Articles tagged with Tissue Structure
A study led by Weill Cornell Medicine researchers found that some ion channels can rearrange into a larger structure, enabling drug delivery. The discovery solves a long-standing mystery about ion channel dynamics and has implications for pharmaceuticals.
A new study from North Carolina State University found that the shape of small bones in the throat, called hyoid bones, may be key to determining whether sabertooth tigers purred or roared. The researchers compared the anatomy of modern roaring cats and purring cats to find that the missing bones in saber-toothed tigers' hyoid structur...
Scientists have created ultra-thin layers of human cells in tube-like structures using the RIFLE technique, enabling the development of lifelike tissue models. This innovation has significant implications for drug development and disease research, offering a more accurate alternative to animal models.
Embryos orchestrate complex tasks by temporarily relocating neurons to create space for incoming progenitor cells, ensuring harmonious organ development. This study's findings have implications beyond retinal development and may shed light on human developmental disorders.
Researchers demonstrate the potential of optical imaging for safely measuring vocal fold elasticity and pliability. The study found good agreement between Brillouin microspectroscopy results and conventional elasticity measurements.
A study published in Cell Death & Disease has characterized the cellular composition and spatial architecture of tumor microenvironment in human multiple primary lung cancers. The researchers identified a previously undescribed sub-population of epithelial cells, CLDN2+ alveolar type II (AT2), specifically enriched in MPLCs.
Research discusses challenges and future directions for porous metallic implant fabrication, focusing on microstructure, biocompatibility, and mechanical properties. The review aims to promote metabolite and nutrient exchange, bone ingrowth, and improved implant-tissue anchorage.
New research uses MRI and CT scans to study the anatomy of primate clitoris, revealing stark differences in morphology across species. The findings suggest that female genitalia have been chronically understudied, with significant diversity in clitoral structure and function.
A new device combines rapid hemorrhage management, infection control, and sensing capabilities for long-term monitoring. The device features a tunable biodegradation rate and can detect bleeding in real-time using a nanowire-based capacitive sensor.
A recent study by researchers at the University of Zurich found that the Notch signaling pathway plays a crucial role in shaping and varying tooth enamel. The team used genetically modified mouse models to analyze the effects of the Notch-ligands on teeth, revealing that their absence affected tooth morphology and enamel formation.
Researchers discovered that a bivalve's hinge can withstand 1,500,000 cycles without fatigue damage. The team proposed a novel design strategy based on the hinge's hierarchical structure to create fatigue-resistant materials.
A 225-million-year-old Brazilian fossil provides the oldest evidence of air sacs in dinosaurs, which enabled these creatures to grow into giants. The discovery sheds light on how these structures evolved over time, contradicting previous assumptions about their development.
A handheld bioprinter has been developed to address limitations of previous designs, paving the way for applications in regenerative medicine, drug development, and custom orthotics. The device's modular design allows for control over printing mixture and properties, enabling repair and regeneration of defective tissues and organs.
Researchers detected Plasmodium falciparum, the deadliest form of malaria, in mummified tissues from Medici family members. The parasite was identified through microscopic and molecular analyses, revealing characteristic ring-shaped structures and Maurer's clefts.
Researchers achieve 3D printing within mini-organs growing in hydrogels, allowing for precise control over shape, activity, and tissue growth. This breakthrough enables the creation of realistic models of organs and disease, with potential applications in cancer research and treatment.
Researchers developed a novel printing method that controls the precise deposition of bioink in embedding medium, achieving accurate and homogeneous structures. The method enables the creation of complex three-dimensional structures with multiple materials, which has potential applications in manufacturing heterogeneous tissue models.
Researchers discovered that vascular toxicity linked to these drugs is unrelated to angiogenesis-related genes, but rather due to changes in vascular architecture. This new understanding will help select the most effective and safe way to modulate angiogenesis in ischemic tissues or cancer.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
The study, led by Professor Takashi Miura of Kyushu University, has discovered that interdigitated cell boundaries have a mathematically scaling pattern with self-similarity. The team used the Edwards-Wilkinson model to simulate and understand the molecular mechanism responsible for these dynamics.
A new forensic science study investigates the decay of infant and juvenile bones, providing insights into decomposition rates and bone degradation. The research helps forensic scientists estimate the time elapsed since remains were at a location and identify suitable bones for DNA sampling.
