Researchers from Peter the Great St.Petersburg Polytechnic University developed a polymer carrier that can load different sizes and structures of genetic material, including siRNAs and mRNAs. The efficiency of delivery was demonstrated on human stem cells, offering new horizons for non-viral delivery systems.
Researchers developed an in vitro human-derived tissue model to study SARS-CoV-2 infection and its progression to ARDS. The model revealed a cellular immune response to the virus, indicating potential for effective treatment with interferon lambda.
Antioxidants prevent imaging damage to conducting polymers, allowing for higher-resolution imaging and new insights into polymer structure. This breakthrough enables further development of soft electronic devices.
Researchers have discovered a strengthening mechanism in biological ceramics by studying the shells of bivalve mollusks. The shell's microscopic structure features nanoscopic defects that improve its structural strength and damage tolerance.
Researchers used synchrotron-based holographic X-ray nano-tomography to study the internal structure of nacre, finding that structural defects attract and cancel each other out, leading to the formation of a perfectly regular tissue. This mechanism could drive not only nacre but also other biogenic structures.
Researchers have developed reconstituted in-vitro human organs called assembloids, which precisely mimic the structure and function of human tissues. The new technology surpasses current organoid technology by modeling complex diseases like cancer and neurological disorders.
The 16th World Stem Cell Summit will be co-located with the 7th annual Regenerative Medicine Essentials Course, featuring joint single-track programming on stem cells, biomaterials, cell therapies, clinical trials, and regulatory matters. The event aims to accelerate regenerative medicine and deliver cures.
A team of researchers discovered that young alligators can regrow their tails up to three-quarters of a foot, or 18% of their total body length. The new tails are complex structures composed of cartilage surrounded by connective tissue with blood vessels and nerves.
Researchers at University of Copenhagen uncover crucial role of RRP7A gene in brain development and formation of primary cilia, which play a key role in controlling neural cell proliferation. The study sheds new light on the mechanisms underlying primary microcephaly, a rare congenital disorder characterized by reduced brain size.
Skoltech researchers have developed a novel method for designing and manufacturing complex-shaped ceramic bone implants with controllable porous structures. The FRep method enables the creation of variable density implants tailored to individual patient needs, enhancing tissue fusion efficiency and overall implant performance.
Researchers have identified isolated lymphoid structures (ILSs) as novel prognostic markers for metastatic colorectal cancer. ILSs, which are integral to the immune system, orchestrate multifaceted immune responses and can predict improved clinical outcomes in patients.
Researchers have developed a novel method to bioprint fibrocartilage, a crucial tissue in knee joints, using a hybrid tissue construct. The study demonstrates the potential of this regenerative medicine treatment for repairing damaged cartilage and restoring knee function.
Researchers have developed an implantable device made from fully rubbery electronics that can monitor and treat heart disease. The epicardial bioelectronics patch can collect electrophysiological activity, temperature, heartbeat, and other indicators simultaneously.
Researchers developed a hybrid sliding-rocking bridge design that sustains less damage compared to conventional bridges. The new design allows for quick and cost-effective repairs, making it more beneficial in the long run.
A team of researchers from Rensselaer Polytechnic Institute developed a deep neural network that can perform nearly as well as more complex dual-energy CT imaging technology. The algorithm produced high-quality approximations with a relative error of less than 2% using single-spectrum CT data.
Extracellular vesicles (EVs) derived from endothelial cells have been shown to revive heart cells after a heart attack and keep them functioning while deprived of oxygen. The researchers demonstrated this functionality in human tissue using a heart-on-a-chip model.
A bioceramic scaffold promotes bone regeneration and repair large bone defects without the need for bone grafts. The study found that the bioceramic converted into well-vascularized bone tissue with a structure similar to native bone.
The study found that thermoplastic materials, such as GC Iso functional sticks and Impression compound green sticks, outperformed silicone impression materials in border molding accuracy. The measured mean negative pressure values showed close values for each patient, highlighting the importance of anatomical features of the prosthetic...
Researchers trained an AI to rapidly assess post-disaster building damage using convolutional neural network (CNN) technology. The model achieved accuracy rates of approximately 94% in classifying building damage levels, making it a valuable tool for crisis responders.
Researchers at the University of Texas at Austin have made a groundbreaking discovery about organoids, stem cell-based tissue surrogates that mimic organs. The team found that organoids on the edges of an extracellular matrix dome respond differently to stimuli compared to those in the center, potentially leading to misleading results.
A team of researchers at Binghamton University has created a porous polydimethylsiloxane (PDMS) material that improves the breathability and accuracy of wearable biosensors. The new material allows for sweat evaporation during exercise, maintaining high-resolution signals.
