Articles tagged with Regulatory T Cells
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Researchers mapped the molecular pathways and signaling circuits of CD8+ T cells responding to infections and cancer. They identified novel biological pathways and discovered highly dynamic processes as these cells develop. The study aims to help advance vaccine development and cancer immunotherapy.
Researchers discovered that replacing missing gut bacteria or restoring a key metabolite called inosine could help treat children with IPEX syndrome, an often fatal autoimmune disease. The study found that probiotic Lactobacillus reuteri and A2A receptor agonists inhibited T cell-mediated autoimmunity, extending the animals' life span.
Researchers found that regulatory T cells in tumors have distinct features and differences compared to normal tissue, making them potential biomarkers or therapeutic targets. The study aims to improve cancer immunotherapies by targeting specific molecules expressed by these immune cells.
A new study reveals that exhausted T cells, which often fail to combat chronic infections and cancer, use a distinct set of molecular circuits. By targeting specific genes involved in PD-1 expression, researchers hope to improve CAR T cell therapy by re-tooling these cells to be more aggressive and effective against cancer.
A team of researchers from ETH Zurich has discovered that a specific subset of blood cells - the regulatory T cells - can suppress lymphedema. This finding could help develop therapies to cure lymphedema by targeting inflammatory responses.
Researchers have developed a new approach to limit side effects of stem cell transplants by stimulating the formation of regulatory T cells in recipients. Pretreating mice with STAR2 protein protected them from developing GvHD, while donor-derived cells retained their ability to kill recipient's tumor cells.
Research led by Catherine Hedrick found that removing ATP-binding cassette transporter G1 (ABCG1) from immune cells increases regulatory T cell production, decreases pro-inflammatory T cells, and reduces atherosclerotic lesions in mice. This suggests that therapies targeting ABCG1 could help control atherosclerosis.
Research suggests that certain microbes in the air can be beneficial for human health, reducing allergy rates and improving immune function. By designing buildings with ventilation systems that bring in fresh outdoor air, architects can facilitate exposure to these beneficial microbes.
Researchers identified a critical immunotherapy target by marking dysfunctional regulatory T cells in glioblastoma multiforme patients. Anti-PD1 therapies may drive further regulatory T cell dysfunction, suggesting potential treatment benefits.
Early antibiotic use can permanently alter the diversity of children's immune cells, potentially leading to increased risks of inflammatory bowel disease and allergies. The study aims to understand how antibiotics impact T cell education and balance in the gut microbiota.
Researchers have developed a novel therapeutic approach using nanomedicines called Navacims that can reprogram white blood cells to become regulatory cells capable of blunting autoimmune responses. The treatment has shown promising results in preclinical models of diabetes, multiple sclerosis, and rheumatoid arthritis.
A study reveals Sharpin's role in regulating survival of immunosuppressive T cells, essential for preventing autoimmune disease and cancer. Sharpin-deficient mice develop severe skin lesions and inflammation due to reduced Treg counts.
Regulatory T cells use autophagy to maintain stability and function during their task of preventing autoimmune disease. Eliminating this process can lead to excessive cell death and loss of identity in the cells.
Researchers at BIDMC have identified a novel strategy to decrease immune responses in inflammatory bowel disease (IBD), by targeting the ecto-enzyme CD39 on Tc1 immune cells and modulating purinergic signaling. This approach shows promise for reducing inflammation and improving symptoms in patients with IBD.
Researchers at Monash University discovered that regulatory T cells can function even when their receptors bind to MHC in a completely different orientation, challenging established views on the immune system. This finding opens up new avenues for investigating and potentially treating autoimmune diseases like type 1 diabetes.
A study published in Cell suggests that melatonin levels correlate with MS symptom severity, particularly during the fall and winter months. Researchers found that melatonin has a protective effect on immune cells, dampening the immune response and reducing disease progression.
Researchers have discovered a potential new treatment for type 1 diabetes using the anti-inflammatory cytokine interleukin-35, which can reverse or cure the disease in mice models. The study also found that IL-35 concentrations are lower in T1D patients than healthy individuals.
A multi-institutional team of researchers has identified an apparently successful treatment for a genetic immune disorder that causes a multitude of health problems. The FDA-approved drug abatacept was tested on a small group of patients, resulting in improved lung function and reduced autoimmunity.
Regulatory T cells (Treg cells) play a critical role in shaping the immune response and maintaining self-tolerance. A recent study by LJI researchers identified a molecular pathway that maintains Treg cell stability and suppressive function, crucial for immune system balance. The discovery suggests that Treg cells may not be stable und...
