Articles tagged with Tumor Tissue
Researchers discovered that cancer cells induce lung tissue inflammation, releasing signals CXCL9 and CXCL10, which aid metastasis growth. The interaction between detached cancer cells and fibroblasts is crucial for metastatic colonization.
The Beckman Institute has developed imaging techniques that capture more information about a tissue compared to traditional methods, allowing for better visualization of extracellular vesicles. These vesicles are known to increase in number and be associated with cancer, particularly breast cancer cells.
Researchers used imaging mass cytometry to analyze 35 protein biomarkers in breast cancer patients, identifying four subcategories of the disease with varying molecular profiles. This breakthrough has the potential to change clinical practice by enabling precision medicine and personalized treatment approaches.
Researchers at North Carolina State University have discovered a high prevalence of Bartonella bacteria in hemangiosarcoma tumors and non-tumor tissues from dogs. The study confirms the link between persistent infection and some types of cancer, highlighting Bartonella's ability to remain undetected within tissue.
A new non-invasive imaging technique using 89Zr-immuno-PET can measure target engagement of therapeutic antibodies in tumors, enabling personalized treatment. This method provides a significant advance over current invasive methods and has important implications for patient care.
Scientists at Peter the Great Saint-Petersburg Polytechnic University create a method of targeted drug delivery to cancer cells using microcapsules made of polymeric compounds and gold nanorods. The technology allows for precise treatment of tumors without harming healthy tissues.
A study published in SPIE Journal of Biomedical Optics found that diffuse reflectance spectroscopy can reliably discriminate between healthy tissue and tumor tissue, regardless of neoadjuvant chemotherapy status. The technique's feasibility for tumor-margin assessment during breast-conserving surgery has been demonstrated.
Researchers have developed a new technology that uses high-voltage pulsed electric fields to extract RNA and proteins from tissues, enabling minimally invasive molecular profiling of tumors. This method shows promise for improving diagnostics and treatment decisions.
Researchers discovered a modified protein in benign-appearing meningiomas that can reveal which are truly benign and which are more dangerous. The finding may inform the discovery of drugs to treat these tumors more effectively.
Research found that KLK6 overexpression induces HMGA2 expression in colon cancer cells, contributing to CRC progression and metastasis. High KLK6 scores were linked to disease recurrence, suggesting its potential role as a biomarker.
Researchers developed a consistent theoretical interpretation of ion beam energy deposition in liquid water jets, crucial for simulating interactions with human tissue. The new model allows for precise targeting of tumors while minimizing damage to adjacent normal tissue.
Stevens researchers create technology to detect skin lesions and determine if they are cancerous or benign using millimeter-wave radiation. The device could reduce unnecessary biopsies by 50% and disrupt the $5.3 billion diagnostic market for skin cancer.
Researchers develop a new imaging technology that uses laser light to distinguish between cancerous and healthy tissues during surgery, potentially eliminating the need for secondary surgeries. This innovation has the potential to save time, money, and anxiety in cancer treatment, while also reducing the economic burden of healthcare.
Two new studies published in Pediatric Blood and Cancer and Acta Oncologica demonstrate the potential benefits of proton therapy for children with brain cancer. Proton therapy shows promising outcomes in improving overall survival and recurrence-free survival rates, particularly in young patients. Additionally, a new technique called p...
Researchers propose focusing high-energy particle beams on small spots deep inside the body to target cancerous tumors precisely, reducing dose to surrounding tissue. The study aims to improve radiotherapy effectiveness and reduce costs using ultra-compact laser-wakefield accelerators.
Researchers at Champalimaud Centre for the Unknown discovered a cell-competition mechanism called fitness fingerprints that allows cancer cells to disguise themselves as healthy cells. By blocking this mechanism, they found that tumour growth can be slowed down, but not eliminated.
Researchers developed a reusable device using carbon dioxide to power a cancer tissue-freezing probe, eliminating the need for expensive argon and anesthesia. The tool shows promise in reducing complications and increasing accessibility to breast cancer treatment in lower-income countries.
A new artificial nose technology helps neurosurgeons identify cancerous tissue during brain tumor surgery by analyzing surgical smoke. The system achieved an accuracy of 83% in classifying samples from brain tumors, with improved performance for low-malignancy tumours.
A study analyzing over 7,000 tumors and normal samples reveals two simple patterns related to NAD production, a biomolecule essential to metabolism. Cancer cells' reliance on specific pathways for NAD production can be exploited with targeted therapies, offering new avenues for treating cancer.
