Articles tagged with Tissue Structure
The Wake Forest Institute for Regenerative Medicine has been awarded a five-year, $24 million grant from the US Department of Health and Human Services to advance its lung-on-a-chip technology. The funding will be used to model the effects of chlorine gas on human lungs and develop treatments for resulting injuries.
Researchers at the University of Münster have developed a new technique that combines two methods to improve the spatial resolution of mass spectrometry imaging. This allows for better understanding of disease processes and potential new strategies for treating them. The technology uses dual-beam laser mass spectrometry, enabling the s...
Researchers at VCU University identified a fundamental factor in maintaining stable multicellular structures: the LINC complex. The study found that disrupting this complex's mechanical properties can lead to rapid cell movement, abnormal division, and collapse of tissue structures.
Researchers develop a high-resolution printing method to create complex tissue shapes in a biocompatible hydrogel containing stem cells. The resulting tissue can be vascularized by adding endothelial cells, enabling the creation of functional bioprinted organs with unprecedented speed and design freedom.
New research published in PNAS reveals that human epithelial cells form fractal-like branching structures under certain conditions, mirroring the self-assembly of particles suspended in a liquid. This discovery sheds light on tissue formation and cellular behavior.
Researchers at McGill University used computer simulations and microscopy to show that pectin and cellulose play a crucial role in sculpting epidermal leaf cells. The study suggests that mechanical forces drive plant cell growth, leading to unique shapes like the jigsaw puzzle-like pattern of leaf skin.
Researchers have developed a new 3D bioprinting technique using rapid changes in pH to create complex collagen-based cardiac structures. The method, called FRESH v2.0, can print tissue architectures up to 10 micrometers resolution and accurately reproduce patient-specific anatomical structures.
Researchers from Stevens Institute of Technology have identified two brain regions vulnerable to side hits that lead to concussions. The study reveals how rotational accelerations cause mechanical vibrations in these regions, resulting in tissue and cell damage. This knowledge can help develop safer sports helmets.
A team from Kyoto University found that collagen in the skin is organized in a mesh-like structure, with elastic fibers following the same orientation. This discovery has significant implications for understanding skin pliability and could lead to breakthroughs in skin grafts and transplantation.
Researchers found a redundant network of proteins connecting embryonic cells, enabling tissues to fold into correct shapes even when individual cells are damaged. This discovery sheds light on the robustness of embryonic development and may help understand birth defects like spina bifida.
Researchers at Rutgers University have developed a technique to assemble proteins into fractal shapes that resemble flowers, trees, or snowflakes. This innovation could lead to new technologies such as bioremediation filters and synthetic matrices for studying human disease and tissue engineering.
A team of researchers found a peculiar tooth composition in great white sharks and their relatives, which is similar to that of the fossil shark Palaeocarcharias stromeri. The shared tooth histology indicates that this small shark gave rise to one of the most iconic shark lineages.
A new scaffold derived from a pig's meniscus has shown promise in repairing torn meniscus tissue. In lab tests, repairs aided by the scaffold resulted in stronger meniscus repairs after four weeks compared to natural healing.
Researchers have developed a process for 3D printing biological tissues without scaffolds using stem cells in a hydrogel bead bath. The printed cells form stable connections and mature into functional tissues, offering potential applications in tissue engineering and regenerative medicine.
Recent advances in stem cell biology have enabled long-term culturing of organotypic intestinal or hepatic tissues derived from tissue-resident or pluripotent stem cells. Organoids can recapitulate the in vivo architecture, functionality, and genetic signature of the corresponding tissue.
Patients who underwent face transplants experienced significant improvements in motor function and sensory perception, with a notable trend towards enhanced quality of life. The study's findings support the potential benefits of this surgery for patients with severe facial injuries.
Researchers are developing a top-down lithography method to create complex tissues and their anatomical microstructures. This approach uses light sheet illumination and special hydrogels to form branched chain structures that serve as a matrix for cell colonization.
Researchers at the University of British Columbia have developed a specialized microscope that can diagnose diseases like skin cancer and perform precise surgery without cutting skin. The technology uses ultrafast infrared lasers to scan tissue quickly and selectively treat diseased structures.
Researchers have developed a method to print complex vascular networks in biocompatible hydrogels using food dye #5, mimicking the architecture of biological tissues. This breakthrough has significant implications for tissue engineering and organ transplantation.
Researchers have successfully grown 3D paper organs with artificial blood vessels that can be populated with cells, providing a more complex structure than traditional 2D cell cultures. The paper organs can mimic the architecture of real tissues, influencing how cells grow and respond to external stimuli.
