Articles tagged with Tissue Structure
Scientists led by George C. Tsokos discover that inhibiting CaMK4 can prevent podocyte damage in lupus-prone mice, reversing classical dogma on inflammation causing kidney damage. The finding opens doors to potential new therapies for autoimmune and non-autoimmune diseases impacting the kidneys.
This study evaluated perioral soft tissue changes after orthognathic surgery using 3D CT scans. Significant post-operative changes were observed in nasolabial and mentolabial angles, while lip width remained unchanged.
A recent study published in eLife discovered that altered collagen structure leads to tissue stiffness during lung fibrosis progression. The researchers identified a compound that blocks LOXL enzymes, which can prevent tissue stiffening and limit fibrosis. This finding suggests new treatment approaches for lung fibrosis.
Researchers have developed a new approach for studying Cryptosporidium using lung and intestinal organoids, which support the complete life cycle of the parasite. This tool enables the testing of drugs and identification of vaccine candidates, providing hope for developing effective treatments.
The study reveals the atomic structure of tropoelastin, a protein responsible for living tissues' flexibility. Researchers decoded the molecular structure using a combination of molecular modeling and experimental observation.
Researchers from SUTD and HUJI develop highly stretchable, UV-curable hydrogels suitable for high-resolution 3D printing. These hydrogels enable the fabrication of complex geometries and high-stretchability structures.
Scientists have successfully programmed cells to self-organize into multi-layered structures reminiscent of simple organisms or embryonic development. These complex cellular assemblies can repair themselves and form complex tissue-like structures, opening doors for wound repair and organ regeneration.
Researchers at UMass Lowell are using origami to create new biomaterials that can grow cells for repairing or regenerating tissues such as skin, bone, cartilage, and blood vessels. The team's paper-based platforms have shown promise in biocompatibility and potential applications for wound care.
A UCLA-led team developed a new 3D printer to create complex artificial tissues from multiple materials. The printer uses stereolithography and a custom-built microfluidic chip, enabling the creation of biocompatible structures with different properties.
Scientists have successfully connected, merged and arranged artificial cells to form complex tissue structures with different connectivity types. This breakthrough enables the creation of artificial cell networks that mimic biological tissues.
A team of scientists has developed a novel tissue clearing solution, OPTIClear, to visualize microscopic structures in the human brain. This breakthrough enables high-resolution imaging of neuronal circuitries and could accelerate research on brain diseases such as Alzheimer's and Parkinson's.
Assistant Professor Karin Gravare Silbernagel will investigate differences in recovery between males and females with Achilles tendinopathy, exploring individualized treatment approaches to improve outcomes. Her research aims to better understand the variabilities in tendon injuries and develop more efficient treatments.
A team of scientists, including those from Google, developed a computer program that can identify structures in unstained brain cells. The program learned to spot features such as cell nuclei, dead cells, and specific types of brain cells by analyzing stained images.
Researchers developed a printing technique combining molecular self-assembly with additive manufacturing to create complex biological structures. This allows for the study of biological scenarios such as cancer growth and immune cell interactions, potentially leading to new drug development.
Case Western Reserve University scientists have engineered natural windpipe replacement structures using patient cells and self-assembling modules. This approach overcomes challenges in current tissue-engineering methods, enabling the creation of functional living tracheas that can be implanted into patients with damaged airways.
Researchers at Rutgers University have created a 4D-printed shape-shifting smart gel that can morph over time and temperatures change. The gel can provide structural rigidity in organs like the lungs and create new applications in soft robotics, biomedical devices, and scaffolds for cell growth.
Researchers at UC Riverside have discovered a unique structure in the mantis shrimp's club that protects it from self-inflicted damage, enabling the development of ultra-strong materials. The club's striated region wraps around the club to prevent catastrophic cracking, similar to hand wraps used by boxers.
Scientists at Imperial College London develop a new 3D printing technique that can replicate biological structures, paving the way for tissue regeneration and replica organs. The method uses cryogenics to create super soft scaffolds that mimic the mechanical properties of organs like the brain and lungs.
A team of researchers from the University of Bonn has discovered a unique type of bony tissue called pneumosteum, which is found in birds and some dinosaurs. This discovery provides new insights into the evolution of their respiratory systems and opens up possibilities for studying extinct species.
Researchers from NTU Singapore and CMU have developed a technique to direct the growth of hydrogel to mimic plant or animal tissue structure and shapes. The team's findings suggest new applications in tissue engineering and soft robotics, where hydrogel is commonly used.
