Articles tagged with Saliva
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A study published in Annals of Oncology found that acupuncture can relieve symptoms of dry mouth (xerostomia) caused by radiotherapy for head and neck cancers. Patients who received acupuncture reported improved dry mouth symptoms, while those receiving oral care education showed no significant improvement.
A new study of human twins suggests that environmental factors play a larger role in shaping the types of microbes in the mouth than genetic background. The research found that saliva samples from identical and fraternal twins showed similar microbial communities, indicating that environment contributes more to oral bacteria.
Researchers have identified a gene strongly linked to appetite regulation as a predictor of premature infants' feeding readiness. The NPY2R biomarker in saliva declines with maturity, allowing non-invasive testing for optimal feeding care.
A new clinical trial aims to develop a simple saliva test that can detect oral cancer in its early stages. The test has the potential to reduce the number of unnecessary biopsies and improve survival rates for patients with this common cancer, which affects over 60,000 people worldwide.
Recent studies have increased interest in salivary biomarkers for diagnostics, but challenges persist in collection, storage, and quantitation of biomarkers. Researchers will discuss standardization procedures and address issues with proteomic methods.
A saliva test used to diagnose HIV has been found to be comparable in accuracy to the traditional blood test, according to a new study. The test showed high sensitivity and specificity rates of 99% and 97%, respectively, making it a promising tool for HIV diagnosis, particularly in high-risk populations.
Researchers demonstrate that an anti-caries DNA vaccine, pGJA-P/VAX, combined with a Salmonella protein adjuvant, enhances saliva IgA responses and protects against dental caries. The study shows that the adjuvant promotes specific immunoglobulin A responses in saliva and offers better protection against caries.
A new saliva test can measure the levels of five key DNA adducts, which form when potentially cancer-causing substances bind to DNA. The test is convenient and non-invasive, making it a potential tool for health promotion and disease prevention.
UC Riverside researcher Joao Pedra to investigate immune system response to rickettsial infections, potentially leading to novel therapeutics against devastating tick-borne diseases.
Researchers at UCLA have developed a patented test that uses methylation patterns in DNA to accurately predict a person's age within five years. This test could offer a new forensic tool for crime-scene investigations, as well as personalized medicine applications, such as tailoring medical interventions based on an individual's bio-ag...
A new screening method using newborn saliva has been shown to effectively identify CMV infection in newborns. The test achieved a sensitivity of 97.4% when dry samples were used, making it a promising tool for widespread screening programs. Researchers are now exploring the contribution of congenital CMV infection to overall hearing loss.
The PARSPORT trial found that intensity-modulated radiotherapy (IMRT) spares the major salivary glands, reducing xerostomia and improving quality of life in head and neck cancer patients. IMRT significantly reduces the incidence of dry mouth and leads to recovery of saliva secretion.
A study from the Monell Center reveals that salivary amylase activity shapes how people perceive starchy food textures. Variability in enzyme levels influences starch digestion and metabolism, potentially impacting insulin resistance and diabetes risk.
Researchers at Mount Sinai School of Medicine found that BPA released from plastic resins used in pediatric dentistry is detectable in saliva after placement in children's mouths. The team recommends using alternative BPA derivatives and taking precautions to reduce exposure.
Researchers analyzed bed bug saliva proteins to understand their role in feeding and potential medical applications. The study found unique enzymes that characterize the saliva profile of Cimex lectularius, a blood-feeding insect with over 250 million-year survival success.
Scientists at Cornell University found that compounds in Guatemalan potato moth larvae saliva increase photosynthesis and starch production in commercial potato plants, resulting in bigger tubers. Yield increases were observed when 10-50% of potatoes were infested, with marketable yields doubling or tripling.
A study found that the traditional 'heel stick' test is not an effective screening tool for cytomegalovirus (CMV) infection in newborns. The test, which involves pricking a baby's heel and analyzing dried blood samples, was unable to detect CMV DNA in up to 40% of infected babies.
Yale researchers have discovered that a protein found in tick saliva helps protect mice from developing Lyme disease. The findings may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites.
The study found that older women have almost twice as many immune-related proteins in their saliva than younger women. This discovery could lead to a simple, noninvasive test for diagnosing and treating age-related diseases in women.
Researchers at UCLA have confirmed the effectiveness of measuring microRNAs in saliva to detect oral squamous cell carcinoma. The study identifies two specific microRNAs, miR-125a and miR-200a, that are present at significantly different levels in the saliva of individuals with oral cancer.
