Articles tagged with Tissue Structure
A team from UNIGE demonstrates that cells can self-organize to generate forces that model the shapes of our tissues. Topological defects create cellular tornadoes that concentrate forces and shape tissues similar to those observed in embryo development.
Researchers used energy dispersive diffraction to create high-resolution 3D maps of bioapatite arrangements within shark centra, revealing key structures and their functions. The study provides insights into the structure-function relationship of the shark skeleton and could be applied to other organisms.
Researchers have designed a nanoparticle system that can deliver fluorescent dyes to diagnose and treat pancreatic cancer tumors. The system overcomes the challenge of reaching cells deep within dense tumor masses, enabling detailed images of tumor structures and potentially targeted therapies.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
A team of researchers at Kumamoto University successfully created complex 3D kidney tissue in the lab using mouse embryonic stem cells. The breakthrough could lead to advances in kidney research and potentially even transplantable organs.
Researchers found that the oral plug, a structure in fin whales, blocks the pharynx and prevents water from entering during lunge feeding. This allows the whale to swallow prey while keeping the respiratory tract protected.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
A team of researchers has identified a mechanical process by which sheets of cells morph into complex shapes, enabling organs to function. The process involves the production of hyaluronic acid, which swells with water and is constrained by thin connectors between cells.
Researchers demonstrate an innovative chemical method to engineer diverse layered hydrogels with wet and slippery properties, suitable for tissue-like models, soft robots, and intelligent devices. The UV-SCIRP method enables the efficient construction of complex hydrogel patterns and non-flat arbitrary-shaped objects.
Researchers developed a method to print skin equivalents with three layers, allowing for complex structures and faster healing. The technique uses suspended layer additive manufacturing and has shown promising results in repairing pig tissue.
Researchers developed a new kind of organoid that grows both heart and gut cells together, mirroring their cooperation in embryonic development. This breakthrough could improve understanding of tissue communication and inform research into congenital disorders.
Researchers at Lehigh University are working on a project funded by the Good Food Institute grant to adapt human tissue engineering techniques for growing meat in the lab. The team is developing a scaffold for meat cells to grow on and using electrochemistry, nanomaterial design, and liposomal delivery vehicles to promote fibrous growth.
Duke researchers developed a method to increase the depth of view of optical coherence tomography (OCT), allowing for clear images from beyond a millimeter beneath the skin's surface. The new technique, known as dual-axis OCT, tilts the light source and detector to collect more scattered light from deep tissues.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
Researchers develop new technique DASP, which uses spherical viscoelastic bio-ink particles to create porous 3D structures. The technology has the potential for human islet transplantation to treat type 1 diabetes.
A lung model mimicking complex anatomy has enabled the assessment of respiratory volumes using a gas-in-scattering-media absorption spectroscopy (GASMAS) technique. The study demonstrates the feasibility of GASMAS to sense changes in gas volume in a controlled environment, paving the way for potential clinical applications.
Optical coherence tomography (OCT) has significant growth potential across various medical applications, including cardiology and dermatology. Miniaturized OCT systems are expected to revolutionize healthcare with compact, mobile, and cost-effective devices.
A team of researchers has found a 390-million-year-old hyper-facet eye system in trilobites that is unique to the animal kingdom. The discovery suggests that this ancient eye may have been an adaptation for life in low light conditions, and could provide insights into the evolution of visual systems.
Researchers developed a WC-20CrC-7Ni coating with high anti-cavitation resistance, extending the life of aquatic environment mechanisms. The coating's fine structure increases surface area, requiring more energy for crack formation. This innovation can protect critical equipment parts in power engineering, metallurgy, and shipbuilding.
Researchers reconstructed the oldest known form of roots in a 407-million-year-old plant fossil, revealing a complex branching system that differed from modern plants. This discovery provides insight into the evolution of early land plants and their impact on the environment.
Researchers developed a pollen-based hybrid ink that can be used to fabricate parts useful for tissue engineering, toxicity testing and drug delivery. The ink is biocompatible, flexible and low in cost, allowing for the creation of customized flexible membranes tailored to human skin contours.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
The researcher is investigating the inflammatory responses produced by exposure to chemical agents, comparing different chemical exposures at both whole-body and tissue levels. The study aims to develop a common treatment for chemical exposures and diagnose the responsible chemicals.