Researchers have uncovered a new set of rules that predict how the tissue of origin influences tumor genetic makeup, with potential implications for targeted cancer therapies. The study found that cancer cells are addicted to specific NAD synthesis pathways, making them vulnerable to targeted interventions.
Researchers at the University of Otago and Indian Statistical Institute have discovered distinct epigenetic markers in oral cancer tissues that are associated with patient survival. The findings, published in the journal Epigenomics, could help save thousands of lives by identifying cancer cells early.
Researchers developed a method to distinguish tumor margins from healthy tissues using bright spot analysis in confocal microscopy. The technique showed promise in differentiating glioblastoma tumors from surrounding brain tissue and has potential applications for tumors without 5-ALA-derived red fluorescence.
Researchers analyzed methods of targeted drug delivery to malignant tumors, exploring passive targeting, active targeting, and cell-mediated targeting. By understanding tumor structure and metabolism, scientists can develop personalized treatment approaches to increase efficiency and reduce side effects.
Researchers developed a new model predicting proton beam effects on tumour and normal tissue more precisely, allowing for effective treatment plans. The study replaced traditional radiobiological models with complex ones, showing improved results for low-energy beams.
New research shows that rapidly dividing cells fuse their mitochondria, increasing oxygen consumption and producing aspartate for cell replication. This process may have implications for cancer diagnosis and treatment.
A new assay can identify patients with lung cancer and quantify PD-L1 expression levels using small, unfixed tissue samples collected via minimally invasive bronchoscopy. This approach can guide therapeutic decisions and potentially save time and money.
Biomedical engineers at Duke University have developed a new photoacoustic imaging technique that can quickly and accurately measure the temperature of deep tissues. This breakthrough has significant implications for thermal-based therapies in cancer treatment.
A review paper highlights the transformative potential of precision and personalized medicine for cancer treatment. The traditional approach focuses on general treatments, while PPM allows for individualized treatments tailored to specific tissues and gene mutations.
Researchers have developed a novel portable optical imaging system that enables real-time visualization of tumor microenvironment in human breast tissue shortly after surgery. The system provides molecular features of breast cancer tissue, allowing for more accurate diagnoses and tracking of tumor progression.
Researchers have identified a molecular mechanism that allows tumor cells to eliminate their neighbors through mechanical competition. The study found that compressed cells are killed by modulated EGFR/ERK signal, which is decreased and then leads to cell death. This discovery suggests a potential therapeutic strategy to halt tumor growth
A study found a correlation between oral cancer progression and the abundance of specific proteins in tumor tissue and saliva. The discovery offers a new parameter for predicting disease progression and may help guide treatment choices.
Researchers at Lund University identified three types of connective tissue cells that affect breast cancer development and metastasis. Patients with vascular fibroblasts or matrix fibroblasts in their tumours have a worse prognosis.
Scientists have developed a new system to rapidly and accurately detect tumor margins during breast cancer surgery, using a 'click-to-sense' acrolein probe that conjugates with live breast cancer cells. The method has been shown to be highly sensitive and selective, with a 97% accuracy rate.
Researchers at SLAC and Stanford are developing accelerator-based technology to reduce the side effects of cancer radiation therapy by vastly shrinking its duration. The goal is to blast cancer cells quickly, reducing the chance that radiation will hit and damage healthy tissue around tumors, making radiation therapy more precise.
Researchers at Karolinska Institutet found that high-risk HPV-positive tumours had a significantly higher five-year relative survival rate of 74% compared to hrHPV-negative tumours at 54%. The presence of high-risk HPV was also associated with earlier detection and improved socioeconomic status.
Researchers at NUST MISIS and University of Calgary create method to monitor virus spread and immune system response in real-time using intravital microscopy. This breakthrough enables visualization of virus behavior in tissues and organs of living animals.
Researchers have developed a new method using TOF-SIMS to map the flow of biomolecules in and around solid tumors. This technique reveals how tumors signal to their microenvironment and sap local tissue resources.
A new microscope system can image living tissue in real time and molecular detail, allowing for the study of concurrent processes within cells and tissue. This technology has the potential to track tumor progression and improve cancer diagnosis.
A new laser-sonic scanner developed by Caltech researchers can detect tumors in the breast in just 15 seconds, providing higher-resolution images than traditional mammography. The technology uses near-infrared light to create detailed images of internal structures without exposing patients to X-ray radiation or discomfort.
A team of researchers has developed a device called SpiderMass that enables surgeons to analyze tissue samples in real-time, potentially speeding up cancer surgery. The device uses mass spectrometry and a new ionization strategy to detect protein biomarkers, which could help identify stray cancer cells faster.