Dry mouth, caused by decreased salivary function, affects one in four Americans and is linked to over 400 prescription and non-prescription drugs. Patients may experience symptoms like constant thirst, difficulty eating or speaking, and increased tooth decay risk.
Researchers have made significant breakthroughs in salivary diagnostics, discovering new biomarkers for detecting oral cancer, acute coronary syndrome, and systemic diseases. The study highlights the potential of saliva as a non-invasive diagnostic tool, offering clear clinical advantages over traditional methods.
Researchers have found a protein in tick saliva that works as a complement inhibitor, improving the health of rats with mild and severe models of myasthenia gravis. The protein, rEV576, may have therapeutic value in human myasthenia gravis and could offer a new treatment option with reduced side effects.
A University of Oregon anthropologist found that women experience poorer dental health than men due to dramatic changes in female-specific hormones, reduced saliva production, and increased food cravings during pregnancy. The study suggests that these factors contribute to a higher risk of cavities in women as they age.
Researchers have identified five biomarkers in saliva that can confirm the presence of oral squamous cell carcinoma with 93% accuracy. The study, led by David T. Wong and Shen Hu, demonstrates a new approach for cancer biomarker discovery using saliva proteomics.
Researchers discovered a compound in human saliva, histatin, that accelerates wound healing. Histatin was found to close almost completely after 16 hours in the wound model.
Researchers developed a nano-bio-chip device that analyzes saliva to detect proteins associated with heart attack, offering a non-invasive and rapid diagnostic tool. The test can identify current heart attacks and predict future risk, potentially saving lives and preventing damage from cardiac disease.
A 2007 case of saliva manipulation in a paternity test led to significant changes in forensic protocols for similar cases. The manipulation attempt was discovered after repeated analysis revealed DNA from two different persons in the suspect's mouth, highlighting the need for special measures to prevent expert error and crime.
The Salivaomics Knowledge Base (SKB) is an in silico saliva diagnostic atlas mapping salivary proteome and transcriptome to human chromosomes. The database includes profiles from healthy individuals and oral cancer patients, allowing for comparisons between groups. Future expansions will include other cancers and diseases.
Researchers have catalogued the complete salivary proteome, a set of proteins in human ductal saliva, which tracks closely with that of blood. This breakthrough promises less invasive and costly disease diagnosis and treatment monitoring.
Researchers have developed novel approaches to analyze proteins in human saliva and diseased heart tissue, potentially leading to earlier diagnoses of heart disease and oral cancer. By tracking changes in protein profiles over time, scientists may identify key biomarkers for therapeutic intervention.
A new molecular signature predicts response to lenalidomide in patients with myelodysplastic syndrome without chromosome 5q deletions. Gene expression profiling identifies a defect in erythroid differentiation, providing potential treatment insights.
Research at Umea University in Sweden has shown that hantavirus exists in human saliva, sparking concerns about its potential spread among humans. The study found virus RNA in saliva samples from 10 out of 14 patients with nephropathia epidemica during last year's epidemic.
Researchers have identified specific protein markers in human saliva that can provide an early, non-invasive diagnosis of breast cancer. The study found 49 proteins that differentiated healthy patients from those with benign and malignant breast tumors.
A recent study published by the University of Texas Medical Branch at Galveston found that bites from uninfected mosquitoes can make West Nile virus worse in lab mice. The research showed a significant increase in mortality rates when mice were exposed to multiple mosquito feedings before being infected with West Nile virus.
The University of California - Los Angeles School of Dentistry has received a $1,876,920 NIH grant to develop an innovative tool for rapid and reliable assessments of the stress response to trauma as evidenced in saliva. This technology aims to unite healthcare providers in delivering comprehensive care to patients with facial trauma.
Researchers found that chronically bullied kids have lower cortisol levels, linked to anxiety and stress. The study suggests a biological marker for early recognition and intervention of long-term psychological effects on youth.
A Sandia National Laboratories handheld device determines if a patient has gum disease and quantifies its advancement in minutes from a tiny saliva sample. The device's technology also shows promise for detecting biotoxins, improving prostate and breast cancer diagnosis, and measuring animal serum in vaccines.
Scientists have identified salivary proteins and RNA sequences that are highly discriminatory for oral cancer and Sjögren's Syndrome. The use of saliva as a diagnostic tool is only a few years away, with the potential to revolutionize disease detection.
Dr. Dowen Birkhed, a renowned expert in dental caries research, has received the prestigious IADR Research in Dental Caries Award. Over 35 years of dedicated research have led to numerous publications and awards.
