Articles tagged with Tumor Tissue
Researchers at Johns Hopkins Medicine found no evidence of cytomegalovirus (CMV) infection in tumor tissues from 125 patients with aggressive brain cancers. The study suggests that targeting the virus may not be effective in treating glioblastoma and other high-grade gliomas, which are common primary brain cancers in adults.
Researchers created functional microtissue technology that mimics human drug responses, identifying effective anti-cancer drugs. The vascularized micro-tumor platform accurately targets both tumor cells and vessels, offering a breakthrough in cancer treatment
Researchers identified LATS as a key player in breast cancer development and treatment. The enzyme's absence leads to increased luminal precursor cells, which can give rise to tumors, and stabilized proteins YAP and TAZ that boost cell proliferation.
Research at the University of Iowa shows that high-dose vitamin C selectively kills cancer cells by generating hydrogen peroxide, a reactive oxygen species. Cancer cells with low catalase activity are more susceptible to damage and death when exposed to high amounts of vitamin C.
UT Southwestern Medical Center researchers developed a nanosensor that amplifies pH signals in tumor cells, distinguishing them from normal cells. The sensor helps surgeons see tumors better during surgery, potentially improving survival and quality of life for cancer patients.
Researchers found that female sex hormones activate immune cells, damaging nerves necessary for vision in children with a rare genetic disorder. Blocking these hormones or suppressing specific immune cells may help save eyesight.
A new optical fiber probe can distinguish between cancer and normal tissues in real-time, allowing for more precise removal of cancerous tissue during surgery. This technology has the potential to reduce the need for additional surgeries to remove leftover cancer.
Necroptosis is a crucial physiological process that regulates cell death and tissue function. Researchers have now found that RIPK1 inhibits another inducer of necroptosis, ZBP1, which triggers inflammation when mutated. This study provides new insights into the regulation of necroptosis and its role in chronic inflammatory diseases.
La Jolla Institute for Immunology researchers have developed a new method to inactivate specific genes in immune cells using enhancer targeting. This approach allows for the precise deletion of genes in one cell type while leaving others intact, opening up new possibilities for targeted therapies.
A significant proportion of macrophages are distributed to tissues before bone marrow function starts, maintaining themselves through stem cell-like renewal. Embryonic-derived macrophages regulate iron metabolism and the growth of the mammary gland in adults.
Researchers develop a system to selectively destroy undifferentiated pluripotent stem cells (PSCs) using a special dye and light. This approach reduces the risk of teratomas, allowing for safer transplantation and potential treatments for various diseases.
Researchers discovered that tumors in fruit flies always originate from specific regions of epithelial tissue, which also occurs in humans and other animals. This finding may lead to a better understanding of cancer development and the discovery of potential treatments.
Researchers at RIT and Rochester Regional Health are advancing thermal imaging techniques for detecting early-stage breast cancer. The collaboration aims to increase the accuracy of screening using a potentially safer and less invasive diagnostic tool.
Three Syracuse University physicists are using a $686,000 NSF grant to study the dynamics and interactions of cancer cells and develop a better understanding of tumor behavior. Their research aims to shed light on tissue behavior, cell segregation, and cell escape.
A new method called MICSSS helps characterize human cells involved in immune responses at the tissue site, before and after treatment with immunotherapy. This technique enables views of co-expression of markers on the same cells while sparing material from tissues.
Researchers at Case Western Reserve University have discovered that analyzing image features from adjacent benign tissues to tumor areas can provide an early warning for patients at higher risk of biochemical recurrence. This study may lead to doctors making decisions sooner about follow-up therapies or more regular monitoring.
A team of Tokyo Tech and UEC researchers developed a luciferin analog, AkaLumine-HCl, that produces near-infrared bioluminescence with improved tissue-penetration efficiency. This allows for highly sensitive deep-tissue imaging in animal experiments, including lung cancer models.
Researchers at the University of Birmingham successfully trained breast cancer patients to achieve single prolonged breath holds of over five minutes, enabling targeted radiotherapy to be administered in just one dose. This breakthrough could improve long-term survival and quality of life for breast cancer patients.
Researchers have developed an oxygen-independent photo-switchable molecule that attacks tumor tissue without oxygen, reducing side effects of conventional photodynamic therapy. The molecule, GS-DProSw, has been tested successfully on animal models and shows promise as a potential anti-tumor agent.
Researchers at Kazan Federal University and the National Academy of Sciences of Ukraine have identified correlations between superoxide, nitric oxide levels and matrix metalloproteinase activity in gastric cancer patients. This discovery could lead to more accurate diagnostics and personalized treatment plans for stomach cancer.
