Articles tagged with Tissue Structure
Researchers solved the structure of α-catenin, a protein crucial for cell binding and tissue formation. The discovery reveals how α-catenin interacts with the cytoskeleton and cadherins to stabilize adhesion complexes.
Researchers at Tufts University developed a novel method for fabricating collagen structures that maintain the protein's natural strength and fiber structure. The new technique, called bioskiving, creates scaffolds with tensile strength stronger than those made using common processing techniques.
Researchers found that breast cancer cells can reorganize into normal structures when exposed to compression force, suggesting a possible new approach to treating the disease. The study used 3D-matrix and elastic chamber to apply forces and observed significant changes in cell behavior.
Scientists create medical needles that easily penetrate surfaces and resist buckling, as well as next-generation medical adhesives. The discovery is based on the unique geometry of porcupine quills, which enable them to penetrate tissue with ease while maintaining high adhesion.
Rice scientists created a computer program that predicts the most stable structures of nanometer-sized collagen, a crucial step toward synthesizing custom collagen. This breakthrough has significant implications for treating diseases and designing drugs, as collagen plays a vital role in holding cells together.
Researchers create dynamic optical projection stereolithography (DOPsL) to print microscale 3D structures in seconds, enabling better cell growth and studying, as well as regenerative medicine applications.
Harvard scientists developed a method to grow 'cyborg' tissues by embedding nanoscale wires into engineered human tissues. They successfully seeded the networks with cells and encouraged them to grow in 3D cultures, enabling real-time monitoring and control of living systems.
A multi-institutional research team has developed a method for embedding networks of biocompatible nanoscale wires within engineered tissues. This allows direct tissue sensing and potentially stimulation, which could lead to the development of engineered tissues that incorporate capabilities for monitoring and stimulation.
Organisms build unnecessary structures during development to avoid disrupting later stages of growth. This approach allows newly evolved traits to emerge at the end of development with less risk of disruption.
Researchers created composites with a loose structure that enables cells to colonize and form three-dimensional tissues. The fibers' spacing can be adjusted to align cells and direct tissue formation, mimicking the human meniscus.
Researchers can now navigate biological tissues from whole embryo to subcellular structures thanks to virtual nanoscopy and enhanced JCB DataViewer. The technique allows for exceptional opportunities for future discoveries by integrating information across cells and tissues.
The NIH is funding the creation of tissue chips with living cells and tissues to model human organs and predict drug safety. These chips will be tested with compounds known to be safe or toxic, ultimately advancing research to help identify reliable drug safety signals.
Engineers at the University of Missouri-Columbia have developed a clog-free ink jet printer inspired by the human eye. The invention uses a droplet of silicone oil to cover the nozzle opening when not in use, eliminating the need for costly replacements and reducing waste.
Researchers at Penn University have developed a method to rapidly create vasculature using 3D printed templates of filament networks, improving the function of engineered living tissues. They used a material composed of sugar and other compounds to create stable vascular systems that can be easily dissolved and replaced with cells.
Researchers at Beckman Institute developed a fast, non-invasive 3D microscopy method that visualizes E. coli sub-cellular structure in three dimensions without disturbing the specimen or using fluorescence or contrast agents.
Researchers have developed engineered microvessels that can grow small human blood vessels in a 3-D structure, allowing for the study of disease progression and development of efficient therapies. The system shows promise in studying various diseases, including cancer, malaria, and clotting disorders.
Researchers at McGill University discovered that heart muscle fibers are arranged in a special 'minimal surface' called the generalized helicoid. This finding offers significant new understanding of heart-wall muscle fiber geometry and could be used to guide tissue repair after heart attacks.
A recent study published in The Journal of Sexual Medicine has confirmed the anatomic existence of the G-spot, a previously elusive structure. The G-spot was found to be a well-delineated sac structure located on the dorsal perineal membrane, measuring 8.1mm x 3.6mm x 0.4mm in dimensions.
Researchers at University of Sheffield have developed a method to assist damaged nerves in repairing naturally, improving chances of restoring sensation and movement in injured limbs. The new technique uses biodegradable synthetic polymer to create guidance conduits that provide physical and chemical cues for nerve growth.
Researchers used a 3D foam replica and wind simulation to study tornado winds far beyond the storm's path. They found that complex terrain disrupts the tornado's structure, causing winds to extend into nearby valleys.
