Articles tagged with Tumor Tissue
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
Researchers at the University of South Australia have developed a new way to deliver chemotherapy drugs, using liposomal formulations that target tumors more effectively. This breakthrough could improve treatment outcomes for thousands of cancer patients, reducing side effects and improving quality of life.
Moffitt researchers have identified key genomic alterations and potential therapeutic targets in transformed cutaneous T-cell lymphoma. The study, which analyzed 56 patient samples, found high tumor mutation burden and UV mutation signatures associated with survival outcomes. The research also uncovered novel therapeutic vulnerabilitie...
Researchers have designed a nanoparticle system that can deliver fluorescent dyes to diagnose and treat pancreatic cancer tumors. The system overcomes the challenge of reaching cells deep within dense tumor masses, enabling detailed images of tumor structures and potentially targeted therapies.
A recent study led by University at Buffalo researchers found that photobiomodulation reduces inflammation, improves blood flow and heals wounds up to 19 days faster. Light therapy accelerated skin healing from cancer radiation therapy by an average of 49-42 days.
Researchers at Northwestern University have developed a novel microfluidic device that can efficiently harvest and sort tumor-eating immune cells from tumors. This technology has shown dramatic results in shrinking tumors in mice compared to traditional methods.
Researchers found that zika virus injections destroyed brain tumors in mice and reduced tumor size in cerebral organoids, with immune cells alerting the system to its existence. This approach opens up prospects for virotherapy treatment of central nervous system tumors.
Researchers at UCSF identify unique immune microenvironments in different types of cancer, paving the way for personalized immunotherapies. The study categorizes tumors into 12 groups based on their immune profile, suggesting that some cancers share similar characteristics despite being from different types.
Scientists have observed that ionizing radiation can cause intermolecular Coulombic decay in organic molecules, leading to damage in DNA and proteins. This new understanding could lead to the development of more effective substances for radiation therapy and improve knowledge of how radiation damages healthy tissue.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
Researchers compared genetic expression profiles of canine acanthomatous ameloblastoma and human oral tumor ameloblastoma, finding similarities in molecular mutations. The study lays groundwork for potential translational medicine, as the dog model may represent a useful clinical model of the disease.
Researchers at Children's Hospital of Philadelphia have developed a novel therapy that targets proteins essential for tumor growth and survival. Using a multi-omics approach, they identified peptides unique to neuroblastoma tumors, which are then targeted by peptide-centric chimeric antigen receptors (PC-CARs).
Researchers at Shinshu University discovered a new type of amyloidosis associated with duodenal neuroendocrine tumors that produce somatostatin. Laser microdissection and liquid chromatography-tandem mass spectrometry techniques were used to identify the amyloid formation.
A multi-center study demonstrated improved overall survival and quality of life for inoperable pancreatic cancer patients treated with MRIdian SMART, with a median survival of 26 months. The treatment showed low rates of major adverse events and was more effective than standard radiation therapy.
Researchers developed two model systems to study peritoneal metastases from colorectal cancer patients. Biomarkers were identified, including severe mutations of the BRCA2 gene, which predict therapy response. These findings offer new hope for treating advanced cases.
Scientists developed a fluorescent spray that specifically targets and illuminates cancerous tissue, enabling precise tumor detection and removal during surgery. The innovative approach offers a solution to the challenge of distinguishing between healthy tissue and cancerous cells.
Researchers created polymersomes that target highly invasive cancer cells, delivering anticancer drugs and preventing metastasis. The nanomachines showed strong antitumor effects in breast cancer models, inhibiting lung metastasis and prolonging survival.
Researchers have developed a new cancer photodrug that can treat deep-seated tumors more effectively and with reduced toxicity. Copper cysteamine photosensitizers allow the production of reactive oxygen species to kill cancer cells, minimizing damage to healthy cells.
Researchers at Karolinska Institutet developed an AI-based tool to improve breast cancer diagnosis and predict recurrence risk. The method divides patients with grade 2 tumours into high-risk and low-risk sub-groups, enabling personalized treatment.
Scientists use modern imaging technology to determine liver cancer subtypes, identifying specific sugar structures that correlate to different subtypes. This approach could lead to earlier detection and more personalized therapies for hepatocellular carcinoma.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.
Researchers have developed a new photodynamic tumor therapy that works for deep tumors, eliminating the need for external irradiation. The 'intelligent' drug consists of four components linked into a single molecule that brings its own light source and switches it on in acidic tumorous tissue.