Researchers have developed a method that uses laser pulses to identify brain tumors without labeling or staining, providing histological detail comparable to conventional techniques. The technique allows for fast and accurate diagnosis in the operating room, potentially enabling real-time tumor detection before surgery.
Researchers at Caltech demonstrate that nanoparticles can selectively target tumors while leaving adjacent healthy tissue intact. The study's findings suggest the presence of the EPR effect in humans, which could lead to more effective cancer therapies with fewer side effects.
Scientists have identified a new gene, GT198, that causes breast cancer and can be used to diagnose the disease early. The gene is normally regulated by estrogen but becomes mutated when it causes rapid growth of cancer cells.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf are exploring the use of high-powered lasers to accelerate ions for cancer treatment. By accelerating ions to therapeutic energies in a short time, they can deposit most of their energy inside tumors while leaving healthy tissue unharmed.
A new study reveals that mandatory tumor tissue requirements in clinical trials delay treatment and reduce patient enrollment. Trials without these requirements show faster treatment initiation and higher enrollment rates.
Vestibular schwannomas cause hearing loss by secreting toxic molecules like TNFa, which damages the inner ear. The study provides a new mechanism for sensorineural hearing loss in these tumors.
Researchers used a novel approach to measure the forces exerted by tumor cells on their surrounding connective tissue. By analyzing tissue deformations, they calculated cell forces with high accuracy, revealing key insights into tumour cell migration and behaviour.
A dominant evolutionary theme emerges to predict cancer clinical outcomes, with tumors trending toward a more primitive ESC state having a worse prognosis. This study analyzed global gene expression profiles from 107 cells types and over 3,000 tumors, demonstrating the robustness of this pattern across various solid tumor cancers.
A new hand-held probe using optical coherence tomography (OCT) technology has been found to correlate well with traditional pathologists' diagnoses in a clinical study, enabling reliable real-time guidance for surgeons. The device can identify differences between cancer cells and normal tissue with high sensitivity and specificity.
Researchers at Brigham and Women's Hospital have developed a new technique to analyze specific hormones in tissue, allowing surgeons to distinguish tumor from normal gland. The technique, called MALDI MSI, can determine hormone composition in under 30 minutes, potentially improving surgical precision.
Researchers at Institut Pasteur successfully inhibit enzyme DPP4 to increase T lymphocyte infiltration into tumors, leading to efficient cancer cell destruction. This innovative treatment combines with existing immunotherapies to eradicate tumors in mice.
A new DNA blood test can identify EGFR mutations in lung cancer patients without accessible tumor tissue, showing an 89% agreement rate with tissue testing. The test's sensitivity was found to be around half of that of traditional tissue testing.
Women with very low breast tissue density experience shorter disease-free survival and overall life expectancies compared to those with high-density breasts. A six-year follow-up study of 270 breast cancer patients found that lower breast tissue density is an independent poor prognostic factor for breast cancer.
Researchers have developed nanocarriers that selectively release drugs in lung tumor areas, improving treatment efficacy by 10-25 times compared to traditional methods. This approach also reduces the total dose of medicines, minimizing undesirable effects.
A new imaging system has been invented to guide cancer surgery, allowing surgeons to detect malignant tissue in real-time. The system uses a fluorescent dye that localizes in tumors and a handheld laser to visualize tumor boundaries, reducing the risk of cancer recurrence.
Researchers found that up to 45% of breast tumors exhibit genetic alterations affecting the CYP2D6 gene, leading to distorted patient genotypes. This has significant implications for tamoxifen therapy, which relies on accurate CYP2D6 testing to guide treatment.
Researchers found high concordance (94%) between EGFR mutations in plasma-derived ctDNA and tumor tissue in NSCLC patients. This suggests that a single plasma sample may be sufficient for mutation status assessment when tumor tissue is unavailable.
Researchers at Caltech have developed a new technique called PARS that allows for whole-body clearing of tissue, enabling the study of individual cells and fine structures. This breakthrough has significant implications for disease diagnosis and development research.
Researchers at the University of Pennsylvania have developed a new technique to help surgeons see the entire tumor during surgery, increasing the likelihood of a positive outcome. The approach uses an injectable dye that accumulates in cancerous tissues, allowing surgeons to remove the entire malignancy.
Researchers at Cold Spring Harbor Laboratory have discovered a new function of the body's most important tumor-suppressing protein, p53. A previously unknown variant of p53 called p53-psi reduces cell adhesion and promotes metastatic potential by interacting with cyclophillin D and generating reactive oxygen species.