Researchers have developed a computational model called 'cell graphs' that links the structure of human tissue to its corresponding biological function. This new tool uses graph theory and can be used to determine whether a tissue sample is cancerous or not, eliminating differences of opinion between doctors.
A UCLA study reveals that migrating cells exhibit a tendency to turn right in response to environmental changes, leading to the formation of diagonal stripes resembling tissue architecture. The researchers believe this phenomenon holds promise for developing new methods for tissue engineering and organ regeneration.
Researchers at Arizona State University have created an imaging technique that allows for atomic-level resolution without damaging biological samples. This breakthrough enables the use of high-intensity X-rays, previously limited by damage caused by the radiation.
Researchers at Northwestern University have developed a new method for creating scaffolds that are more flexible and less time-intensive than current technology. The process uses ceramic nanoparticles and elastic polymers to create highly interconnected pores that do not require the use of salt.
Researchers at UC San Diego developed a new method for culturing complex tissue in three-dimensional arrangements. The approach allows for the production of tissue culture scaffolds with multiple structurally and chemically distinct layers, enabling broader accessibility and potential applications in tissue engineering.
Scientists at Berkeley Lab have discovered a rotational motion called CAMo that plays a critical role in the formation of spherical acini structures in breast cells. Without CAMo, cells lose their structure and become randomly motile, leading to malignancy.
Scientists at NPL developed a functional model of the native extracellular matrix, providing structural support for cells to aid growth and proliferation. The model could lead to advances in regenerative medicine by mimicking the complex nano-to-microscale structure of the ECM.
Using a mathematical model, scientists found that spatial tissue structure slows down genetic mutation accumulation, delaying cancer onset. The study suggests that structured populations take longer to reach critical mutations, reducing the risk of cancer.
Scientists have created a novel combination of additives that enable gelatin to mimic the acoustical and optical properties of soft tissue in humans. The resulting tissue 'phantoms' can be used to test photoacoustic and ultrasonic imaging technologies, which are increasingly being used in clinical applications.
Researchers integrated 3-D imaging techniques to better understand facial structure and contours, underlying bone, muscles, nerves, and vessels in face transplantation. This technology allows for customized procedures and real-time user interaction to assess eligibility and plan the surgery.
Researchers developed a new method using two-photon polymerization with multiple foci to create finely detailed structures, such as tissue scaffolds and microneedles, more quickly than traditional techniques. This enables faster production of microscale medical devices for tissue engineering applications.
The Christchurch earthquake ruptured a previously unmapped fault, causing widespread liquefaction-induced damage. Eight papers focus on structural and geotechnical damages associated with strong ground motion shaking.
Scientists at the University of California at Berkeley developed a technique to direct benign viruses to self-assemble into thin-film structures with complex properties. By controlling the physical environment, they created films with specific bending properties and guided cell growth, shedding light on biological tissue assembly in na...
Engineers and scientists at UC Berkeley developed a simple, single-step process to direct M13 phages to serve as structural building blocks. The resulting thin-film structures exhibit complex properties, such as bending light and guiding cell growth. The technique sheds light on the self-assembly of biological tissues in nature.
Researchers at UC Berkeley have developed a self-templating material assembly process using a harmless virus to mimic the formation of complex structures from helical macromolecules like collagen. The technique allows for control over the type of pattern formed, enabling the creation of materials with diverse functions.
Researchers at Empa have developed self-healing membranes for inflatable structures that can plug up holes on their own, inspired by the rapid wound sealing process of climbing plants. The technology has shown promising results in lab tests, with a membrane able to hold for eight hours after being punctured.
A multidisciplinary approach using laser technology has been successfully employed to fabricate tiny scaffolds for cell delivery and growth in damaged neural tissue. This study demonstrates the potential of direct laser writing in tissue engineering, enabling precise control over scaffold design and structure.
Researchers at MIT have created a way to make microparticles of nearly any shape using temperature-sensitive materials, allowing for precise placement of drugs and cells. This technique enables the creation of artificial tissues that mimic natural tissue structures.
Researchers urge more stringent building standards to reduce property damage and loss of life in tornado and hurricane-prone areas. The new report highlights the need for tailored construction practices that consider local risks and specific storm events.
The new discs mimic the natural structure of human discs, with improved mechanical properties over time. This breakthrough could lead to a significant reduction in chronic back and neck pain, allowing patients to maintain their mobility and quality of life.