Scientists create hybrid composite scaffolds with aligned nanofibrous architectures to improve cell seeding efficiency, proliferation rates, and morphogenesis. The findings have potential applications in tissue repairing and regenerative medicine.
Researchers at Hokkaido University developed a hybrid hydrogel combining natural squid tissues with synthetic polymers, exhibiting hierarchical anisotropy and toughness.
Researchers designed a small fluorescent protein that emits and absorbs light in the near-infrared spectrum, allowing for deeper and clearer biomedical images. The protein's ability to penetrate tissue enables the capture of detailed images of complex structures and cells.
Researchers from MPI-CBG and IMP define metrics for organ development, providing a framework to transform the field of organoids into an engineering discipline. They discover that tissue connectivity emerges from two processes: fusion of separate epithelia or self-fusion of a single epithelium.
Researchers at Weill Cornell Medicine have developed a new computational method to map the architecture of human tissues in unprecedented detail. This approach enables powerful new diagnostic strategies for a wide range of diseases, including cancer and chronic conditions.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Researchers have mapped four new areas of the human anterior prefrontal cortex that play a major role in cognitive functions, including attention selection and decision making. The newly identified areas show significant inter-subject variability, with two being relatively larger in females than males.
Researchers have created a biomimetic mineralized layer that replicates the structure of natural tooth enamel, exhibiting increased nanohardness and surpassing the natural tissue in terms of strength. The new material can be used to restore or repair damaged enamel due to abrasion, erosion, or improper diet.
Researchers at the University of Zurich have developed a new immunotherapy strategy to eliminate fibroblasts in targeted manner, reducing lung and liver fibrosis in mice. The treatment triggers an immune response via cytotoxic T-cells, eliminating activated connective tissue cells while leaving resting cells undamaged.
Researchers developed a novel way to visualize densely packed molecules using expansion microscopy, allowing for the first time their imaging. The technique enables visualization of nanostructures found in neurons and Alzheimer's-linked amyloid beta plaques.
Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.
Researchers at Texas A&M University created a device that harnesses quantum fluctuations to enhance spectroscopy results in Brillouin microscopy, increasing image clarity and accuracy. The new source significantly improves the signal-to-noise ratio, allowing for better visualization of biological structures and properties.
Researchers at Terasaki Institute create micro-organospheres for direct viral infection, immune cell penetration, and high-throughput therapeutic drug screening. The technology holds promise for personalized medicine, tumor therapy and rapid drug testing.
A team of researchers developed a deep learning pipeline to analyze vascular system images of plants with high accuracy. The pipeline can detect vascular bundles, identify specific zones, and perform statistical analysis of traits in different stem internodes. This study has the potential to improve crop resilience and food security.
Researchers at Hebrew University have developed a new method using quantitative MRI to diagnose early-stage Parkinson's disease. This technique reveals biological changes in the brain, enabling early diagnosis and monitoring of treatment efficacy.
University of Toronto researchers develop a lab-grown model of the human left heart ventricle made with living heart cells. The bioartificial tissue construct beats strongly enough to pump fluid inside a bioreactor and offers new possibilities for studying heart diseases and testing potential therapies. Future work aims to increase the...
Bioengineers from Harvard John A. Paulson School of Engineering and Applied Sciences create first biohybrid model of human ventricles with helically aligned beating cardiac cells, increasing blood pumping efficiency by up to 50%. The model was made possible using Focused Rotary Jet Spinning (FRJS), a new method of additive textile manu...
A new study explores the characteristics of 36 basic variants of the Holliday junction, a fundamental building block used in DNA nanoforms. The results show that sequences forming the four protruding arms of the junction can enhance or hinder crystallization processes.
Researchers at City University of Hong Kong developed a simple exfoliation method to prepare ultrathin films of small intestine tissues, which exhibit piezoelectricity. The team's findings reveal the hierarchical structure of collagen fibers as the key to generating the piezoelectric effect.
A collaborative initiative aims to establish common protocols for assessing and comparing diffuse optics systems used in medical diagnosis. The study presents the results of a multi-laboratory comparison of 12 institutions and 28 systems, proposing simple numeric values for easy comparison across instruments.
