Articles tagged with Tissue Structure
A team of scientists has created a comprehensive atlas of early mammalian morphogenesis, revealing that individual events such as cell divisions and movements are highly chaotic. However, the embryos as a whole end up looking very similar to one another, with physical laws driving them to form a specific morphology shared among mammals.
A University of Virginia engineer developed a workflow to combine advanced imaging technologies for improved understanding of porous bone, which could inform disease detection. The method allows for three-dimensional rendering of bone structure across various length scales.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
A research team has successfully recreated wrinkle structures in biological tissue in vitro, revealing the mechanisms behind their formation. The study found that compressive forces and dehydration play a crucial role in wrinkle formation, mirroring aging skin effects.
Researchers have developed a new technique to study anisotropic materials, capturing full complexity of light behavior in these materials. The method revealed detailed insights into how light scatters differently along various directions within materials, allowing retrieval of scattering tensor coefficients.
Researchers have created the first spatial map of malaria infection in the mouse liver using Spatial Transcriptomics and single-cell RNA-sequencing. This discovery sheds light on the parasite's lifecycle, revealing changes in host cell gene expression near infected areas.
A WVU biologist is studying how genes establish animal body plans and contribute to regenerative abilities. He has identified Hox genes as key players in planarian regeneration, suggesting their functions may differ in highly regenerative versus poorly regenerative organisms.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
A new study reveals that the protein CRTC plays a crucial role in maintaining a healthy heart by ensuring it is neither too thick nor too thin. The research also shows that overexpression of CRTC causes cardiac hypertrophy, leading to adverse cardiovascular events.
Terasaki Institute scientists have created a novel bioink derived from egg whites, offering abundant proteins and excellent biocompatibility. This breakthrough technology has the potential to create more accurate tissue models for drug testing and develop functional tissue replacements for regenerative medicine applications.
Researchers developed core-shell microfibrous scaffolds that excel in rotator cuff repair, restoring natural morphology and mechanical properties. The acellular, in situ tissue engineering technology harnesses stem cell regenerative abilities to provide robust biological regeneration without cell seeding.
A UVA research team has developed biomaterials with controlled mechanical properties matching those of various human tissues, representing a significant leap in bioprinting technologies. Their unique digital assembly of spherical particles (DASP) technique can deposit particles of biomaterial in a supporting matrix to build 3D structur...
Researchers have determined the structure of molecules within an Alzheimer's disease brain for the first time using cryo-electron tomography and fluorescence microscopy. This study revealed the molecular structure of tau protein and its arrangement with amyloid plaques, providing new insights into the pathology of the disease.
The study reveals that the electric blue spots of the bluespotted ribbontail ray are produced by unique skin cells with a stable 3D arrangement of nanoscale spheres containing reflecting nanocrystals. The team believes this colouration provides camouflage benefits to the stingrays, allowing them to blend with their surroundings.
A new 3D printing strategy enables creation of complex gradient pore structures, enhancing processing capabilities for biomimetic manufacturing and bioprinting. The approach allows for precise control over filament diameter, enabling the fabrication of 1D, 2D, and 3D gradient structures.
Researchers compared human hearts with those of great apes, discovering a more compact muscle structure in humans, related to greater cardiac function. This finding supports the hypothesis that human heart evolved to meet higher demands of human physiology, such as larger brain size and physical activity.
A University of Houston researcher has made a breakthrough discovery about the development of the heart in the womb, revealing that a certain gene deletion can cause a common type of heart muscle disease called left ventricular non-compaction.
Researchers at Duke University created an ultrathin silk membrane that helps cells grow into functional tissues used for research, enabling the development of kidney disease models. The new membrane improves communication and growth between cells, mimicking natural human organ structures.
Engineers developed a material that mimics human bone for orthopedic femur restoration, providing optimized support and protection from external forces. This innovative approach uses machine learning, optimization, and 3D printing to create a fully controllable computational framework.
Researchers used supercomputers to study how fruit fly embryo cells develop into wings, offering a window into human development and possible treatments for birth defects. The team found that actomyosin drives much of the development process, particularly in the lower wing disc flattening.
Researchers found that UTIs can provoke structural changes in breast tissue in mice, which are reversible once the infections are resolved. The study suggests a possible link between UTIs and abnormal breast cell growth, highlighting the importance of considering everyday occurrences on women's well-being.