Researchers from St. Petersburg Electrotechnical University LETI propose a novel approach to cancer treatment using magnetic nanoparticles for targeted drug delivery. The method aims to minimize cytostatics' toxic effects on healthy tissues while maximizing accumulation in tumor tissue.
High-intensity focused ultrasound (HIFU) technology is being explored for its potential to destroy cancerous tumours while minimizing damage to healthy tissue. Researchers at the University of Waterloo have made significant progress in understanding how HIFU works on a cellular level, paving the way for future clinical trials.
Researchers at Tel Aviv University successfully printed the first entirely active and viable glioblastoma tumor using a 3D printer. The 3D-bioprinted model includes functional blood vessels that simulate a real tumor, making it a promising tool for predicting treatment efficacy and drug development.
Researchers at Massachusetts General Hospital uncover key factors that enable immune cells to survive in tumor environments, including the chemokine CXCL16. This understanding may lead to more effective immunotherapies for cancer patients.
Researchers at UB aim to reduce unwanted toxicity in cancer treatments by combining antibody-drug conjugates with payload-binding selectivity enhancers. The five-year study may lead to safer and more effective treatments for 1.8 million US cancer patients.
Researchers at St. Jude Children's Research Hospital have developed a more accurate laboratory model for studying retinoblastoma, a rare pediatric eye cancer. The models closely mimic the biology of patient tumors and provide an important resource for studying the earliest stages of the disease as well as screening new therapies.
Researchers at UTA are developing a new diagnostic tool for small breast tumors, using nanoparticles and ultrasound to detect temperature differences in the body. The technique has the potential to reduce anxiety and costs associated with biopsy procedures, while also improving treatment outcomes.
Scientists at Princess Máxima Center developed a new imaging technique to study millions of cells in 3D tissue, revealing hundreds of features from each individual cell. The technique helps analyze molecular profiles and cell shape, potentially improving diagnosis and treatment for children's cancers.
A team of researchers from KTH Royal Institute of Technology has developed a novel nanoparticle design that enhances the contrast of living tissues for X-ray fluorescence imaging. This breakthrough enables early stage tumor detection with lower doses of radiation.
Researchers discovered that head and neck cancer cells subvert adjacent normal tissue to promote aggressive invasion and metastasis. The study found that two proteins secreted by cancer cells suppress a key gene, DMBT1, in nearby healthy tissue.
Researchers at the University of Zurich have developed a new technology called SHREAD that enables cancer tumors to produce therapeutic agents on demand, reducing side effects and improving delivery of Covid-related therapies.
Research reveals CABYR-a/b and CABYR-c proteins are expressed in a subset of colorectal cancers, making them potential targets for specific immunotherapy. The study found that these proteins are highly expressed in 70% of patients with relative expression ratios over 1.
Researchers have developed a six-color imaging platform inspired by mantis shrimp eyes to accurately label tumors in mice and visualize lymph nodes near breast cancer tumors. The system detected cancerous tissue in 92% of cases and successfully integrated into the operating room without disrupting surgeons' workflow.
A new optical diffraction tomography technique allows for high-resolution imaging of thick tissue sections without chemical staining, increasing diagnostic speed and accuracy. The method has been demonstrated to visualize individual cells and multicellular tissue architectures with subcellular resolution.
Researchers at Brigham and Women's Hospital have developed personalized, 3D-printed shields to shield patients undergoing radiation therapy. The device can reduce tissue injury by up to 15% in the gastrointestinal tract for prostate cancer patients, and by up to 30% in the mouth for head and neck cancer patients.
A new type of ultrasound scan, shear wave elastography, has been shown to detect residual cancerous tissue in the brain more sensitively than traditional methods. The technique, which measures tissue stiffness and stretchiness, could improve surgical outcomes and reduce the risk of tumor recurrence.
Specialized proteins called cadherins join forces to make cells stick together, forming bonds 30 times stronger than individual strengths. This discovery could lead to more life-like artificial tissues and tumor-busting drugs.
Researchers discovered that human tumours contain solid and fluid cell clusters, enabling cancer cells to move and multiply. The study's findings could lead to improved cancer diagnosis and therapy, with potential applications in detecting metastatic cancer cells.
Researchers developed a new X-ray imaging scanner that provides surgeons with a full 3D image of extracted tissue lumps, allowing for improved detection of diseased tissue. This technology has the potential to significantly reduce the need for repeat operations in breast cancer patients.