Researchers at PTB have developed an experiment to measure the stopping power of tissue for carbon ions, which will improve dosing for cancer therapy. The study found that carbon ions are less strongly stopped in liquid water than in water vapour.
A Purdue-designed tool uses mass spectrometry to analyze brain tumor tissue, providing color-coded images that reveal the location and nature of tumor cells. The tool has been successfully used in two surgical procedures, offering a significant improvement over current methods.
As women age, their breast cells lose responsiveness to their surroundings, leading to increased tumor growth and higher risk of breast cancer. Researchers at Berkeley Lab discovered that multipotent progenitor cells, responsible for maintaining healthy tissue, fail to perceive differentiation cues as they age.
A new nanoparticle called Cu-Cy has been discovered to slow tumor growth in lab studies when combined with X-ray exposure. The treatment shows promise as a more efficient and cost-effective alternative to existing photodynamic therapy methods.
UCSF researchers found that breast tissue stiffening in cancer development leads to tumor progression, triggering the production of a molecule associated with worse clinical outcomes. The discovery may lead to more accurate prognosis and new treatment strategies targeting structural changes in breast cancers.
Researchers at ETH Zurich have developed hot nanoparticles that can kill tumour tissue with heat by absorbing near-infrared light. The particles are coated with a silicon dioxide layer and aggregate in a way that allows them to absorb light and generate heat.
A team of scientists created wearable technology that helps surgeons visualize cancer cells by making them glow blue, reducing the need for follow-up surgeries and associated costs. The innovation uses a custom video display, head-mounted device, and targeted molecular agent to distinguish cancer cells from healthy tissue.
Researchers developed a method using Raman spectroscopy to distinguish normal brain tissue from brain tumor tissue, achieving up to 99.5% accuracy in distinguishing between the two. The technique has the potential to improve outcomes for patients undergoing surgery to remove glioblastoma multiforme (GBM), a deadly type of brain tumor.
Researchers at LMU identified ZNF281 as a critical factor in colon cancer metastasis, driving the transition from epithelial to mesenchymal cells. The protein's inhibition prevents metastasis in mice, suggesting a potential therapeutic strategy for colon cancer treatment.
Researchers aim to create a system that acquires data from various sensors during surgery and integrates it with pre-operative information to produce dynamic, real-time maps. This will enable surgeons to work more easily and safely, while also enabling the robot to assist in semi-automating surgical sub-tasks.
Researchers found that a 3-week radiotherapy course is comparable to the traditional 5-week treatment in terms of tumour control rates. The study also revealed reduced damage to healthy tissue and fewer hospital visits with the shorter treatment schedule.
Researchers at the University of Nottingham have developed a highly accurate prototype technique to detect cancerous tissue during surgery. This technique can produce detailed maps of tissue rich in information at the molecular level, enabling fast and objective diagnosis of cancer cells.
Researchers have developed a new imaging technology, SRS microscopy, that allows surgeons to distinguish between brain tissue and tumors at a microscopic level. This technique can guide surgeons in the operating room and potentially improve surgical outcomes for patients with glioblastoma multiforme.
Researchers have developed a new laser-based technology that can distinguish between cancerous and healthy brain tissue in real-time during surgery. This could lead to better outcomes and longer survival rates for patients with glioblastoma multiforme, the most deadly type of brain tumor.
A team of Johns Hopkins graduate students has designed a device to inspect breast tissue in real-time, reducing the need for follow-up surgeries. The device applies an adhesive film to the tissue, preventing damage and allowing pathologists to quickly review samples within 20 minutes.
A new software toolkit combines deformable anthropomorphic models with precision dosimetry to determine the most effective cancer-killing dose for every patient. This approach enables personalized radionuclide drug therapies, leading to improved outcomes and better survival rates.
Scientists have designed nanoparticles that can flip from a sphere to a net-like structure in response to tumor signals, accumulating at the site of cancer. This new approach aims to target treatments specifically to diseased cells, overcoming current limitations.
The new system uses micro-robotics to provide surgeons with a better view of bladder tumors, allowing for more accurate diagnoses and easier tumor removal. The device can operate in challenging environments and has been shown to have sub-millimeter precision.
Researchers discovered a calcified ovarian teratoma in a Roman-age skeleton, shedding light on the presence of this tumour in antiquity. The tumour contained four anomalous teeth and a small bone fragment, providing valuable information for the study of ancient diseases.
A University of Colorado Cancer Center study found that SPARC acts as an anti-inflammatory drug, reducing tumor growth and metastasis in bladder cancer. The protein is produced by healthy tissue to mute tumors, but aggressive cancers suppress its production, leading to faster disease progression.