Researchers from FAU Harbor Branch adapted Structure-from-Motion photogrammetry to generate 3D models for tracking lesion progression and impacts on diseased coral colonies. The study found that stony coral tissue loss disease prevalence varied significantly across location, but not through time.
Researchers developed gel drops from four amino acid peptides that support cell growth and induce blood vessel formation. The microgels were successfully used to grow endothelial cells on their surfaces, which then extended into tubular blood vessels.
Researchers found a regulatory cell type, mesenchymal cells, control liver regeneration through cell-to-cell contacts. The study suggests that the wrong number of contacts between populations can lead to cancer or chronic liver diseases.
Researchers created a 3D view of diseased lung tissue using microCT to reveal that TB granulomas are complex and branched, with unique connections to airways. This has significant implications for treatment, including the potential for aerosolized drug delivery to reduce treatment times.
A national survey reveals a pronounced lack of needed skills in the regenerative medicine biomanufacturing workforce, highlighting key findings and recommendations to address this gap. The study suggests five strategies for developing the workforce ecosystem, including faculty development opportunities, work-based learning, and policy ...
Researchers have developed 3D-printed tissue scaffolds that degrade harmlessly while promoting tissue regeneration. The scaffolds showed excellent biocompatibility and the ability to support cell migration, ingrowth of tissues, and revascularisation.
A NIST-led study comparing 27 MRI scanners found significant bias and variation in T1 measurements, which can affect diagnosing brain tumors. The study recommends establishing rigorous quality control procedures for quantitative MRI to promote confidence and stability in measurement techniques.
Researchers at Northwestern University and Shirley Ryan AbilityLab have discovered that muscles lose sarcomeres -- their smallest building blocks -- after a stroke. This loss results in shorter muscle fibers and tighter muscles, making it harder for patients to regain function.
The study used live tissue imaging to show that cell migration drives the growth of the mammary bud, while ring cells exert contractile force through the actomyosin network. This novel mechanism for invagination may be essential for developing organs.
Researchers found significant correlations between brain capillary curvature and neurite thickness radius in schizophrenia patients, but not between capillary diameter and neurite thickness. The study suggests neurovascular abnormalities contribute to schizophrenia.
Researchers at UC San Diego developed a high-throughput 3D bioprinting technology that can produce 96-well arrays of living human tissue samples in just 30 minutes, accelerating preclinical drug screening and disease modeling. This could potentially reduce the time and cost associated with drug development.
A new 3D bioprinting technique uses multicompartmental bioprinting to direct cell orientation within deposited hydrogel fibers. The method provides favorable environments for cell proliferation and morphological cues to guide cell alignment.
A team of researchers developed a unique scaffolding material for engineered tissues that can be fine-tuned to mimic natural tissue properties. This allows for the creation of customized replacement skin, cartilage, or other tissue for patients, with potential applications in regenerative medicine and tissue engineering.
Researchers used ground surveys and Damage Proxy Maps from NASA satellites to assess structural and façade damage in Beirut after the 2020 explosion. Satellite-based maps were effective at identifying severely damaged buildings but less effective for intermediate damage levels.
Researchers discovered a new molecule, K162, that inhibits beta-amyloid toxicity and protects neurons from damage. The study provides hope for alternative therapeutic strategies against Alzheimer's disease.
Researchers from Niigata University used 3D imaging to analyze the morphology of the human uterine endometrium and adenomyotic lesions. The study reveals a unique plexus network structure in the basal glands, which is detected in all samples regardless of age or menstrual cycle phase.
Researchers developed a hyaluronic acid hydrogel system to stabilize damaged cartilage, pausing its degeneration and promoting the formation of a protective barrier. The therapy was shown to enhance healing and restore regular activity to chondrocytes in lab tests.
Scientists have developed a new microscopy technique that can acquire 3D super-resolution images of subcellular structures deep inside biological tissue, including the brain. This breakthrough enables researchers to study subtle changes in neurons over time, during learning, or as a result of disease.