A team of scientists measured the puncture performance of viper fangs using a custom-built machine. The study found that the angle of the fang's tip contributes most to its sharpness, with narrower tips performing better than wider ones.
Researchers discovered female bottlenose dolphins have well-developed clitorises with erectile tissue similar to humans. The location of the clitoris near the vaginal opening suggests it can be easily stimulated during copulation.
Scientists use tiny needles and electric current to reshape cartilage without cutting or suturing. By electrolyzing water in the tissue, they reduce charge density and make the cartilage more malleable, allowing for precise shaping.
Researchers created biocompatible structures on the basis of chitin obtained from crab shells through mechanochemical synthesis. The resulting structures can be used to replace damaged soft tissues in the human body, and have been shown to be biodegradable and non-toxic.
The Slide-seq technique generates detailed three-dimensional maps of tissues, revealing the location and activity of cell types and genes. This platform offers unparalleled views of tissue function, allowing researchers to study cellular relationships, gene expression, and responses to perturbations.
Pelvic organ prolapse is a debilitating disorder that affects half of all women over 50. Researchers at Virginia Tech hope to address the problem through new tissue models and surgical mesh grafts. The goal is to develop treatment approaches that are patient-specific, reducing the risk of complications such as pain and infection.
Researchers created a bioreactor to study heart tissue's mechanics in sync with the body's beats, revealing changes in force similar to those observed in living hearts. The device allows for adjustment of contraction parameters to mimic normal or disease conditions, enabling studies on high blood pressure's effects on heart cells.
Researchers at KAUST created a library of fluorescently marked, GPR-1-overexpressing strains to interrogate gene function and study transgenerational epigenetic inheritance. This tool allows scientists to generate worms with recoded genomes for synthetic biology applications.
Researchers at the University of Sheffield have developed a new method to protect concrete from fire damage using recycled tire fibers. The fibers reduce spalling and strengthen steel reinforcements, preventing collapse and structural failure.
Researchers developed sensors to map cell-generated forces in 3D tissues, finding that small tensions can balance large compressive loads. This insight could help understand developmental processes and develop novel tissue-engineering strategies.
Scientists found that sponges hollow out and take over reef skeletons to protect themselves from predators, using chemical and mechanical techniques. Ocean acidification enhances this process, making it possible to predict future coral reef conditions more accurately.
Researchers at NC State University have created 3D-printed flexible mesh structures that can be controlled with applied magnetic fields while floating on water. The structures can also mimic the properties of water striders and have potential applications as soft robots or tissue scaffolds.
Researchers created a self-curving cornea by molding cells to form a desired shape, mimicking the natural cornea. The 4D tissue structure was achieved through innovative cell actuators that forced surrounding tissue to move in a predetermined manner.
Russian scientists developed a new method to study biomechanical changes in tissues after laser surgery, improving the accuracy and safety of eye surgeries. The method uses optical coherence tomography (OCT), which visualizes tissue structure by infrared light scattering, to quantify mechanical properties changes before and after laser...
Scientists develop acoustic tweezers capable of independently levitating a range of small-sized objects using sound waves. This technology offers several advantages over optical tweezers, including the ability to penetrate biological tissue safely and non-invasively, making it ideal for cell manipulation applications.
Researchers found that collagen fibrils in mammalian tissues become stronger and tougher when repeatedly stretched and relaxed. This discovery has significant implications for understanding tissue mechanics and designing better biocompatible materials for wound healing and tissue growth.
Researchers developed a mathematical model showing that two types of cellular asymmetry govern the shaping of cells into sheets and tubes. Altering one polarity can simulate diverse shapes, with initial cell arrangement and external boundaries influencing outcomes.
Scientists have made fruit flies transparent using a new clearing method, allowing for high-resolution imaging of complex neural networks. This breakthrough enables the study of the connectome and behavior of Drosophila melanogaster, with potential applications in understanding neurodegenerative diseases.
A team at Kyoto University has discovered that individual cells sense and modulate themselves to form the spherical shape of the eye through a process called self-bending. This phenomenon generates a hinge that pushes cells into the cup-like structure, resulting in the formation of an optic cup.
Researchers designed proteins that snap together spontaneously to form long, helical structures, mimicking natural protein filaments. The creation of these self-assembling filaments could lead to the development of new materials, including fibers stronger than spider silk and nano-scale wire circuitry.