Researchers have identified amylase, an enzyme in saliva, as a biochemical marker linked to sleep loss. Flies subjected to prolonged sleep deprivation showed increased amylase levels, similar to humans who were kept awake for extended periods. The discovery aims to develop diagnostic tools and improve understanding of sleep disorders.
Researchers developed a safer method for large-scale malaria screening using PCR tests in urine and saliva, instead of blood. This approach reduces the risk of spreading HIV and other diseases, while maintaining high sensitivity for clinically significant infections.
Cysteine-containing chewing gum may help eliminate acetaldehyde, a carcinogenic compound found in saliva and upper digestive tract. Long-term randomized controlled trials are needed to prove its potential cancer-preventive effects.
A UK study found that saliva can be tested for signs of periodontal disease, a condition characterized by persistent inflammation and tissue breakdown. The research team identified biomarkers in saliva that could aid in diagnosing and monitoring the disease.
A study found that higher-than-normal levels of IL-1-beta in saliva are associated with increased bone loss. Osteonectin levels inversely correlate with bone loss, suggesting this marker may measure periodontal health. The researchers hope to develop a biomarker test for early detection and monitoring.
Scientists have developed a standardized saliva RNA test for oral cancer detection, showing high accuracy rates in detecting oral cancer. The test has been confirmed to be highly accurate in identifying four saliva oral cancer RNA biomarkers, reducing mortality and morbidity for oral cancer patients.
A new saliva test detects changes in alpha amylase levels, offering a more comprehensive understanding of the body's response to caffeine and stress. The study found that moderate doses of caffeine improve task performance but excessive amounts can lead to decreased performance.
A new study finds that the quality of a dog-owner relationship has no impact on thunderstorm-phobic dogs' stress responses. However, dogs living with other dogs in the household exhibited less pronounced stress reactivity and faster recovery times.
Researchers have discovered a mechanism by which bean plants can prevent fluid loss when injured, using contractile protein bodies that change shape in response to calcium concentrations. Vetch aphids overcome this blockage by injecting saliva into the plant.
Researchers at Forsyth Institute have identified three bacteria associated with oral squamous cell carcinoma (OSCC), a deadly form of cancer. The study found that elevated levels of these bacteria in saliva can indicate the presence of OSCC, raising hopes for an early diagnostic marker and potentially saving lives.
A study found six common bacteria in OSCC patients at significantly higher levels than controls. Three species were found to correctly predict over 80% of oral cancer cases, offering a potential non-invasive diagnostic test.
Researchers at UCLA isolated biomarkers from saliva that accurately predicted oral squamous cell carcinoma in 90% of cases. These biomarkers, known as salivary transcriptomes, also showed promise for detecting head and neck cancers. The study's findings suggest a potential breakthrough in early disease detection.
Researchers are developing saliva testing technology to detect diseases like cancer, predict cavities, and identify drug use. Preliminary results show that analyzing protein sugars in saliva can determine an individual's vulnerability to cavities.
A new study found that HSV-1 DNA was present in the eyes and mouths of nearly all healthy participants, highlighting the widespread nature of the virus. The research suggests that controlling virus excretion could limit transmission and is a simple way to evaluate new antiviral drugs.
Researchers discovered distinct patterns of mRNA in saliva that can indicate developing oral cancer. The study found that a salivary test could identify cancer patients with high accuracy, potentially replacing current diagnostic tests.
Researchers have identified up to 28 proteins in saliva, including biomarkers for diseases like cancer. Saliva testing may become a life-saving alternative to blood tests in developing nations where early diagnosis is critical.
A recent study found that teenage girls are more likely than boys to start smoking, with 31% of girls and 16% of boys aged 15-16 regularly indulging. The researchers suggest that positive attitudes towards smoking, living with smokers, and having friends who smoke may contribute to this trend.
Researchers discovered that nitrite in saliva significantly increases gastric mucosal blood flow and mucus thickness, suggesting a potential link between bad breath and gastric ulcers. This finding also has implications for conditions like sickle cell anemia.
A new study by University of Michigan researchers suggests the risk for recurrent yeast infections is related to a woman's immune response to the yeast. Women who have had cunnilingus or masturbation with saliva in the past month were more likely to develop recurrent yeast infections.
Researchers have developed a technology that can detect chemical contaminants in saliva, enabling rapid diagnosis of pesticide exposure and potential nerve gas poisoning. The innovation could be used to monitor farm workers and diagnose accidents or terrorist attacks.