Researchers found that local stress induced by crowding leads to differentiation, triggering the movement of stem cells upwards in the tissue. This mechanism helps maintain balanced numbers of stem and differentiated cells, ensuring proper skin function.
Belgian researchers have created a new artificial ovary prototype that resembles human ovarian tissue in terms of architecture and rigidity. The fibrin-based design could be used for ovary transplant, providing alternatives for women with infertility or cancer patients unable to conceive after treatment.
Researchers have developed a one-stage technology for producing artificial nano-hydroxyapatite with increased biocompatibility and controllable properties. The material can be used in orthopedics, pharmaceuticals, aesthetic medicine and coatings for medical devices.
Researchers at Penn State have developed a novel method to create high-resolution and repeatable 3D polymer fiber patterns on nonconductive materials for tissue engineering. This combination of 3D printing and electrospinning enables the growth of complex tissues with seamless structures, potentially replacing expensive donor tissues.
The study reveals that protein ZO-1 perceives mechanical signals and activates cellular responses accordingly, influencing epithelial cell proliferation and differentiation. Targeted inhibition of ZO-1 in tumors could be a potential pathway to explore for cancer treatment.
A new study by Sanford Burnham Prebys Medical Discovery Institute identifies a crucial signaling pathway for angiogenesis, the growth of new blood vessels from pre-existing ones. The findings may improve current strategies to increase blood flow in ischemic tissues associated with atherosclerosis and diabetes.
A novel imaging system called Ultrasound Bioprobe enables high-resolution views of sub-cellular structures in live cells, overcoming previous limitations. This breakthrough has potential applications in early diagnostics and therapeutic strategies for diseases.
Researchers demonstrated that nanotwins in metal's atomic lattice stabilize defects associated with repetitive strain, limiting accumulation of fatigue-related damage. This work shows a promising approach to creating more fatigue-resistant metals.
Army researchers have discovered subtle variations in the dynamic behavior of materials under fatigue cycles, including shifts in natural frequency. The study aims to develop new sensing techniques for predicting service life and enabling self-responsive, damage-adaptive structures.
Researchers at Osaka University developed a non-invasive imaging technique using multiphoton microscopy (MPM) to quantify cancer severity. The method, called non-labeling multiphoton microscopy (NL-MPM), uses second harmonic generation and autofluorescence to detect malignancy with high accuracy.
Researchers are developing living patches that mimic heart muscle cells, blood vessels and optical circuitry to create implantable heart tissue. The goal is to produce a true-to-life 'heart on a chip' to aid the pharmaceutical industry in developing better treatments for arrhythmia.
A breakthrough discovery in cardiovascular fibrosis research has led to a potential treatment for multiple fibrotic human diseases. The study identified a specific cytokine as a key driver of cardiac fibrosis, paving the way for the development of first-in-class therapeutics.
A new virtual model of mouse lung function has been developed to better understand the relative importance of different factors contributing to lung changes in chronic inflammation. The study found that changes in lung recruitment and elastic fiber density were mainly responsible for declining lung function.
Researchers at Midwestern University discovered that the muscles controlling mammalian perineal structures follow a simple ancient pattern, dating back over 360 million years. This finding defines placental mammals as a group and reveals the evolutionary innovation of cloacal separation into distinct structures.
A new non-invasive approach using polarized light can help surgeons identify nerves in real-time, minimizing nerve damage and improving surgical outcomes. The technique has been shown to outperform visual inspection with an accuracy rate of 100% compared to 77%.
Scientists at the University of Oxford have developed a new method to 3D-print laboratory-grown cells into high-resolution tissue constructs. The approach improves cell survival rates and enables the fabrication of patterned cellular constructs that mimic natural tissues.
Researchers at Michigan Technological University have developed new probes that can detect low pH in living cells without causing photobleaching. The probes are coated with a simple sugar found in fruits and emit light in two different ways, making them highly sensitive to pH and gentle on cells.
Researchers at Northwestern University have developed a range of bioactive tissue papers made from materials derived from organs, which can potentially be used to support natural hormone production in young cancer patients and aid wound healing. The new biomaterials are thin, flexible, and pliable enough to fold into origami structures.
A team of international researchers developed a bioprinted 3D vascularized liver tissue model that mimics in vivo drug administration, providing a more accurate system for drug toxicity testing. The new model's endothelial layer delays drug diffusion response, offering a potential mechanism to optimize drug absorption.
Researchers at Worcester Polytechnic Institute are developing a patch using biopolymer microthreads seeded with genetically engineered cardiac cells to improve heart function after a heart attack. The goal is to create a composite patch that can restore contractile function and provide additional strength and contractile force.