A study published in Developmental Cell found that a signal from the tumor necrosis factor (TNF) signaling molecule Eiger reduces tension in tissue barrier cells, allowing immune cells like macrophages to pass through more easily. This mechanism was previously unknown and has potential importance beyond fruitflies to vertebrates.
A recent study published in Biomaterials found that stiffer breast tissue creates an environment more prone to cancer. Cancer cells can manipulate surrounding healthy cells to their own benefit, favoring tumor growth in stiff tissues.
Researchers have developed next-generation contrast agents that can be turned off using ultrasound, allowing for clearer MRI scans. The new technology relies on nanoscale structures called gas vesicles, which bounce back sound waves and react differently to magnetic fields.
Researchers have developed a novel technique that enables them to visualize biological targets in deep tissues without damaging tissues or labeling with fluorescent molecules. The method, which uses selectively guided light waves, overcomes the limitations of current optical imaging techniques.
A new approach to analyzing prostate gland tissue uses cellular metabolites to differentiate between aggressive and less aggressive tumors. The study found that metabolite levels can predict tumor grade, stage, and recurrence risk, helping guide treatment strategy.
Researchers from Cincinnati Children's Hospital Medical Center and Yokohama City University report a high-volume production method for bioengineered human gut and liver tissues that avoids tumor risks. The new approach uses genetically stable posterior gut endodermal progenitor cells, which can be programmed to form different tissue ty...
Researchers at Lobachevsky University have synthesized a multifunctional compound with anti-tumor properties, achieved through the combination of a photoactive organic dye, biological vector, linker, and hydrophilizing fragments. The new compound selectively accumulates in tumor tissues due to its ability to bind to growth factor recep...
A Korean research team developed a world-first multimodal biomicroscopic system to analyze tumor characteristics and improve cancer resection techniques. The system combines optical multispectral imaging, high-frequency ultrasound, and radiation force imaging to detect tumors at high resolution.
Scientists improve photothermal properties of bismuth sulfide nanorods by adding gold nanodots, increasing heat generation in tumor cells under near-infrared light irradiation. This leads to enhanced inhibition of tumor growth with no toxic side effects.
A new study proposes a way to directly observe predicted ion-induced shock waves, which can help optimize ion-beam cancer therapy. Shock waves contribute to thermomechanical damage in tumour tissue, increasing the volume of cells exposed to reactive species.
A pilot study shows that fluorescent imaging with antibody cetuximab can specifically distinguish cancer from normal tissue in patients with glioblastoma. The technique allows surgeons to visualize tumors more clearly, potentially leading to better progression-free survival.
A team of researchers from the University of Texas at Austin has created an accurate and efficient method to characterize gliomas, the most common and aggressive type of primary brain tumor. Their system combined biophysical models with machine learning algorithms to analyze Magnetic Resonance imaging data, achieving top results in a c...
Scientists developed a handheld probe, MasSpec Pen, for non-destructive cancer diagnosis within minutes. The device analyzes tissue samples using tiny volumes of water, identifying tumors with high sensitivity and specificity.
Healthy skin cells have been found to actively correct tissue flaws created by cancerous cells, eliminating tumors in mouse models. The study highlights the importance of normal cells in maintaining tissue health and functionality.
A study by researchers at the Center for Genomic Regulation reveals that mistakes made by a DNA spellchecker can lead to cancer mutations. The findings suggest that high levels of alcohol and exposure to sunlight can shift the balance of DNA repair mechanisms, causing errors in critical parts of the genome.
Researchers have developed a new technique to image the inner structure of organs and tumors, revealing the extracellular matrix in unprecedented detail. This breakthrough has significant implications for cancer research, organ regeneration, and tissue engineering.
Researchers found that DNA methylation analysis can predict cancer versus normal tissue with over 95% accuracy, identifying metastases with 97% correctness. This method could improve outcomes by providing more accurate diagnoses, particularly for indolent or aggressive tumors.
Scientists have developed a bioorthogonal labeling approach to identify sialylated glycoproteins in prostate cancer tissue, which could serve as tumor markers. The method allows for direct assessment of tumor metabolism in its natural environment, providing insights into cancer biology.
Researchers analyzed tissue contraction to determine surgical margins for feline tumors, finding that current guidelines are often inadequate. The study suggests that more precise preoperative planning can lead to better outcomes and reduced morbidity for affected cats.
A University of Zurich study analyzed archived tissues from dog mammary tumors to understand breast carcinoma in both species. The researchers found that tumor cells reprogram healthy cells, promoting tumor growth, a mechanism also observed in human breast carcinoma.