Fish can have scaled, armoured or naked skin; researchers found that only naked fish can develop a bony armour. The protective state of their skin influenced their choice of open water or sea floor habitats.
A study analyzing tornado wind speed and size data from 120 events found that stronger and wider tornadoes exist than damage-based estimates indicated. The median peak wind speeds were around 60 m/s, sufficient for Enhanced Fujita scale ratings of 2-3.
Researchers have successfully generated lab-grown mini-thyroid organs from patients' own thyroid tissue, which can produce thyroid hormones. The study provides a potentially unlimited source of lab-grown thyroid tissue and may lead to new therapy options for hypothyroidism.
A single human cranium discovered in an Italian cave reveals evidence of ancient funerary treatment and transportation. The skull, dated to the Eneolithic period between 3630-3380 BC, shows signs of lesions indicating removal of soft tissues during a funeral ritual.
Researchers at the University of Illinois Chicago have developed new 4D hydrogels that can change shape in response to external trigger signals. These materials may help create tissues with more realistic architecture by simulating forces that drive movement during development, leading to improved tissue engineering outcomes.
The study found that breast cancer cells switch between two distinct states: mesenchymal and amoeboidal, which are influenced by tissue fiber alignment. The level of fiber alignment is crucial in determining the progression of breast cancers. Understanding this mechanism can help predict and treat metastatic disease.
Researchers at OHSU have developed a new method to quickly map single-cell genomes and clarify spatial cell positions within complex tissues. This technique has the potential to precisely identify and target cells in diseases like cancer or stroke, allowing for novel therapies.
Researchers create synthetic biomaterials mimicking tendon structure and strength through freeze-casting and salting-out processes. The new hydrogels show promise for temporary wound closure, long-term tissue replacement, and wearable medical device coatings.
Researchers developed novel hydrogel-based 4D materials that can change shape in response to physiological stimuli, supporting high cell densities and mimicking natural tissue development. These materials have potential for bioengineering blood vessels, organs, and studying biological processes involved in early development.
Scientists have mapped the structure of neuropil, a fundamental type of brain tissue organization, in C. elegans using innovative melding of network analysis and imaging strategies. The study revealed four layers with distinct domains for processing sensory information and motor behaviors, providing insights into how the brain integrat...
Researchers at Purdue University have developed tissue-engineered components to support larynx reconstruction after cancer or trauma. The implants utilize customized engineered tissue replacements with dynamic muscle component fabricated from patient's own cells.
Researchers used a novel 3D microscopy technique to study crownlike structures in adipose tissue, finding they are actually concentric spheres surrounding an empty core. This discovery may lead to new treatments for obesity-related diseases like type 2 diabetes and cardiovascular disorders.
Researchers at KAUST have developed custom polymer dots that emit ultrabright light in the shortwave infrared region, allowing for high-resolution imaging of structures deep within biological tissues. This breakthrough enables detection of nano-sized particles and single molecules with single-molecule sensitivity.
Researchers from Carnegie Mellon University developed a new 3D-bioprinting approach, FRESH, which enables advanced tissue fabrication by holding bioinks in place until they are cured. This method solves the distortion problem of soft and liquid bioinks, enabling the creation of functional adult-sized tissues and organs.
A team of researchers has proposed a new composite foundation system using inexpensive polymeric materials to protect structures sitting on deep foundations. The novel technique uses geotextile layers to isolate the building from the ground, reducing impact of large ground deformations due to fault rupture.
Researchers found that neuron structures differ between brain areas and individuals, with variations in shape and curvature affecting cognitive functions. The study used nanotomography to analyze brain tissue samples from 34 schizophrenia and 4 control cases.
Researchers from Peter the Great St.Petersburg Polytechnic University developed a polymer carrier that can load different sizes and structures of genetic material, including siRNAs and mRNAs. The efficiency of delivery was demonstrated on human stem cells, offering new horizons for non-viral delivery systems.
Researchers developed an in vitro human-derived tissue model to study SARS-CoV-2 infection and its progression to ARDS. The model revealed a cellular immune response to the virus, indicating potential for effective treatment with interferon lambda.