Scientists at the University of Manchester have identified crucial molecules that allow regulatory T cells to function and cure active inflammation. This discovery could lead to improved therapies for autoimmune diseases such as type I diabetes, rheumatoid arthritis, and inflammatory bowel disease.
Researchers at SLU discover a mechanism to train potentially aggressive T-cells to become regulatory T cells that police other T cells' responses. Increased expression of CD5 helps these self-reactive T-cells survive and become 'T-cell policemen', minimizing the risk of autoimmune disease.
Researchers aim to improve stability of transplanted regulatory T cells using computational modeling and analysis. The goal is to develop new treatment options for diseases characterized by excessive inflammation.
Scientists at Mainz University have discovered a new sub-population of regulatory T cells linked to allergic asthma. The Treg cell type plays a decisive role in developing and manifesting the disease, making it a promising early diagnostic indicator.
Research from St. Jude Children's Research Hospital reveals that PTEN tumor suppressor protein is essential for proper regulatory T cell function, helping to prevent autoimmune diseases. The study identified a crucial role of PTEN in controlling Tfh cells and autoantibody production, offering new focus for improving treatment.
Researchers develop a novel method to determine how T cells differentiate into specialized types of cells that help eradicate infected cells. The study identifies two previously unknown factors, Cyclin T1 and Cdk9, which work together during T cell differentiation.
Scientists have discovered that gut immunity actively maintains healthy bacterial communities through precise regulation of immunoglobulin A production by regulatory T cells. This complex interplay between the immune system and bacteria is crucial for preventing autoimmune disorders associated with dysbiosis in the gut.
Researchers at the Garvan Institute of Medical Research have discovered that B cells participate in the development of regulatory T cells, which control how killer T cells behave. This finding has implications for treating autoimmunity and preventing transplant rejection.
Scientists have discovered that endogenous dendritic cell-derived interleukin-27 promotes tumor growth by recruiting regulatory T-cells. This finding suggests that targeting IL-27 could lead to more effective cancer immunotherapies.
Researchers at La Jolla Institute for Immunology have identified a novel interaction between Protein Kinase C-η and CTLA-4, a key immune checkpoint receptor. This finding may lead to new tumor immunotherapy strategies targeting CTLA-4.
A study published in The Journal of Immunology found that Interleukin 21 (IL-21) contributes to fatal inflammatory disease, particularly when another cytokine is deficient. Removing IL-21 can greatly subdue the inflammatory response and may help people with chronic inflammation due to defective T cell regulation.
Researchers found that loss of TSC1 in T cells disrupted the balance between regulatory and effector T cells, leading to severe inflammation. The study suggests that fine-tuning mTOR activity through regulators like TSC1 may be beneficial for treating autoimmune and inflammatory diseases.
Researchers found that regulatory T-cells express high levels of the enzyme ALDH and are resistant to cyclophosphamide, allowing them to protect patients from graft-versus-host disease. This discovery may lead to new therapies to prevent or treat cancer relapse after a transplant.
A new study found that butyrate, a fatty acid produced by gut bacteria, induces the production of regulatory T cells in the gut, boosting the immune system. This discovery supports the use of butyrate as therapy for inflammatory bowel diseases like Crohn's disease and may lead to personalized preventive medicine.
Researchers found that Itch maintains the stability of regulatory T cells (Tregs), which promotes Th2 inflammatory responses and severe airway inflammation in mice. This study highlights the importance of Itch in regulating immune responses and preventing allergic diseases.
Researchers have discovered a link between prenatal exposure to tobacco smoke and increased risk of allergies in children. High levels of microRNA-223 were found in pregnant women exposed to cigarette smoke, correlating with low regulatory T-cell numbers in their babies' cord blood.
Researchers at Helmholtz Centre for Infection Research found that lymph nodes in certain locations produce more regulatory T cells, which mediate tolerance to harmless substances. This 'location-specific memory' is crucial for maintaining the balance of the immune system and preventing autoimmune diseases.
Researchers at St. Jude Children's Research Hospital discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. The mechanism focuses on regulatory T cells and proteins semaphorin-4a (Sema4a) and neuropilin-1 (Nrp1).
Researchers at Johns Hopkins Children's Center have identified a genetic pathway implicated in various allergic disorders, including asthma and eczema. A faulty protein called transforming growth factor-beta (TGF-beta) disrupts immune cell function, leading to the development of allergies.
Researchers have uncovered the cell death processes that determine regulatory T cell numbers, which can lead to better treatments for autoimmune diseases. The discovery of Bcl-2 family proteins as determinants of regulatory T cell numbers offers new ways to control these cells and potentially suppress autoimmune disease.