A new study reveals that the behavior of p53, a key tumor-suppressor protein, over time determines whether tissues can survive radiation exposure. In vulnerable tissues, p53 levels remain high, leading to cell death, while in more radioresistant tissues, p53 levels oscillate, allowing cells to survive.
Researchers have developed a technology that uses near-infrared hyperspectral imaging (NIR-HSI) along with machine learning to visualize tumors in deep tissue and covered by a mucosal layer. The technique was tested on 12 patients with confirmed cases of gastrointestinal stromal tumors (GISTs), achieving an accuracy of 86% in identifyi...
A new technique, vocal passive elastography (V-PE), uses ultrasound imaging and singing to determine the presence of a tumor in the thyroid gland. By analyzing the speed of shear waves created by vibrations from a person's voice, researchers can measure the elasticity of surrounding tissue.
Scientists developed vanadium-doped titanium dioxide spindles that sensitize cancerous tumors to ultrasound waves, killing tumor cells without harming healthy tissue. The spindles catalyze chemical processes in the tumor microenvironment, attacking cells with sound waves and chemotherapy.
Research found that neutrophils, a type of white blood cell, cause tissue death in brain cancer tissues, leading to poor survival rates for glioblastoma patients. The study identified ferroptosis as the underlying mechanism, which promotes tumor growth.
Researchers found that cytotoxic T lymphocytes (CTLs) dig slow-moving channels through the extracellular matrix to facilitate fast movement of other CTLs. The study suggests modulating ECM properties could enhance immune response efficiency and lead to new therapeutic strategies in cancer treatment.
Cell division becomes softer and deformable in response to mechanical forces from neighboring cells, altering its orientation. This study reveals a new mechanism influencing tissue dynamics and may have implications for clinical studies.
Researchers at Massachusetts General Hospital have identified four distinct physical properties of cancer, including elevated solid stress and increased stiffness, which contribute to its sustained growth and destructive power. These findings point to new research opportunities and treatment approaches.
A new technology makes it possible to analyze all the tissue removed from a tumor in 3D without cutting, significantly increasing the reliability of diagnosis. This revolutionizes pathology and provides new insights into cancer development, potentially leading to improved treatment options.
Researchers at KIST demonstrated the mechanism behind secondary cavitation clouds generated during HIFU treatment, allowing for precise removal of target tissue. The study laid the groundwork for ultra-precision focused ultrasound technology, enabling safe and effective destruction of tumor cells without surgery.
Researchers found that certain chemotherapeutic agents can promote tissue overgrowth in normal tissues, while an innate immune signaling pathway in fibroblasts causes stem cells to proliferate. This discovery has broad implications for diseases associated with the immune system, including psoriasis and cancer.
Scientists discovered that mechanical properties of tissue elements surrounding pre-malignant cells influence the development of basal and squamous cell carcinomas, two common forms of skin cancer. The research may help predict how a tumor will evolve and lead to novel anti-cancer therapies.
Researchers propose using nanomaterials to elevate oxygen levels in tumor tissues, reducing resistance to therapies. Additionally, therapeutic gas-generating and radical-generating nanomaterials can control oxygen delivery and induce cell death, offering new avenues for hypoxic tumor treatment.
Recent research provides state-of-the-art knowledge on phosphate metabolism, shedding light on underlying mechanisms and advances in managing hypo- and hyperphosphatemia. Expert reviews highlight potential new directions for future research to benefit patients with related disorders.
Researchers biofabricated human colorectal cancer organoids to understand how tumors grow in their natural microenvironment and respond to treatments. The study replicated native tumor tissue in a laboratory model and validated its effects on whole-body physiology, paving the way for new therapies targeting the extracellular matrix.
Researchers developed an AI algorithm to analyse tissue samples from cancer patients, distinguishing between healthy and cancerous tissues and identifying patterns of DNA and RNA changes. The study highlights the potential of AI for improving cancer diagnosis, prognosis, and treatment.
Photodynamic therapy has been shown to be effective in treating localized tumors, including ovarian cancer, through the introduction of photosensitizers that selectively accumulate in tumor tissue, producing singlet oxygen and other active radicals to destroy cells.
A study by researchers at the University of Zurich mapped immune cells in different types of brain tumors, revealing tumor-specific instructions for tissue-invasive leukocytes. The findings provide a basis for developing tailored immunotherapies for various types of brain tumors.
Researchers at Tohoku University have developed a technique to visualize stiffness in soft tissues using x-rays, offering greater resolution than current methods like ultrasound and MRI. This allows for the identification of smaller and deeper tissue problems, such as lesions, which can be indicative of early-stage diseases.