The new technique, 3D optical coherence refraction tomography (3D OCRT), produces highly detailed images revealing features difficult to observe with traditional OCT. It has the potential for biomedical research and eventually more accurate medical diagnostic imaging.
Researchers from Arizona State University investigate autoantibodies in healthy individuals, revealing their pervasiveness and role in human health and disease. The findings aim to improve diagnostics and therapeutics for a range of illnesses.
Researchers from Tokyo University of Science discovered that bony fish head cartilage contains abundant proteoglycans, including aggrecan, with similar CS structures to salmon nasal cartilage. This finding reveals the potential of sturgeon as an alternative source of CSPGs for health food formulations.
A new computer-aided diagnostic tool, Deep-Lung Parenchyma-Enhancing (DLPE), uses artificial intelligence to reveal signs of pulmonary fibrosis in COVID long-haulers, helping to explain respiratory symptoms and improve disease management.
Researchers developed PASTE, a method to analyze spatial transcriptomics data in three dimensions, enabling biologists to better understand cell environments and identify rare cell types. The technique can integrate information from multiple tissue slices, providing a more complete picture of gene expression within tissues.
A UNIGE team discovered that cells in curved tissues swell by 50% before returning to normal, opening avenues for in vitro organ culture. This active phenomenon can be harnessed to control spontaneous growth of organoids and develop new materials with volume increase upon folding.
A team from the Terasaki Institute for Biomedical Innovation has created a method to repair tendons using silk fibroin scaffolds, which showed improved healing and regeneration of injured tendons. The scaffold combines silk fibroin with GelMA to promote cell attachment, growth, and differentiation.
Scientists have created cilia-free human pluripotent stem cells that exhibit symptoms of ciliopathy, such as polycystic kidney disease. These cells can be used to study the cause of these diseases and guide therapy development.
Researchers at Binghamton University have discovered that human skin's unique structure allows it to maximize both durability and flexibility. The team created artificial skin membranes that mimicked the structure of mammalian skin, testing their puncture toughness and deformability.
Researchers at Stevens Institute of Technology are pushing through technical barriers in organ printing by leveraging decades-old technique and computational modeling. The team aims to create any type of organ at any time, including skin on an open wound, using microfluidic bio-printing.
Researchers developed a new framework to extract meaningful vectorial metrics from Mueller matrix elements, providing insights into exotic material characterization and precise cancer boundary detection. The framework establishes a universal metric for calculating different physical properties of target objects.
Scientists at Scripps Research have developed a new tissue-clearing method that makes it easier to analyze large biological samples and study diseases. The HYBRiD method combines elements of prior approaches and uses hydrogels to protect molecules, enabling routine use in high-level biosafety facilities.
A new technology called MediSCAPE has been developed by Columbia Engineers that can capture real-time cellular detail in living tissues. This allows doctors to make informed decisions about tumor removal without needing to remove tissue and wait for pathology results.
A recent Cornell University study reveals that white-tailed deer can shed and transmit the COVID-19 virus for up to five days following infection. The virus replicates in the deer's respiratory tract, lymphoid tissues, and central nervous system, making them a potential reservoir for the virus in nature.
Researchers at Brigham and Women's Hospital discovered a tissue-modifying molecule that can target intestinal stem cells and signal them to create Paneth cells, a rare but important cell type. This could represent a new therapeutic pathway for diseases such as inflammatory bowel disease and graft-versus-host disease.
A recent study published in Applied In Vitro Toxicology found that tobacco-free nicotine pouches exhibit reduced levels of toxicants and biological activity compared to combustible cigarette smoke. The products, manufactured by Imperial Brands, showed substantially reduced genotoxicity and cytotoxicity in three toxicological assays.
Researchers developed a new imaging approach called VascuViz to visualize blood vessels at different spatial scales. The method enables detailed mathematical models and complementary images to clarify the role of blood flow in health and disease, advancing our understanding of tissues throughout the body.
GeniPhys Inc. has received a two-year, $974,349 Small Business Innovation Research (SBIR) grant from the National Science Foundation to advance the commercialization of its initial product, Collymer Self Assembling Scaffold (Collymer SAS). The grant will be used to scale up manufacturing capabilities and file key regulatory submissions...