Articles tagged with Regulatory T Cells
Researchers have developed a protocol to expand regulatory T cells ex vivo, which can induce tolerance to donor tissue and control graft-versus-host disease. This approach may lead to the development of new clinical trials using CD4+CD25+ regulatory T cells.
Researchers at Duke University Medical Center have developed a strategy using erythropoietin to enhance heart function and prevent cell death after ischemic injury. A novel protective effect of erythropoietin has been shown in the infarcted heart, demonstrating a therapeutic window of opportunity for acute protection and long-term pres...
The study identifies three novel genes EDG1, PAK2, and TRAC-1 that repress T-cell receptor signalling in T-cells. These genes were discovered using a retroviral approach that allowed researchers to screen for genes critical for immune regulation.
Salicylic acid has been shown to downregulate two key genes in Staphylococcus aureus, leading to reduced virulence and ability to adhere to host cells. Meanwhile, osteopontin has been found to play a critical role in the development of rheumatoid arthritis by facilitating cell adhesion and immune response modulation.
Researchers have discovered a protein in the eye that can successfully treat an autoimmune disease by converting conventional T cells into regulatory T cells. The study found significant reduction in uveitis severity and prevention of disease onset in mice models.
A new study has found that a second set of immune cells, known as regulatory T cells, prevent attack cells from acting against cancer. The study discovered that these regulatory T cells communicate with the attack cells via a messenger chemical called TGF-beta.
The study found that a critical balance exists between T helper cells and regulatory T cells in preventing autoimmunity. Regulatory T cells can suppress the development of autoimmunity in lupus-prone mice, suggesting a potential new approach to treating autoimmune disorders.
Researchers at the University of Iowa have discovered that perforin and interferon gamma regulate the initial immune response and residual protective immunity. These molecules control T cell generation, survival, and differentiation, allowing for a precise balance between responding to pathogens and exhausting the immune system.
Researchers identified a novel subset of T-cells called CD4-CD8- double negative regulatory T cells that can regulate killer T-cells and prevent rejection of donor tissue. These cells act as a kind of decoy, binding to the same antigen as killer T-cells and being destroyed, thereby inhibiting the immune response.
A study found that IL-2 plus HAART treatment reduced the number of resting CD4+ T cells harboring HIV, making it harder for the virus to replicate. Researchers detected no replication-competent HIV in peripheral blood samples from patients treated with IL-2 plus HAART.