Researchers found that mTORC1 serves as a rheostat to control regulatory T cells, which suppress the immune system's inflammatory response. The study challenges prior understanding of the mTOR pathway's role in regulating specialized T cells.
Researchers found that estrogen and interleukin-6 collude to cause immune cell misconduct and fuel autoimmune liver damage. Female mice with intact ovaries developed worse liver damage than those without ovaries, suggesting a key role for estrogen in the condition.
A subset of regulatory T cells has been identified that can remove pathogenic T cells, inhibiting disease progression in RA-like conditions. Small proteins have also been found to induce more of these beneficial T cells.
A study led by Columbia University Medical Center researchers found that an important branch of the immune system mounts a surprisingly robust anti-inflammatory T cell response to prevent atherosclerosis progression. Regulatory T cells suppress pro-inflammatory effector T cells and macrophages, reducing disease severity.
Research reveals IkBNS promotes formation of Foxp3, key feature of regulatory T cells, and influences NFkB family of transcription factors. Manipulating IkBNS could lead to therapeutic breakthroughs for autoimmune diseases and inflammation.
A growing body of literature suggests that alterations in regulatory T cell function may contribute to the development of sepsis. Manipulating these cells may offer a promising approach to treating patients with septic shock. The Journal of Interferon & Cytokine Research reviews the current understanding of this complex immune response.
A new study led by University of Pennsylvania researchers has identified a crucial signaling molecule involved in counterbalancing the immune system attack. Regulatory T cells, or Tregs, play a key role in suppressing inflammatory responses and preventing autoimmune diseases.
A new study published in Nature suggests that vaccines could be developed to prevent premature birth and pregnancy complications by stimulating the production of immune suppressive cells. These cells, which are generated during pregnancy, can tolerate foreign antigens and provide protection to the fetus.
Researchers found that T cell imbalance increases risk for gastrointestinal infection recurrence, particularly in C. difficile cases. Patients with recurrent infections had higher levels of regulatory and TH17 cells, which could lead to targeted molecular therapies.
Researchers reveal that Langerhans cells can perform either immunosuppressive or immunostimulatory functions depending on the situation. They found that LCs induce proliferation of regulatory T cells to maintain tolerance under normal conditions, but also stimulate protective immune responses against pathogens.
A study by Vanderbilt University Medical Center researchers has found that disruptions in the immune system's regulation may play a role in necrotizing enterocolitis (NEC), a deadly disease affecting premature infants. The findings suggest a new target for therapeutic interventions to prevent NEC.
Scientists at the University of Nottingham discovered a new mechanism that explains how infections can trigger multiple sclerosis relapses. Regulatory T cells, which regulate immune responses, become less inhibitory when stimulated by bacterial or viral molecules, leading to increased inflammation.
A new study found that growing up on a farm increases regulatory T-lymphocytes, cells that damp down the immune system and limit immune responses. This shift in cell ratio is associated with reduced antibody responses to food proteins and lower risk of allergies.
Regulatory T cells (Tregs) downregulate helper T cell activity, suppressing immune response. This can lead to cancer progression and escape from immune defense. The study aims to understand Treg mode of action and develop immune therapies against cancer.
UCSF researchers found that tissues can remember and activate T regulatory cells to defend against autoimmune diseases. The discovery may lead to new strategies for fighting autoimmunity and preventing transplant rejection.
Georgia Health Sciences University researchers aim to identify early events in Sjögren's syndrome development to improve diagnosis and treatment. The study focuses on immune cells, particularly dendritic cells and T cells, to understand how the disease unfolds.
Researchers at Moffitt Cancer Center have found a way to 'expand' regulatory T-cell (Treg) cells to prevent graft-versus-host disease (GVHD), a serious risk in many cell transplants. The new method uses dendritic cells to activate Tregs, offering a potential breakthrough in preventing GVHD while sparing beneficial immune responses.
Researchers at University of North Carolina Health Care identified genetic underpinnings of Foxp3-expressing regulatory T cells, crucial for preventing autoimmune and inflammatory disease. The study sheds light on potential therapeutic targets for diseases like type I diabetes, arthritis, and lupus.
A new study published in Immunity sheds light on the complex mechanisms underlying immune tolerance and regulatory T cells. Researchers discovered that GATA-3 controls Foxp3 expression, revealing a crucial role for this transcription factor in regulating Treg function and immune response.
A specialized regulatory T cell that expresses three specific genes has been discovered to shut down the mass production of antibodies in the immune system. This finding has potential implications for treating cancer and autoimmune diseases.
Researchers at the University of Minnesota have identified a potential therapy to boost resistance against prenatal infections by manipulating an immune suppressive cell type. This approach allows pregnant women to more efficiently fight off infections without compromising pregnancy outcome.