Engineers at the University of Colorado Boulder have developed a 3D printing method that allows for fine-grain control over rigidity, enabling the creation of complex geometries similar to those found in blood vessels. This technology could lead to personalized treatments for hypertension and vascular diseases.
Karen Kasza, a researcher at Columbia Engineering, has won a Packard Fellowship for her work on understanding tissue development and morphology. Her lab aims to use novel approaches to engineer functional tissues for medical applications.
Researchers at Oak Ridge National Laboratory are providing critical geospatial data to support first responders in disaster scenarios. They use novel computing techniques to extract meaningful information from satellite images, enabling FEMA to prioritize damage assessments and recovery operations.
A team of researchers has created a breakthrough in 3D bioprinting by integrating oxygen-sensitive nanoparticles into gel materials, enabling real-time monitoring of metabolic activity and microenvironment of cells within living structures.
The Cluster of Excellence PoL aims to understand the organization of living matter and its mechanisms. The researchers hope to shed light on tissue formation and structure, which will provide solutions to pressing bioengineering and health issues.
Kyungsuk Yum and his doctoral student Amirali Nojoomi developed a process to program 2-D hydrogels for space- and time-controlled swelling and shrinking, enabling the formation of complex 3-D shapes and motions. The technology has potential applications in bioinspired soft robotics and artificial muscles.
Researchers at Toyohashi University of Technology have discovered a new ultrasonic wave phenomenon that enables precise and nondestructive detection of fatigue and early damage in thin plate materials. This technology surpasses conventional methods, allowing for accurate evaluation of material damage even before it occurs.
Scientists at Kyoto University have discovered a protein, AIP1, that plays a crucial role in regulating cell arrangement during wing development in fruitflies. The study reveals how cells sense and respond to tissue tension, which is essential for shaping tissues like wings.
Researchers develop 3-D tissue culture models to study host-microbe interactions and combat infectious diseases. The models mimic native tissues and offer valuable insights into mechanisms of infection, aiding in the design of effective vaccines and therapeutic agents.
New research reveals that low-severity burns weaken soil structure, increasing risk of erosion, while also releasing organic carbon into the atmosphere, contributing to climate change. Soils in burned areas show deteriorating physical properties over weeks and months.
Researchers used state-of-the-art techniques to measure cell forces and stresses in zebrafish embryos, discovering a fundamental physical mechanism for shaping embryonic tissues. This finding provides insight into human health issues like cancer formation and organ engineering.
A study published in PLOS ONE found that the jaw joint bone structure of carnivorans is more closely related to their body size than their diet. Researchers used 3D printing and CT scans to analyze the mandibular condyle, a key joint in the jaw, and discovered no significant correlation between diet and jaw joint strength or complexity.
Brigham and Women's Hospital researchers have developed a method to bioprint complex tubular structures that mimic native vessels and ducts in the body. The 3D bioprinting technique allows for fine-tuning of printed tissues' properties, enabling potentially viable replacements for damaged tissue.
A study published in Cell found that cells in a three-dimensional environment divide chromosomes correctly, while those in a two-dimensional environment make mistakes. This discovery could help explain why chromosome errors are common in cancerous cells.
Researchers have developed a new class of endoscopic imaging catheters that overcome the limitations of current systems, achieving higher resolution and functionality. The nano-optic endoscope incorporates metalenses into its design, enabling high-resolution imaging at extended depth of focus without complex optical components.
Researchers at the University of Bristol have developed a new experimental protocol to create synthetic fossils in the lab. This method uses sediment filtration to mimic the conditions of deep burial and has successfully preserved soft tissues, including feathers and leaves, similar to exceptional fossils. The findings offer insights i...
Scientists led by George C. Tsokos discover that inhibiting CaMK4 can prevent podocyte damage in lupus-prone mice, reversing classical dogma on inflammation causing kidney damage. The finding opens doors to potential new therapies for autoimmune and non-autoimmune diseases impacting the kidneys.
This study evaluated perioral soft tissue changes after orthognathic surgery using 3D CT scans. Significant post-operative changes were observed in nasolabial and mentolabial angles, while lip width remained unchanged.
A recent study published in eLife discovered that altered collagen structure leads to tissue stiffness during lung fibrosis progression. The researchers identified a compound that blocks LOXL enzymes, which can prevent tissue stiffening and limit fibrosis. This finding suggests new treatment approaches for lung fibrosis.
Researchers have developed a new approach for studying Cryptosporidium using lung and intestinal organoids, which support the complete life cycle of the parasite. This tool enables the testing of drugs and identification of vaccine candidates, providing hope for developing effective treatments.