New research highlights the importance of diffusion gradients in regulating stem cells and tissue development. The study explores how gas and nutrient concentrations influence stem cell potency, differentiation, and metabolism. It also introduces novel models for understanding diffusion processes in three-dimensional tissue constructs.
Researchers at Texas A&M University have developed a new method for propagating light through human tissue, enabling deeper brain imaging and potential applications in medical imaging and driving safety. The technique involves making tiny holes to pass light through, increasing optical transmission by a factor of 100.
Researchers have developed a way to engineer liver tissue by organizing tiny subunits that contain three types of cells embedded into a biodegradable scaffold. The engineered livers expanded 50-fold after implantation in mice with damaged livers and performed normal liver functions.
A new optical clearing technique allows researchers to study the 3D structure of blood clots, which could lead to a better understanding of heart attacks and stroke. The technique enables microscopic imaging up to 1 millimeter into a clot, providing insights into clot contraction and formation.
Researchers from Imperial College London have used a new technique called 'optical clearing' to image adult heart tissue in 3D, revealing intricate networks of tiny blood vessels and collagen scaffold. This breakthrough could help doctors monitor the spread of stiff scar tissue and track patient responses to treatments.
The study sheds light on the functions of sweat gland components, revealing key roles for myoepithelial cells and nerve interactions. The findings have implications for treating disorders of the perspiratory system and could lead to new treatments for heatstroke.
Researchers have developed a new technique to image the inner structure of organs and tumors, revealing the extracellular matrix in unprecedented detail. This breakthrough has significant implications for cancer research, organ regeneration, and tissue engineering.
Recent developments in biofabrication can potentially regenerate cartilage and treat joint damage. Biofabrication allows for the generation of complex living structures using digital medical images as blueprints.
Scientists propose Induced Cell Turnover (ICT) to coordinate endogenous cell ablation with replacement cell administration. This method aims to manually vacate niches for new cells to engraft, minimizing the formation of scar tissue and promoting controlled turnover of aged tissues.
Researchers at Wyss Institute have enhanced Organs-on-Chips technology to monitor cell health and electrical activity, enabling the study of human organ physiology and potential drug responses. The new design allows for real-time assessment of trans-epithelial electrical resistance and electrical activity of living cells.
Scientists at the University of Basel have developed a procedure that allows binding single gold atoms to polymer chains on silicone membranes. This enables the formation of ultra-thin conductive layers on silicone rubber, opening up new possibilities for medical implants.
Researchers at UC Davis have successfully grown lab-grown tissue similar to natural cartilage, demonstrating its potential to treat joint disease. The new material exhibits similar composition and mechanical properties as native cartilage, showing great promise for implantation into damaged joints.
This study evaluated the effects of fluoride bleaching agents on human enamel. It found that fluorine bleaching agents increased the concentration of fluorine, calcium, and phosphorus ions in the enamel without altering its microhardness.
A new handheld scanner allows for non-invasive imaging of skin layers and blood vessels in psoriasis patients, enabling the assessment of disease severity and potential treatment options. The technology has the potential to improve diagnosis and therapy of other diseases such as skin cancer and diabetes.
A team of researchers at the University of Gothenburg has developed a method to generate cartilage tissue by printing stem cells using a 3D-bioprinter. The resulting cartilage is extremely similar to human cartilage, with properties and structures identical to those found in natural cartilage.
A new method called Bone CLARITY enables the observation of stem cells within intact bones, facilitating research into osteoporosis and bone interactions with other organs. Researchers used this technique to test a new drug developed for treating osteoporosis, revealing increased stem cell proliferation in response to the treatment.
Researchers at KU Leuven have successfully grown three-dimensional cultures of the endometrium in a laboratory dish, shedding light on the monthly menstrual cycle and its regulation by female hormones. The new technique enables the study of diseases such as endometrial atrophy and cancer, as well as drug discovery and screening.
Researchers at Columbia University have developed a new optical microscopy platform with drastically enhanced detection sensitivity, allowing for simultaneous labeling and imaging of up to 24 specific biomolecules. This breakthrough has the potential to transform understanding of complex biological systems, including the human cell map...
Researchers developed organoids that resemble human brain structure, investigating rare congenital brain defect Miller-Dieker syndrome. The study reveals disrupted stem cell division leading to poor organization and early differentiation of nerve cells.
Researchers at the University of Wisconsin-Madison have developed a novel technology using decellularized plant husks to create three-dimensional scaffolds for human stem cells. The scaffolds are made from cellulose and exhibit properties such as strength, rigidity, porosity, and surface area that are ideal for biomedical applications.