Researchers discovered that hadrosaurs and other dinosaurs have a unique trabecular bone structure capable of supporting large weights, different from mammals and birds. This adaptation allowed them to carry massive loads without excessive skeletal weight.
A research team led by Dr. Alida Bailleul has found that ovarian follicles can be preserved in fossils more than 120 million years old, confirming the function of a single functional ovary in birds. The study uses scanning electron microscopy and other methods to analyze fossilized tissues and compare them to extant bird follicles.
Researchers at Wake Forest Institute for Regenerative Medicine have developed an optimized cellular platform for delivering Factor 8 to treat patients with hemophilia A. The new approach uses human placental cells to produce therapeutic levels of Factor 8, potentially providing a long-term correction for the disease.
A team of researchers has made significant progress in developing a quantum body scanner that can detect cancer with high accuracy. By analyzing the transmission of vector vortex beams through scattering media, they have overcome major hurdles in biomedical imaging. The study's findings suggest that vector vortex beams can preserve the...
Scientists at WFIRM have successfully engineered uterine tissue that supports fertilization, fetal development, and live birth. The study's findings suggest a regenerative medicine solution to treat uterine defects, avoiding organ rejection and the need for antirejection drugs.
The study reveals that matrix-bound vesicles (MBVs) have a similar size to liquid-phase EVs but contain different proteins, lipids, and microRNAs. MBVs also share common characteristics with parent cells, suggesting a possible origin from mitochondria.
Researchers have uncovered a previously unknown substructure in healthy bone tissue using new X-ray techniques, revealing deviations in the orientation of nanocrystals. This discovery has significant implications for understanding bone diseases and developing new biomaterials.
Researchers have developed a new non-invasive ultrasound method that compensates for distortions in soft tissue structure, providing ideal resolution and contrast optimized for each pixel. This approach has applications in biomedical diagnosis, optical microscopy, and industrial material inspection.
SourceCNRS·JournalProceedings of the National Academy of Sciences·DateJun 11, 2020
Scientists at University of Colorado Denver create complex, porous lattice structure using liquid crystal elastomers (LCEs) to mimic cartilage and other biological tissues. The material exhibits exceptional elasticity and dissipation capabilities, making it suitable for applications in football helmets and spinal implants.
Researchers developed two experimental devices to study the harmful effects of hyperperistalsis on synthetic uterine tissue. The study found that peristaltic shear stresses caused alterations to endometrial epithelial cells and myometrial smooth muscle cells.
Researchers at Texas A&M University have developed new biomaterials to advance the field of 3D bioprinting functional tissues. They created a highly printable bioink that can be used to engineer 3D-functional bone tissues, which could potentially create new treatments for patients suffering from arthritis and bone fractures.
Researchers have developed an algorithm that combines gradient methods with fast Fourier transforms to quantify the organization of cardiac myofibrils in heart cells, providing a better understanding of heart cell defects. The technique has potential applications in advanced drug screens and cell-based therapies.
Researchers used 'Lettere Patenti' documents to calculate intensities for a 1703 earthquake sequence in central Italy, revealing that the main earthquakes were likely intensity V or VI. The study provides a more realistic view of the earthquakes' impact than historical reports, shedding new light on seismic intensity assessment.
A Cornell University research team, led by plant biologist Michael Scanlon, has received a five-year $1.8 million grant from the National Science Foundation to study maize stem cell development and organ formation.
Purdue researchers develop new technology to overcome resolution limit of light-based microscopy, allowing for high-resolution imaging of biomolecules within cells. This advancement has the potential to reveal structural complexities in neurodegenerative diseases like Alzheimer's, enabling better understanding and treatment.
Researchers have developed a multipurpose nanoscale bio-probe that allows precise monitoring of iron disorders in cells, tissue, and body fluids. The test is more sensitive and specific than current blood testing methods, enabling early disease diagnosis and potential prevention of serious diseases.
Researchers created 3D brain-region specific spheroids to study complex developmental processes and neuropsychiatric diseases. The spheroids can be connected to form fused structures called brain assembloids, allowing for the investigation of inaccessible developmental processes.
Researchers have successfully 3D printed coral-inspired structures that can grow dense populations of microscopic algae, up to 100 times more densely than natural corals. This breakthrough could lead to the development of efficient bioreactors for producing algae-based biofuels and help restore coral reefs.
Researchers developed a new imaging technique, XDFI-CT, to visualize the 3D internal structure of the nipple. The study reveals three distinct types of duct arrangements and provides evidence for the 'sick lobe theory' that non-invasive breast cancer begins in a single mammary lobe.