Researchers at MIT have developed a new high-speed 3D imaging system based on optical coherence tomography (OCT) technology, enabling real-time visualization of microscopic features in the esophagus and colon. The system promises to improve cancer screening by detecting pre-cancerous changes and guiding endoscopic therapies.
The study reveals that EphB-ephrin bindings activate metaloprotease ADAM10, destroying binding between distinct cell types and preventing cell mixing. This mechanism is crucial for maintaining tissue organization in the intestinal epithelium.
Researchers link inadequate connections between building members to excessive damage from tornadoes. While modern codes are generally adequate, their enforcement is often lax. The study's findings underscore the need for better building practices and code compliance to reduce storm damage.
Researchers found widespread soil liquefaction in Japan, exceeding expectations, and raising concerns about its impact on vulnerable locations such as Portland, Ore. and the Pacific Northwest. The phenomenon can cause structures to shift or sink, significantly magnifying damage.
A new system allows for the measurement of power that cells employ to assemble into three-dimensional tissue. The research helps engineers evaluate how quickly cell types will combine into desired structures.
ES cells can differentiate into retinal precursors and form an optic cup-like structure in vitro without external signaling sources. The tissue undergoes a four-step morphological rearrangement to assume the optic cup shape, driven by cell division and epithelial expansion.
Rafael Davalos has developed a method to treat cancerous tumors using irreversible electroporation, achieving complete remission in a seven-year-old dog. He aims to explore its potential in treating other pathologies, such as cardiac arrhythmias and glioblastoma multiforme.
Researchers discovered that human mammary epithelial cells possess lineage-specific intrinsic abilities to self-organize into domains of lineage specificity, maintaining healthy bi-layered branching organization. The study provides insights into the coordination of stem cell differentiation and tissue architecture maintenance.
Researchers have shown how laminin influences genetic information inside a cell's nucleus, while its destruction plays a detrimental role in tumor development. The study also identifies laminin-111 as the regulator of nuclear actin, a key mediator of epithelial cell quiescence.
Researchers have discovered the structure of tropoelastin, a key component of elastin that provides elasticity to human tissues. The molecule has near-perfect elasticity, allowing it to stretch up to eight times its original length and return to its shape with no loss of energy.
Muscle cell fusion is a previously thought to be mutually consented event, but research reveals it's actually an invasive battle where one cell forces the other using finger-like projections.
Researchers at UC San Diego discovered that Wnt proteins stimulate planar cell polarity signaling in growth cones, guiding nerves to their proper targets. This finding provides critical understanding of brain wiring mechanisms and may pave the way for nervous system repair and regeneration.
Researchers found that vitamin D-deficient mice had reduced lung volume, lower airway resistance, and smaller lungs compared to control mice. The study suggests a potential link between vitamin D deficiency and obstructive lung disease, highlighting the need for future studies on prevention and treatment strategies.
A study by Columbia University researchers found that pre-menopausal Chinese-American women have greater bone strength than Caucasian women due to a higher plate-to-rod ratio in trabecular bone. The study used advanced 3-D imaging analysis technique Individual Trabeculae Segmentation (ITS) to analyze bone microstructure.
Researchers successfully created complex, functioning intestinal tissue in a lab using pluripotent stem cells, opening doors to unprecedented studies of human intestinal development and disease. The breakthrough also paves the way for therapeutic applications, including transplantation and drug absorption.
Researchers at Arizona State University have developed a material that can detect and heal cracks in structural materials, increasing toughness by 11 times. The innovative 'autonomous adaptive structure' uses shape-memory polymers to mimic biological systems' healing traits.
A study found that whole-body MRI can detect soft-tissue injuries in infants with suspected child abuse. However, its effectiveness in detecting skeletal injuries is limited. The imaging modality may still be useful as a supplement to skeletal surveys in selected cases.
Researchers successfully differentiate embryonic stem cells into lung tissue using a natural cell-depleted lung matrix, demonstrating improved cell retention and organization. This breakthrough finding holds promise for developing clinical applications for engineered lung tissue.
A new imaging technique, combining photoacoustic tomography and a smart contrast agent, produces three-dimensional images of melanoma with high accuracy. This enables surgeons to remove only the malignant tissue while maintaining clean margins.
Scientists use topological optimization to create experimental 3D structures for facial bone replacement, which can withstand chewing forces and facilitate speaking and swallowing. The team plans to grow bone around these lightweight structures using tissue engineering techniques.