Articles tagged with Trypanosoma
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Researchers at EMBL Grenoble identified significant differences between the trypanosomal and human nuclear cap-binding complex, a key player in cellular RNA metabolism. The study reveals major differences that could serve as a potential drug target for treating neglected tropical diseases.
Researchers have discovered that climate change and tsetse fly control measures can drive molecular changes in African trypanosomes, enabling them to infect animals without flies. New strains with reduced life cycles have been detected in Asia, South America, and southern Europe.
Researchers found that infected individuals with multiple strains of the T. cruzi parasite were better able to control the disease, while those with a progressive form had fewer strains. This discovery provides a new framework for developing more effective treatments and vaccines.
Molecular biologists Ruslan Afasizhev and Inna Afasizheva have discovered the architecture of molecular machines involved in RNA editing in a disease-causing parasite. This understanding could potentially help treat African sleeping sickness, which is usually fatal and has limited treatment options.
Researchers at IOCB Prague have determined the first cryo-EM structures of a surface receptor of Trypanosoma brucei gambiense in complex with human complement factor C3. This discovery sheds light on how the parasite avoids clearance from the human bloodstream and survives within the immune system.
Researchers at Karolinska Institutet have mapped the formation of hybrid strains in Trypanosoma cruzi, a parasite causing chronic infection and severe symptoms. These hybrids are more effective at evading the immune system and causing disease, but understanding their formation can help develop new diagnostic and treatment methods.
A new mechanism has been discovered that decorates the end tails of RNA molecules in a parasite causing sleeping sickness, preventing their degradation and potentially increasing virulence. This fundamental discovery opens new avenues for treatment strategies for this disease, as well as other RNA-based infections/diseases.
Researchers found that Chagas trypanosomes change the bacterial community in predatory bugs' intestines, leading to a decrease in diversity and an increase in certain pathogenic bacteria. The study also identified four bacteria species crucial for bug survival, which could be used to develop defensive substances against the parasite.
Scientists have identified a promising vaccine target for animal African trypanosomiasis (AAT), a disease causing significant economic impact on livestock in Africa and South America. The vaccine candidate showed long-lasting protection against infection in mice, offering a potential solution to the devastating effects of AAT.
Researchers at CNRS have identified a novel protein, KSRP, specific to the ribosomes of trypanosome parasites. Inhibiting its activity leads to parasite death. This discovery opens the path to developing new, safer therapies for Chagas disease and African sleeping sickness.
Researchers have identified a promising therapeutic target for African trypanosomiasis, also known as sleeping sickness. The newly discovered TbALPH1 enzyme triggers the degradation of messenger RNA and is unique to the parasite's biology.
A team of researchers discovered that the parasite Trypanosoma brucei has an internal clock, enabling it to adjust its composition and functions according to the day-night cycle. This finding could lead to more efficient treatment with chronotherapy, a concept already applied in other diseases.
A study published in PLOS Neglected Diseases reveals that Chagas disease has a significant presence in the Rio Grande Valley of Texas, affecting up to 30% of those infected with Trypanosoma cruzi developing fatal cardiomyopathy. The research estimates 4,600 people are currently infected and 1,300 at risk for cardiac disease.
Researchers discovered that Trypanosoma brucei parasites can sense their environment, exchange messages, and coordinate movements when seeded onto a surface. This social behavior opens up new avenues for understanding other supposedly solitary parasites like those responsible for malaria and epidemic diarrhea.
Researchers identified BILBO1 as crucial for Flagellar Pocket formation in trypanosomes. The protein is essential for the structure's functions, including endo- and exocytosis. Inhibition of BILBO1 function is fatal to the parasite.
A novel form of trypanosomiasis has been identified in India, resulting from a deficiency in apolipoprotein L-1. Analysis revealed that the patient's serum lacked the protein's trypanolytic activity, which normally destroys parasites.
The sequencing of three deadly parasite genomes has revealed a core of 6,200 genes in common among the parasites, providing new targets for drug development. This discovery also highlights the potential for designing targeted vaccines and improved diagnostics for each parasite.