A team of researchers has developed a hemostasis sponge that swiftly staunchs kidney bleeding and facilitates wound recovery. The material uses kidney-derived decellularized extracellular matrix to recreate the kidney's microenvironment, boasting high biocompatibility.
The study reveals that TM4SF19 protein inhibits a pump in lysosomes, impeding macrophage clearance of dead cells. Macrophages lacking TM4SF19 demonstrate enhanced efficacy in clearing dead adipocytes, reducing weight gain and metabolic dysfunction. The findings may open new avenues for treating obesity and related metabolic disorders.
Fossilized bone fragments from Western and Central Europe have been identified as belonging to gigantic ichthyosaurs due to their unique microstructure. The discovery sheds new light on an ongoing debate among paleontologists, suggesting that these massive sea creatures could have reached lengths similar to the modern blue whale.
Researchers at NTU Singapore successfully grew 'mini kidneys' in the lab, grafted them into live mice, and found a potential treatment for polycystic kidney disease by boosting autophagy. The study suggests that minoxidil could be used to reduce cysts in the novel mouse model.
New research at Hokkaido University reveals that acoustic fat bodies in toothed whales were once jaw muscles and bone marrow. The findings suggest an evolutionary tradeoff between auditory and feeding ecology, leading to the loss of chewing muscles and adaptation to echolocation.
Researchers describe two Jurassic mammaliaforms from China, revealing dental diversification and the emergence of middle ear ossicles. The findings support a classic example of vertebrate evolution and provide new insights into early mammalian phylogeny.
Researchers discovered that neonatal spinal cord ECM significantly enhanced NPC proliferation, migration, and differentiation compared to adult ECM. This study highlights the critical role of early developmental spinal cord ECM in orchestrating spinal cord regeneration processes.
Researchers develop AI-powered method to rapidly predict multiple protein configurations, understanding protein dynamics and functions. This breakthrough has the potential to revolutionize drug discovery by uncovering more targets for new treatments.
A study discovers that traditional Chinese ice-ray lattice designs can provide unique stiffness and strength under asymmetric loads, offering an alternative to conventional gridshells. The research also explores the potential of integrating complex geometry into facade design and micro-scale material design.
The study reveals Brat's role in regulating wing imaginal discs regeneration by modulating downstream growth factors. Flies with reduced Brat demonstrated improved wing regeneration but also exhibited deficiencies in cell-fate specification, highlighting the delicate balance required for proper regeneration.
A new AI-powered tool developed by the University of Copenhagen and 3Shape predicts how teeth will move, allowing orthodontists to ensure braces are neither too loose nor too tight. The tool uses scanned imagery of teeth and bone structures to simulate how braces should fit, reducing trial and error.
Researchers developed a machine-learning model to assess prostate cancer biopsy samples, overcoming limitations of traditional methods. The new model, nnU-Net, provides accurate 3D segmentation of glandular tissue structures, leading to better prognostic analyses and potential improvements in patient outcomes.
Scientists have created a way to correct distorted light patterns in real time without needing to reapply the same distortion. This method uses nonlinear optics and exploits difference frequency generation to produce an aberration-free output beam.
Researchers analyzed tissue and fecal samples from 90 stranded marine mammals to study the distribution of toxic elements. The study found that Risso's dolphins and short-finned pilot whales had high concentrations of mercury, cadmium, and lead, while dwarf sperm whales had low levels.
Researchers discover how S1P molecules are released from SPNS2 protein via small cavities, enabling potential treatment for inflammatory diseases. The study provides a foundation for designing future drugs targeting the protein.
Researchers have created a hydrogel that can be used to heal damaged heart tissue and improve cancer treatments. The gel is made from cellulose nanocrystals derived from wood pulp and has a nanofibrous architecture that replicates the properties of human tissues.
Researchers used a novel microscopy technique to image human brain tissue with unprecedented detail, revealing new cells and structures previously invisible. The method could help diagnose tumors, generate more accurate prognoses, and guide treatment decisions.
A team of University of Copenhagen researchers has created a large reference catalogue of plant cell wall compositions from 287 species, representing the entire plant kingdom. The study reveals that carbohydrate composition is more closely related to a plant's family history than its habitat and growth form.
Researchers introduce trehalose into hydrogels to form hydrogen bond interactions, improving dehydration resistance, lubrication performance, mechanical properties, and manufacturing accuracy. This discovery proposes a new design principle for high-precision manufacturing of hydrogel materials.
