Researchers found that pancreatic cancer growth can be arrested by blocking the Hedgehog signaling pathway, which is active in human embryonic development. This pathway has been linked to several other types of cancer and may offer a new treatment avenue for pancreatic cancer.
A recent study found that women widowed less than a year experience more mental and physical problems compared to those who were married or widowed for longer. However, these women's mental health improved over time with social support.
A study found that chronic drinking elevates cortisol levels both during intoxication and withdrawal, impacting overall health. Elevated cortisol is also associated with increased risk of medical and psychiatric problems such as diabetes and cognitive deficits.
A study found that chronic alcoholism can cause damage to both the prefrontal cortex and cerebellum, leading to deficits in executive functioning and balance. The research suggests that lesions in the frontocerebellar circuitry may compound their effects on these functions.
Research confirms that female alcoholics experience more severe cardiovascular effects from heavy drinking than male counterparts, with these effects emerging sooner and at lower consumption levels. This phenomenon, known as 'telescoping,' highlights the need for women to be aware of their increased risk of heart disease due to alcohol...
Researchers found genetic mutations in PHF9 disrupt critical intracellular repair mechanisms, leading to Fanconi Anemia's serious complications. The discovery highlights the importance of PHF9 as a potent cog in DNA repair machinery, with potential implications for preventing excessive DNA damage and cancer.
The study identifies three novel genes EDG1, PAK2, and TRAC-1 that repress T-cell receptor signalling in T-cells. These genes were discovered using a retroviral approach that allowed researchers to screen for genes critical for immune regulation.
A longitudinal study found black and Hispanic couples are two to three times more likely to report partner violence than white couples, even after controlling for socio-demographic and psychosocial variables. The study identified ethnic differences in risk factors for partner violence.
Researchers at PhageTech identified phage-derived antimicrobial proteins that inhibit bacterial growth and kill bacteria in diverse ways. The company's technology platform has led to the discovery of novel bacterial targets essential to bacterial growth, which are being screened for small molecule compounds as potential new antibiotics.
Women in marriages with high relationship satisfaction show lower levels of cardiovascular risk factors, including blood pressure, cholesterol levels, and body mass index. High marital satisfaction also promotes healthy behaviors and protects against social isolation.
Researchers discovered that sensory cells in mouse inner ear develop rapidly between days 16 and 17 of gestation, mirroring human fetal development. Understanding this process is crucial for regenerating sensory hair cells in the human ear.
Researchers discovered the protein PHF9, which disables the function of the FA pathway, a network critical for DNA repair, blood development, and fertility. This breakthrough provides new insights into Fanconi anemia, a rare genetic cancer-susceptibility syndrome affecting millions worldwide.