The journal has announced its most frequently cited papers from 2018-19, which will be freely accessible. These papers focus on various aspects of musculoskeletal research, including bone metabolism, osteoimmunology, and gut-muscle axis.
A team of scientists has identified a triple-helix structure in calcium acetate hemihydrate, a compound formed on an ancient artwork through corrosion. The structure is similar to that found in collagen proteins and may have potential applications for bioinorganic chemistry.
A new experimental protocol developed by EPFL's Laboratory for Soft Bioelectronic Interfaces (LSBI) helps test and validate soft, personalized implants. The four-step process includes developing anatomically accurate prototypes and fine-tuning through tests.
Researchers have developed a new biomaterial that can be 3D printed to create tissue-like vascular structures, which could enable the recreation of vasculature in the lab. The material exhibits biologically relevant properties and has the capacity to withstand flow, making it suitable for building complex robust structures.
The researchers developed a system of miniaturized organs that can detect harmful effects of drugs before they are prescribed to patients. The miniature organs, created using biofabrication techniques, mimic human tissues and organs, enabling the detection of toxicity in drugs approved for human use.
Researchers developed a handheld 3D bioprinter to treat volumetric muscle loss, allowing for direct scaffold deposition into defect sites. The bioprinter prints gelatin-based hydrogels that mimic native tissue properties and adhere precisely to surrounding tissues.
A compound called Naphthyridine-Azaquinolone (NA) has been found to reverse the length of DNA repeat expansions that cause Huntington's disease in a mouse model and cells from individuals affected by the disease. The study suggests NA could be a potential drug therapy for individuals who inherit the disease.
A study reveals that the unique architecture of the lip of the suction disc, featuring vertically oriented collagen fibers, provides elasticity for maximizing contact with substrates and maintains adhesive force. The discovery could lead to improved biomimetic suckers with enhanced functionality.
A Yale-led team of researchers discovered that the transverse arch in the human foot, not previously studied, is responsible for nearly half of the foot's stiffness. This finding challenges conventional thinking about the human foot's structure and evolution.
Researchers at Berkeley Lab uncover mechanisms behind dinosaur blood vessel preservation and identify diverse giant viruses worldwide. The study uses X-ray imaging and spectromicroscopy to demonstrate how soft tissue structures may be preserved in dinosaur bones.
Researchers at Rutgers University have developed a new 'bio-ink' for 3D printing that can serve as scaffolds for growing human tissues. The ink combines modified hyaluronic acid and polyethylene glycol to form a gel with controlled stiffness and binding sites for cells, enabling precise tissue growth and repair.
Researchers found that a body clock mechanism boosts collagen production when we're most active, replenishing sacrificial fibrils at night. This discovery sheds light on the extracellular matrix and its role in maintaining body structure, with implications for understanding aging and wound healing.
Researchers at CNIC discovered a 'disarmament' mechanism in neutrophils that reduces their toxic capacity to prevent damage to healthy tissues. This innate system, driven by CXCR2 and circadian rhythms, helps regulate the immune response and could have implications for treating conditions like myocardial infarction and stroke.
Researchers develop 'flash and freeze' method to study structure and function of synapses in intact neural circuits. The method allows for simultaneous observation of structural changes during signaling, revealing a near-identity between structurally and functionally defined vesicle pools.
The 'substantially human' concept proposes a legal boundary for living organisms with human characteristics. This approach would help courts, scientists, and physicians navigate emerging biotechnologies.
Scientists developed a new method to evaluate meat quality using fluorescence spectroscopy, which is precise in classifying meat into standard quality categories. The method detects specific compounds that emit light of a specific frequency range, agreeing with the assumption that connective and adipose tissue make meat more tender.
A multidisciplinary team of researchers at UMass Amherst is investigating the effects of fat tissue on skeletal muscle structure and function. The study aims to understand how fat infiltration affects muscle strength and identify potential health benefits.
Recent advancements in 3D bioprinting have the potential to revolutionize organ transplantation by enabling customized organs for patients. However, significant technical challenges need to be overcome, including biomimicry, vascularization, and tissue maturation.
A research team at Toyohashi University of Technology has developed a donut-shaped kirigami device for EMG recordings, reducing device displacement on large deformable muscle surfaces. The device enables accurate and robust signal acquisition, offering potential for prosthesis control in amputees.
Scientists have developed a 3D model of the human liver to improve diagnosis of non-alcoholic fatty liver disease. The model reveals new critical tissue alterations, providing insights into pathophysiology and contributing to high-definition medical diagnosis.