UAB researchers have created a 3D, three-layer nanomatrix vascular sheet that mimics human atherosclerosis, enabling high-throughput drug screening. The model replicates key features of the disease and has been validated with two classic atherosclerosis drugs.
Researchers have identified a 3D fragment of fossilized skin that is at least 21 million years older than previously described skin fossils. The ancient skin shares features with reptiles alive today, highlighting the importance of epidermis for survival in terrestrial environments.
A biorobotic heart with a silicone robotic pump system can mimic the structure and function of a healthy or diseased heart. The device allows surgeons and researchers to demonstrate various interventions while collecting real-time data, bridging gaps between current simulators and animal studies.
The iStar tool uses advanced techniques to capture both detailed views of individual cells and broader tissue patterns, enabling doctors to diagnose cancers that might otherwise go undetected. It also predicts gene activities at near-single-cell resolution, paving the way for molecular disease diagnosis.
Researchers developed 3D-printed flat-bone-mimetic bioceramic scaffolds to restore critical-sized cranial defects. The scaffolds, inspired by human cranial bones, promoted in vitro cell proliferation, osteogenic differentiation, and angiogenic activities.
A research team at Texas Tech University Health Sciences Center discovered a unique sodium pump variant in brine shrimp that enables them to thrive in high-salinity environments. This NKA variant uses more energy than common variants, allowing the animal to maintain steeper Na+ gradients.
Researchers found that Arctic seals' unique nasal structures allow them to conserve 94% of water during breathing, giving them an evolutionary advantage in the Arctic. The study's findings suggest that similar adaptations could be beneficial for other species in diverse environments.
Researchers at Linköping University used advanced diffusion MRI to examine the brains of patients with persisting symptoms after COVID-19 and found differences in white matter structure. This study provides new insights into the underlying mechanisms of post-COVID neurological problems.
Researchers at Nagoya University have discovered a unique healing mechanism in newts that could aid humans in recovering faster from tendon injuries. By understanding how newts regenerate damaged tendons without scar tissue, scientists hope to develop more effective treatments for human athletes.
Researchers used spatial transcriptomics to analyze cancer cells at the edge and center of tumors, finding distinct gene expression patterns that can predict clinical outcomes and response to therapy. These findings hold promise for improving treatment strategies across various cancer types.
Researchers from Tsinghua University provide an overview of biofabrication methods for single-cell feature building blocks to reconstruct engineered living systems. The techniques aim to replicate natural tissues with precise control over microenvironment and structure, benefiting biomedicine applications.
A new deblurring algorithm has been developed to improve the resolution of microscopy images without amplifying noise. This breakthrough technique, called 'deblurring by pixel reassignment,' uses local gradients to sharpen images while preserving larger structures.
Scientists have discovered the open and closed states of the coronavirus E ion channel, which could help develop antiviral drugs to reduce inflammation. The study's findings provide insights into the channel's structure and function, allowing researchers to design molecules that can bind to it and prevent inflammation.
A Brazilian physicist has developed an alternative method that reduces calculation time for simulating light absorption by molecules from two days to a few hours. This allows for high-resolution microscopy and the creation of precise 3D structures for data storage, with potential applications in medicinal treatments.
A study found that ocean acidification reduced the strength and density of fleshy seaweed tissues, making them more fragile and susceptible to damage. The research suggests that this could have drastic effects on coastal ecosystems, leading to a decrease in seaweed coverage and negatively impacting organisms dependent on these habitats.
Using computational topology, Brown researchers have developed an algorithm that profiles shapes and spatial patterns in embryos, enabling the study of how cells assemble into tissue-like architectures. The new approach uses persistence images to rapidly compare large datasets, reducing computation time from hours to seconds.
A new imaging technique, multifocal acoustic radiation force-based reverberant optical coherence elastography (RevOCE), has been developed to measure the elasticity of multiple eye components simultaneously. This approach offers high resolution measurements of the stiffness of eye structures and could revolutionize how we study ocular ...
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers at UC Riverside have discovered a new cell type in the thymus that is similar to M cells found in the gut and airways. The newly discovered cells are like gatekeepers, acting as antigen-delivery cells for the immune system in organs such as the intestine and lung.
Researchers developed a noninvasive technique to visualize and differentiate nerve tissue using multispectral photoacoustic imaging. The study revealed the optimal wavelengths for identifying nerve tissue, which could improve nerve detection and segmentation techniques.