers at MIT have developed a way to measure oxygen levels of pancreatic islet cells over long periods, enabling them to predict which implants will be most effective in treating diabetes. This breakthrough could lead to better designs for artificial pancreas systems.
Researchers have made significant progress with UVA's artificial pancreas, a device that automates blood-sugar level monitoring and insulin injection. The International Diabetes Closed Loop Trial has provided early results from its nationwide clinical trial, examining the algorithm's use in smartphone apps and embedded devices.
The interoperable Artificial Pancreas System smartphone app has shown improved time in the target glucose range and a statistically significant reduction in time below 70mg/dL. The study suggests that this system could provide personalized care for patients with diabetes, offering flexibility and convenience.
Researchers at Stanford University have developed a zinc-based regenerative drug that selectively targets insulin-producing cells in the pancreas, potentially paving the way for more appealing alternatives to insulin injections. The method uses chelation to deliver a drug to beta cells, which have a strong affinity for zinc.
Researchers studied pancreas duct formation in mice and found that the network resembles road networks, with stronger ducts expanding and weaker ones shrinking. This study may lead to better understanding and treatment of cystic fibrosis and other diseases involving abnormal duct formation.
A pilot study found crystalline particles of titanium dioxide in pancreas specimens with Type 2 diabetes, suggesting a possible link between the white pigment and the disease. The study suggests that increased use of titanium dioxide may contribute to the global rise in T2D cases.
Researchers at Oregon State University have developed transparent transistors that can be fabricated onto curved surfaces, paving the way for improved diabetes therapy. This innovation is a key step towards creating an artificial pancreas, which can detect blood sugar levels and transmit information to a wearable insulin pump.
A review of 41 trials involving over 1000 people with type 1 diabetes found that artificial pancreas systems provided almost two and a half extra hours of normal blood glucose levels per day. The treatment also reduced time spent in both hyperglycaemia and hypoglycaemia compared to other types of insulin-based therapy.
Researchers at CNIO discovered that a gene controlling inflammation also increases pancreatic cancer risk. The study suggests new strategies for prevention and detection of the disease.
A new study published in Cancer Cell suggests that stress accelerates the development of pancreatic cancer by triggering the release of 'fight-or-flight' hormones. Beta-blockers, commonly used medications that inhibit these hormones, were found to increase survival in a mouse model of the disease.
Researchers from Wake Forest Institute for Regenerative Medicine discovered that sodium percarbonate and calcium peroxide improved insulin-producing cell function and viability in lab-built bioartificial pancreas. Oxygen-generating materials could potentially supplement cells' high oxygen needs, aiding in diabetes treatment.
Congenital hyperinsulinism is caused by a genetic mutation that leads to permanent activation of the GDH protein, resulting in excessive insulin production. This triggers chronic hypoglycaemia, brain damage, and intellectual retardation. A new study may pave the way for novel therapies, including a drug that inhibits the GDH accelerator.
University of Toronto researchers successfully transplanted healthy pancreatic cells under the skin to produce insulin, restoring normal blood sugar levels in a short period. The study's findings suggest that this method could provide a more manageable and efficient way to treat type 1 diabetes.
A minimally invasive approach to treating chronic pancreas disease resulted in fewer complications, shorter hospital stays, and less need for opioids. The procedure also showed promising results in reducing pain scores and opioid therapy needs.
A pilot study found that a University of Virginia-developed artificial pancreas helped young children with Type 1 diabetes better control their condition. The device automatically monitors and regulates blood-sugar levels, reducing the need for frequent finger pricks and insulin injections.
Researchers at the University of Helsinki have discovered that premature cell differentiation caused by a STAT3 gene mutation can lead to underdeveloped pancreas and early onset of neonatal diabetes. The study used induced pluripotent stem cells to examine the impact of the mutation on pancreatic development.
A modified Fistula Risk Score (FRS) based on ACS NSQIP data helps surgeons identify high-risk patients for anastomotic leak after pancreas resection. The risk score also assesses the quality of patient care and evaluates new interventions to prevent fistula development.
A new study finds that an artificial pancreas system improves blood glucose control better than usual home management for children aged 5 to 8 years with type 1 diabetes. The wearable device uses computer algorithms to track blood sugar levels and adjust insulin dosing, resulting in a longer time in the target range.
Researchers have successfully reprogrammed liver cells to behave like precursor cells that give rise to the pancreas, paving the way for potential cell therapies for type I diabetes. By altering a single gene, the team induced an identity crisis in liver cells, which then developed into cells with pancreatic properties.
A team of researchers has identified a common regulatory grammar in islet cells that affects the activity of Regulatory Factor X, a master regulator involved in gene expression. Many Type 2 diabetes-linked DNA changes disrupt this grammar, leading to a range of health problems.
The Helmholtz Zentrum München will receive 1.5 million euros to develop stem cell culture models on a chip for investigating pancreatic diseases and testing therapy options. The goal is to explore biology, identify points of attack, and potentially develop beta cell replacement therapy.
Four NIH-funded research projects aim to test and refine fully automated artificial pancreas systems, replacing traditional methods for managing type 1 diabetes. The studies will evaluate safety, efficacy, user-friendliness, and cost, with the goal of bringing these life-changing devices to those who need them.
Clinical trials are now enrolling at the University of Virginia Health System to test an artificial pancreas that automatically regulates blood-sugar levels in people with type 1 diabetes. The trials will examine safety, effectiveness, and cost as well as physical and emotional health.
A new study found that low thyroid hormone levels before birth impair the growth and development of the fetal pancreas, affecting insulin-secreting cells. This could lead to increased risk of pancreatic disorders and type 2 diabetes in later life.
Researchers at UT Southwestern Medical Center have identified a novel mechanism by which the stress hormone FGF21 protects the pancreas from damage caused by digestive enzymes. This discovery may lead to new treatments for pancreatitis, a potentially life-threatening inflammation of the pancreas.
The bionic pancreas system successfully reduced average blood glucose levels and decreased the risk of hypoglycemia in patients with type 1 diabetes living at home. The system's automated monitoring and dose delivery significantly improved blood sugar control, reducing the risk of severe hypoglycemia and nocturnal episodes.
Research reveals a significant link between elevated blood fats and acute pancreatitis, with even mild increases posing a ninefold greater risk. The study's findings highlight the need for further research into the role of common fats in disease development.